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FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
FABP4 (Fatty Acid Binding Protein 4) is a Protein Coding gene. Diseases associated with FABP4 include Liposarcoma Of Bone and Coronary Restenosis. Among its related pathways are Mesenchymal Stem Cells and Lineage-specific Markers and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transporter activity and fatty acid binding. An important paralog of this gene is PMP2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005324 | long-chain fatty acid transporter activity | ISS | -- |
GO:0005504 | fatty acid binding | TAS | 2481498 |
GO:0008289 | lipid binding | IEA | -- |
GO:0036041 | long-chain fatty acid binding | ISS | -- |
GO:0051427 | hormone receptor binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | TAS | 16130169 |
GO:0005811 | lipid droplet | TAS | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Lipoprotein metabolism | ||
2 | Metabolism |
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3 | Glucose / Energy Metabolism | ||
4 | PPAR signaling pathway | ||
5 | Regulation of lipolysis in adipocytes |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001816 | cytokine production | IEA | -- |
GO:0006469 | negative regulation of protein kinase activity | IEA | -- |
GO:0009617 | response to bacterium | IEA | -- |
GO:0015909 | long-chain fatty acid transport | ISS | -- |
GO:0019433 | triglyceride catabolic process | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
oleic acid | Approved, Investigational, Vet_approved | Pharma | Agonist, Full agonist, Activator, Activation, Carrier | 0 | ||
Palmitic Acid | Approved | Pharma | Agonist, Full agonist, Carrier | 27 | ||
propanoic acid | Approved, Vet_approved | Pharma | Agonist, Full agonist, Carrier | 0 | ||
arachidonic acid | Experimental | Pharma | Activator, Agonist, Inhibitor, Activation, Potentiation, Carrier | 40 | ||
(5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE | Experimental | Pharma | Carrier | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
BMS 309403 | FABP4 inhibitor,potent and selective | 300657-03-8 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||
SP2: | - | ||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FABP4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
FABP4 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | FABP4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fabp4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fabp4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | FABP4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FABP4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pmp2 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | lbp-5 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
756429 | Likely Benign: not provided | 81,479,438(-) | T/C | SYNONYMOUS_VARIANT | |
769342 | Benign: not provided | 81,478,898(-) | G/A | SYNONYMOUS_VARIANT | |
769744 | Benign: not provided | 81,480,601(-) | A/G | INTRON_VARIANT | |
rs1319351179 | A breast cancer sample | p.Glu23Asp |
Disorder | Aliases | PubMed IDs |
---|---|---|
liposarcoma of bone |
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coronary restenosis |
|
|
transitional cell carcinoma |
|
|
body mass index quantitative trait locus 11 |
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non-alcoholic fatty liver disease |
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|