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FABP4 Gene(Protein Coding)

Fatty Acid Binding Protein 4

GCID:
GC08M081478
GIFtS:
54
Genes Participants
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Aliases for FABP4 Gene

Aliases for FABP4 Gene

  • Fatty Acid Binding Protein 4 2 3 5
  • Adipocyte-Type Fatty Acid-Binding Protein 3 4
  • Adipocyte Fatty Acid Binding Protein 2 3
  • Adipocyte Lipid-Binding Protein 3 4
  • A-FABP 3 4
  • AFABP 3 4
  • ALBP 3 4
  • Fatty Acid Binding Protein 4, Adipocyte 3
  • Fatty Acid-Binding Protein, Adipocyte 3
  • Epididymis Secretory Protein Li 104 3
  • Fatty Acid-Binding Protein 4 4
  • HEL-S-104 3
  • AP2 3

External Ids for FABP4 Gene

Previous GeneCards Identifiers for FABP4 Gene

  • GC08M081268
  • GC08M082439
  • GC08M082113
  • GC08M082440
  • GC08M082553
  • GC08M082390
  • GC08M077880

Summaries for FABP4 Gene

Entrez Gene Summary for FABP4 Gene

  • FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP4 Gene

FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Pleomorphic Lipoma and Cerebellar Liponeurocytoma. Among its related pathways are Lipoprotein metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is PMP2.

UniProtKB/Swiss-Prot for FABP4 Gene

  • Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

Additional gene information for FABP4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP4 Gene

Genomics for FABP4 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FABP4 Gene

Promoters and enhancers for FABP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I081482 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 558.3 +0.1 99 1.1 JUND USF1 JUN FABP4 FABP9 ENSG00000253859
GH08I081496 Enhancer 0.6 ENCODE dbSUPER 6.6 -13.4 -13414 0.8 RXRA REST NR2F2 PMP2 FABP4 LOC101927118 ENSG00000253859
GH08I081363 Enhancer 0.9 Ensembl ENCODE 4.4 +119.0 118981 2.4 ELK4 USF1 JUN USF2 CEBPB BATF GABPA JUND RBAK ZNF692 ZFAND1 ENSG00000254162 PMP2 FABP4 IMPA1 LOC105375926 ENSG00000253859
GH08I081492 Enhancer 0.7 FANTOM5 ENCODE dbSUPER 5.5 -9.4 -9384 0.3 FABP4 LOC101927118 ENSG00000253859
GH08I081421 Enhancer 0.3 ENCODE 5 +60.8 60751 1.9 JUN PMP2 FABP4 CHMP4C ENSG00000253859 LOC105375926
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FABP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FABP4 gene promoter:

Genomic Locations for FABP4 Gene

Genomic Locations for FABP4 Gene
chr8:81,478,419-81,483,263
(GRCh38/hg38)
Size:
4,845 bases
Orientation:
Minus strand
chr8:82,390,654-82,395,498
(GRCh37/hg19)

Genomic View for FABP4 Gene

Genes around FABP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FABP4 Gene

Proteins for FABP4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15090-FABP4_HUMAN
    Recommended name:
    Fatty acid-binding protein, adipocyte
    Protein Accession:
    P15090
    Secondary Accessions:
    • Q6IBA1

    Protein attributes for FABP4 Gene

    Size:
    132 amino acids
    Molecular mass:
    14719 Da
    Quaternary structure:
    • Homodimer. Interacts with PPARG (By similarity). Monomer.

    Three dimensional structures from OCA and Proteopedia for FABP4 Gene

neXtProt entry for FABP4 Gene

Protein Expression for FABP4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FABP4 Gene

No Post-translational modifications

Other Protein References for FABP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FABP4 Gene

Domains & Families for FABP4 Gene

Gene Families for FABP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FABP4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FABP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15090

UniProtKB/Swiss-Prot:

FABP4_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP4: view

Function for FABP4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FABP4 Gene

GENATLAS Biochemistry:
fatty acid-binding protein 4,adipocyte
UniProtKB/Swiss-Prot Function:
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).

Gene Ontology (GO) - Molecular Function for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005504 fatty acid binding IEA,TAS --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP4: view
genes like me logo Genes that share phenotypes with FABP4: view

Animal Models for FABP4 Gene

MGI Knock Outs for FABP4:

Animal Model Products

miRNA for FABP4 Gene

miRTarBase miRNAs that target FABP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP4 Gene

Localization for FABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
peroxisome 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005811 lipid droplet TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with FABP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FABP4 Gene

Pathways & Interactions for FABP4 Gene

genes like me logo Genes that share pathways with FABP4: view

SIGNOR curated interactions for FABP4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0006810 transport IEA --
GO:0019433 triglyceride catabolic process TAS --
GO:0042632 cholesterol homeostasis IEA --
genes like me logo Genes that share ontologies with FABP4: view

Drugs & Compounds for FABP4 Gene

Products:

  1. Drug

(30) Drugs for FABP4 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Investigational, Vet_approved Pharma Full agonist, Agonist, Carrier 0
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist, Carrier 23
arachidonic acid Experimental Nutra Activator, Carrier 33
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE Experimental Pharma Carrier 0
1-Anilino-8-Naphthalene Sulfonate Experimental Pharma Carrier 0

(16) Additional Compounds for FABP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for FABP4 Gene

Compound Action Cas Number
BMS 309403 FABP4 inhibitor,potent and selective 300657-03-8
genes like me logo Genes that share compounds with FABP4: view

Drug Products

Transcripts for FABP4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FABP4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(270) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP4 Gene

Fatty acid binding protein 4, adipocyte:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for FABP4 Gene

GeneLoc Exon Structure for
FABP4
ECgene alternative splicing isoforms for
FABP4

Expression for FABP4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FABP4 Gene

mRNA expression in normal human tissues for FABP4 Gene
mRNA expression by GTEx for FABP4 GenemRNA expression by BioGPS for FABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.6), Adipose - Subcutaneous (x15.7), and Breast - Mammary Tissue (x11.3).

Protein differential expression in normal tissues from HIPED for FABP4 Gene

This gene is overexpressed in Adipocyte (35.0) and Nasopharynx (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FABP4 Gene



Protein tissue co-expression partners for FABP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FABP4 Gene:

FABP4

SOURCE GeneReport for Unigene cluster for FABP4 Gene:

Hs.391561

Evidence on tissue expression from TISSUES for FABP4 Gene

  • Liver(4.5)
  • Heart(4.1)
  • Muscle(3.1)
  • Skin(2.8)
  • Intestine(2.4)
  • Lung(2.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with FABP4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP4 Gene

Orthologs for FABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FABP4 33 34
  • 99.75 (n)
dog
(Canis familiaris)
 Mammalia -- 34
  • 95 (a)
 OneToMany
-- 34
  • 93 (a)
 OneToMany
FABP4 33
  • 92.68 (n)
-- 34
  • 92 (a)
 OneToMany
-- 34
  • 90 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia FABP4 33 34
  • 89.39 (n)
mouse
(Mus musculus)
 Mammalia Fabp4 33 16 34
  • 86.11 (n)
rat
(Rattus norvegicus)
 Mammalia Fabp4 33
  • 83.84 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 83 (a)
 OneToMany
-- 34
  • 20 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves FABP4 33 34
  • 73.48 (n)
lizard
(Anolis carolinensis)
 Reptilia FABP4 34
  • 63 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia pmp2 33
  • 60.05 (n)
worm
(Caenorhabditis elegans)
 Secernentea lbp-5 33
  • 50.51 (n)
Species where no ortholog for FABP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FABP4 Gene

ENSEMBL:
Gene Tree for FABP4 (if available)
TreeFam:
Gene Tree for FABP4 (if available)

Paralogs for FABP4 Gene

Paralogs for FABP4 Gene

(15) SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FABP4: view

Variants for FABP4 Gene

Sequence variations from dbSNP and Humsavar for FABP4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
VAR_036320 A breast cancer sample p.Glu23Asp
rs1000773487 -- 81,483,003(-) G/A/C intron_variant
rs1000985765 -- 81,483,545(-) G/A upstream_transcript_variant
rs1001941666 -- 81,483,555(-) T/C upstream_transcript_variant
rs1002255934 -- 81,481,648(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FABP4 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781
nsv611608 CNV loss 21841781

Variation tolerance for FABP4 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP4 Gene

Human Gene Mutation Database (HGMD)
FABP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene

Disorders for FABP4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for FABP4 Gene - From: HGMD, DISEASES, and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search FABP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FABP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FABP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP4 Gene

Publications for FABP4 Gene

  1. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PMID: 20156355) Khalyfa A … Gozal D (Lipids in health and disease 2010) 3 22 44 58
  2. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PMID: 15015141) Damcott CM … Ferrell RE (Metabolism: clinical and experimental 2004) 3 22 44 58
  3. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PMID: 2481498) Baxa CA … Bernlohr DA (Biochemistry 1989) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients. (PMID: 19842034) Hancke K … Weiss JM (Breast cancer research and treatment 2010) 3 22 58

Products for FABP4 Gene

Sources for FABP4 Gene

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