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This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis... See more...
Aliases for F3 Gene
Aliases for F3 Gene
External Ids for F3 Gene
- HGNC: 3541
- NCBI Entrez Gene: 2152
- Ensembl: ENSG00000117525
- OMIM®: 134390
- UniProtKB/Swiss-Prot: P13726
Previous GeneCards Identifiers for F3 Gene
- GC01M095396
- GC01M094200
- GC01M094345
- GC01M094466
- GC01M094706
- GC01M094994
- GC01M093116
Summaries for F3 Gene
-
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
GeneCards Summary for F3 Gene
F3 (Coagulation Factor III, Tissue Factor) is a Protein Coding gene. Diseases associated with F3 include Disseminated Intravascular Coagulation and Carotid Artery Thrombosis. Among its related pathways are Collagen chain trimerization and Formation of Fibrin Clot (Clotting Cascade). Gene Ontology (GO) annotations related to this gene include phospholipid binding and cytokine receptor activity. An important paralog of this gene is IL20RA.
UniProtKB/Swiss-Prot Summary for F3 Gene
-
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Additional gene information for F3 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for F3 Gene
Genomics for F3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for F3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around F3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for F3
- Top Transcription factor binding sites by QIAGEN in the F3 gene promoter:
-
- AREB6
- ATF
- E47
- MyoD
- Pax-5
- STAT3
- Tal-1
Genomic Locations for F3 Gene
Latest Assembly
- chr1:94,529,173-94,541,759
- (GRCh38/hg38)
- Size:
- 12,587 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:94,994,729-95,007,315
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 12,587 bases
- Orientation:
- Minus strand
Genomic View for F3 Gene
Genes around F3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p21.3 by HGNC
- 1p21.3 by Entrez Gene
- 1p21.3 by Ensembl
F3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for F3 Gene
Proteins for F3 Gene
-
Protein details for F3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13726-TF_HUMAN
- Recommended name:
- Tissue factor
- Protein Accession:
- P13726
- D3DT47
- Q6FHG2
- Q86WH4
Protein attributes for F3 Gene
- Size:
- 295 amino acids
- Molecular mass:
- 33068 Da
- Quaternary structure:
-
- Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
Three dimensional structures from OCA and Proteopedia for F3 Gene
Protein Expression for F3 Gene
Post-translational modifications for F3 Gene
Other Protein References for F3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ F3 Antibody
- Alomone Labs, Ltd. Anti-Human PAR1 (F2R) (extracellular)-FITC Antibody
- Novus Biologicals Antibodies for F3
-
Abcam antibodies for F3
- Invitrogen Antibodies for F3 (AFLGC-F3)
- antibodies-online: Show 115 available F3 Antibodies ranked by validation data
- Compare Top F3 Antibodies
-
Recommended
- 118 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for F3
- Sino Biological Antibodies for F3
Protein products for research
- G Biosciences Human CD142/Tissue factor/F3, Lyophilized
- RayBiotech Recombinant Human CD142 / F3
- Search Origene for MassSpec and Protein Over-expression Lysates for F3
- Origene Custom Protein Services for F3
- Sino Biological Recombinant Proteins for F3
- Sino Biological Cell Lysates for F3
- ProSpec Recombinant Proteins for F3
- antibodies-online: Show 47 available F3 Proteins ranked by validation data
- Compare Top F3 Proteins
-
ProSci Proteins for F3
-
Abcam proteins for F3
Assay products for research
- G Biosciences Immunotag™ Tissue factor ELISA Kit
- RayBiotech Human Coagulation Factor III ELISA
- Novus Biologicals ELISA Kits for F3
- antibodies-online: Show 121 available F3 Elisa Kits ranked by validation data
- Compare Top F3 Elisa Kits
-
Quality Products:
- ABIN1117504
- ABIN415041
- ABIN367607
- ABIN414666
- ABIN4993036
- ABIN612783
- ABIN1380021
- ABIN2702921
- ABIN2708124
- ABIN6719791
- ABIN415624
- ABIN2859236
- ABIN832487
- ABIN5563530
- ABIN492020
- ABIN1029983
- ABIN2761957
- ABIN1117386
- ABIN2702922
- ABIN5524401
- ABIN431567
- ABIN1117500
- ABIN1114206
- ABIN368173
- ABIN5524404
- ABIN578945
- ABIN5670875
- ABIN5670874
- ABIN1572638
- ABIN627395
- ABIN431343
- ABIN1572639
- ABIN368490
- ABIN1567493
- ABIN5524403
- ABIN628555
- ABIN5659268
- ABIN2539681
- ABIN2951879
- ABIN6227932
-
Abcam assays for F3
- Sino Biological Assays for F3
No data available for DME Specific Peptides for F3 Gene
Domains & Families for F3 Gene
Gene Families for F3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for F3 Gene
- InterPro:
- Blocks:
-
- Tissue factor
Suggested Antigen Peptide Sequences for F3 Gene
- GenScript: Design optimal peptide antigens:
-
- Thromboplastin (TF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13726- Family:
-
- Belongs to the tissue factor family.
