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Aliases for FAAH Gene

Aliases for FAAH Gene

  • Fatty Acid Amide Hydrolase 2 3 5
  • Anandamide Amidohydrolase 1 3 4
  • Oleamide Hydrolase 1 3 4
  • Fatty-Acid Amide Hydrolase 1 3
  • EC 3.5.1.n2 56
  • EC 3.5.1.99 4
  • EC 3.5.1 56
  • FAAH-1 3
  • FAAH1 4
  • PSAB 3

External Ids for FAAH Gene

Previous GeneCards Identifiers for FAAH Gene

  • GC01P046501
  • GC01P045816
  • GC01P046246
  • GC01P046229
  • GC01P046572
  • GC01P046632
  • GC01P046860
  • GC01P044975

Summaries for FAAH Gene

Entrez Gene Summary for FAAH Gene

  • This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]

GeneCards Summary for FAAH Gene

FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include Polysubstance Abuse and Cannabis Dependence. Among its related pathways are Metabolism and Arachidonic acid metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH2.

UniProtKB/Swiss-Prot for FAAH Gene

  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Tocris Summary for FAAH Gene

  • Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.

Additional gene information for FAAH Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAAH Gene

Genomics for FAAH Gene

GeneHancer (GH) Regulatory Elements for FAAH Gene

Promoters and enhancers for FAAH Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I046393 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 308 1.7 ARNT ZFP64 ARID4B NEUROD1 SIN3A ZNF2 YY1 CBX5 KLF13 SP3 FAAH NSUN4 LRRC41 NASP FAAHP1
GH01I046338 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7.4 -52.7 -52717 5.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NSUN4 LRRC41 GPBP1L1 LURAP1 RPL7AP16 EFCAB14-AS1 UQCRH RPS15AP10 MOB3C PIK3R3
GH01I045749 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 6.2 -643.0 -643011 3.1 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 IPP LOC105378693 LRRC41 TOE1 GPBP1L1 HECTD3 CCDC163 RPL7AP16 MUTYH MAST2
GH01I046299 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.9 -91.5 -91487 5.6 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 LRRC41 GC01P046304 GC01P046305 UQCRH GPBP1L1 LURAP1 TOE1 RPL7AP16 EFCAB14-AS1 NASP
GH01I046401 Enhancer 1.2 Ensembl ENCODE 6.1 +7.8 7769 1.3 HDGF ARNT ARID4B NEUROD1 SIN3A DMAP1 GLI4 ZNF2 ZBTB7B ZNF48 EFCAB14 FAAH FAAHP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FAAH on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAAH gene promoter:

Genomic Locations for FAAH Gene

Genomic Locations for FAAH Gene
chr1:46,394,265-46,413,848
(GRCh38/hg38)
Size:
19,584 bases
Orientation:
Plus strand
chr1:46,859,937-46,879,520
(GRCh37/hg19)

Genomic View for FAAH Gene

Genes around FAAH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAAH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAAH Gene

Proteins for FAAH Gene

  • Protein details for FAAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00519-FAAH1_HUMAN
    Recommended name:
    Fatty-acid amide hydrolase 1
    Protein Accession:
    O00519
    Secondary Accessions:
    • D3DQ19
    • Q52M86
    • Q5TDF8

    Protein attributes for FAAH Gene

    Size:
    579 amino acids
    Molecular mass:
    63066 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FAAH Gene

Selected DME Specific Peptides for FAAH Gene

O00519:
  • DIGGSIR
  • GGSIRFP
  • ALPGASG

Post-translational modifications for FAAH Gene

No Post-translational modifications

Other Protein References for FAAH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FAAH Gene

Gene Families for FAAH Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for FAAH Gene

Suggested Antigen Peptide Sequences for FAAH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00519

UniProtKB/Swiss-Prot:

FAAH1_HUMAN :
  • Belongs to the amidase family.
Family:
  • Belongs to the amidase family.
genes like me logo Genes that share domains with FAAH: view

Function for FAAH Gene

Molecular function for FAAH Gene

GENATLAS Biochemistry:
fatty acid amide hydroxylase,expressed in liver and brain not in heart and lung,degrading neuromodulatory fatty acids such as oleamide and anandamide
UniProtKB/Swiss-Prot CatalyticActivity:
Anandamide + H(2)O = arachidonic acid + ethanolamine.
UniProtKB/Swiss-Prot CatalyticActivity:
Oleamide + H(2)O = oleic acid + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by O-aryl carbamates and alpha-keto heterocytes.
UniProtKB/Swiss-Prot Function:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

Enzyme Numbers (IUBMB) for FAAH Gene

Phenotypes From GWAS Catalog for FAAH Gene

Gene Ontology (GO) - Molecular Function for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004040 amidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0017064 fatty acid amide hydrolase activity TAS,IEA --
GO:0047372 acylglycerol lipase activity IEA --
genes like me logo Genes that share ontologies with FAAH: view
genes like me logo Genes that share phenotypes with FAAH: view

Animal Models for FAAH Gene

MGI Knock Outs for FAAH:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FAAH Gene

Localization for FAAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAAH Gene

Endomembrane system; Single-pass membrane protein. Cytoplasm, cytoskeleton. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAAH gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytoskeleton 3
plasma membrane 2
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005856 cytoskeleton IEA --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FAAH: view

Pathways & Interactions for FAAH Gene

genes like me logo Genes that share pathways with FAAH: view

Pathways by source for FAAH Gene

1 Cell Signaling Technology pathway for FAAH Gene
1 BioSystems pathway for FAAH Gene
1 PharmGKB pathway for FAAH Gene
1 KEGG pathway for FAAH Gene
1 GeneGo (Thomson Reuters) pathway for FAAH Gene

Gene Ontology (GO) - Biological Process for FAAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009062 fatty acid catabolic process IDA 9122178
GO:0019369 arachidonic acid metabolic process TAS --
genes like me logo Genes that share ontologies with FAAH: view

No data available for SIGNOR curated interactions for FAAH Gene

Drugs & Compounds for FAAH Gene

(63) Drugs for FAAH Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiopental Approved, Vet_approved Pharma Target, inhibitor 39
Acetaminophen Approved Pharma Target, inhibitor 1014
oleic acid Approved, Investigational, Vet_approved Pharma Full agonist, Agonist 0
Propofol Approved, Investigational, Vet_approved Pharma Enzyme, substrate 1189
Aripiprazole Approved, Investigational Pharma Antagonist Antipsychotic, High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist 373

(17) Additional Compounds for FAAH Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxypropofol
PDP-EA
861891-72-7

(5) Tocris Compounds for FAAH Gene

Compound Action Cas Number
JNJ 1661010 Selective, reversible FAAH inhibitor 681136-29-8
PDP-EA FAAH activator 861891-72-7
PF 3845 Selective FAAH inhibitor 1196109-52-0
PF 750 Selective FAAH inhibitor 959151-50-9
TC-F 2 Potent, reversible and selective FAAH inhibitor 1304778-15-1

(14) ApexBio Compounds for FAAH Gene

Compound Action Cas Number
AACOCF3 Inhibitor of cPLA2/anandamide hydrolysis/FAAH 149301-79-1
AM 1172 Inhibitor of anandamide uptake and FAAH,potent and selective 251908-92-6
FAAH inhibitor 1 326866-17-5
JNJ-1661010 FAAH inhibitor,potent and selective 681136-29-8
JZL 195 1210004-12-8
LY2183240 Blocker of anandamide uptake,highly potent 874902-19-9
PF 750 959151-50-9
PF-04457845 FAAH inhibitor,potent and exquisitely selective 1020315-31-4
PF-3845 FAAH ihibitor,highly potent and selective 1196109-52-0
SA 47 792236-07-8
SA 57 1346169-63-8
TAK 21d 1143578-94-2
TC-F 2 1304778-15-1
URB597 FAAH inhibitor,potent and selective 546141-08-6
genes like me logo Genes that share compounds with FAAH: view

Drug Products

Transcripts for FAAH Gene

Unigene Clusters for FAAH Gene

Fatty acid amide hydrolase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAAH Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - -
SP2: - - - - - -
SP3:
SP4:
SP5:

Relevant External Links for FAAH Gene

GeneLoc Exon Structure for
FAAH
ECgene alternative splicing isoforms for
FAAH

Expression for FAAH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAAH Gene

Protein differential expression in normal tissues from HIPED for FAAH Gene

This gene is overexpressed in Testis (18.9), Islet of Langerhans (7.9), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FAAH Gene



Protein tissue co-expression partners for FAAH Gene

NURSA nuclear receptor signaling pathways regulating expression of FAAH Gene:

FAAH

SOURCE GeneReport for Unigene cluster for FAAH Gene:

Hs.720143

mRNA Expression by UniProt/SwissProt for FAAH Gene:

O00519-FAAH1_HUMAN
Tissue specificity: Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

Evidence on tissue expression from TISSUES for FAAH Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with FAAH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAAH Gene

Orthologs for FAAH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FAAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAAH 34 33
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAAH 33 34
  • 89.41 (n)
cow
(Bos Taurus)
Mammalia FAAH 34 33
  • 87.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Faah 33
  • 84.23 (n)
mouse
(Mus musculus)
Mammalia Faah 33 16 34
  • 84.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAAH 34
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAAH 34
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAAH 33 34
  • 63.48 (n)
lizard
(Anolis carolinensis)
Reptilia FAAH 34
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11306 33
zebrafish
(Danio rerio)
Actinopterygii FAAH 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30502 35
  • 39 (a)
CG5191 34
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea faah-1 33 34
  • 45.58 (n)
C25A1.5 35
  • 45 (a)
B0218.2 35
  • 35 (a)
F58H7.2 35
  • 35 (a)
faah-2 34
  • 34 (a)
OneToMany
faah-3 34
  • 32 (a)
OneToMany
Y56A3A.12a 35
  • 31 (a)
Y56A3A.12b 35
  • 31 (a)
Y56A3A.5 35
  • 30 (a)
Y41C4A.2 35
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMD2 34 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08356 33
  • 45.26 (n)
Species where no ortholog for FAAH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FAAH Gene

ENSEMBL:
Gene Tree for FAAH (if available)
TreeFam:
Gene Tree for FAAH (if available)

Paralogs for FAAH Gene

Paralogs for FAAH Gene

(1) SIMAP similar genes for FAAH Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FAAH Gene

genes like me logo Genes that share paralogs with FAAH: view

Variants for FAAH Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FAAH Gene

FAAH1_HUMAN-O00519
Genetic variations in FAAH can be associated with susceptibility to polysubstance abuse [MIM:606581]. At homozygosity, variant Thr-129 is strongly associated with drug and alcohol abuse, and methamphetamine dependence.

Sequence variations from dbSNP and Humsavar for FAAH Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs324420 risk-factor, Polysubstance abuse, susceptibility to 46,405,089(+) C/A coding_sequence_variant, missense_variant
rs772931153 A breast cancer sample 46,408,541(+) C/A coding_sequence_variant, missense_variant
rs1000118692 -- 46,400,304(+) G/A intron_variant
rs1000247574 -- 46,407,204(+) G/A intron_variant
rs1000401890 -- 46,412,971(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAAH Gene

Variant ID Type Subtype PubMed ID
nsv829748 CNV loss 17160897
nsv546162 CNV loss 21841781
esv2761743 CNV gain 21179565

Variation tolerance for FAAH Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAAH Gene

Human Gene Mutation Database (HGMD)
FAAH
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FAAH

Disorders for FAAH Gene

MalaCards: The human disease database

(9) MalaCards diseases for FAAH Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
polysubstance abuse
  • polysubstance abuse, susceptibility to
cannabis dependence
  • marijuana abuse
autoimmune encephalitis
  • hashimoto's encephalitis
hallucinogen dependence
post-traumatic stress disorder
  • traumatic neurosis
- elite association - COSMIC cancer census association via MalaCards
Search FAAH in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FAAH

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FAAH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FAAH Gene

Publications for FAAH Gene

  1. The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. (PMID: 16972078) Flanagan JM … Sipe JC (Human genetics 2006) 3 4 22 44 58
  2. Molecular characterization of human and mouse fatty acid amide hydrolases. (PMID: 9122178) Giang DK … Cravatt BF (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  3. Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. (PMID: 20010914) Proudnikov D … Kreek MJ (The pharmacogenomics journal 2010) 3 22 44 58
  4. Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity. (PMID: 20044928) Müller TD … Hinney A (BMC medical genetics 2010) 3 22 44 58
  5. [C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and adipocytokine levels in the morbidly obese]. (PMID: 20189896) De Luis DA … Romero E (Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 2010) 3 22 44 58

Products for FAAH Gene

Sources for FAAH Gene

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