Aliases for F3 Gene
External Ids for F3 Gene
Previous GeneCards Identifiers for F3 Gene
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
GeneCards Summary for F3 Gene
F3 (Coagulation Factor III, Tissue Factor) is a Protein Coding gene. Diseases associated with F3 include Disseminated Intravascular Coagulation and Carotid Artery Thrombosis. Among its related pathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include phospholipid binding and cytokine receptor activity. An important paralog of this gene is IL20RA.
UniProtKB/Swiss-Prot Summary for F3 Gene
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.