This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis... See more...

Aliases for F3 Gene

Aliases for F3 Gene

  • Coagulation Factor III, Tissue Factor 2 3 5
  • Tissue Factor 2 3 4
  • Coagulation Factor III (Thromboplastin, Tissue Factor) 2 3
  • TF 3 4
  • Coagulation Factor III 4
  • Thromboplastin 4
  • CD142 Antigen 4
  • CD142 3
  • TFA 3

External Ids for F3 Gene

Previous GeneCards Identifiers for F3 Gene

  • GC01M095396
  • GC01M094200
  • GC01M094345
  • GC01M094466
  • GC01M094706
  • GC01M094994
  • GC01M093116

Summaries for F3 Gene

Entrez Gene Summary for F3 Gene

  • This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for F3 Gene

F3 (Coagulation Factor III, Tissue Factor) is a Protein Coding gene. Diseases associated with F3 include Carotid Artery Thrombosis and Disseminated Intravascular Coagulation. Among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include phospholipid binding and cytokine receptor activity. An important paralog of this gene is IL20RA.

UniProtKB/Swiss-Prot Summary for F3 Gene

  • Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Gene Wiki entry for F3 Gene

Additional gene information for F3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for F3 Gene

Genomics for F3 Gene

GeneHancer (GH) Regulatory Elements for F3 Gene

Promoters and enhancers for F3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J094539 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 752.5 +0.6 610 9.3 SMARCE1 POLR2A MYC HLF TEAD4 SP1 MAFK CBFA2T2 BACH1 SP7 F3 lnc-ABCD3-1 lnc-ARHGAP29-7 SLC44A3 SLC44A3-AS1 ABCD3 MIR12133-001 piR-33614-012 lnc-F3-3
GH01J094712 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 15.8 -172.0 -171953 2.1 MLX RBPJ NR2F6 ATF1 CREB1 NFYC CEBPB MAX SP1 ELF3 F3 SLC44A3 SLC44A3-AS1 lnc-SLC44A3-3 MIR378G
GH01J094641 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -104.0 -103954 9.1 SMARCE1 POLR2A TEAD4 CBFA2T2 SMARCA4 TRIM24 BRCA1 CEBPB HDAC1 CHD2 F3 SLC44A3 SLC44A3-AS1 lnc-F3-4 RF00998-006
GH01J094753 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -214.0 -214035 5.8 RBPJ NR2F6 MYC HLF L3MBTL2 MAX ZNF652 ELF3 SP1 MAFK SLC44A3 F3 SLC44A3-AS1 ARHGAP29 RWDD3 MIR378G
GH01J094579 Enhancer 0.9 Ensembl ENCODE 17.2 -38.3 -38344 2.8 POLR2A ZNF148 MAFK ZNF644 FOSL2 IKZF1 PRDM10 SMARCC1 CTBP1 NFE2L2 F3 piR-41245-014 ENSG00000223675 lnc-F3-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F3 gene promoter:
  • AREB6
  • ATF
  • E47
  • MyoD
  • Pax-5
  • STAT3
  • Tal-1

Genomic Locations for F3 Gene

Genomic Locations for F3 Gene
chr1:94,529,173-94,541,857
(GRCh38/hg38)
Size:
12,685 bases
Orientation:
Minus strand
chr1:94,994,732-95,007,413
(GRCh37/hg19)
Size:
12,682 bases
Orientation:
Minus strand

Genomic View for F3 Gene

Genes around F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F3 Gene

Proteins for F3 Gene

  • Protein details for F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13726-TF_HUMAN
    Recommended name:
    Tissue factor
    Protein Accession:
    P13726
    Secondary Accessions:
    • D3DT47
    • Q6FHG2
    • Q86WH4

    Protein attributes for F3 Gene

    Size:
    295 amino acids
    Molecular mass:
    33068 Da
    Quaternary structure:
    • Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

    Three dimensional structures from OCA and Proteopedia for F3 Gene

    Alternative splice isoforms for F3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for F3 Gene

Post-translational modifications for F3 Gene

  • Glycosylation at Asn156 and Asn169
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Invitrogen Antibodies for F3 (AFLGC-F3)

No data available for DME Specific Peptides for F3 Gene

Domains & Families for F3 Gene

Gene Families for F3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for F3 Gene

GenScript: Design optimal peptide antigens:
  • Thromboplastin (TF_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13726

UniProtKB/Swiss-Prot:

TF_HUMAN :
  • Belongs to the tissue factor family.
Family:
  • Belongs to the tissue factor family.
genes like me logo Genes that share domains with F3: view

Function for F3 Gene

Molecular function for F3 Gene

UniProtKB/Swiss-Prot Function:
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
UniProtKB/Swiss-Prot Induction:
TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
GENATLAS Biochemistry:
coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7

Phenotypes From GWAS Catalog for F3 Gene

Gene Ontology (GO) - Molecular Function for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 3455766
GO:0004252 contributes_to serine-type endopeptidase activity IDA 24998411
GO:0004896 cytokine receptor activity IBA 21873635
GO:0005515 protein binding IPI 8598903
GO:0005543 phospholipid binding IDA 17469850
genes like me logo Genes that share ontologies with F3: view
genes like me logo Genes that share phenotypes with F3: view

Animal Models for F3 Gene

MGI Knock Outs for F3:
  • F3 F3<tm1.1Dwr>
  • F3 F3<tm1Jld>
  • F3 F3<tm1Dco>
  • F3 F3<tm1Gjb>
  • F3 F3<tm1Dwr>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F3

