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FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] See more...
Aliases for FABP4 Gene
Aliases for FABP4 Gene
External Ids for FABP4 Gene
- HGNC: 3559
- Entrez Gene: 2167
- Ensembl: ENSG00000170323
- OMIM: 600434
- UniProtKB: P15090
Previous GeneCards Identifiers for FABP4 Gene
- GC08M081268
- GC08M082439
- GC08M082113
- GC08M082440
- GC08M082553
- GC08M082390
- GC08M077880
Summaries for FABP4 Gene
-
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
GeneCards Summary for FABP4 Gene
FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Coronary Restenosis and Cerebellar Liponeurocytoma. Among its related pathways are Developmental Biology and PPAR signaling pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is PMP2.
UniProtKB/Swiss-Prot Summary for FABP4 Gene
-
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Additional gene information for FABP4 Gene
- Monarch Initiative
- Search for FABP4 at DataMed
- Search for FABP4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP4 Gene
Genomics for FABP4 Gene
GeneHancer (GH) Regulatory Elements for FABP4 Gene
Promoters and enhancers for FABP4 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J081482 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE dbSUPER | 758.2 | +1.1 | 1062 | 4 | USF1 JUND JUN | FABP4 lnc-FABP9-1 IMPA1 PMP2 FABP9 ENSG00000253859 | |
| GH08J081496 | Enhancer | 0.6 | ENCODE dbSUPER | 6.6 | -13.4 | -13414 | 0.8 | RXRA NR2F2 REST | PMP2 FABP4 ENSG00000253374 ENSG00000253859 | |
| GH08J081363 | Enhancer | 0.8 | Ensembl ENCODE | 4.4 | +119.0 | 118963 | 6.2 | IKZF1 IKZF2 CEBPB ZNF692 GABPA RBAK JUND ELF1 USF1 FOS | PMP2 ZFAND1 ENSG00000254162 CHMP4C FABP4 IMPA1 HSALNG0066571 lnc-FABP5-1 | |
| GH08J081492 | Enhancer | 0.6 | FANTOM5 ENCODE dbSUPER | 5.5 | -9.4 | -9384 | 0.3 | FABP4 ENSG00000253374 ENSG00000253859 | ||
| GH08J081368 | Enhancer | 0.6 | Ensembl | 4.5 | +113.5 | 113463 | 3.2 | CTCF IKZF1 IKZF2 DPF2 BCL11A RUNX3 ZNF335 BATF FEZF1 ATF7 | HSALNG0066571 PMP2 FABP4 IMPA1 lnc-FABP5-1 HSALNG0066572 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FABP4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FABP4 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- C/EBPbeta
- POU3F1
- PPAR-alpha
- USF-1
- USF1
Genomic Locations for FABP4 Gene
Genomic Locations for FABP4 Gene
- chr8:81,478,419-81,483,263
- (GRCh38/hg38)
- Size:
- 4,845 bases
- Orientation:
- Minus strand
- chr8:82,390,654-82,395,498
- (GRCh37/hg19)
- Size:
- 4,845 bases
- Orientation:
- Minus strand
Genomic View for FABP4 Gene
Genes around FABP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.13 by HGNC
- 8q21.13 by Entrez Gene
- 8q21.13 by Ensembl
FABP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FABP4 Gene
Proteins for FABP4 Gene
-
Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15090-FABP4_HUMAN
- Recommended name:
- Fatty acid-binding protein, adipocyte
- Protein Accession:
- P15090
- Q6IBA1
Protein attributes for FABP4 Gene
- Size:
- 132 amino acids
- Molecular mass:
- 14719 Da
- Quaternary structure:
-
- Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG (By similarity).