Function for F3 Gene
Molecular function for F3 Gene
- UniProtKB/Swiss-Prot Function:
- Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
- UniProtKB/Swiss-Prot Induction:
- TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
- GENATLAS Biochemistry:
- coagulation factor III,single chain glycoprotein,44kDa,initiating blood coagulation by complexing with F7
Phenotypes From GWAS Catalog for F3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 3455766 |
| GO:0004252 | contributes_to serine-type endopeptidase activity | IDA | 24998411 |
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 8598903 |
| GO:0005543 | phospholipid binding | IDA | 17469850 |
Phenotypes for F3 Gene
- MGI mutant phenotypes for F3:
-
inferred from 8 alleles
- normal phenotype
- nervous system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- hematopoietic system phenotype
- neoplasm
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for F3:
Animal Models for F3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for F3 - Starting at $85 >
- * F3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for F3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F3
-
Santa Cruz Biotechnology (SCBT) CRISPR for F3
miRNA for F3 Gene
- miRTarBase miRNAs that target F3
-
- mmu-miR-223-3p (MIRT009709)
- mmu-miR-17-5p (MIRT009972)
- mmu-miR-149-5p (MIRT014563)
- hsa-miR-375 (MIRT019927)
- hsa-miR-130b-3p (MIRT020315)
- hsa-miR-124-3p (MIRT022817)
- hsa-miR-93-5p (MIRT028146)
- hsa-miR-26b-5p (MIRT029798)
- hsa-miR-508-3p (MIRT477176)
- hsa-miR-935 (MIRT477177)
- hsa-miR-6876-5p (MIRT477178)
- hsa-miR-4476 (MIRT477179)
- hsa-miR-519c-3p (MIRT477180)
- hsa-miR-519b-3p (MIRT477181)
- hsa-miR-519a-3p (MIRT477182)
- hsa-miR-224-5p (MIRT477183)
- hsa-miR-4735-3p (MIRT477184)
- hsa-miR-18b-5p (MIRT477185)
- hsa-miR-18a-5p (MIRT477186)
- hsa-miR-4796-3p (MIRT477187)
- hsa-miR-548ah-5p (MIRT477188)
- hsa-miR-3609 (MIRT477189)
- hsa-miR-6835-3p (MIRT477190)
- hsa-miR-4422 (MIRT477191)
- hsa-miR-223-3p (MIRT477192)
- hsa-miR-20a-5p (MIRT477193)
- hsa-miR-106b-5p (MIRT477194)
- hsa-miR-519d-3p (MIRT477195)
- hsa-miR-20b-5p (MIRT477196)
- hsa-miR-526b-3p (MIRT477197)
- hsa-miR-17-5p (MIRT477198)
- hsa-miR-106a-5p (MIRT477199)
- mmu-miR-590-3p (MIRT583702)
- mmu-miR-539-3p (MIRT583703)
- mmu-miR-381-3p (MIRT583704)
- hsa-miR-18a-3p (MIRT763228)
- hsa-miR-335-5p (MIRT765650)
- hsa-miR-4290 (MIRT768400)
- hsa-miR-4453 (MIRT769193)
- hsa-miR-4538 (MIRT770229)
- hsa-miR-5695 (MIRT775102)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for F3
- Browse OriGene Inhibitory RNA Products For F3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F3
Clone products for research
- Applied Biological Materials (abm): Clones for F3 - Starting at $45 >
- * F3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for F3
- Addgene plasmids for F3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F3
Cell Lines for research
-
Horizon Cell Lines for F3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F3 Gene
Localization for F3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for F3 Gene
- [Isoform 1]: Membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| peroxisome | 3 |
| nucleus | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 19065458 |
| GO:0005886 | plasma membrane | NAS,TAS | -- |
| GO:0009986 | cell surface | IDA | 17898544 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for F3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of Fibrin Clot (Clotting Cascade) |
Extrinsic Prothrombin Activation Pathway
.01
|
|
| 2 | Complement and coagulation cascades | ||
| 3 | Adhesion |
-
|
|
| 4 | Angiogenesis (CST) | ||
| 5 | AGE-RAGE signaling pathway in diabetic complications | ||
Pathways by source for F3 Gene
1 BioSystems pathway for F3 Gene
3 Reactome pathways for F3 Gene
2 KEGG pathways for F3 Gene
1 GeneGo (Thomson Reuters) pathway for F3 Gene
- Immune response IL-1 signaling pathway
1 R&D Systems pathway for F3 Gene
2 Qiagen pathways for F3 Gene
- Blood Coagulation Cascade
- Extrinsic Prothrombin Activation Pathway
2 Cell Signaling Technology pathways for F3 Gene
Interacting Proteins for F3 Gene
GPS-Prot Interaction Network for F3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 17898544 |
| GO:0002541 | activation of plasma proteins involved in acute inflammatory response | IDA | 17469850 |
| GO:0002543 | activation of blood coagulation via clotting cascade | IC | 17469850 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 17898544 |
| GO:0007596 | blood coagulation | IDA | 8632006 |
Drugs & Compounds for F3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Simvastatin | Approved | Pharma | HMG-CoA reductase inhibitor | 592 | ||
