Aliases for FAIM2 Gene

Aliases for FAIM2 Gene

  • Fas Apoptotic Inhibitory Molecule 2 2 3 4 5
  • TMBIM2 2 3 4
  • NMP35 2 3 4
  • LFG2 2 3 4
  • LFG 2 3 4
  • Transmembrane BAX Inhibitor Motif-Containing Protein 2 3 4
  • Neural Membrane Protein 35 3 4
  • Protein Lifeguard 2 3 4
  • KIAA0950 2 4
  • Transmembrane BAX Inhibitor Motif Containing 2 2
  • NGP35 3
  • FAIM2 5

External Ids for FAIM2 Gene

Previous GeneCards Identifiers for FAIM2 Gene

  • GC12M050517
  • GC12M050316
  • GC12M049977
  • GC12M048546
  • GC12M050260
  • GC12M047291

Summaries for FAIM2 Gene

GeneCards Summary for FAIM2 Gene

FAIM2 (Fas Apoptotic Inhibitory Molecule 2) is a Protein Coding gene. Diseases associated with FAIM2 include Ventilation Pneumonitis and Obsessive-Compulsive Disorder. Among its related pathways are CASP8 activity is inhibited. An important paralog of this gene is TMBIM1.

UniProtKB/Swiss-Prot Summary for FAIM2 Gene

  • Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

Additional gene information for FAIM2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAIM2 Gene

Genomics for FAIM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAIM2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049902 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 633.1 +1.5 1501 4.6 PRDM10 POLR2A PATZ1 ZNF600 ZBTB20 SP2 JUND CEBPB CTBP1 FOXK2 FAIM2 LINC02395 BCDIN3D
GH12J049909 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.6 -6.4 -6384 4 CREB1 ZHX2 ZIC2 PKNOX1 PATZ1 ZNF600 ZNF148 KLF9 MGA SP2 LINC02396 LINC02395 FAIM2 AQP2
GH12J049823 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.7 +77.7 77699 6.3 TEAD4 PRDM10 REST ZNF629 LEF1 IKZF1 RFX5 ZNF692 POLR2A PRDM1 BCDIN3D-AS1 SMARCD1 LMBR1L FAIM2 ASIC1 DDX23 CERS5 KMT2D TUBA1A ENSG00000272368
GH12J049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 13 +637.7 637711 6.6 CEBPG SP1 HNRNPL CREB1 PRDM10 ZNF629 REST TFE3 IKZF1 KDM1A TUBA1C ENSG00000258101 DDX23 KMT2D KANSL2 CCNT1 BCDIN3D ENSG00000271547 LMBR1L SMARCD1
GH12J049055 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.6 +845.7 845714 6.7 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 TFE3 RFX1 SIX5 DDX23 LMBR1L ENSG00000271547 KANSL2 KMT2D CCNT1 SENP1 BCDIN3D PRPF40B PARK7P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAIM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAIM2

Top Transcription factor binding sites by QIAGEN in the FAIM2 gene promoter:
  • GCNF
  • GCNF-1
  • GCNF-2
  • Hlf
  • LCR-F1
  • Pax-5
  • Pbx1a
  • RelA
  • RP58

Genomic Locations for FAIM2 Gene

Genomic Locations for FAIM2 Gene
37,322 bases
Minus strand
37,322 bases
Minus strand

Genomic View for FAIM2 Gene

Genes around FAIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAIM2 Gene

Proteins for FAIM2 Gene

  • Protein details for FAIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein lifeguard 2
    Protein Accession:
    Secondary Accessions:
    • A8K1W6
    • B3KR08
    • Q9UJY9
    • Q9Y2F7

    Protein attributes for FAIM2 Gene

    316 amino acids
    Molecular mass:
    35110 Da
    Quaternary structure:
    • Interacts with FAS/TNFRSF6 and BAX.
    • Sequence=AAF06327.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA76794.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FAIM2 Gene


neXtProt entry for FAIM2 Gene

Post-translational modifications for FAIM2 Gene

  • Glycosylation at Asn191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FAIM2 Gene

Domains & Families for FAIM2 Gene

Gene Families for FAIM2 Gene

Protein Domains for FAIM2 Gene


Suggested Antigen Peptide Sequences for FAIM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33409 fis, clone BRACE2010598, highly similar to Fas apoptotic inhibitory molecule 2 (B3KR08_HUMAN)
  • Transmembrane BAX inhibitor motif-containing protein 2 (FAIM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BI1 family. LFG subfamily.
  • Belongs to the BI1 family. LFG subfamily.
genes like me logo Genes that share domains with FAIM2: view

Function for FAIM2 Gene

Molecular function for FAIM2 Gene

UniProtKB/Swiss-Prot Function:
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
UniProtKB/Swiss-Prot Induction:
Regulated by the AKT1/LEF1 pathway in breast cancer cell lines.

