Aliases for F2RL3 Gene
External Ids for F2RL3 Gene
Previous GeneCards Identifiers for F2RL3 Gene
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for F2RL3 Gene
F2RL3 (F2R Like Thrombin Or Trypsin Receptor 3) is a Protein Coding gene. Diseases associated with F2RL3 include Asthma and Lung Cancer. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.
UniProtKB/Swiss-Prot Summary for F2RL3 Gene
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.