Protein Expression for FABP4 Gene
Post-translational modifications for FABP4 Gene
Other Protein References for FABP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FABP4 Antibody
- NSJ Bioreagents FABP4 Antibody
- Atlas Antibodies Anti-FABP4 Antibody
-
Creative Biolabs
- Recombinant Mouse Anti-FABP4 Antibody (CA33)
- Recombinant Mouse Anti-FABP4 Antibody Fab Fragment (CA33)
- Chicken Anti-FABP4 Polyclonal IgY (BRD-0835MZ)
- Mouse Anti-FABP4 Recombinant Antibody (CBXF-2805)
- Mouse Anti-FABP4 Recombinant Antibody (3F4)
- Hi-Affi™ Recombinant Rabbit Anti-FABP4 Monoclonal Antibody (TH84DS)
- Mouse Anti-FABP4 Recombinant Antibody (CBXF-2385)
- Mouse Anti-FABP4 (AA 1-132) Recombinant Antibody (CBXF-2803)
- Mouse Anti-FABP4 (AA 61-121) Recombinant Antibody (5H11A4E11)
- Mouse Anti-FABP4 Recombinant Antibody (CBXF-1494)
- Mouse Anti-FABP4 Recombinant Antibody (CBXF-2804)
- Mouse Anti-FABP4 (AA 1-132) Recombinant Antibody (CBXF-0245)
- Mouse Anti-FABP4 Recombinant Antibody (9B8D)
- Mouse Anti-FABP4 Recombinant Antibody (CBYC-A955)
- Rabbit Anti-FABP4 Recombinant Antibody (CBXF-2222)
- Mouse Anti-FABP4 Recombinant Antibody (CBXF-0246)
- Hi-Affi™ Recombinant Rabbit Anti-FABP4 Monoclonal Antibody (DS1236AB)
- Rat Anti-FABP4 Recombinant Antibody (CBXF-2561)
- Recombinant Human Anti-FABP4 Antibody (FabCA33)
- Recombinant Mouse Anti-Human FABP4 Antibody (clone 9B8D)
- Chicken Anti-FABP4 Polyclonal IgY (BRD-0856MZ)
-
Custom Antibody ServicesOriGene Antibodies for FABP4
- Novus Biologicals Antibodies for FABP4
-
Abcam antibodies for FABP4
- Invitrogen Antibodies for FABP4 (AFLGC-FABP4)
- antibodies-online: Show 85 available FABP4 Antibodies ranked by validation data
- Compare Top FABP4 Antibodies
-
Recommended
- 188 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 73 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FABP4
- Sino Biological Antibodies for FABP4
Protein Products
- G Biosciences Human FABP4/A-FABP, Lyophilized
- Atlas Antibodies PrEST Antigen FABP4
- Creative Diagnostics Human FABP4 peptide
- Search Origene for MassSpec and Protein Over-expression Lysates for FABP4
- Origene Custom Protein Services for FABP4
- Sino Biological Cell Lysates for FABP4
- Sino Biological Recombinant Proteins for FABP4
- ProSpec Recombinant Proteins for FABP4
-
ProSci Proteins for FABP4
-
Abcam proteins for FABP4
Assay Products
- RayBiotech Human FABP4/A-FABP ELISA
- Aviva Systems Biology FABP4 ELISA Kit (Human) : 96 Wells (OKEH00277) and FABP4 ELISA Kit (Human) (OKCD07598)
- antibodies-online: Show 88 available FABP4 Elisa Kits ranked by validation data
- Compare Top FABP4 Elisa Kits
-
Quality Products:
- ABIN6730861
- ABIN1113278
- ABIN414793
- ABIN2684217
- ABIN456998
- ABIN1569693
- ABIN5564617
- ABIN5524344
- ABIN579439
- ABIN5510643
- ABIN425027
- ABIN2684218
- ABIN1569694
- ABIN1884596
- ABIN5524345
- ABIN5510642
- ABIN814518
- ABIN627815
- ABIN5594464
- ABIN457201
- ABIN432282
- ABIN1569695
- ABIN1884597
- ABIN5524347
- ABIN5510730
- ABIN626999
- ABIN5594465
- ABIN510033
- ABIN512237
- ABIN991668
- ABIN1133077
No data available for DME Specific Peptides for FABP4 Gene
Domains & Families for FABP4 Gene
Gene Families for FABP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FABP4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FABP4 Gene
- GenScript: Design optimal peptide antigens:
-
- Fatty acid binding protein 4, adipocyte (E7DVW4_HUMAN)
- Fatty acid-binding protein 4 (FABP4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15090UniProtKB/Swiss-Prot:
FABP4_HUMAN :- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
- Domain:
-
- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Family:
-
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Function for FABP4 Gene
Molecular function for FABP4 Gene
- UniProtKB/Swiss-Prot Function:
- Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
- GENATLAS Biochemistry:
- fatty acid-binding protein 4,adipocyte
Phenotypes From GWAS Catalog for FABP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005324 | long-chain fatty acid transporter activity | ISS | -- |
| GO:0005504 | fatty acid binding | TAS | 2481498 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0036041 | long-chain fatty acid binding | ISS | -- |
| GO:0051427 | hormone receptor binding | IEA | -- |
