This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containi... See more...

Aliases for F7 Gene

Aliases for F7 Gene

  • Coagulation Factor VII 2 3 4 5
  • Eptacog Alfa 2 3 4
  • Coagulation Factor VII (Serum Prothrombin Conversion Accelerator) 2 3
  • FVII Coagulation Protein 2 3
  • Proconvertin 3 4
  • EC 4 51
  • SPCA 3 4
  • Serum Prothrombin Conversion Accelerator 4
  • Factor VII 2
  • EC 3.4.21 51
  • F7 5

External Ids for F7 Gene

Previous GeneCards Identifiers for F7 Gene

  • GC13P112370
  • GC13P108397
  • GC13P112846
  • GC13P111708
  • GC13P112808
  • GC13P113760
  • GC13P094198

Summaries for F7 Gene

Entrez Gene Summary for F7 Gene

  • This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]

GeneCards Summary for F7 Gene

F7 (Coagulation Factor VII) is a Protein Coding gene. Diseases associated with F7 include Factor Vii Deficiency and Myocardial Infarction. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Gamma carboxylation, hypusine formation and arylsulfatase activation. Gene Ontology (GO) annotations related to this gene include calcium ion binding and serine-type endopeptidase activity. An important paralog of this gene is F9.

UniProtKB/Swiss-Prot Summary for F7 Gene

  • Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

Gene Wiki entry for F7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for F7 Gene

Genomics for F7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for F7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J113105 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 261.2 0.0 -38 1.1 CHD2 CEBPA FOXA1 ZNF217 ZIC2 HOMEZ KDM6A FOXA2 ZNF511 SMAD4 F7 HSALNG0099562 MCF2L F10 HSALNG0099560 LOC107984590
GH13J113107 Enhancer 0.3 Ensembl 250.7 +1.3 1328 0.2 EGR1 NFIC F7 HSALNG0099562 MCF2L M81357 F10
GH13J113021 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -82.7 -82694 2.8 MXD4 CEBPA ZIC2 KDM6A THAP11 CEBPB ZNF511 SMAD4 SAP130 RXRA MCF2L F7 MCF2L-AS1 F10 F10-AS1 KARS1P2 PROZ lnc-F7-6 LOC107984590 MN298678-022
GH13J113182 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 10.7 +80.5 80468 6.5 SP1 MXD4 FEZF1 CEBPA FOXA1 DEK IKZF1 ZNF217 BRCA1 ZEB1 PROZ PCID2 CUL4A KARS1P2 F10-AS1 F10 GRTP1 F7 LAMP1 ENSG00000269356
GH13J113489 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 6.3 +386.6 386605 8.4 ZBTB10 SP1 FEZF1 CEBPA NR2C1 MNT IKZF1 SMAD5 MBD2 ZEB1 TMCO3 ADPRHL1 DCUN1D2 HSALNG0099597 TUBGCP3 PCID2 GRTP1 CDC16 DCUN1D2-AS CHAMP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for F7

Top Transcription factor binding sites by QIAGEN in the F7 gene promoter:
  • AP-1
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for F7 Gene

Latest Assembly
14,913 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
14,898 bases
Plus strand

(GRCh37/hg19 by Ensembl)
14,891 bases
Plus strand

Genomic View for F7 Gene

Genes around F7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F7 Gene

Proteins for F7 Gene

  • Protein details for F7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coagulation factor VII
    Protein Accession:
    Secondary Accessions:
    • B0YJC8
    • Q14339
    • Q5JVF1
    • Q5JVF2
    • Q9UD52
    • Q9UD53
    • Q9UD54

    Protein attributes for F7 Gene

    466 amino acids
    Molecular mass:
    51594 Da
    Quaternary structure:
    • Heterodimer of a light chain and a heavy chain linked by a disulfide bond.

    Three dimensional structures from OCA and Proteopedia for F7 Gene

    Alternative splice isoforms for F7 Gene


neXtProt entry for F7 Gene

Selected DME Specific Peptides for F7 Gene


Post-translational modifications for F7 Gene

  • The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • O- and N-glycosylated. N-glycosylation at Asn-205 occurs cotranslationally and is mediated by STT3A-containing complexes, while glycosylation at Asn-382 is post-translational and is mediated STT3B-containing complexes before folding. O-fucosylated by POFUT1 on a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines.
  • Can be either O-glucosylated or O-xylosylated at Ser-112 by POGLUT1 in vitro.
  • Glycosylation at Ser112, Ser120, Asn205, and Asn382
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FA7_HUMAN (98)

Antibodies for research

  • Invitrogen Antibodies for F7 (AFLGC-F7)

Domains & Families for F7 Gene

Gene Families for F7 Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for F7 Gene

  • Serine protease, trypsin family
  • Chymotrypsin serine protease family (S1) signature
  • Aspartic acid and asparagine hydroxylation site
  • Type II EGF-like signature
  • EGF-like calcium-binding
  • Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  • Coagulation factor GLA domain signature

Suggested Antigen Peptide Sequences for F7 Gene

GenScript: Design optimal peptide antigens:
  • Coagulation factor VII (A3RMR0_HUMAN)
  • Coagulation factor VII (A3RMR1_HUMAN)
  • Serum prothrombin conversion accelerator (FA7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with F7: view

Function for F7 Gene

Molecular function for F7 Gene

UniProtKB/Swiss-Prot Function:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.; EC=;.
GENATLAS Biochemistry:
coagulation factor VII,vitamin K-dependent (serum protein conversion accelerator),the active form being generated by the cleavage of Arg152-Ile153 peptide bond and complexing to cofactor F3 of tissue factor

Enzyme Numbers (IUBMB) for F7 Gene

Phenotypes From GWAS Catalog for F7 Gene

Gene Ontology (GO) - Molecular Function for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004252 contributes_to serine-type endopeptidase activity IEA,IDA 24998411
GO:0005102 signaling receptor binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 3455766
genes like me logo Genes that share ontologies with F7: view
genes like me logo Genes that share phenotypes with F7: view

Human Phenotype Ontology for F7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for F7 Gene

MGI Knock Outs for F7:
  • F7 F7<tm1Pec>
  • F7 F7<tm1b(EUCOMM)Hmgu>

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for F7 Gene

Localization for F7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F7 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with F7: view

Pathways & Interactions for F7 Gene

genes like me logo Genes that share pathways with F7: view

Gene Ontology (GO) - Biological Process for F7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002690 positive regulation of leukocyte chemotaxis IBA,IDA 17991872
GO:0006508 proteolysis IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007596 blood coagulation IEA,IDA 8632006
genes like me logo Genes that share ontologies with F7: view

No data available for SIGNOR curated interactions for F7 Gene

Drugs & Compounds for F7 Gene

(30) Drugs for F7 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anti-inhibitor coagulant complex Approved, Investigational Pharma Target, Enzyme, agonist, substrate 15
Coagulation Factor IX (Recombinant) Approved, Investigational Pharma Target, ligand 0
Coagulation Factor IX Human Approved Pharma Target, ligand 0
Coagulation factor VIIa Recombinant Human Approved Pharma Target 0
Kappadione Approved Pharma Target, agonist 0

(7) Additional Compounds for F7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for F7 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor 865479-71-6
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
CORM-3 Exhibits anti-inflammatory/cardioprotective effects 475473-26-8
Rivaroxaban Factor Xa inhibitor 366789-02-8
genes like me logo Genes that share compounds with F7: view

Drug products for research

Transcripts for F7 Gene

mRNA/cDNA for F7 Gene

12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for F7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for F7 Gene

GeneLoc Exon Structure for

Expression for F7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for F7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

mRNA differential expression in normal tissues according to GTEx for F7 Gene

This gene is overexpressed in Liver (x46.1).

Protein differential expression in normal tissues from HIPED for F7 Gene

This gene is overexpressed in Plasma (33.9) and Serum (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F7 Gene

Protein tissue co-expression partners for F7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for F7

SOURCE GeneReport for Unigene cluster for F7 Gene:


mRNA Expression by UniProt/SwissProt for F7 Gene:

Tissue specificity: Plasma.

Evidence on tissue expression from TISSUES for F7 Gene

  • Liver(4.7)
  • Blood(3.4)
  • Heart(3.2)
  • Muscle(2.9)
  • Nervous system(2.9)
  • Kidney(2.8)
  • Lung(2.7)
  • Intestine(2.6)
  • Spleen(2.6)
  • Eye(2.1)
  • Skin(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for F7 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • face
  • head
  • nose
  • uterus
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with F7: view

Orthologs for F7 Gene

This gene was present in the common ancestor of animals.

Orthologs for F7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F7 30 31
  • 98.72 (n)
(Canis familiaris)
Mammalia F7 30 31
  • 81.35 (n)
(Bos Taurus)
Mammalia F7 30 31
  • 77.36 (n)
(Rattus norvegicus)
Mammalia F7 30
  • 77.3 (n)
(Mus musculus)
Mammalia F7 30 17 31
  • 77.25 (n)
(Monodelphis domestica)
Mammalia F7 31
  • 64 (a)
(Gallus gallus)
Aves F7 30 31
  • 59.78 (n)
(Anolis carolinensis)
Reptilia F7 31
  • 56 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia f7 30
  • 57.98 (n)
(Danio rerio)
Actinopterygii zgc:163025 30
  • 57.51 (n)
F7 31
  • 45 (a)
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG9294 32
  • 36 (a)
CG13744 32
  • 35 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
Species where no ortholog for F7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for F7 Gene

Gene Tree for F7 (if available)
Gene Tree for F7 (if available)
Evolutionary constrained regions (ECRs) for F7: view image

Paralogs for F7 Gene

(54) SIMAP similar genes for F7 Gene using alignment to 6 proteins:

  • E9PH36_HUMAN
  • F5H8B0_HUMAN
  • L8EC53_HUMAN
genes like me logo Genes that share paralogs with F7: view

Variants for F7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for F7 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
870809 Likely Benign: not provided 113,106,903(+) T/C
870810 Pathogenic: not provided 113,110,851(+) G/A
871655 Pathogenic: not provided 113,118,854(+) G/A
NM_019616.4(F7):c.1181G>A (p.Trp394Ter)
881415 Uncertain Significance: Factor VII deficiency 113,115,794(+) C/T
NM_019616.4(F7):c.499C>T (p.Pro167Ser)
881416 Uncertain Significance: Factor VII deficiency 113,116,846(+) G/A
NM_019616.4(F7):c.586G>A (p.Val196Met)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for F7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for F7 Gene

Variant ID Type Subtype PubMed ID
dgv1129e59 CNV duplication 20981092
dgv250e201 CNV deletion 23290073
dgv251e201 CNV deletion 23290073
dgv3426n54 CNV gain 21841781
dgv3427n54 CNV loss 21841781
dgv3428n54 CNV loss 21841781
dgv3429n54 CNV gain 21841781
esv1083485 CNV insertion 17803354
esv1400714 CNV insertion 17803354
esv1703089 CNV insertion 17803354
esv22720 CNV loss 19812545
esv2748244 CNV deletion 23290073
esv2748245 CNV deletion 23290073
esv2748246 CNV deletion 23290073
esv2748247 CNV deletion 23290073
esv2748248 CNV deletion 23290073
esv2748249 CNV deletion 23290073
esv2748250 CNV deletion 23290073
esv2748258 CNV deletion 23290073
esv2748259 CNV deletion 23290073
esv2748260 CNV deletion 23290073
esv3393777 CNV duplication 20981092
esv5028 CNV loss 18987735
nsv1048814 CNV gain 25217958
nsv1051556 CNV gain 25217958
nsv1071129 CNV deletion 25765185
nsv1126354 CNV deletion 24896259
nsv518044 CNV gain 19592680
nsv563268 CNV loss 21841781
nsv563269 CNV loss 21841781
nsv563270 CNV loss 21841781
nsv563276 CNV loss 21841781
nsv563278 CNV gain 21841781
nsv563280 CNV loss 21841781
nsv563281 CNV loss 21841781
nsv64704 CNV deletion 16902084
nsv818996 CNV gain 17921354
nsv832724 CNV loss 17160897
nsv951925 CNV deletion 24416366
nsv951926 CNV deletion 24416366

Variation tolerance for F7 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F7 Gene

Disorders for F7 Gene

MalaCards: The human disease database

(60) MalaCards diseases for F7 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
factor vii deficiency
  • f7 deficiency
myocardial infarction
  • myocardial infarction, susceptibility to
hemorrhagic disease
  • hemorrhagic diathesis
blood coagulation disease
  • coagulation protein disease
hemophilia a
  • hema
- elite association - COSMIC cancer census association via MalaCards
Search F7 in MalaCards View complete list of genes associated with diseases


  • Factor VII deficiency (FA7D) [MIM:227500]: A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels. {ECO:0000269 PubMed:10862079, ECO:0000269 PubMed:11091194, ECO:0000269 PubMed:11129332, ECO:0000269 PubMed:12472587, ECO:0000269 PubMed:14717781, ECO:0000269 PubMed:1634227, ECO:0000269 PubMed:18976247, ECO:0000269 PubMed:19432927, ECO:0000269 PubMed:19751712, ECO:0000269 PubMed:2070047, ECO:0000269 PubMed:21206266, ECO:0000269 PubMed:21372693, ECO:0000269 PubMed:26761581, ECO:0000269 PubMed:7974346, ECO:0000269 PubMed:7981691, ECO:0000269 PubMed:8043443, ECO:0000269 PubMed:8204879, ECO:0000269 PubMed:8242057, ECO:0000269 PubMed:8364544, ECO:0000269 PubMed:8652821, ECO:0000269 PubMed:8844208, ECO:0000269 PubMed:8883260, ECO:0000269 PubMed:8940045, ECO:0000269 PubMed:9414278, ECO:0000269 PubMed:9452082, ECO:0000269 PubMed:9576180}. Note=The disease is caused by variants affecting the gene represented in this entry.

Genatlas disease for F7 Gene


Additional Disease Information for F7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with F7: view

Publications for F7 Gene

  1. Detection of two missense mutations and characterization of a repeat polymorphism in the factor VII gene (F7). (PMID: 1634227) Marchetti G … Bernardi F (Human genetics 1992) 3 4 23 74
  2. Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. (PMID: 18976247) Herrmann FH … Greifswald Factor FVII Deficiency Study Group (Haemophilia : the official journal of the World Federation of Hemophilia 2009) 3 4 41
  3. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study. (PMID: 19415820) Maitland-van der Zee AH … Eckfeldt JH (Pharmacogenetics and genomics 2009) 3 23 41
  4. [The connection between Arg353Gln polymorphism of coagulation factor VII and recurrent miscarriages]. (PMID: 19323053) Seremak-Mrozikiewicz A … Mrozikiewicz PM (Ginekologia polska 2009) 3 23 41
  5. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F … Hingorani AD (Human molecular genetics 2009) 3 23 41

Products for F7 Gene

Sources for F7 Gene