Aliases for FAAP24 Gene
External Ids for FAAP24 Gene
Previous HGNC Symbols for FAAP24 Gene
Previous GeneCards Identifiers for FAAP24 Gene
FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FAAP24 Gene
FAAP24 (FA Core Complex Associated Protein 24) is a Protein Coding gene. Diseases associated with FAAP24 include Fanconi Anemia, Complementation Group T and Fanconi Anemia, Complementation Group N. Among its related pathways are Fanconi anemia pathway and DNA Double-Strand Break Repair.
UniProtKB/Swiss-Prot Summary for FAAP24 Gene
Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.