| Coagulation factor VII human | Approved, Investigational | Pharma | Target, activator | 0 | ||
| Coagulation factor VIIa Recombinant Human | Approved | Pharma | Target | 0 | ||
| [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA | Experimental | Pharma | Target | 0 | ||
| [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(3) ApexBio Compounds for F3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 5-R-Rivaroxaban | Factor Xa (FXa) inhibitor | 865479-71-6 |
| BIBR 953 (Dabigatran, Pradaxa) | Thrombin inhibitor,potent,reversible and direct | 211914-51-1 |
| CORM-3 | Exhibits anti-inflammatory/cardioprotective effects | 475473-26-8 |
Drug products for research
- G Biosciences Human CD142/Tissue factor/F3, Lyophilized
- RayBiotech Recombinant Human CD142 / F3
- ApexBio compounds for F3
Transcripts for F3 Gene
mRNA/cDNA for F3 Gene
- 2 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000334047 2298 nts (view in UCSC)
- ENST00000370207 1879 nts (view in UCSC)
- ENST00000478217 472 nts (view in UCSC)
- ENST00000480356 1193 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for F3 - Starting at $85 >
- * F3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for F3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F3
-
Santa Cruz Biotechnology (SCBT) CRISPR for F3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for F3
- Browse OriGene Inhibitory RNA Products For F3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F3
Clone products for research
- Applied Biological Materials (abm): Clones for F3 - Starting at $45 >
- * F3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for F3
- Addgene plasmids for F3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||
| SP8: | - | - | - |
Relevant External Links for F3 Gene
- GeneLoc Exon Structure for
- F3
Expression for F3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Conjunctival Epithelium
- Corneal Epithelium
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
- Placenta (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
- Dermis (Integumentary System)
- Fibroblasts
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Epidermis (Integumentary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Frontal cortex (16.3), Retina (15.6), and Pancreas (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for F3
SOURCE GeneReport for Unigene cluster for F3 Gene:
Hs.62192mRNA Expression by UniProt/SwissProt for F3 Gene:
P13726-TF_HUMAN
Tissue specificity:
Lung, placenta and pancreas.
Evidence on tissue expression from TISSUES for F3 Gene
- Nervous system(4.5)
- Heart(3.6)
- Blood(3.5)
- Lung(3.3)
- Muscle(3.2)
- Skin(3.1)
- Intestine(3.1)
- Kidney(3)
- Liver(2.9)
- Gall bladder(2.9)
- Stomach(2.8)
- Pancreas(2.7)
- Lymph node(2.7)
- Spleen(2.7)
- Thyroid gland(2.6)
- Bone marrow(2.6)
- Urine(2.6)
- Adrenal gland(2.5)
- Eye(2.5)
- Bone(2.1)
Primer products for research
-
OriGene qPCR primer pairs for F3
-
OriGene qPCR primer pairs and template standards for F3
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for F3 Gene
Orthologs for F3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | F3 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | F3 29 |
|
||
| TF 30 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | F3 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | F3 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | F3 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | F3 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | F3 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | F3 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | F3 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | f3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | f3a 29 30 |
|
OneToMany | |
| f3b 30 |
|
OneToMany |
- Species where no ortholog for F3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for F3 Gene
- ENSEMBL:
- Gene Tree for F3 (if available)
- TreeFam:
- Gene Tree for F3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for F3: view image
- Alliance of Genome Resources:
- Additional Orthologs for F3
Paralogs for F3 Gene
Variants for F3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for F3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs114064069 | Likely Benign: not provided | 94,540,309(-) |
T/C NM_001993.5(F3):c.160A>G (p.Ile54Val) |
MISSENSE | |
| rs143237190 | Benign: not provided | 94,536,099(-) |
T/C NM_001993.5(F3):c.278A>G (p.Asp93Gly) |
MISSENSE | |
| rs148395733 | Likely Benign: not provided | 94,540,351(-) |
C/T NM_001993.5(F3):c.118G>A (p.Ala40Thr) |
MISSENSE | |
| rs3789683 | Benign: not provided | 94,530,506(-) |
C/Tp.Gly281Glu NM_001993.5(F3):c.842G>A (p.Gly281Glu) |
MISSENSE | |
| rs3917604 | Benign: not provided | 94,540,363(-) |
