FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008] See more...

Aliases for FABP4 Gene

Aliases for FABP4 Gene

  • Fatty Acid Binding Protein 4 2 3 5
  • A-FABP 2 3 4
  • Adipocyte-Type Fatty Acid-Binding Protein 3 4
  • Fatty Acid-Binding Protein, Adipocyte 3 4
  • Adipocyte Fatty Acid Binding Protein 2 3
  • Adipocyte Lipid-Binding Protein 3 4
  • AFABP 3 4
  • ALBP 3 4
  • AP2 2 3
  • Fatty Acid Binding Protein 4, Adipocyte 3
  • Epididymis Secretory Protein Li 104 3
  • Fatty Acid-Binding Protein 4 4
  • HEL-S-104 3
  • FABP4 5

External Ids for FABP4 Gene

Previous GeneCards Identifiers for FABP4 Gene

  • GC08M081268
  • GC08M082439
  • GC08M082113
  • GC08M082440
  • GC08M082553
  • GC08M082390
  • GC08M077880

Summaries for FABP4 Gene

Entrez Gene Summary for FABP4 Gene

  • FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for FABP4 Gene

FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Liposarcoma Of Bone and Coronary Restenosis. Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is PMP2.

UniProtKB/Swiss-Prot Summary for FABP4 Gene

  • Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP4 Gene

Genomics for FABP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FABP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J081482 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 608.2 +1.0 1035 4 USF1 JUND JUN SPI1 FABP4 lnc-FABP9-1 IMPA1 PMP2 LOC101927118 FABP9 ENSG00000253859
GH08J081496 Enhancer 0.6 ENCODE dbSUPER 6.7 -13.4 -13441 0.8 REST NR2F2 RXRA PMP2 FABP4 lnc-FABP9-1 ENSG00000253374 LOC101927118 ENSG00000253859 FABP12
GH08J081363 Enhancer 0.8 Ensembl ENCODE 4.4 +118.9 118936 6.2 ZNF692 IKZF2 RBAK JUND CEBPB USF1 GABPA FOS ELK4 ELF1 PMP2 ZFAND1 ENSG00000254162 CHMP4C FABP4 IMPA1 HSALNG0066571 lnc-FABP5-1 FABP5
GH08J081492 Enhancer 0.6 FANTOM5 ENCODE dbSUPER 5.5 -9.4 -9411 0.3 FABP4 lnc-FABP9-1 ENSG00000253374 LOC101927118 ENSG00000253859 FABP12
GH08J081368 Enhancer 0.6 Ensembl 4.5 +113.4 113436 3.2 CTCF TEAD4 IKZF2 DPF2 RELB RUNX3 ZNF444 BCL11A ZNF335 BATF HSALNG0066571 PMP2 FABP4 IMPA1 lnc-FABP5-1 HSALNG0066572 FABP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FABP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FABP4

Top Transcription factor binding sites by QIAGEN in the FABP4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • POU3F1
  • PPAR-alpha
  • USF-1
  • USF1

Genomic Locations for FABP4 Gene

Genomic Locations for FABP4 Gene
chr8:81,478,419-81,483,236
(GRCh38/hg38)
Size:
4,818 bases
Orientation:
Minus strand
chr8:82,390,654-82,395,498
(GRCh37/hg19)
Size:
4,845 bases
Orientation:
Minus strand

Genomic View for FABP4 Gene

Genes around FABP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP4 Gene

Proteins for FABP4 Gene

  • Protein details for FABP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15090-FABP4_HUMAN
    Recommended name:
    Fatty acid-binding protein, adipocyte
    Protein Accession:
    P15090
    Secondary Accessions:
    • Q6IBA1

    Protein attributes for FABP4 Gene

    Size:
    132 amino acids
    Molecular mass:
    14719 Da
    Quaternary structure:
    • Monomer (PubMed:15357969, PubMed:17077479). Homodimer. Interacts with PPARG (By similarity).

    Three dimensional structures from OCA and Proteopedia for FABP4 Gene

neXtProt entry for FABP4 Gene

Post-translational modifications for FABP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FABP4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FABP4

No data available for DME Specific Peptides for FABP4 Gene

Domains & Families for FABP4 Gene

Gene Families for FABP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FABP4 Gene

InterPro:
Blocks:
  • Cytosolic fatty-acid binding protein
ProtoNet:

Suggested Antigen Peptide Sequences for FABP4 Gene

GenScript: Design optimal peptide antigens:
  • Fatty acid binding protein 4, adipocyte (E7DVW4_HUMAN)
  • Fatty acid-binding protein 4 (FABP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15090

UniProtKB/Swiss-Prot:

FABP4_HUMAN :
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Domain:
  • Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP4: view

Function for FABP4 Gene

Molecular function for FABP4 Gene

UniProtKB/Swiss-Prot Function:
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
GENATLAS Biochemistry:
fatty acid-binding protein 4,adipocyte

Phenotypes From GWAS Catalog for FABP4 Gene

Gene Ontology (GO) - Molecular Function for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005324 long-chain fatty acid transporter activity ISS --
GO:0005504 fatty acid binding TAS 2481498
GO:0008289 lipid binding IEA --
GO:0036041 long-chain fatty acid binding ISS --
GO:0051427 hormone receptor binding IEA --
genes like me logo Genes that share ontologies with FABP4: view
genes like me logo Genes that share phenotypes with FABP4: view

Animal Models for FABP4 Gene

MGI Knock Outs for FABP4:

