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This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
F3 (Coagulation Factor III, Tissue Factor) is a Protein Coding gene. Diseases associated with F3 include Disseminated Intravascular Coagulation and Carotid Artery Thrombosis. Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include phospholipid binding and cytokine receptor activity. An important paralog of this gene is IL20RA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002020 | protease binding | IPI | 3455766 |
GO:0004252 | contributes_to serine-type endopeptidase activity | IDA | 24998411 |
GO:0004896 | cytokine receptor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 8598903 |
GO:0005543 | phospholipid binding | IDA | 17469850 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IDA | 19065458 |
GO:0005886 | plasma membrane | NAS,TAS | -- |
GO:0009986 | cell surface | IDA | 17898544 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Formation of Fibrin Clot (Clotting Cascade) |
Extrinsic Prothrombin Activation Pathway
.01
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2 | Complement and coagulation cascades | ||
3 | Adhesion |
-
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4 | Angiogenesis (CST) | ||
5 | AGE-RAGE signaling pathway in diabetic complications |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 17898544 |
GO:0002541 | activation of plasma proteins involved in acute inflammatory response | IDA | 17469850 |
GO:0002543 | activation of blood coagulation via clotting cascade | IC | 17469850 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 17898544 |
GO:0007596 | blood coagulation | IDA | 8632006 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Simvastatin | Approved | Pharma | Inhibitor, Competitive | HMG-CoA reductase inhibitor | 582 | |
Coagulation factor VII human | Approved, Investigational | Pharma | Target, activator | 0 | ||
Coagulation factor VIIa Recombinant Human | Approved | Pharma | Target | 0 | ||
[2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | Experimental | Pharma | Target | 0 | ||
[5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
5-R-Rivaroxaban | Factor Xa (FXa) inhibitor | 865479-71-6 |
BIBR 953 (Dabigatran, Pradaxa) | Thrombin inhibitor,potent,reversible and direct | 211914-51-1 |
CORM-3 | Exhibits anti-inflammatory/cardioprotective effects | 475473-26-8 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||
SP8: | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | F3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | F3 30 |
|
||
TF 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | F3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | F3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | F3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | F3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | F3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | F3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | F3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | f3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | f3a 30 31 |
|
OneToMany | |
f3b 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708858 | Benign: not provided | 94,533,194(-) | G/A | MISSENSE_VARIANT | |
715332 | Benign: not provided | 94,536,099(-) | T/C | MISSENSE_VARIANT | |
717135 | Benign: not provided | 94,540,363(-) | T/C | MISSENSE_VARIANT | |
727908 | Likely Benign: not provided | 94,540,351(-) | C/T | MISSENSE_VARIANT | |
789150 | Likely Benign: not provided | 94,540,309(-) | T/C | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
disseminated intravascular coagulation |
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carotid artery thrombosis |
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factor vii deficiency |
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factor xii deficiency |
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antiphospholipid syndrome |
|