The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on m... See more...

Aliases for FABP7 Gene

Aliases for FABP7 Gene

  • Fatty Acid Binding Protein 7 2 3 5
  • Brain-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein, Brain 3 4
  • Brain Lipid-Binding Protein 3 4
  • B-FABP 3 4
  • FABPB 3 4
  • BLBP 3 4
  • MRG 3 4
  • Mammary-Derived Growth Inhibitor-Related 3
  • Mammary-Derived Growth Inhibitor Related 4
  • Fatty Acid Binding Protein 7, Brain 2
  • Hypothetical Protein DKFZp547J2313 3
  • Fatty Acid-Binding Protein 7 4
  • Brain Lipid Binding Protein 2

External Ids for FABP7 Gene

Previous GeneCards Identifiers for FABP7 Gene

  • GC06P122871
  • GC06P123058
  • GC06P123035
  • GC06P123081
  • GC06P123142
  • GC06P120677
  • GC06P123100

Summaries for FABP7 Gene

Entrez Gene Summary for FABP7 Gene

  • The gene encodes a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. The encoded protein is important in the establishment of the radial glial fiber in the developing brain. Alternative splicing and promoter usage results in multiple transcript variants encoding different isoforms. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Jan 2016]

GeneCards Summary for FABP7 Gene

FABP7 (Fatty Acid Binding Protein 7) is a Protein Coding gene. Diseases associated with FABP7 include Subependymal Giant Cell Astrocytoma and Optic Nerve Glioma. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is FABP3.

UniProtKB/Swiss-Prot Summary for FABP7 Gene

  • B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Gene Wiki entry for FABP7 Gene

Additional gene information for FABP7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP7 Gene

Genomics for FABP7 Gene

GeneHancer (GH) Regulatory Elements for FABP7 Gene

Promoters and enhancers for FABP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J122778 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 536.4 +1.2 1178 4.6 YY1 TAF1 SP1 REST FABP7 SMPDL3A lnc-SERINC1-8
GH06J122797 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 +20.2 20168 4.7 FOXK2 ZBTB40 NCOR1 FOS KDM6A ZBTB25 SKI TEAD1 TBX3 ZKSCAN8 FABP7 SMPDL3A lnc-SERINC1-6 lnc-SERINC1-8
GH06J122717 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 14.9 -61.6 -61633 1.1 PKIB ENSG00000287818 FABP7 SMPDL3A ENSG00000272472
GH06J122832 Enhancer 0.8 FANTOM5 ENCODE 12.7 +53.7 53680 0.8 ATF2 OSR2 WT1 POLR2A ZNF843 ZNF18 SMARCA4 TBP ZEB2 ATF7 lnc-SMPDL3A-2 lnc-SERINC1-8 FABP7 SMPDL3A PKIB SERINC1 CLVS2 lnc-SERINC1-6
GH06J122770 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9 -7.7 -7700 4 CTCF CUX1 GATAD2B CTBP1 CEBPG RAD21 CEBPB DPF2 HIC1 ZBTB40 FABP7 PKIB SMPDL3A piR-30764-013
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FABP7 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FABP7

Top Transcription factor binding sites by QIAGEN in the FABP7 gene promoter:
  • Cart-1
  • Egr-4
  • Evi-1
  • HNF-4alpha1
  • HOXA3
  • NF-1
  • STAT3
  • TBP
  • USF-1
  • USF1

Genomic Locations for FABP7 Gene

Genomic Locations for FABP7 Gene
chr6:122,779,501-122,784,074
(GRCh38/hg38)
Size:
4,574 bases
Orientation:
Plus strand
chr6:123,100,620-123,105,219
(GRCh37/hg19)
Size:
4,600 bases
Orientation:
Plus strand

Genomic View for FABP7 Gene

Genes around FABP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP7 Gene

Proteins for FABP7 Gene

  • Protein details for FABP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15540-FABP7_HUMAN
    Recommended name:
    Fatty acid-binding protein, brain
    Protein Accession:
    O15540
    Secondary Accessions:
    • B2R4L1
    • O14951
    • Q6IAU7
    • Q9H047

    Protein attributes for FABP7 Gene

    Size:
    132 amino acids
    Molecular mass:
    14889 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FABP7 Gene

    Alternative splice isoforms for FABP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FABP7 Gene

Post-translational modifications for FABP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP7 Gene

No data available for DME Specific Peptides for FABP7 Gene

Domains & Families for FABP7 Gene

Gene Families for FABP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FABP7 Gene

Blocks:
  • Cytosolic fatty-acid binding protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FABP7 Gene

GenScript: Design optimal peptide antigens:
  • Mammary-derived growth inhibitor related (FABP7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15540

UniProtKB/Swiss-Prot:

FABP7_HUMAN :
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP7: view

Function for FABP7 Gene

Molecular function for FABP7 Gene

UniProtKB/Swiss-Prot Function:
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).

