Aliases for FAAH Gene
External Ids for FAAH Gene
Previous GeneCards Identifiers for FAAH Gene
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
GeneCards Summary for FAAH Gene
FAAH (Fatty Acid Amide Hydrolase) is a Protein Coding gene. Diseases associated with FAAH include Polysubstance Abuse and Cannabis Dependence. Among its related pathways are Arachidonic acid metabolism and GABAergic synapse. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and carbon-nitrogen ligase activity, with glutamine as amido-N-donor. An important paralog of this gene is FAAH2.
UniProtKB/Swiss-Prot Summary for FAAH Gene
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Fatty acid amide hydrolase, (FAAH, Oleamide hydrolase, Anandamide amidohydrolase), is an integral membrane protein that hydrolyzes bioactive amides, including anandamide, to free fatty acid and ethanolamine. FAAH belongs to the serine hydrolase enzyme family.