This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008] See more...

Aliases for FAAH Gene

Aliases for FAAH Gene

  • Fatty Acid Amide Hydrolase 2 3 5
  • Fatty-Acid Amide Hydrolase 1 3 4
  • Anandamide Amidohydrolase 1 3 4
  • Fatty Acid Ester Hydrolase 3 4
  • Oleamide Hydrolase 1 3 4
  • FAAH-1 2 3
  • EC 3.5.1.n2 50
  • EC 3.5.1.99 4
  • EC 3.1.1.- 4
  • EC 3.5.1 50
  • FAAH1 4
  • PSAB 3
  • FAAH 5

External Ids for FAAH Gene

Previous GeneCards Identifiers for FAAH Gene

  • GC01P046501
  • GC01P045816
  • GC01P046246
  • GC01P046229
  • GC01P046572
  • GC01P046632
  • GC01P046860
  • GC01P044975

Summaries for FAAH Gene

Entrez Gene Summary for FAAH Gene

  • This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAAH Gene

FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include Polysubstance Abuse and Cannabis Dependence. Among its related pathways are Arachidonic acid metabolism and phospholipases. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot Summary for FAAH Gene

  • Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).

Tocris Summary for FAAH Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FAAH Gene

Genomics for FAAH Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FAAH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J046393 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 258.3 0.0 -8 2.2 ZNF600 ZNF580 ZNF10 BRCA1 POLR2A ZIC2 YY1 MXD4 CHD2 ZNF341 FAAH HSALNG0003328 NSUN4 LRRC41 GPBP1L1 RPL7AP16 NASP RPS15AP10 EFCAB14-AS1
GH01J046395 Promoter 0.4 Ensembl 250.7 +1.4 1384 0.2 EGR2 FAAH NSUN4 NONHSAG001339.2 DMBX1
GH01J046352 Promoter 0.3 EPDnew 250.3 -41.3 -41322 0.1 piR-57138-011 FAAH LRRC41 UQCRH piR-41501 NSUN4
GH01J046338 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7.4 -52.8 -52769 5.5 BCLAF1 SP1 NCOR1 ZNF207 MYC ZNF600 IKZF1 SIX5 SSRP1 JUND NSUN4 lnc-LRRC41-3-001 lnc-LRRC41-3-002 LRRC41 GPBP1L1 RPL7AP16 EFCAB14-AS1 LURAP1 UQCRH RPS15AP10
GH01J046299 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 5.9 -91.1 -91130 6.4 SP1 ZNF207 MYC IKZF1 NCOR1 ZNF600 SIX5 JUND ZNF580 POLR2A LRRC41 HSALNG0003317 UQCRH LURAP1 NASP EFCAB14 ZSWIM5 FAAH CCDC163 TMEM69
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAAH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FAAH

Top Transcription factor binding sites by QIAGEN in the FAAH gene promoter:
  • aMEF-2
  • Evi-1
  • HTF
  • Lmo2
  • LyF-1
  • MEF-2
  • MEF-2A
  • Pax-5
  • STAT3

Genomic Locations for FAAH Gene

Latest Assembly
chr1:46,394,317-46,413,848
(GRCh38/hg38)
Size:
19,532 bases
Orientation:
Plus strand

Previous Assembly
chr1:46,859,989-46,879,517
(GRCh37/hg19 by Entrez Gene)
Size:
19,529 bases
Orientation:
Plus strand

chr1:46,859,937-46,879,520
(GRCh37/hg19 by Ensembl)
Size:
19,584 bases
Orientation:
Plus strand

Genomic View for FAAH Gene

Genes around FAAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH Gene

Proteins for FAAH Gene

  • Protein details for FAAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00519-FAAH1_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 1
    Protein Accession:
    O00519
    Secondary Accessions:
    • D3DQ19
    • Q52M86
    • Q5TDF8

    Protein attributes for FAAH Gene

    Size:
    579 amino acids
    Molecular mass:
    63066 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH Gene

Selected DME Specific Peptides for FAAH Gene

O00519:
  • DIGGSIR
  • GGSIRFP
  • ALPGASG

Post-translational modifications for FAAH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FAAH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FAAH Gene

Gene Families for FAAH Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for FAAH Gene

InterPro:
Blocks:
  • Amidase

Suggested Antigen Peptide Sequences for FAAH Gene

GenScript: Design optimal peptide antigens:
  • Oleamide hydrolase 1 (FAAH1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00519

UniProtKB/Swiss-Prot:

FAAH1_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH: view

Function for FAAH Gene

Molecular function for FAAH Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:17015445, PubMed:19926788). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:17015445). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine; Xref=Rhea:RHEA:26136, ChEBI:CHEBI:2700, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57603; EC=3.5.1.99; Evidence={ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788, ECO:0000269|PubMed:9122178};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+); Xref=Rhea:RHEA:26506, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30823, ChEBI:CHEBI:116314; EC=3.5.1.99; Evidence={ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:9122178};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine; Xref=Rhea:RHEA:45060, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57603, ChEBI:CHEBI:71466; Evidence={ECO:0000269|PubMed:17015445};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-hexadecanoylethanolamine = ethanolamine + hexadecanoate; Xref=Rhea:RHEA:45064, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:57603, ChEBI:CHEBI:71464; Evidence={ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + hexadecanamide = hexadecanoate + NH4(+); Xref=Rhea:RHEA:62984, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:74475; Evidence={ECO:0000269|PubMed:9122178};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + tetradecamide = NH4(+) + tetradecanoate; Xref=Rhea:RHEA:62992, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30807, ChEBI:CHEBI:137125; Evidence={ECO:0000269|PubMed:9122178};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine; Xref=Rhea:RHEA:63148, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:146191, ChEBI:CHEBI:507393; Evidence={ECO:0000269|PubMed:17015445};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+); Xref=Rhea:RHEA:62976, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32387, ChEBI:CHEBI:142684; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+); Xref=Rhea:RHEA:63016, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32395, ChEBI:CHEBI:137830; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+); Xref=Rhea:RHEA:63008, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32375, ChEBI:CHEBI:146168; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+); Xref=Rhea:RHEA:63028, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32392, ChEBI:CHEBI:146166; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+); Xref=Rhea:RHEA:62996, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:71589, ChEBI:CHEBI:146163; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+); Xref=Rhea:RHEA:63000, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:77223, ChEBI:CHEBI:146164; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+); Xref=Rhea:RHEA:63004, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:77220, ChEBI:CHEBI:146165; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+); Xref=Rhea:RHEA:63020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:30245, ChEBI:CHEBI:82984; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol; Xref=Rhea:RHEA:63052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:32395, ChEBI:CHEBI:78033; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+); Xref=Rhea:RHEA:63120, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938, ChEBI:CHEBI:32426, ChEBI:CHEBI:146167; Evidence={ECO:0000250|UniProtKB:P97612};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine; Xref=Rhea:RHEA:35563, ChEBI:CHEBI:15377, ChEBI:CHEBI:32372, ChEBI:CHEBI:57603, ChEBI:CHEBI:71465; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate; Xref=Rhea:RHEA:63124, ChEBI:CHEBI:15377, ChEBI:CHEBI:25629, ChEBI:CHEBI:57603, ChEBI:CHEBI:85299; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine; Xref=Rhea:RHEA:63128, ChEBI:CHEBI:15377, ChEBI:CHEBI:23858, ChEBI:CHEBI:57603, ChEBI:CHEBI:146186; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate; Xref=Rhea:RHEA:63140, ChEBI:CHEBI:15377, ChEBI:CHEBI:31014, ChEBI:CHEBI:132049, ChEBI:CHEBI:507393; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)-tetracosenoate + ethanolamine; Xref=Rhea:RHEA:63144, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:57603, ChEBI:CHEBI:146187; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-docosanoyl-taurine = docosanoate + taurine; Xref=Rhea:RHEA:63156, ChEBI:CHEBI:15377, ChEBI:CHEBI:23858, ChEBI:CHEBI:146196, ChEBI:CHEBI:507393; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine; Xref=Rhea:RHEA:63160, ChEBI:CHEBI:15377, ChEBI:CHEBI:32392, ChEBI:CHEBI:146198, ChEBI:CHEBI:507393; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-tricosanoyl-taurine = taurine + tricosanoate; Xref=Rhea:RHEA:63164, ChEBI:CHEBI:15377, ChEBI:CHEBI:79007, ChEBI:CHEBI:146197, ChEBI:CHEBI:507393; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoate + glycine = H2O + N-(9Z-octadecenoyl)glycine; Xref=Rhea:RHEA:51316, ChEBI:CHEBI:15377, ChEBI:CHEBI:30823, ChEBI:CHEBI:57305, ChEBI:CHEBI:133992; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine; Xref=Rhea:RHEA:64108, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:57305, ChEBI:CHEBI:59002; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine; Xref=Rhea:RHEA:64116, ChEBI:CHEBI:15377, ChEBI:CHEBI:32395, ChEBI:CHEBI:33384, ChEBI:CHEBI:149697; Evidence={ECO:0000250|UniProtKB:O08914};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Vmax=9.7 nmol/min/mg enzyme for the hydrolysis of oleamide ((9Z)-octadecenamide) {ECO:0000269|PubMed:17015445}; Vmax=2.1 nmol/min/mg enzyme for the hydrolysis of N-palmitoyl ethanolamine (N-hexadecanoyl ethanolamine) {ECO:0000269|PubMed:17015445}; Vmax=5.6 nmol/min/mg enzyme for the hydrolysis of N-oleoyl ethanolamine (N-(9Z-octadecenoyl)-ethanolamine) {ECO:0000269|PubMed:17015445}; Vmax=17 nmol/min/mg enzyme for the hydrolysis of anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine) {ECO:0000269|PubMed:17015445}; Vmax=0.75 nmol/min/mg enzyme for the hydrolysis of N-oleoyltaurine (N-(9Z-octadecenoyl)-taurine) {ECO:0000269|PubMed:17015445}; pH dependence: Optimum pH is around 9.0. {ECO:0000269|PubMed:17015445};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocycles (PubMed:17015445). Inhibited by trifluoromethyl ketone (PubMed:9122178).
GENATLAS Biochemistry:
fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide

Enzyme Numbers (IUBMB) for FAAH Gene

Phenotypes From GWAS Catalog for FAAH Gene

Gene Ontology (GO) - Molecular Function for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004040 amidase activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0017064 fatty acid amide hydrolase activity TAS --
GO:0047372 acylglycerol lipase activity IEA,ISS --
genes like me logo Genes that share ontologies with FAAH: view
genes like me logo Genes that share phenotypes with FAAH: view

Animal Models for FAAH Gene

MGI Knock Outs for FAAH:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAAH

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAAH Gene

Localization for FAAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH Gene

Endomembrane system. Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAAH gene
Compartment Confidence
cytoskeleton 4
plasma membrane 3
extracellular 3
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005856 cytoskeleton IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAAH: view

Pathways & Interactions for FAAH Gene

genes like me logo Genes that share pathways with FAAH: view

Pathways by source for FAAH Gene

1 BioSystems pathway for FAAH Gene
1 PharmGKB pathway for FAAH Gene
1 KEGG pathway for FAAH Gene
1 GeneGo (Thomson Reuters) pathway for FAAH Gene
  • Anandamide biosynthesis and metabolism
1 Cell Signaling Technology pathway for FAAH Gene

Gene Ontology (GO) - Biological Process for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0009062 fatty acid catabolic process IDA 9122178
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process TAS --
GO:0052651 monoacylglycerol catabolic process ISS --
genes like me logo Genes that share ontologies with FAAH: view

No data available for SIGNOR curated interactions for FAAH Gene

Drugs & Compounds for FAAH Gene

(67) Drugs for FAAH Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiopental Approved, Vet_approved Pharma Target, inhibitor 50
Acetaminophen Approved Pharma Enzyme, substrate 1412
oleic acid Approved, Investigational, Vet_approved Pharma 0
cannabidiol Approved, Investigational Pharma Enzyme, inhibitor 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0

(16) Additional Compounds for FAAH Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxypropofol
PDP-EA
861891-72-7

(5) Tocris Compounds for FAAH Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor 681136-29-8
PDP-EA FAAH activator 861891-72-7
PF 3845 Selective FAAH inhibitor 1196109-52-0
PF 750 Selective FAAH inhibitor 959151-50-9
TC-F 2 Potent, reversible and selective FAAH inhibitor 1304778-15-1

(12) ApexBio Compounds for FAAH Gene

Compound Action Cas Number
AACOCF3 Inhibitor of cPLA2/anandamide hydrolysis/FAAH 149301-79-1
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
JNJ-1661010 FAAH inhibitor,potent and selective 681136-29-8
JZL 195 1210004-12-8
LY2183240 Blocker of anandamide uptake,highly potent 874902-19-9
PF 750 959151-50-9
PF-3845 FAAH ihibitor,highly potent and selective 1196109-52-0
SA 47 792236-07-8
SA 57 1346169-63-8
TAK 21d 1143578-94-2
TC-F 2 1304778-15-1
URB597 FAAH inhibitor,potent and selective 546141-08-6
genes like me logo Genes that share compounds with FAAH: view

Drug products for research

Transcripts for FAAH Gene

mRNA/cDNA for FAAH Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FAAH

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for FAAH Gene

GeneLoc Exon Structure for
FAAH

Expression for FAAH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FAAH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAAH Gene

This gene is overexpressed in Testis (18.9), Islet of Langerhans (7.9), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAAH Gene



Protein tissue co-expression partners for FAAH Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FAAH

SOURCE GeneReport for Unigene cluster for FAAH Gene:

Hs.720143

mRNA Expression by UniProt/SwissProt for FAAH Gene:

O00519-FAAH1_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

Evidence on tissue expression from TISSUES for FAAH Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(4.4)
  • Skin(2.4)
  • Kidney(2.4)
  • Adrenal gland(2.3)
  • Intestine(2.2)
  • Thyroid gland(2.1)
  • Pancreas(2)
  • Heart(2)
  • Muscle(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with FAAH: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAAH Gene

Orthologs for FAAH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAAH 29 30
  • 99.42 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAAH 29 30
  • 89.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAAH 29 30
  • 87.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Faah 29
  • 84.23 (n)
Mouse
(Mus musculus)
Mammalia Faah 29 16 30
  • 84.05 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAAH 30
  • 54 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAAH 30
  • 43 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAAH 29 30
  • 63.48 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAAH 30
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11306 29
Zebrafish
(Danio rerio)
Actinopterygii FAAH 30
  • 50 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG30502 31
  • 39 (a)
CG5191 30
  • 20 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea faah-1 29 30
  • 45.58 (n)
OneToMany
C25A1.5 31
  • 45 (a)
B0218.2 31
  • 35 (a)
F58H7.2 31
  • 35 (a)
faah-2 30
  • 34 (a)
OneToMany
faah-3 30
  • 32 (a)
OneToMany
Y56A3A.12a 31
  • 31 (a)
Y56A3A.12b 31
  • 31 (a)
Y56A3A.5 31
  • 30 (a)
Y41C4A.2 31
  • 28 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 30 32
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 57 (a)
OneToMany
-- 30
  • 49 (a)
OneToMany
-- 30
  • 41 (a)
OneToMany
-- 30
  • 40 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU08356 29
  • 45.26 (n)
Species where no ortholog for FAAH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for FAAH Gene

ENSEMBL:
Gene Tree for FAAH (if available)
TreeFam:
Gene Tree for FAAH (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FAAH: view image
Alliance of Genome Resources:
Additional Orthologs for FAAH

Paralogs for FAAH Gene

Paralogs for FAAH Gene

(1) SIMAP similar genes for FAAH Gene using alignment to 1 proteins:

  • FAAH1_HUMAN

Pseudogenes.org Pseudogenes for FAAH Gene

genes like me logo Genes that share paralogs with FAAH: view

Variants for FAAH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH Gene

FAAH1_HUMAN-O00519
Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FAAH Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
767669 Benign: not provided 46,406,314(+) T/.
NM_001441.3(FAAH):c.897= (p.Cys299=)
NO_SEQUENCE_ALTERATION
rs1048770401 Likely Benign: not provided 46,412,217(+) T/C
NM_001441.3(FAAH):c.1431T>C (p.Pro477=)
SYNONYMOUS
rs137933045 Benign: not provided 46,405,033(+) G/A
NM_001441.3(FAAH):c.329G>A (p.Gly110Glu)
MISSENSE
rs1398134148 Likely Benign: not provided 46,406,338(+) C/T
NM_001441.3(FAAH):c.921C>T (p.Pro307=)
SYNONYMOUS
rs145105174 Likely Benign: not provided 46,406,301(+) G/A
NM_001441.3(FAAH):c.884G>A (p.Arg295Gln)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FAAH Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FAAH Gene

Variant ID Type Subtype PubMed ID
esv2761743 CNV gain 21179565
nsv546162 CNV loss 21841781
nsv829748 CNV loss 17160897

Variation tolerance for FAAH Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAAH Gene

Human Gene Mutation Database (HGMD)
FAAH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAAH
Leiden Open Variation Database (LOVD)
FAAH

SNP Genotyping and Copy Number Assays for research

Disorders for FAAH Gene

MalaCards: The human disease database

(22) MalaCards diseases for FAAH Gene - From: OMI, GTR, COP, and GCD

Disorder Aliases PubMed IDs
polysubstance abuse
  • polysubstance abuse, susceptibility to
cannabis dependence
  • marijuana abuse
hallucinogen dependence
somatoform disorder
  • physiological malfunction arising from mental factor
autoimmune encephalitis
  • hashimoto's encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search FAAH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FAAH

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FAAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH Gene

Publications for FAAH Gene

  1. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. (PMID: 16972078) Flanagan JM … Sipe JC (Human genetics 2006) 3 4 22 40
  2. Molecular characterization of human and mouse fatty acid amide hydrolases. (PMID: 9122178) Giang DK … Cravatt BF (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22
  3. C358A missense polymorphism of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese females. (PMID: 20065978) de Luis DA … Romero E (International journal of obesity (2005) 2010) 3 22 40
  4. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PMID: 20044928) Müller TD … Hinney A (BMC medical genetics 2010) 3 22 40
  5. [C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and adipocytokine levels in the morbidly obese]. (PMID: 20189896) De Luis DA … Romero E (Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 2010) 3 22 40

Products for FAAH Gene

Sources for FAAH Gene