Phenotypes for FABP4 Gene
- MGI mutant phenotypes for FABP4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FABP4:
Animal Models for FABP4 Gene
- MGI Knock Outs for FABP4:
-
- Fabp4 Fabp4<tm1Brsp>
Animal Model Products
-
Taconic Biosciences Mouse Models for FABP4
CRISPR Products
-
OriGene CRISPR knockouts for FABP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FABP4
- genomics-online: gRNA clones - Search for available FABP4 gRNA products
- Overview of 129 available FABP4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FABP4 - Select products 50% OFF >
- * FABP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FABP4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP4
miRNA for FABP4 Gene
- miRTarBase miRNAs that target FABP4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FABP4
- Browse OriGene Inhibitory RNA Products For FABP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4
- genomics-online: shRNA clones - Search for available FABP4 shRNA products
- Overview of 129 available FABP4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FABP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FABP4
- genomics-online: cdna clones - Search for available FABP4 CDNA products
- Overview of 129 available FABP4 gene related products
- orf clones - Search for available FABP4 ORF products
- Overview of 129 available FABP4 gene related products
- Applied Biological Materials (abm): Clones for FABP4 - Select products 50% OFF >
- * FABP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FABP4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for FABP4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP4 Gene
Localization for FABP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene
- Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250 UniProtKB:P04117}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | TAS | 16130169 |
| GO:0005811 | lipid droplet | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FABP4 Gene
Pathways & Interactions for FABP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lipoprotein metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Glucose / Energy Metabolism | ||
| 4 | PPAR signaling pathway | ||
| 5 | Regulation of lipolysis in adipocytes | ||
Pathways by source for FABP4 Gene
6 Reactome pathways for FABP4 Gene
2 KEGG pathways for FABP4 Gene
1 Cell Signaling Technology pathway for FABP4 Gene
Interacting Proteins for FABP4 Gene
Selected Interacting proteins:
P15090-FABP4_HUMAN
ENSP00000256104
for FABP4 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for FABP4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001816 | cytokine production | IEA | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
| GO:0009617 | response to bacterium | IEA | -- |
| GO:0015909 | long-chain fatty acid transport | ISS | -- |
| GO:0019433 | triglyceride catabolic process | TAS | -- |
Drugs & Compounds for FABP4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| oleic acid | Approved, Investigational, Vet_approved | Pharma | Full agonist, Agonist, Activation, Activator, Carrier | 0 | ||
| Palmitic Acid | Approved | Pharma | Full agonist, Agonist, Carrier | 25 | ||
| propanoic acid | Approved, Vet_approved | Pharma | Full agonist, Agonist, Carrier | 0 | ||
| arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation, Carrier | 38 | ||
| (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE | Experimental | Pharma | Carrier | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for FABP4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS 309403 | FABP4 inhibitor,potent and selective | 300657-03-8 |
Drug Products
- G Biosciences Human FABP4/A-FABP, Lyophilized
- Atlas Antibodies PrEST Antigen FABP4
- Creative Diagnostics Human FABP4 peptide
- ApexBio compounds for FABP4
Transcripts for FABP4 Gene
mRNA/cDNA for FABP4 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (270) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256104 941 bps (ENST00000256104.4)
- ENST00000518669 510 bps (ENST00000518669.5)
- ENST00000522659 627 bps (ENST00000522659.1)
- ENST00000521734 761 bps (ENST00000521734.1)
CRISPR Products
-
OriGene CRISPR knockouts for FABP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FABP4
- genomics-online: gRNA clones - Search for available FABP4 gRNA products
- Overview of 129 available FABP4 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FABP4 - Select products 50% OFF >
- * FABP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FABP4 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP4
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FABP4
- Browse OriGene Inhibitory RNA Products For FABP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4
- genomics-online: shRNA clones - Search for available FABP4 shRNA products
- Overview of 129 available FABP4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FABP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FABP4
- genomics-online: cdna clones - Search for available FABP4 CDNA products
- Overview of 129 available FABP4 gene related products
- orf clones - Search for available FABP4 ORF products
- Overview of 129 available FABP4 gene related products
- Applied Biological Materials (abm): Clones for FABP4 - Select products 50% OFF >
- * FABP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FABP4 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | - | ||||||||||||
| SP3: |
Expression for FABP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Preadipocytes Subcutaneous White Adipose
- Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
- Preadipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Dermal Fibroblasts Dorsal Dermis
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Corneal Epithelium
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Mesenchymal Stem Cells
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Duct Cells Pancreatic Ducts
- Heart (Cardiovascular System)
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Endothelium (Cardiovascular System)
- Breast (Uncategorized)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FABP4 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x17.6), Adipose - Subcutaneous (x15.7), and Breast - Mammary Tissue (x11.3).
This gene is overexpressed in Adipocyte (35.0) and Nasopharynx (22.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP4 Gene
NURSA nuclear receptor signaling pathways regulating expression of FABP4 Gene:
FABP4SOURCE GeneReport for Unigene cluster for FABP4 Gene:
Hs.391561Evidence on tissue expression from TISSUES for FABP4 Gene
- Liver(4.5)
- Heart(4.1)
- Muscle(3.1)
- Skin(2.8)
- Intestine(2.5)
- Lung(2.4)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for FABP4
-
OriGene qPCR primer pairs and template standards for FABP4
- genomics-online: primer clones - Search for available FABP4 Primer products
- Overview of 129 available FABP4 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP4 Gene
Orthologs for FABP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FABP4 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| FABP4 32 |
|
||||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | FABP4 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fabp4 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fabp4 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | FABP4 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FABP4 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pmp2 32 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | lbp-5 32 |
|
- Species where no ortholog for FABP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Evolution for FABP4 Gene
- ENSEMBL:
- Gene Tree for FABP4 (if available)
- TreeFam:
- Gene Tree for FABP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FABP4: view image
Paralogs for FABP4 Gene
Paralogs for FABP4 Gene
(15) SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:
- FABP4_HUMAN
- E5RIR0_HUMAN
- E7DVW4_HUMAN
Variants for FABP4 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1319351179 | A breast cancer sample | 81,483,099(-) | T/A | coding_sequence_variant, missense_variant | |
| rs1000773487 | -- | 81,483,003(-) | G/A/C | intron_variant | |
| rs1000985765 | -- | 81,483,545(-) | G/A | upstream_transcript_variant | |
| rs1001941666 | -- | 81,483,555(-) | T/C | upstream_transcript_variant | |
| rs1002255934 | -- | 81,481,648(-) | G/A | intron_variant |
Residual Variation Intolerance Score:
59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FABP4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene
Disorders for FABP4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| coronary restenosis |
|
|
| cerebellar liponeurocytoma |
|
|
| bladder urothelial carcinoma |
|
|
| body mass index quantitative trait locus 11 |
|
|
| overnutrition |
|
|
Search FABP4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FABP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FABP4 Gene
Publications for FABP4 Gene
- Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PMID: 20156355) Khalyfa A … Gozal D (Lipids in health and disease 2010) 3 23 43 56
- Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PMID: 15015141) Damcott CM … Ferrell RE (Metabolism: clinical and experimental 2004) 3 23 43 56
- Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PMID: 2481498) Baxa CA … Bernlohr DA (Biochemistry 1989) 2 3 4 56
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
- Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. (PMID: 20413122) Solà R … Anguera A (Atherosclerosis 2010) 3 43 56
ExternalLinks
Products for FABP4 Gene
- View all 8 R&D Systems FABP4 (FABP4/A-FABP) Products
- View all 4 R&D Systems FABP4 (FABP4/A-FABP) Primary Antibodies
- View all 3 R&D Systems FABP4 (FABP4/A-FABP) ELISAs
- View all R&D Systems FABP4 (FABP4/A-FABP) Luminex Assays
- Learn more about R&D Systems custom FABP4 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for FABP4
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene sirna, shrna, and RNAi products in human, mouse, rat for FABP4
- Browse OriGene Inhibitory RNA Products For FABP4
- OriGene qPCR primer pairs for FABP4
- OriGene qPCR primer pairs and template standards for FABP4
- OriGene CRISPR knockouts for FABP4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FABP4
- Sino Biological Human cDNA Clone for FABP4
- Sino Biological Cell Lysates for FABP4
- Sino Biological Recombinant Proteins for FABP4
- Sino Biological Antibodies for FABP4
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FABP4
- Novus Biologicals proteins and lysates for FABP4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FABP4
- Abcam proteins for FABP4
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for FABP4
- Taconic Biosciences Mouse Models for FABP4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FABP4 (AFLGC-FABP4)
- ApexBio compounds for FABP4
- antibodies-online: Show 85 available FABP4 Antibodies ranked by validation data
- Compare Top FABP4 Antibodies
- Recommended
- 188 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 73 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- antibodies-online: Show 88 available FABP4 Elisa Kits ranked by validation data
- Compare Top FABP4 Elisa Kits
- Quality Products:
- ABIN6730861
- ABIN1113278
- ABIN414793
- ABIN2684217
- ABIN456998
- ABIN1569693
- ABIN5564617
- ABIN5524344
- ABIN579439
- ABIN5510643
- ABIN425027
- ABIN2684218
- ABIN1569694
- ABIN1884596
- ABIN5524345
- ABIN5510642
- ABIN814518
- ABIN627815
- ABIN5594464
- ABIN457201
- ABIN432282
- ABIN1569695
- ABIN1884597
- ABIN5524347
- ABIN5510730
- ABIN626999
- ABIN5594465
- ABIN510033
- ABIN512237
- ABIN991668
- ABIN1133077
- antibodies-online: Show 44 available FABP4 Proteins ranked by validation data
- Compare Top FABP4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FABP4
- Search Santa Cruz Biotechnology (SCBT) for FABP4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FABP4
- Horizon Cell Lines for FABP4
- genomics-online: cdna clones - Search for available FABP4 CDNA products
- Overview of 129 available FABP4 gene related products
- orf clones - Search for available FABP4 ORF products
- Overview of 129 available FABP4 gene related products
- genomics-online: gRNA clones - Search for available FABP4 gRNA products
- Overview of 129 available FABP4 gene related products
- genomics-online: primer clones - Search for available FABP4 Primer products
- Overview of 129 available FABP4 gene related products
- genomics-online: shRNA clones - Search for available FABP4 shRNA products
- Overview of 129 available FABP4 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FABP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FABP4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FABP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4
Sources for FABP4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource