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FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] See more...
Aliases for FABP4 Gene
Aliases for FABP4 Gene
External Ids for FABP4 Gene
- HGNC: 3559
- Entrez Gene: 2167
- Ensembl: ENSG00000170323
- OMIM: 600434
- UniProtKB: P15090
Previous GeneCards Identifiers for FABP4 Gene
- GC08M081268
- GC08M082439
- GC08M082113
- GC08M082440
- GC08M082553
- GC08M082390
- GC08M077880
Summaries for FABP4 Gene
-
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
GeneCards Summary for FABP4 Gene
FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Liposarcoma Of Bone and Coronary Restenosis. Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is PMP2.
UniProtKB/Swiss-Prot Summary for FABP4 Gene
-
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Additional gene information for FABP4 Gene
- HGNC(3559)
- Entrez Gene(2167)
- Ensembl(ENSG00000170323)
- OMIM(600434)
- UniProtKB(P15090)
- Open Targets Platform(ENSG00000170323)
- Monarch Initiative
- Search for FABP4 at DataMed
- Search for FABP4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP4 Gene
Genomics for FABP4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FABP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FABP4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FABP4
- Top Transcription factor binding sites by QIAGEN in the FABP4 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- C/EBPbeta
- POU3F1
- PPAR-alpha
- USF-1
- USF1
Genomic Locations for FABP4 Gene
Genomic Locations for FABP4 Gene
- chr8:81,478,419-81,483,236
- (GRCh38/hg38)
- Size:
- 4,818 bases
- Orientation:
- Minus strand
- chr8:82,390,654-82,395,498
- (GRCh37/hg19)
- Size:
- 4,845 bases
- Orientation:
- Minus strand
Genomic View for FABP4 Gene
Genes around FABP4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.13 by HGNC
- 8q21.13 by Entrez Gene
- 8q21.13 by Ensembl
FABP4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FABP4 Gene
Proteins for FABP4 Gene
-
Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15090-FABP4_HUMAN
- Recommended name:
- Fatty acid-binding protein, adipocyte
- Protein Accession:
- P15090
- Q6IBA1
Protein attributes for FABP4 Gene
- Size:
- 132 amino acids
- Molecular mass:
- 14719 Da
- Quaternary structure:
-
- Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG (By similarity).
Protein Expression for FABP4 Gene
Post-translational modifications for FABP4 Gene
Other Protein References for FABP4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences FABP4 / AP2 Antibody (LS-B4227) and FABP4 / AP2 Antibody (LS-B1595)
- G Biosciences Immunotag™ FABP4 Antibody
- NSJ Bioreagents FABP4 Antibody
- Creative Diagnostics Anti-FABP4 monoclonal antibody, clone 4H2
-
Custom Antibody ServicesOriGene Antibodies for FABP4
- Novus Biologicals Antibodies for FABP4
-
Abcam antibodies for FABP4
- Invitrogen Antibodies for FABP4 (AFLGC-FABP4)
- antibodies-online: Show 85 available FABP4 Antibodies ranked by validation data
- Compare Top FABP4 Antibodies
-
Recommended
- 188 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 4 DB Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 73 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FABP4
- Sino Biological Antibodies for FABP4
Protein Products
- G Biosciences Human FABP4/A-FABP, Lyophilized
- Creative Biomart Recombinant Human Fatty Acid Binding Protein (Adipocyte),His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for FABP4
- Origene Custom Protein Services for FABP4
- Sino Biological Recombinant Proteins for FABP4
- Sino Biological Cell Lysates for FABP4
- ProSpec Recombinant Proteins for FABP4
-
ProSci Proteins for FABP4
-
Abcam proteins for FABP4
Assay Products
- RayBiotech Human FABP4/A-FABP ELISA
- Novus Biologicals ELISA Kits for FABP4
- antibodies-online: Show 88 available FABP4 Elisa Kits ranked by validation data
- Compare Top FABP4 Elisa Kits
-
Quality Products:
- ABIN6730861
- ABIN1113278
- ABIN414793
- ABIN2684217
- ABIN456998
- ABIN1569693
- ABIN5564617
- ABIN5524344
- ABIN579439
- ABIN5510643
- ABIN425027
- ABIN2684218
- ABIN1569694
- ABIN1884596
- ABIN5524345
- ABIN5510642
- ABIN814518
- ABIN627815
- ABIN5594464
- ABIN457201
- ABIN432282
- ABIN1569695
- ABIN1884597
- ABIN5524347
- ABIN5510730
- ABIN626999
- ABIN5594465
- ABIN510033
- ABIN512237
- ABIN991668
- ABIN1133077
No data available for DME Specific Peptides for FABP4 Gene
Domains & Families for FABP4 Gene
Gene Families for FABP4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FABP4 Gene
- InterPro:
- Blocks:
-
- Cytosolic fatty-acid binding protein
- ProtoNet:
Suggested Antigen Peptide Sequences for FABP4 Gene
- GenScript: Design optimal peptide antigens:
-
- Fatty acid binding protein 4, adipocyte (E7DVW4_HUMAN)
- Fatty acid-binding protein 4 (FABP4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15090UniProtKB/Swiss-Prot:
FABP4_HUMAN :- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
- Domain:
-
- Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
- Family:
-
- Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Function for FABP4 Gene
Molecular function for FABP4 Gene
- UniProtKB/Swiss-Prot Function:
- Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
- GENATLAS Biochemistry:
- fatty acid-binding protein 4,adipocyte
Phenotypes From GWAS Catalog for FABP4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005324 | long-chain fatty acid transporter activity | ISS | -- |
| GO:0005504 | fatty acid binding | TAS | 2481498 |
| GO:0008289 | lipid binding | IEA | -- |
| GO:0036041 | long-chain fatty acid binding | ISS | -- |
| GO:0051427 | hormone receptor binding | IEA | -- |
Phenotypes for FABP4 Gene
- MGI mutant phenotypes for FABP4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FABP4:
Animal Models for FABP4 Gene
- MGI Knock Outs for FABP4:
-
- Fabp4 Fabp4<tm1Brsp>
Animal Model Products
-
Taconic Biosciences Mouse Models for FABP4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FABP4 - Select products 50% OFF >
- * FABP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FABP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FABP4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP4
miRNA for FABP4 Gene
- miRTarBase miRNAs that target FABP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FABP4
- Browse OriGene Inhibitory RNA Products For FABP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4
Clone Products
- Applied Biological Materials (abm): Clones for FABP4 - Select products 50% OFF >
- * FABP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FABP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FABP4
Cell Line Products
-
Horizon Cell Lines for FABP4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP4 Gene
Localization for FABP4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene
- Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250 UniProtKB:P04117}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 3 |
| peroxisome | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | TAS | 16130169 |
| GO:0005811 | lipid droplet | TAS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FABP4 Gene
Pathways & Interactions for FABP4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lipoprotein metabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Glucose / Energy Metabolism | ||
| 4 | PPAR signaling pathway | ||
| 5 | Regulation of lipolysis in adipocytes | ||
Pathways by source for FABP4 Gene
6 Reactome pathways for FABP4 Gene
2 KEGG pathways for FABP4 Gene
1 R&D Systems pathway for FABP4 Gene
1 Cell Signaling Technology pathway for FABP4 Gene
Interacting Proteins for FABP4 Gene
Selected Interacting proteins:
P15090-FABP4_HUMAN
ENSP00000256104
for FABP4 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for FABP4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001816 | cytokine production | IEA | -- |
| GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
| GO:0009617 | response to bacterium | IEA | -- |
| GO:0015909 | long-chain fatty acid transport | ISS | -- |
| GO:0019433 | triglyceride catabolic process | TAS | -- |
Drugs & Compounds for FABP4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| oleic acid | Approved, Investigational, Vet_approved | Pharma | Agonist, Full agonist, Activator, Activation, Carrier | 0 | ||
| Palmitic Acid | Approved | Pharma | Agonist, Full agonist, Carrier | 27 | ||
| propanoic acid | Approved, Vet_approved | Pharma | Agonist, Full agonist, Carrier | 0 | ||
| arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation, Carrier | 40 | ||
| (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE | Experimental | Pharma | Carrier | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for FABP4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BMS 309403 | FABP4 inhibitor,potent and selective | 300657-03-8 |
Drug Products
- G Biosciences Human FABP4/A-FABP, Lyophilized
- Creative Biomart Recombinant Human Fatty Acid Binding Protein (Adipocyte),His-tagged
- ApexBio compounds for FABP4
Transcripts for FABP4 Gene
mRNA/cDNA for FABP4 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256104 911 nts (view in UCSC)
- ENST00000518669 510 nts (view in UCSC)
- ENST00000521734 761 nts (view in UCSC)
- ENST00000522659 627 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FABP4 - Select products 50% OFF >
- * FABP4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FABP4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FABP4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FABP4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FABP4
- Browse OriGene Inhibitory RNA Products For FABP4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4
Clone Products
- Applied Biological Materials (abm): Clones for FABP4 - Select products 50% OFF >
- * FABP4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FABP4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FABP4
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | - | ||||||||||||
| SP3: |
Relevant External Links for FABP4 Gene
- GeneLoc Exon Structure for
- FABP4
Expression for FABP4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Preadipocytes Subcutaneous White Adipose
- Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
- Preadipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Dermal Fibroblasts Dorsal Dermis
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Corneal Epithelium
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Mesenchymal Stem Cells
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Duct Cells Pancreatic Ducts
- Heart (Cardiovascular System)
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
-
Pancreas (Endocrine System)
- Duct Cells Pancreatic Ducts
- Gut Tube (Gastrointestinal Tract)
- Kidney (Urinary System)
- Thymus (Hematopoietic System)
- Breast (Uncategorized)
- Endothelium (Cardiovascular System)
-
Colon (Gastrointestinal Tract)
-
Placenta (Extraembryonic Tissues)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adrenal Gland (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FABP4 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x17.6), Adipose - Subcutaneous (x15.7), and Breast - Mammary Tissue (x11.3).
This gene is overexpressed in Adipocyte (35.0) and Nasopharynx (22.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FABP4
SOURCE GeneReport for Unigene cluster for FABP4 Gene:
Hs.391561Evidence on tissue expression from TISSUES for FABP4 Gene
- Liver(4.6)
- Heart(4.3)
- Muscle(3.6)
- Skin(3.3)
- Intestine(3.3)
- Nervous system(3.1)
- Lung(2.9)
- Thyroid gland(2.8)
- Kidney(2.8)
- Spleen(2.7)
- Pancreas(2.7)
- Blood(2.7)
- Bone marrow(2.6)
- Adrenal gland(2.6)
- Lymph node(2.5)
- Gall bladder(2.5)
- Bone(2.5)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for FABP4
-
OriGene qPCR primer pairs and template standards for FABP4
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP4 Gene
Orthologs for FABP4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FABP4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| FABP4 30 |
|
||||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | FABP4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fabp4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fabp4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | FABP4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FABP4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pmp2 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | lbp-5 30 |
|
- Species where no ortholog for FABP4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for FABP4 Gene
- ENSEMBL:
- Gene Tree for FABP4 (if available)
- TreeFam:
- Gene Tree for FABP4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FABP4: view image
Paralogs for FABP4 Gene
Paralogs for FABP4 Gene
(15) SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:
- FABP4_HUMAN
- E5RIR0_HUMAN
- E7DVW4_HUMAN
Variants for FABP4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FABP4 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 756429 | Likely Benign: not provided | 81,479,438(-) | T/C | SYNONYMOUS_VARIANT | |
| 769342 | Benign: not provided | 81,478,898(-) | G/A | SYNONYMOUS_VARIANT | |
| 769744 | Benign: not provided | 81,480,601(-) | A/G | INTRON_VARIANT | |
| rs1319351179 | A breast cancer sample | p.Glu23Asp |
Residual Variation Intolerance Score:
59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FABP4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene
Disorders for FABP4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| liposarcoma of bone |
|
|
| coronary restenosis |
|
|
| transitional cell carcinoma |
|
|
| body mass index quantitative trait locus 11 |
|
|
| non-alcoholic fatty liver disease |
|
|
Search FABP4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FABP4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FABP4 Gene
Publications for FABP4 Gene
- Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PMID: 20156355) Khalyfa A … Gozal D (Lipids in health and disease 2010) 3 23 41
- Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PMID: 15015141) Damcott CM … Ferrell RE (Metabolism: clinical and experimental 2004) 3 23 41
- Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PMID: 2481498) Baxa CA … Bernlohr DA (Biochemistry 1989) 2 3 4
- Circulating adipocyte fatty acid binding protein levels in healthy preterm infants: Positive correlation with weight gain and total-cholesterol levels. (PMID: 20231079) Siahanidou T … Chrousos G (Early human development 2010) 3 23
- Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. (PMID: 20009357) Hsu BG … Wang JH (Circulation journal : official journal of the Japanese Circulation Society 2010) 3 23
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Products for FABP4 Gene
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