Aliases for FABP9 Gene

Aliases for FABP9 Gene

  • Fatty Acid Binding Protein 9 2 3 5
  • T-FABP 2 3 4
  • Testis-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein 9 3 4
  • PERF15 2 3
  • PERF 2 3
  • TLBP 3 4
  • Fatty Acid Binding Protein 9, Testis 3
  • Testis Fatty Acid Binding Protein 2
  • Testis Lipid Binding Protein 3
  • Testis Lipid-Binding Protein 4
  • FABP9 5

External Ids for FABP9 Gene

Previous GeneCards Identifiers for FABP9 Gene

  • GC00U990100
  • GC08U900525
  • GC08M082534
  • GC08M082370
  • GC08M077860

Summaries for FABP9 Gene

GeneCards Summary for FABP9 Gene

FABP9 (Fatty Acid Binding Protein 9) is a Protein Coding gene. Diseases associated with FABP9 include Esophagus Carcinoma In Situ. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is PMP2.

Additional gene information for FABP9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP9 Gene

Genomics for FABP9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FABP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J081346 Enhancer 0.7 Ensembl ENCODE 11.4 +111.1 111078 10.2 POLR2A CEBPB MAFF EP300 JUN TRIM28 ZNF143 HSALNG0066569 PMP2 FABP9 HSALNG0066567 LOC105375925 FABP5
GH08J081488 Enhancer 0.5 FANTOM5 dbSUPER 13 -27.4 -27357 0.2 CEBPB FABP9 PMP2 FABP4 lnc-FABP9-1 LOC101927118 ENSG00000253374 ENSG00000253859 FABP12
GH08J081486 Enhancer 0.3 Ensembl dbSUPER 13 -24.8 -24822 0.4 FABP9 PMP2 FABP4 lnc-FABP9-1 LOC101927118 ENSG00000253374 ENSG00000253859 FABP12
GH08J081482 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 0.4 -20.6 -20622 4 USF1 JUND JUN SPI1 FABP4 lnc-FABP9-1 IMPA1 PMP2 LOC101927118 FABP9 ENSG00000253859
GH08J081447 Promoter 0.3 EPDnew 0.4 +14.1 14120 0.1 PMP2 ENSG00000253859 FABP9 LOC101927118
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FABP9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FABP9

Top Transcription factor binding sites by QIAGEN in the FABP9 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • FOXO4
  • Gfi-1
  • LUN-1
  • POU2F1
  • POU2F1a
  • Sp1

Genomic Locations for FABP9 Gene

Genomic Locations for FABP9 Gene
chr8:81,458,253-81,461,579
(GRCh38/hg38)
Size:
3,327 bases
Orientation:
Minus strand
chr8:82,370,576-82,373,814
(GRCh37/hg19)
Size:
3,239 bases
Orientation:
Minus strand

Genomic View for FABP9 Gene

Genes around FABP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP9 Gene

Proteins for FABP9 Gene

  • Protein details for FABP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0Z7S8-FABP9_HUMAN
    Recommended name:
    Fatty acid-binding protein 9
    Protein Accession:
    Q0Z7S8

    Protein attributes for FABP9 Gene

    Size:
    132 amino acids
    Molecular mass:
    15093 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP9 Gene

neXtProt entry for FABP9 Gene

Post-translational modifications for FABP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP9 Gene

Domains & Families for FABP9 Gene

Gene Families for FABP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FABP9 Gene

InterPro:
Blocks:
  • Cytosolic fatty-acid binding protein
ProtoNet:

Suggested Antigen Peptide Sequences for FABP9 Gene

GenScript: Design optimal peptide antigens:
  • Testis-type fatty acid-binding protein (FABP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q0Z7S8

UniProtKB/Swiss-Prot:

FABP9_HUMAN :
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP9: view

Function for FABP9 Gene

Phenotypes From GWAS Catalog for FABP9 Gene

Gene Ontology (GO) - Molecular Function for FABP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP9: view
genes like me logo Genes that share phenotypes with FABP9: view

Animal Models for FABP9 Gene

MGI Knock Outs for FABP9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FABP9 Gene

Localization for FABP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP9 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP9 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FABP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FABP9 Gene

Pathways & Interactions for FABP9 Gene

genes like me logo Genes that share pathways with FABP9: view

Interacting Proteins for FABP9 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 24)
STRING Interaction Network
Selected Interacting proteins: ENSP00000368362 Q0Z7S8-FABP9_HUMAN for FABP9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FABP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP9: view

No data available for SIGNOR curated interactions for FABP9 Gene

Drugs & Compounds for FABP9 Gene

No Compound Related Data Available

Transcripts for FABP9 Gene

mRNA/cDNA for FABP9 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP9

Alternative Splicing Database (ASD) splice patterns (SP) for FABP9 Gene

No ASD Table

Relevant External Links for FABP9 Gene

GeneLoc Exon Structure for
FABP9

Expression for FABP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x45.4) and Skin - Sun Exposed (Lower leg) (x5.2).

Protein differential expression in normal tissues from HIPED for FABP9 Gene

This gene is overexpressed in Hair follicle (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP9 Gene



Protein tissue co-expression partners for FABP9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FABP9

SOURCE GeneReport for Unigene cluster for FABP9 Gene:

Hs.653176

Evidence on tissue expression from TISSUES for FABP9 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with FABP9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP9 Gene

Orthologs for FABP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FABP9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FABP9 30 31
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FABP9 30 31
  • 84.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FABP9 30 31
  • 82.58 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fabp9 30 17 31
  • 79.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fabp9 30
  • 78.54 (n)
Oppossum
(Monodelphis domestica)
Mammalia FABP9 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
Species where no ortholog for FABP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FABP9 Gene

ENSEMBL:
Gene Tree for FABP9 (if available)
TreeFam:
Gene Tree for FABP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FABP9: view image

Paralogs for FABP9 Gene

(15) SIMAP similar genes for FABP9 Gene using alignment to 1 proteins:

  • FABP9_HUMAN
genes like me logo Genes that share paralogs with FABP9: view

Variants for FABP9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FABP9 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
781143 Benign: not provided 81,461,519(-) A/G MISSENSE_VARIANT
785256 Benign: not provided 81,459,295(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FABP9 Gene

Structural Variations from Database of Genomic Variants (DGV) for FABP9 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781

Variation tolerance for FABP9 Gene

Gene Damage Index Score: 3.07; 50.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP9 Gene

Disorders for FABP9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FABP9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophagus carcinoma in situ
  • carcinoma in situ of esophagus
- elite association - COSMIC cancer census association via MalaCards
Search FABP9 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with FABP9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP9 Gene

Publications for FABP9 Gene

  1. A novel testicular protein, with sequence similarities to a family of lipid binding proteins, is a major component of the rat sperm perinuclear theca. (PMID: 7958448) Oko R … Morales CR (Developmental biology 1994) 2 3
  2. The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance. (PMID: 27779102) Al Fayi MS … Ke Y (Oncotarget 2016) 3
  3. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3
  4. Serum adipocyte-fatty acid binding protein discriminates patients with permanent and temporary body weight loss. (PMID: 18803274) Stejskal D … Bronsky J (Journal of clinical laboratory analysis 2008) 3

Products for FABP9 Gene

Sources for FABP9 Gene