Aliases for F5 Gene
External Ids for F5 Gene
Previous GeneCards Identifiers for F5 Gene
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
GeneCards Summary for F5 Gene
F5 (Coagulation Factor V) is a Protein Coding gene. Diseases associated with F5 include Factor V Deficiency and Thrombophilia Due To Activated Protein C Resistance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and copper ion binding. An important paralog of this gene is F8.
UniProtKB/Swiss-Prot Summary for F5 Gene
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.