Aliases for F2RL2 Gene
External Ids for F2RL2 Gene
Previous GeneCards Identifiers for F2RL2 Gene
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]
GeneCards Summary for F2RL2 Gene
F2RL2 (Coagulation Factor II Thrombin Receptor Like 2) is a Protein Coding gene. Diseases associated with F2RL2 include Achondroplasia and Thrombophlebitis Migrans. Among its related pathways are Signaling by GPCR and ADP signalling through P2Y purinoceptor 1. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.
UniProtKB/Swiss-Prot Summary for F2RL2 Gene
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.