Aliases for FADS6 Gene

Aliases for FADS6 Gene

  • Fatty Acid Desaturase 6 2 3 4 5
  • Fatty Acid Desaturase Domain Family, Member 6 2 3
  • EC 1.14.19.- 4
  • FP18279 3
  • FADS6 5

External Ids for FADS6 Gene

Previous GeneCards Identifiers for FADS6 Gene

  • GC17M070386
  • GC17M072873
  • GC17M068283

Summaries for FADS6 Gene

GeneCards Summary for FADS6 Gene

FADS6 (Fatty Acid Desaturase 6) is a Protein Coding gene. Among its related pathways are oleate biosynthesis. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is FADS1.

Additional gene information for FADS6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FADS6 Gene

Genomics for FADS6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FADS6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074893 Promoter 1 EPDnew Ensembl 600.7 +0.2 203 0.4 SP1 EZH2 NR2C2 GABPB1 SAFB HNF4A HNF4G EGR1 SP5 FADS6 FDXR
GH17J075010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.3 -118.5 -118463 3.9 BRCA1 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 RFX1 MRPL58 HID1 KCTD2 CDR2L FADS6 RECQL5 UNK CDK3 ATP5PD GGA3
GH17J074840 Enhancer 1.1 ENCODE CraniofacialAtlas dbSUPER 11 +51.9 51886 2.9 HNRNPL CTCF ZIC2 RBFOX2 PATZ1 REST ZNF740 ZNF600 ZNF341 ZFX piR-44944 GRIN2C FDXR FADS6 lnc-SLC9A3R1-4 TMEM104
GH17J074807 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 14.2 +85.2 85202 2.4 ZFHX2 SPI1 RCOR1 CHD2 lnc-NAT9-2 GRIN2C RAB37 FADS6 TMEM104 NAT9 CD300E KCTD2 KIF19 lnc-SLC9A3R1-4
GH17J075009 Enhancer 1 Ensembl ENCODE dbSUPER 10.8 -115.6 -115588 0.4 FOXA1 ZIC2 ZNF561 ZBTB44 ZBTB20 ZNF10 TSHZ1 ZSCAN5C OSR2 BCL11A CDR2L RNU6-362P KCTD2 ATP5PD FADS6 MRPL58 piR-56216-002 MN298678-030
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FADS6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FADS6

Top Transcription factor binding sites by QIAGEN in the FADS6 gene promoter:
  • AhR
  • AP-1
  • Arnt
  • Bach1
  • c-Fos
  • Egr-3
  • Gfi-1
  • NRSF form 1
  • NRSF form 2

Genomic Locations for FADS6 Gene

Genomic Locations for FADS6 Gene
chr17:74,877,302-74,893,803
(GRCh38/hg38)
Size:
16,502 bases
Orientation:
Minus strand
chr17:72,873,428-72,889,708
(GRCh37/hg19)
Size:
16,281 bases
Orientation:
Minus strand

Genomic View for FADS6 Gene

Genes around FADS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FADS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FADS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADS6 Gene

Proteins for FADS6 Gene

  • Protein details for FADS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9I5-FADS6_HUMAN
    Recommended name:
    Fatty acid desaturase 6
    Protein Accession:
    Q8N9I5
    Secondary Accessions:
    • Q17RQ7
    • Q6XYE1

    Protein attributes for FADS6 Gene

    Size:
    356 amino acids
    Molecular mass:
    40447 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04349.1; Type=Miscellaneous discrepancy; Note=The N-terminus contains a duplication of the repeated 'MEPTEP' sequence. It is unclear whether such duplication is due to a sequencing error or a polymorphism.; Evidence={ECO:0000305};

    Alternative splice isoforms for FADS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FADS6 Gene

Post-translational modifications for FADS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADS6 Gene

No data available for DME Specific Peptides for FADS6 Gene

Domains & Families for FADS6 Gene

Gene Families for FADS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FADS6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FADS6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59012, highly similar to Homo sapiens fatty acid desaturase domain family, member 6 (FADS6), mRNA (B4DEP0_HUMAN)
  • Fatty acid desaturase 6 (FADS6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9I5

UniProtKB/Swiss-Prot:

FADS6_HUMAN :
  • Belongs to the fatty acid desaturase type 1 family.
Family:
  • Belongs to the fatty acid desaturase type 1 family.
genes like me logo Genes that share domains with FADS6: view

Function for FADS6 Gene

Enzyme Numbers (IUBMB) for FADS6 Gene

Phenotypes From GWAS Catalog for FADS6 Gene

Gene Ontology (GO) - Molecular Function for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with FADS6: view
genes like me logo Genes that share phenotypes with FADS6: view

Animal Models for FADS6 Gene

MGI Knock Outs for FADS6:
  • Fads6 Fads6<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for FADS6

CRISPR Products

miRNA for FADS6 Gene

miRTarBase miRNAs that target FADS6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FADS6

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FADS6 Gene

Localization for FADS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FADS6 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FADS6 gene
Compartment Confidence
plasma membrane 3
peroxisome 2
endoplasmic reticulum 0
cytosol 0

Gene Ontology (GO) - Cellular Components for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FADS6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FADS6 Gene

Pathways & Interactions for FADS6 Gene

PathCards logo

SuperPathways for FADS6 Gene

SuperPathway Contained pathways
1 oleate biosynthesis
genes like me logo Genes that share pathways with FADS6: view

Pathways by source for FADS6 Gene

1 BioSystems pathway for FADS6 Gene

UniProtKB/Swiss-Prot Q8N9I5-FADS6_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Interacting Proteins for FADS6 Gene

Gene Ontology (GO) - Biological Process for FADS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FADS6: view

No data available for SIGNOR curated interactions for FADS6 Gene

Drugs & Compounds for FADS6 Gene

No Compound Related Data Available

Transcripts for FADS6 Gene

mRNA/cDNA for FADS6 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FADS6

Alternative Splicing Database (ASD) splice patterns (SP) for FADS6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for FADS6 Gene

GeneLoc Exon Structure for
FADS6

Expression for FADS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FADS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)
  • Ovary (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for FADS6 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.4), Small Intestine - Terminal Ileum (x4.9), and Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for FADS6 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FADS6 Gene



Protein tissue co-expression partners for FADS6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FADS6

SOURCE GeneReport for Unigene cluster for FADS6 Gene:

Hs.448845

Evidence on tissue expression from TISSUES for FADS6 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FADS6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FADS6 Gene

Orthologs for FADS6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADS6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FADS6 30 31
  • 98.95 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FADS6 30 31
  • 87.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FADS6 30 31
  • 84.71 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fads6 30 17 31
  • 82.35 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fads6 30
  • 81.76 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FADS6 31
  • 73 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FADS6 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FADS6 30 31
  • 70.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FADS6 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fads6 30
  • 60.48 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100538024 30
  • 62.18 (n)
CABZ01073954.1 31
  • 52 (a)
OneToOne
Species where no ortholog for FADS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FADS6 Gene

ENSEMBL:
Gene Tree for FADS6 (if available)
TreeFam:
Gene Tree for FADS6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FADS6: view image

Paralogs for FADS6 Gene

Paralogs for FADS6 Gene

genes like me logo Genes that share paralogs with FADS6: view

Variants for FADS6 Gene

Additional dbSNP identifiers (rs#s) for FADS6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FADS6 Gene

Variant ID Type Subtype PubMed ID
esv2662692 CNV deletion 23128226
esv2670185 CNV deletion 23128226
esv2677388 CNV deletion 23128226
esv3429588 CNV insertion 20981092
esv3554779 CNV deletion 23714750
esv3582911 CNV loss 25503493
esv3641248 CNV loss 21293372
esv3641249 CNV loss 21293372
esv3641250 CNV loss 21293372
esv3641251 CNV loss 21293372
nsv1142904 CNV tandem duplication 24896259
nsv457909 CNV gain 19166990
nsv518292 CNV loss 19592680
nsv576026 CNV gain 21841781
nsv833540 CNV loss 17160897
nsv952367 CNV deletion 24416366

Variation tolerance for FADS6 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FADS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FADS6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FADS6 Gene

Disorders for FADS6 Gene

No disorders were found for FADS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FADS6 Gene

Publications for FADS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for FADS6 Gene

Sources for FADS6 Gene