Phenotypes From GWAS Catalog for FAIM2 Gene

genes like me logo Genes that share phenotypes with FAIM2: view

Animal Models for FAIM2 Gene

MGI Knock Outs for FAIM2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAIM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAIM2 Gene

Localization for FAIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAIM2 Gene

Cell membrane. Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAIM2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
endoplasmic reticulum 3
golgi apparatus 3
nucleus 2
extracellular 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAIM2: view

Pathways & Interactions for FAIM2 Gene

PathCards logo

SuperPathways for FAIM2 Gene

SuperPathway Contained pathways
1 CASP8 activity is inhibited
genes like me logo Genes that share pathways with FAIM2: view

Pathways by source for FAIM2 Gene

1 BioSystems pathway for FAIM2 Gene

Gene Ontology (GO) - Biological Process for FAIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia IEA --
GO:0006915 apoptotic process IEA --
GO:0021549 cerebellum development ISS --
GO:0021680 cerebellar Purkinje cell layer development ISS --
GO:0021681 cerebellar granular layer development ISS --
genes like me logo Genes that share ontologies with FAIM2: view

No data available for SIGNOR curated interactions for FAIM2 Gene

Drugs & Compounds for FAIM2 Gene

No Compound Related Data Available

Transcripts for FAIM2 Gene

mRNA/cDNA for FAIM2 Gene

7 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAIM2

Alternative Splicing Database (ASD) splice patterns (SP) for FAIM2 Gene

No ASD Table

Relevant External Links for FAIM2 Gene

GeneLoc Exon Structure for

Expression for FAIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAIM2 Gene

mRNA differential expression in normal tissues according to GTEx for FAIM2 Gene

This gene is overexpressed in Brain - Cortex (x6.7), Brain - Frontal Cortex (BA9) (x6.0), and Brain - Anterior cingulate cortex (BA24) (x4.8).

Protein differential expression in normal tissues from HIPED for FAIM2 Gene

This gene is overexpressed in Frontal cortex (45.8) and Spinal cord (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FAIM2 Gene

Protein tissue co-expression partners for FAIM2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAIM2

SOURCE GeneReport for Unigene cluster for FAIM2 Gene:


mRNA Expression by UniProt/SwissProt for FAIM2 Gene:

Tissue specificity: Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

Evidence on tissue expression from TISSUES for FAIM2 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Skin(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with FAIM2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FAIM2 Gene

Orthologs for FAIM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAIM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAIM2 30 31
  • 99.68 (n)
(Bos Taurus)
Mammalia FAIM2 30 31
  • 91.98 (n)
(Canis familiaris)
Mammalia FAIM2 30 31
  • 90.3 (n)
(Rattus norvegicus)
Mammalia Faim2 30
  • 89.14 (n)
(Mus musculus)
Mammalia Faim2 30 17 31
  • 88.61 (n)
(Monodelphis domestica)
Mammalia FAIM2 31
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia FAIM2 31
  • 63 (a)
(Gallus gallus)
Aves -- 31
  • 76 (a)
LOC101749262 30
  • 75.56 (n)
-- 31
  • 71 (a)
(Anolis carolinensis)
Reptilia FAIM2 31
  • 74 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia faim2 30
  • 67.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4832 30
(Danio rerio)
Actinopterygii faim2a 30
  • 61.54 (n)
FAIM2 31
  • 59 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Nmda1 31
  • 34 (a)
(Caenorhabditis elegans)
Secernentea tag-120 30 31
  • 48.7 (n)
Y42H9AR.2 31
  • 35 (a)
xbx-6 31
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BXI1 31
  • 24 (a)
Species where no ortholog for FAIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FAIM2 Gene

Gene Tree for FAIM2 (if available)
Gene Tree for FAIM2 (if available)
Evolutionary constrained regions (ECRs) for FAIM2: view image

Paralogs for FAIM2 Gene

Paralogs for FAIM2 Gene

(5) SIMAP similar genes for FAIM2 Gene using alignment to 6 proteins:

  • B3KR08_HUMAN
  • F8VV65_HUMAN
  • F8W1L3_HUMAN
  • H0YIR3_HUMAN Pseudogenes for FAIM2 Gene

genes like me logo Genes that share paralogs with FAIM2: view

Variants for FAIM2 Gene

Additional dbSNP identifiers (rs#s) for FAIM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FAIM2 Gene

Variant ID Type Subtype PubMed ID
dgv815n106 CNV duplication 24896259
dgv816n106 CNV tandem duplication 24896259
dgv820e59 CNV duplication 20981092
dgv821e59 CNV tandem duplication 20981092
esv2568002 CNV deletion 19546169
esv2624094 CNV deletion 19546169
esv2745867 CNV deletion 23290073
esv2745868 CNV deletion 23290073
esv3303014 CNV tandem duplication 20981092
esv3388362 CNV duplication 20981092
esv8771 CNV gain 19470904
esv9408 CNV gain 19470904
esv9667 CNV loss 19470904
nsv1071030 CNV deletion 25765185
nsv1076390 CNV duplication 25765185
nsv1120258 CNV tandem duplication 24896259
nsv1122730 CNV deletion 24896259
nsv1125546 CNV tandem duplication 24896259
nsv1129160 CNV insertion 24896259
nsv1139657 CNV deletion 24896259
nsv1145601 CNV deletion 24896259
nsv1146546 CNV duplication 26484159
nsv522972 CNV gain 19592680
nsv525920 CNV loss 19592680
nsv558835 CNV gain 21841781
nsv558836 CNV loss 21841781
nsv832407 CNV loss 17160897
nsv952178 CNV deletion 24416366

Variation tolerance for FAIM2 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAIM2 Gene

Disorders for FAIM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FAIM2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ventilation pneumonitis
  • air-conditioner and humidifier lung
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards
Search FAIM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FAIM2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FAIM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAIM2 Gene

Publications for FAIM2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. LFG: an anti-apoptotic gene that provides protection from Fas-mediated cell death. (PMID: 10535980) Somia NV … Verma IM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4
  3. The anti-apoptotic protein lifeguard is expressed in breast cancer cells and tissues. (PMID: 20336406) Bucan V … Vogt PM (Cellular & molecular biology letters 2010) 3 4
  4. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 41
  5. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PMID: 20215397) Ng MC … Ma RC (The Journal of clinical endocrinology and metabolism 2010) 3 41

Products for FAIM2 Gene

  • Signalway Proteins for FAIM2

Sources for FAIM2 Gene