Clone Products

  • Addgene plasmids for F3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F3 Gene

Localization for F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F3 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
peroxisome 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 19065458
GO:0005886 plasma membrane NAS,TAS --
GO:0009986 cell surface IDA 17898544
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with F3: view

Pathways & Interactions for F3 Gene

genes like me logo Genes that share pathways with F3: view

Pathways by source for F3 Gene

1 R&D Systems pathway for F3 Gene
2 Qiagen pathways for F3 Gene
  • Blood Coagulation Cascade
  • Extrinsic Prothrombin Activation Pathway
2 Cell Signaling Technology pathways for F3 Gene

SIGNOR curated interactions for F3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 17898544
GO:0002541 activation of plasma proteins involved in acute inflammatory response IDA 17469850
GO:0002543 activation of blood coagulation via clotting cascade IC 17469850
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 17898544
GO:0007596 blood coagulation IDA 8632006
genes like me logo Genes that share ontologies with F3: view

Drugs & Compounds for F3 Gene

(82) Drugs for F3 Gene - From: DrugBank, PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 568
Coagulation factor VII human Approved, Investigational Pharma Target, activator 0
Coagulation factor VIIa Recombinant Human Approved Pharma Target 0
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA Experimental Pharma Target 0
[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Experimental Pharma Target 0

(61) Additional Compounds for F3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for F3 Gene

Compound Action Cas Number
5-R-Rivaroxaban Factor Xa (FXa) inhibitor 865479-71-6
BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct 211914-51-1
CORM-3 Exhibits anti-inflammatory/cardioprotective effects 475473-26-8
genes like me logo Genes that share compounds with F3: view

Transcripts for F3 Gene

mRNA/cDNA for F3 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F3

Clone Products

  • Addgene plasmids for F3

Alternative Splicing Database (ASD) splice patterns (SP) for F3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -

Relevant External Links for F3 Gene

GeneLoc Exon Structure for
F3
ECgene alternative splicing isoforms for
F3

Expression for F3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for F3 Gene

This gene is overexpressed in Frontal cortex (16.3), Retina (15.6), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F3 Gene



NURSA nuclear receptor signaling pathways regulating expression of F3 Gene:

F3

SOURCE GeneReport for Unigene cluster for F3 Gene:

Hs.62192

mRNA Expression by UniProt/SwissProt for F3 Gene:

P13726-TF_HUMAN
Tissue specificity: Lung, placenta and pancreas.

Evidence on tissue expression from TISSUES for F3 Gene

  • Nervous system(4.4)
  • Blood(3.9)
  • Heart(3.6)
  • Lung(3.5)
  • Muscle(3)
  • Intestine(2.7)
  • Kidney(2.7)
  • Liver(2.7)
  • Skin(2.7)
  • Pancreas(2.3)
  • Bone marrow(2.2)
  • Gall bladder(2.2)
  • Stomach(2.2)
  • Lymph node(2)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with F3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for F3 Gene

Orthologs for F3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia F3 33 32
  • 99.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia F3 32
  • 82.08 (n)
TF 33
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia F3 33 32
  • 79.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia F3 17 33 32
  • 69.54 (n)
rat
(Rattus norvegicus)
Mammalia F3 32
  • 67.96 (n)
oppossum
(Monodelphis domestica)
Mammalia F3 33
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia F3 33
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves F3 33 32
  • 56.42 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia F3 33
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia f3 32
  • 53.19 (n)
zebrafish
(Danio rerio)
Actinopterygii f3a 33 32
  • 48.76 (n)
OneToMany
f3b 33
  • 30 (a)
OneToMany
Species where no ortholog for F3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F3 Gene

ENSEMBL:
Gene Tree for F3 (if available)
TreeFam:
Gene Tree for F3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for F3: view image

Paralogs for F3 Gene

Pseudogenes.org Pseudogenes for F3 Gene

genes like me logo Genes that share paralogs with F3: view

Variants for F3 Gene

Sequence variations from dbSNP and Humsavar for F3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000017502 -- 94,528,689(-) C/T downstream_transcript_variant
rs1000327297 -- 94,541,444(-) C/G intron_variant
rs1000402405 -- 94,541,739(-) G/A/T 5_prime_UTR_variant
rs1000446004 -- 94,540,524(-) A/G intron_variant
rs1000665954 -- 94,541,646(-) T/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for F3 Gene

Variant ID Type Subtype PubMed ID
nsv1899 CNV insertion 18451855

Variation tolerance for F3 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F3 Gene

Human Gene Mutation Database (HGMD)
F3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
F3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F3 Gene

Disorders for F3 Gene

MalaCards: The human disease database

(123) MalaCards diseases for F3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search F3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for F3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F3 Gene

Publications for F3 Gene

  1. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PMID: 19168442) Eisenreich A … Rauch U (Circulation research 2009) 3 4 23 56
  2. Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PMID: 19027114) Undas A … Tracz W (Atherosclerosis 2009) 3 23 43 56
  3. Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PMID: 16239598) Mälarstig A … Siegbahn A (Arteriosclerosis, thrombosis, and vascular biology 2005) 3 23 43 56
  4. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer ND … Sladek R (PloS one 2012) 3 43 56
  5. Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith NL … Hayward C (Circulation 2011) 3 43 56

Products for F3 Gene

  • Addgene plasmids for F3

Sources for F3 Gene