Aliases for FABP12 Gene

Aliases for FABP12 Gene

  • Fatty Acid Binding Protein 12 2 3 5
  • Fatty Acid-Binding Protein 12 3 4
  • Probable Fatty Acid-Binding Protein ENSP00000353650 3
  • Intracellular Fatty Acid-Binding Protein FABP12 3
  • Fatty Acid Binding Protein ORF 3
  • FABP12 5

External Ids for FABP12 Gene

Previous GeneCards Identifiers for FABP12 Gene

  • GC08M082602
  • GC08M082437
  • GC08M077927

Summaries for FABP12 Gene

GeneCards Summary for FABP12 Gene

FABP12 (Fatty Acid Binding Protein 12) is a Protein Coding gene. Diseases associated with FABP12 include Fascioliasis and Schistosomiasis. Among its related pathways are Metabolism and Lipoprotein metabolism. Gene Ontology (GO) annotations related to this gene include transporter activity and lipid binding. An important paralog of this gene is PMP2.

UniProtKB/Swiss-Prot Summary for FABP12 Gene

Additional gene information for FABP12 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FABP12 Gene

Genomics for FABP12 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FABP12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J081539 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 600.2 +50.7 50730 1.9 FOS STAT1 STAT3 RCOR1 USF2 JUN SMARCA4 CHD2 FABP12 ENSG00000253374 ZFAND1 NONHSAG050622.2 piR-48965-140 FABP4 LOC101927118
GH08J081591 Enhancer 0.6 Ensembl 600.7 -0.2 -237 0.2 CTCF REST RAD21 CEBPA CEBPB ZNF444 SMC3 ZNF654 NFIL3 HLF FABP12 NIPA2P4 lnc-IMPA1-3 IMPA1
GH08J081590 Promoter 0.3 EPDnew 600.7 +0.5 505 0.1 FABP12 piR-48965-140 FABP4
GH08J081630 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 0.3 -42.1 -42149 5.3 HNRNPL CTCF ZNF512 PRDM1 ZFX CEBPA NRF1 KLF9 HES1 POLR2A IMPA1P1 lnc-IMPA1-2 IMPA1 ZFAND1 CHMP4C SLC10A5P1 lnc-IMPA1-1 FABP12
GH08J081685 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 -95.5 -95537 1.6 HNRNPL GATAD2A REST ZNF512 RFX1 KDM1A POLR2A BACH1 TARDBP LARP7 IMPA1 lnc-SLC10A5-2 piR-34822-315 CHMP4C SLC10A5P1 lnc-IMPA1-1 FABP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FABP12 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FABP12

Top Transcription factor binding sites by QIAGEN in the FABP12 gene promoter:
  • AP-1
  • ATF6
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • Ik-1
  • Lhx3a
  • LHX3b

Genomic Locations for FABP12 Gene

Genomic Locations for FABP12 Gene
chr8:81,524,673-81,590,664
(GRCh38/hg38)
Size:
65,992 bases
Orientation:
Minus strand
chr8:82,437,216-82,443,613
(GRCh37/hg19)
Size:
6,398 bases
Orientation:
Minus strand

Genomic View for FABP12 Gene

Genes around FABP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FABP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FABP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FABP12 Gene

Proteins for FABP12 Gene

  • Protein details for FABP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFH5-FBP12_HUMAN
    Recommended name:
    Fatty acid-binding protein 12
    Protein Accession:
    A6NFH5
    Secondary Accessions:
    • B7SUN0

    Protein attributes for FABP12 Gene

    Size:
    140 amino acids
    Molecular mass:
    15565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FABP12 Gene

Post-translational modifications for FABP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FABP12 Gene

No data available for DME Specific Peptides for FABP12 Gene

Domains & Families for FABP12 Gene

Gene Families for FABP12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FABP12 Gene

Suggested Antigen Peptide Sequences for FABP12 Gene

GenScript: Design optimal peptide antigens:
  • Fatty acid-binding protein 12 (FBP12_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NFH5

UniProtKB/Swiss-Prot:

FBP12_HUMAN :
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Family:
  • Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
genes like me logo Genes that share domains with FABP12: view

Function for FABP12 Gene

Molecular function for FABP12 Gene

UniProtKB/Swiss-Prot Function:
May play a role in lipid transport.

Phenotypes From GWAS Catalog for FABP12 Gene

Gene Ontology (GO) - Molecular Function for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with FABP12: view

Phenotypes for FABP12 Gene

genes like me logo Genes that share phenotypes with FABP12: view

Animal Models for FABP12 Gene

MGI Knock Outs for FABP12:
  • Fabp12 Fabp12<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FABP12 Gene

Localization for FABP12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FABP12 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FABP12 Gene

Pathways & Interactions for FABP12 Gene

genes like me logo Genes that share pathways with FABP12: view

Interacting Proteins for FABP12 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 17)
STRING Interaction Network
Selected Interacting proteins: ENSP00000353650 A6NFH5-FBP12_HUMAN for FABP12 Gene via STRING IID

Gene Ontology (GO) - Biological Process for FABP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019433 triglyceride catabolic process TAS --
genes like me logo Genes that share ontologies with FABP12: view

No data available for SIGNOR curated interactions for FABP12 Gene

Drugs & Compounds for FABP12 Gene

(20) Drugs for FABP12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(26) Additional Compounds for FABP12 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FABP12: view

Transcripts for FABP12 Gene

mRNA/cDNA for FABP12 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FABP12

Alternative Splicing Database (ASD) splice patterns (SP) for FABP12 Gene

No ASD Table

Relevant External Links for FABP12 Gene

GeneLoc Exon Structure for
FABP12

Expression for FABP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FABP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FABP12 Gene

This gene is overexpressed in Testis (x23.8), Esophagus - Mucosa (x10.1), Vagina (x7.9), and Cervix - Ectocervix (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FABP12

SOURCE GeneReport for Unigene cluster for FABP12 Gene:

Hs.586370

mRNA Expression by UniProt/SwissProt for FABP12 Gene:

A6NFH5-FBP12_HUMAN
Tissue specificity: Expressed in a number of retinoblastoma cell lines.
genes like me logo Genes that share expression patterns with FABP12: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FABP12 Gene

Orthologs for FABP12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FABP12 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FABP12 30 31
  • 99.52 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FABP12 30 31
  • 86.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FABP12 30 31
  • 85.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fabp12 30 17 31
  • 84.73 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fabp12 30
  • 82.19 (n)
Oppossum
(Monodelphis domestica)
Mammalia FABP12 31
  • 43 (a)
OneToOne
Species where no ortholog for FABP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FABP12 Gene

ENSEMBL:
Gene Tree for FABP12 (if available)
TreeFam:
Gene Tree for FABP12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FABP12: view image

Paralogs for FABP12 Gene

(15) SIMAP similar genes for FABP12 Gene using alignment to 2 proteins:

  • FBP12_HUMAN
  • H0YAS1_HUMAN

Pseudogenes.org Pseudogenes for FABP12 Gene

genes like me logo Genes that share paralogs with FABP12: view

Variants for FABP12 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FABP12 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
789297 Benign: not provided 81,531,265(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FABP12 Gene

Structural Variations from Database of Genomic Variants (DGV) for FABP12 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781
nsv6274 CNV insertion 18451855

Variation tolerance for FABP12 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FABP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FABP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FABP12 Gene

Disorders for FABP12 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FABP12 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fascioliasis
  • fasciola hepatica infection
schistosomiasis
  • katayama fever
acute myocardial infarction
hypotrichosis
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with FABP12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FABP12 Gene

Publications for FABP12 Gene

  1. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis. (PMID: 18786628) Liu RZ … Godbout R (Genomics 2008) 2 3 4
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4
  3. Marie Unna hereditary hypotrichosis accompanied by multiple familial trichoepithelioma in a Chinese family. (PMID: 30809827) Huang Y … Liu W (The Journal of dermatology 2019) 3
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
  5. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3

Products for FABP12 Gene

Sources for FABP12 Gene