Animal Model Products

CRISPR Products

miRNA for FABP4 Gene

miRTarBase miRNAs that target FABP4

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FABP4 Gene

Localization for FABP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FABP4 Gene

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export. {ECO:0000250 UniProtKB:P04117}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 3
peroxisome 3
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm TAS 16130169
GO:0005811 lipid droplet TAS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with FABP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FABP4 Gene

Pathways & Interactions for FABP4 Gene

genes like me logo Genes that share pathways with FABP4: view

SIGNOR curated interactions for FABP4 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for FABP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0009617 response to bacterium IEA --
GO:0015909 long-chain fatty acid transport ISS --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP4: view

Drugs & Compounds for FABP4 Gene

(28) Drugs for FABP4 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
oleic acid Approved, Investigational, Vet_approved Pharma Agonist, Full agonist, Activator, Activation, Carrier 0
Palmitic Acid Approved Pharma Agonist, Full agonist, Carrier 27
propanoic acid Approved, Vet_approved Pharma Agonist, Full agonist, Carrier 0
arachidonic acid Experimental Pharma Activator, Agonist, Inhibitor, Activation, Potentiation, Carrier 40
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE Experimental Pharma Carrier 0

(18) Additional Compounds for FABP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for FABP4 Gene

Compound Action Cas Number
BMS 309403 FABP4 inhibitor,potent and selective 300657-03-8
genes like me logo Genes that share compounds with FABP4: view

Transcripts for FABP4 Gene

mRNA/cDNA for FABP4 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP4

Alternative Splicing Database (ASD) splice patterns (SP) for FABP4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -
SP3:

Relevant External Links for FABP4 Gene

GeneLoc Exon Structure for
FABP4

Expression for FABP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP4 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.6), Adipose - Subcutaneous (x15.7), and Breast - Mammary Tissue (x11.3).

Protein differential expression in normal tissues from HIPED for FABP4 Gene

This gene is overexpressed in Adipocyte (35.0) and Nasopharynx (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FABP4 Gene



Protein tissue co-expression partners for FABP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FABP4

SOURCE GeneReport for Unigene cluster for FABP4 Gene:

Hs.391561

Evidence on tissue expression from TISSUES for FABP4 Gene

  • Liver(4.6)
  • Heart(4.3)
  • Muscle(3.6)
  • Skin(3.3)
  • Intestine(3.3)
  • Nervous system(3.1)
  • Lung(2.9)
  • Thyroid gland(2.8)
  • Kidney(2.8)
  • Spleen(2.7)
  • Pancreas(2.7)
  • Blood(2.7)
  • Bone marrow(2.6)
  • Adrenal gland(2.6)
  • Lymph node(2.5)
  • Gall bladder(2.5)
  • Bone(2.5)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with FABP4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP4 Gene

Orthologs for FABP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FABP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FABP4 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
FABP4 30
  • 92.68 (n)
-- 31
  • 92 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia FABP4 30 31
  • 89.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fabp4 30 17 31
  • 86.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fabp4 30
  • 83.84 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 20 (a)
OneToMany
Chicken
(Gallus gallus)
Aves FABP4 30 31
  • 73.48 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FABP4 31
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia pmp2 30
  • 60.05 (n)
Worm
(Caenorhabditis elegans)
Secernentea lbp-5 30
  • 50.51 (n)
Species where no ortholog for FABP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for FABP4 Gene

ENSEMBL:
Gene Tree for FABP4 (if available)
TreeFam:
Gene Tree for FABP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FABP4: view image

Paralogs for FABP4 Gene

(15) SIMAP similar genes for FABP4 Gene using alignment to 3 proteins:

  • FABP4_HUMAN
  • E5RIR0_HUMAN
  • E7DVW4_HUMAN
genes like me logo Genes that share paralogs with FABP4: view

Variants for FABP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FABP4 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
756429 Likely Benign: not provided 81,479,438(-) T/C SYNONYMOUS_VARIANT
769342 Benign: not provided 81,478,898(-) G/A SYNONYMOUS_VARIANT
769744 Benign: not provided 81,480,601(-) A/G INTRON_VARIANT
rs1319351179 A breast cancer sample p.Glu23Asp

Additional dbSNP identifiers (rs#s) for FABP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for FABP4 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781
nsv611608 CNV loss 21841781

Variation tolerance for FABP4 Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP4 Gene

Human Gene Mutation Database (HGMD)
FABP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP4 Gene

Disorders for FABP4 Gene

MalaCards: The human disease database

(20) MalaCards diseases for FABP4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FABP4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FABP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FABP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP4 Gene

Publications for FABP4 Gene

  1. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. (PMID: 20156355) Khalyfa A … Gozal D (Lipids in health and disease 2010) 3 23 41
  2. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. (PMID: 15015141) Damcott CM … Ferrell RE (Metabolism: clinical and experimental 2004) 3 23 41
  3. Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. (PMID: 2481498) Baxa CA … Bernlohr DA (Biochemistry 1989) 2 3 4
  4. Circulating adipocyte fatty acid binding protein levels in healthy preterm infants: Positive correlation with weight gain and total-cholesterol levels. (PMID: 20231079) Siahanidou T … Chrousos G (Early human development 2010) 3 23
  5. Fasting serum level of fatty-acid-binding protein 4 positively correlates with metabolic syndrome in patients with coronary artery disease. (PMID: 20009357) Hsu BG … Wang JH (Circulation journal : official journal of the Japanese Circulation Society 2010) 3 23

Products for FABP4 Gene

Sources for FABP4 Gene