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The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]
FAF2 (Fas Associated Factor Family Member 2) is a Protein Coding gene. Diseases associated with FAF2 include Dermatitis and Neuronopathy, Distal Hereditary Motor, Type Viii. Among its related pathways are Innate Immune System and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and lipase inhibitor activity. An important paralog of this gene is FAF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18711132 |
GO:0031625 | ubiquitin protein ligase binding | IDA | 18775313 |
GO:0035473 | lipase binding | IDA | 23297223 |
GO:0043130 | ubiquitin binding | IDA | 18775313 |
GO:0055102 | lipase inhibitor activity | IDA | 23297223 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA,IDA | 23297223 |
GO:0005811 | lipid droplet | IEA,IDA | 14741744 |
GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex | IDA | 18775313 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Glucose / Energy Metabolism |
Symbol | External ID(s) | Details |
---|---|---|
VCP | ||
ABCB7 | ||
ABCD3 | ||
ABCF2-H2BE1 | ||
ABHD17B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006986 | response to unfolded protein | IEA | -- |
GO:0030433 | ubiquitin-dependent ERAD pathway | IMP | 24215460 |
GO:0030970 | retrograde protein transport, ER to cytosol | IMP | 25660456 |
GO:0034389 | lipid droplet organization | IMP | 23297223 |
GO:0043086 | negative regulation of catalytic activity | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FAF2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FAF2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FAF2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FAF2 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Faf2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Faf2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FAF2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FAF2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FAF2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | faf2 30 |
|
||
Str.16110 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | faf2 30 31 |
|
OneToOne | |
Dr.28227 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7247 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Faf 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007977 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | UBX3 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT4G10790 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0520600 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01928 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ucp10 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8928 31 |
|
OneToMany | |
CSA.4720 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1023853 | CNV | gain | 25217958 |
nsv1109748 | CNV | deletion | 24896259 |
nsv521107 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dermatitis |
|
|
neuronopathy, distal hereditary motor, type viii |
|
|
neuroschistosomiasis |
|
|
frontotemporal dementia and/or amyotrophic lateral sclerosis 1 |
|
|