Phenotypes From GWAS Catalog for FABP7 Gene

Gene Ontology (GO) - Molecular Function for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA,TAS --
genes like me logo Genes that share ontologies with FABP7: view
genes like me logo Genes that share phenotypes with FABP7: view

Animal Models for FABP7 Gene

MGI Knock Outs for FABP7:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP7 Gene

Localization for FABP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP7 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005911 cell-cell junction IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with FABP7: view

Pathways & Interactions for FABP7 Gene

genes like me logo Genes that share pathways with FABP7: view

Pathways by source for FABP7 Gene

SIGNOR curated interactions for FABP7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FABP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development TAS 9375786
GO:0008285 negative regulation of cell proliferation TAS 9250612
GO:0019433 triglyceride catabolic process TAS --
GO:0021846 cell proliferation in forebrain IEA --
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with FABP7: view

Drugs & Compounds for FABP7 Gene

(6) Drugs for FABP7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docosahexaenoic acid Approved, Investigational Pharma Full agonist, Agonist, Carrier 0
oleic acid Approved, Investigational, Vet_approved Pharma Full agonist, Agonist, Activation, Activator, Carrier 0
alpha-linolenic acid Approved, Investigational Nutra Full agonist, Agonist, Carrier 0
Icosapent Approved Nutra Carrier, agonist Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0
Gamma-Homolinolenic acid Investigational Nutra Carrier 0

(5) Additional Compounds for FABP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP7: view

Transcripts for FABP7 Gene

mRNA/cDNA for FABP7 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP7 Gene

No ASD Table

Relevant External Links for FABP7 Gene

GeneLoc Exon Structure for
FABP7

Expression for FABP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP7 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.8), Brain - Cerebellum (x7.2), Brain - Amygdala (x5.9), Brain - Hippocampus (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.6).

Protein differential expression in normal tissues from HIPED for FABP7 Gene

This gene is overexpressed in Fetal Brain (28.1), Retina (23.0), and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FABP7

SOURCE GeneReport for Unigene cluster for FABP7 Gene:

Hs.26770

mRNA Expression by UniProt/SwissProt for FABP7 Gene:

O15540-FABP7_HUMAN
Tissue specificity: Expressed in brain and other neural tissues.

Evidence on tissue expression from TISSUES for FABP7 Gene

  • Nervous system(4.9)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with FABP7: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP7 Gene

Orthologs for FABP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP7 31 30
  • 99.75 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FABP7 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FABP7 31 30
  • 92.68 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FABP7 31 30
  • 92.17 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fabp7 30
  • 86.62 (n)
mouse
(Mus musculus)
Mammalia Fabp7 17 31 30
  • 85.35 (n)
chicken
(Gallus gallus)
Aves FABP7 31 30
  • 81.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FABP7 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fabp7 30
  • 81.57 (n)
Str.17054 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15814 30
zebrafish
(Danio rerio)
Actinopterygii fabp7a 31
  • 83 (a)
OneToMany
fabp7b 31 30
  • 73.23 (n)
OneToMany
fabp7 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12474 30
fruit fly
(Drosophila melanogaster)
Insecta fabp 31 30
  • 54.82 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta FABP_ANOGA_a 30
  • 54.55 (n)
worm
(Caenorhabditis elegans)
Secernentea lbp-6 31
  • 47 (a)
ManyToMany
lbp-5 31
  • 40 (a)
ManyToMany
lbp-7 31
  • 37 (a)
ManyToMany
lbp-9 31
  • 36 (a)
ManyToMany
lbp-8 31
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
Cin.2819 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2819 30
Species where no ortholog for FABP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FABP7 Gene

ENSEMBL:
Gene Tree for FABP7 (if available)
TreeFam:
Gene Tree for FABP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FABP7: view image

Paralogs for FABP7 Gene

(15) SIMAP similar genes for FABP7 Gene using alignment to 1 proteins:

  • FABP7_HUMAN

Pseudogenes.org Pseudogenes for FABP7 Gene

genes like me logo Genes that share paralogs with FABP7: view

Variants for FABP7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FABP7 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
774070 Benign: not provided 122,781,134(+) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
782479 Benign: not provided 122,781,200(+) T/C SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs431905492 Not Provided: not provided 122,780,453(+) GA/G FRAMESHIFT_VARIANT
rs2279381 - p.Thr61Met

Additional dbSNP identifiers (rs#s) for FABP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for FABP7 Gene

Variant ID Type Subtype PubMed ID
nsv1035007 CNV gain 25217958
nsv830791 CNV gain 17160897

Variation tolerance for FABP7 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP7 Gene

Human Gene Mutation Database (HGMD)
FABP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP7 Gene

Disorders for FABP7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FABP7 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FABP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FABP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FABP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP7 Gene

Publications for FABP7 Gene

  1. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). (PMID: 9375786) Shimizu F … Fujiwara T (Biochimica et biophysica acta 1997) 2 3 4 23 54
  2. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (PMID: 19554614) Iwayama Y … Yoshikawa T (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 23 41 54
  3. Solution structure of fatty acid-binding protein from human brain. (PMID: 12479569) Rademacher M … Lücke C (Molecular and cellular biochemistry 2002) 3 4 23 54
  4. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. (PMID: 10854433) Balendiran GK … Sacchettini JC (The Journal of biological chemistry 2000) 3 4 23 54
  5. Correlation of B-FABP and GFAP expression in malignant glioma. (PMID: 9591779) Godbout R … Day RS (Oncogene 1998) 3 4 23 54

Products for FABP7 Gene

Sources for FABP7 Gene