T/Cp.Thr36Ala NM_001993.5(F3):c.106A>G (p.Thr36Ala) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.34;
41.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for F3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F3 Gene
Disorders for F3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| disseminated intravascular coagulation |
|
|
| carotid artery thrombosis |
|
|
| thrombophilia due to activated protein c resistance |
|
|
| factor vii deficiency |
|
|
| antiphospholipid syndrome |
|
|
Search F3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for F3
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for F3 Gene
Publications for F3 Gene
- Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. (PMID: 19168442) Eisenreich A … Rauch U (Circulation research 2009) 3 4 22
- Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease. (PMID: 19027114) Undas A … Tracz W (Atherosclerosis 2009) 3 22 40
- Genetic variations in the tissue factor gene are associated with clinical outcome in acute coronary syndrome and expression levels in human monocytes. (PMID: 16239598) Mälarstig A … Siegbahn A (Arteriosclerosis, thrombosis, and vascular biology 2005) 3 22 40
- A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer ND … Sladek R (PloS one 2012) 3 40
- Genetic predictors of fibrin D-dimer levels in healthy adults. (PMID: 21502573) Smith NL … Hayward C (Circulation 2011) 3 40
ExternalLinks
Products for F3 Gene
- View all 23 R&D Systems F3 (Coagulation Factor III/Tissue Factor) Products
- View all R&D Systems F3 (Coagulation Factor III/Tissue Factor) Proteins and Enzymes
- View all 17 R&D Systems F3 (Coagulation Factor III/Tissue Factor) Primary Antibodies
- View all 3 R&D Systems F3 (Coagulation Factor III/Tissue Factor) ELISAs
- View all R&D Systems F3 (Coagulation Factor III/Tissue Factor) Luminex Assays
- View all R&D Systems F3 (Coagulation Factor III/Tissue Factor) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom F3 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for F3
- Origene Custom Protein Services for F3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for F3
- Browse OriGene Inhibitory RNA Products For F3
- OriGene qPCR primer pairs for F3
- OriGene qPCR primer pairs and template standards for F3
- OriGene CRISPR knockouts for F3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For F3
- Sino Biological Human cDNA Clone for F3
- Sino Biological Recombinant Proteins for F3
- Sino Biological Cell Lysates for F3
- Sino Biological Antibodies for F3
- Sino Biological Assays for F3
- Browse Recombinant Proteins
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for F3
- Novus Biologicals proteins and lysates for F3
- Novus Biologicals ELISA Kits for F3
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for F3
- Abcam proteins for F3
- Abcam assays for F3
- Find your target
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- ApexBio compounds for F3
- VectorBuilder Custom and pre-made DNA vectors for F3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for F3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for F3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for F3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for F3
- Addgene plasmids for F3
- antibodies-online: Show 115 available F3 Antibodies ranked by validation data
- Compare Top F3 Antibodies
- Recommended
- 118 WB Antibodies (anti-human)
- 49 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 23 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 30 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- antibodies-online: Show 121 available F3 Elisa Kits ranked by validation data
- Compare Top F3 Elisa Kits
- Quality Products:
- ABIN1117504
- ABIN415041
- ABIN367607
- ABIN414666
- ABIN4993036
- ABIN612783
- ABIN1380021
- ABIN2702921
- ABIN2708124
- ABIN6719791
- ABIN415624
- ABIN2859236
- ABIN832487
- ABIN5563530
- ABIN492020
- ABIN1029983
- ABIN2761957
- ABIN1117386
- ABIN2702922
- ABIN5524401
- ABIN431567
- ABIN1117500
- ABIN1114206
- ABIN368173
- ABIN5524404
- ABIN578945
- ABIN5670875
- ABIN5670874
- ABIN1572638
- ABIN627395
- ABIN431343
- ABIN1572639
- ABIN368490
- ABIN1567493
- ABIN5524403
- ABIN628555
- ABIN5659268
- ABIN2539681
- ABIN2951879
- ABIN6227932
- antibodies-online: Show 47 available F3 Proteins ranked by validation data
- Compare Top F3 Proteins
- Search Santa Cruz Biotechnology (SCBT) for F3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for F3
- Custom Antibody ServicesProSci Antibodies for F3
- ProSci Proteins for F3
- Horizon Cell Lines for F3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for F3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F3
Sources for F3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources