Aliases for F2RL3 Gene
External Ids for F2RL3 Gene
Previous GeneCards Identifiers for F2RL3 Gene
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for F2RL3 Gene
F2RL3 (F2R Like Thrombin Or Trypsin Receptor 3) is a Protein Coding gene. Diseases associated with F2RL3 include Asthma and Lung Cancer. Among its related pathways are Complement and coagulation cascades and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.
UniProtKB/Swiss-Prot Summary for F2RL3 Gene
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.