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Aliases for FABP12 Gene

Aliases for FABP12 Gene

  • Fatty Acid Binding Protein 12 2 3 5

External Ids for FABP12 Gene

Previous GeneCards Identifiers for FABP12 Gene

  • GC08M082602
  • GC08M082437
  • GC08M077927

Summaries for FABP12 Gene

GeneCards Summary for FABP12 Gene

FABP12 (Fatty Acid Binding Protein 12) is a Protein Coding gene. Diseases associated with FABP12 include Schistosomiasis. Among its related pathways are Lipoprotein metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is PMP2.

UniProtKB/Swiss-Prot for FABP12 Gene

  • May play a role in lipid transport.

Additional gene information for FABP12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FABP12 Gene

Genomics for FABP12 Gene

GeneHancer (GH) Regulatory Elements for FABP12 Gene

Promoters and enhancers for FABP12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I081587 Enhancer 0.5 ENCODE 0.8 +2.6 2555 0.2 KLF1 ZFP36 EP300 TCF7L2 FABP12 FTH1P11
GH08I081605 Enhancer 0.8 ENCODE 0.4 -15.7 -15683 1 ELF3 FOXA2 MLX ZSCAN9 RAD21 RARA YY1 SMARCC2 CREM THAP11 IMPA1 NIPA2P4 FABP12 IMPA1P1
GH08I081557 Enhancer 0.8 Ensembl ENCODE 0.3 +32.4 32388 0.8 RXRA MAX RAD21 GABPA YY1 JUND ATF3 ZBTB33 HNF4A IMPA1 FABP12 FTH1P11 LOC101927118
GH08I081539 Enhancer 0.8 Ensembl ENCODE 0.2 +50.6 50570 1.7 STAT1 JUN ZNF529 USF2 STAT3 RCOR1 FOS CHD2 ZFAND1 FTH1P11 LOC101927118 FABP12
GH08I081542 Enhancer 0.5 ENCODE 0.2 +47.6 47643 1.8 ZNF316 CEBPB ZBTB33 EP300 PMP2 FTH1P11 LOC101927118 FABP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FABP12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FABP12 gene promoter:

Genomic Locations for FABP12 Gene

Genomic Locations for FABP12 Gene
chr8:81,524,981-81,590,596
(GRCh38/hg38)
Size:
65,616 bases
Orientation:
Minus strand
chr8:82,437,216-82,443,613
(GRCh37/hg19)

Genomic View for FABP12 Gene

Genes around FABP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP12 Gene

Proteins for FABP12 Gene

  • Protein details for FABP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFH5-FBP12_HUMAN
    Recommended name:
    Fatty acid-binding protein 12
    Protein Accession:
    A6NFH5
    Secondary Accessions:
    • B7SUN0

    Protein attributes for FABP12 Gene

    Size:
    140 amino acids
    Molecular mass:
    15565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FABP12 Gene

Post-translational modifications for FABP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP12 Gene

No data available for DME Specific Peptides for FABP12 Gene

Domains & Families for FABP12 Gene

Gene Families for FABP12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FABP12 Gene

Suggested Antigen Peptide Sequences for FABP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFH5

UniProtKB/Swiss-Prot:

FBP12_HUMAN :
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP12: view

Function for FABP12 Gene

Molecular function for FABP12 Gene

UniProtKB/Swiss-Prot Function:
May play a role in lipid transport.

Gene Ontology (GO) - Molecular Function for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP12: view

Phenotypes for FABP12 Gene

MGI mutant phenotypes for FABP12:
inferred from 1 alleles
GenomeRNAi human phenotypes for FABP12:
genes like me logo Genes that share phenotypes with FABP12: view

Animal Models for FABP12 Gene

MGI Knock Outs for FABP12:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FABP12 Gene

Localization for FABP12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP12 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FABP12 Gene

Pathways & Interactions for FABP12 Gene

genes like me logo Genes that share pathways with FABP12: view

Interacting Proteins for FABP12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353650%0d%0a9606.ENSP00000256104%0d%0a9606.ENSP00000244289%0d%0a9606.ENSP00000250838%0d%0a
Selected Interacting proteins: A6NFH5-FBP12_HUMAN ENSP00000353650 for FABP12 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for SIGNOR curated interactions for FABP12 Gene

Drugs & Compounds for FABP12 Gene

(20) Drugs for FABP12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(26) Additional Compounds for FABP12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP12: view

Transcripts for FABP12 Gene

mRNA/cDNA for FABP12 Gene

(4) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FABP12 Gene

Fatty acid binding protein 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FABP12 Gene

No ASD Table

Relevant External Links for FABP12 Gene

GeneLoc Exon Structure for
FABP12
ECgene alternative splicing isoforms for
FABP12

Expression for FABP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FABP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP12 Gene

This gene is overexpressed in Testis (x23.8), Esophagus - Mucosa (x10.1), Vagina (x7.9), and Cervix - Ectocervix (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of FABP12 Gene:

FABP12

SOURCE GeneReport for Unigene cluster for FABP12 Gene:

Hs.586370

mRNA Expression by UniProt/SwissProt for FABP12 Gene:

A6NFH5-FBP12_HUMAN
Tissue specificity: Expressed in a number of retinoblastoma cell lines.
genes like me logo Genes that share expression patterns with FABP12: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP12 Gene

Orthologs for FABP12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FABP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FABP12 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia FABP12 33 34
  • 86.67 (n)
cow
(Bos Taurus)
Mammalia FABP12 33 34
  • 85.95 (n)
mouse
(Mus musculus)
Mammalia Fabp12 33 16 34
  • 84.73 (n)
rat
(Rattus norvegicus)
Mammalia Fabp12 33
  • 82.19 (n)
oppossum
(Monodelphis domestica)
Mammalia FABP12 34
  • 43 (a)
OneToOne
Species where no ortholog for FABP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FABP12 Gene

ENSEMBL:
Gene Tree for FABP12 (if available)
TreeFam:
Gene Tree for FABP12 (if available)

Paralogs for FABP12 Gene

Paralogs for FABP12 Gene

(15) SIMAP similar genes for FABP12 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for FABP12 Gene

genes like me logo Genes that share paralogs with FABP12: view

Variants for FABP12 Gene

Sequence variations from dbSNP and Humsavar for FABP12 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000000210 -- 81,564,988(-) AAAAAAA/AAAAAAAA genic_upstream_transcript_variant, intron_variant
rs1000188887 -- 81,545,469(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000209553 -- 81,546,889(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000221331 -- 81,545,819(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000227223 -- 81,541,495(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FABP12 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781
nsv6274 CNV insertion 18451855

Variation tolerance for FABP12 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP12 Gene

Disorders for FABP12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FABP12 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
schistosomiasis
  • katayama fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FABP12

genes like me logo Genes that share disorders with FABP12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP12 Gene

Publications for FABP12 Gene

  1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PMID: 18786628) Liu RZ … Godbout R (Genomics 2008) 2 3 4 58
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 58
  3. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3 58
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  5. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. (PMID: 19554614) Iwayama Y … Yoshikawa T (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 22 58

Products for FABP12 Gene

Sources for FABP12 Gene

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