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Aliases for F2RL2 Gene

Aliases for F2RL2 Gene

  • Coagulation Factor II Thrombin Receptor Like 2 2 3 5
  • Thrombin Receptor-Like 2 3 4
  • PAR-3 3 4
  • PAR3 3 4
  • Coagulation Factor II Receptor-Like 2 (Protease-Actovated Receptor 3) 3
  • Coagulation Factor II (Thrombin) Receptor-Like 2 2
  • Coagulation Factor II Receptor-Like 2 4
  • Proteinase-Activated Receptor 3 3
  • Proteinase-Activated Receptor-3 2
  • Protease-Activated Receptor 3 3

External Ids for F2RL2 Gene

Previous GeneCards Identifiers for F2RL2 Gene

  • GC05M074718
  • GC05M076147
  • GC05M075951
  • GC05M075995
  • GC05M075947
  • GC05M071119

Summaries for F2RL2 Gene

Entrez Gene Summary for F2RL2 Gene

  • This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

GeneCards Summary for F2RL2 Gene

F2RL2 (Coagulation Factor II Thrombin Receptor Like 2) is a Protein Coding gene. Among its related pathways are G-AlphaQ Signaling and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and thrombin-activated receptor activity. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for F2RL2 Gene

  • Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Gene Wiki entry for F2RL2 Gene

Additional gene information for F2RL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL2 Gene

Genomics for F2RL2 Gene

GeneHancer (GH) Regulatory Elements for F2RL2 Gene

Promoters and enhancers for F2RL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J076714 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.2 -93.7 -93728 4.4 ZFP64 SIN3A ZNF48 YY1 POLR2B GLIS2 ZNF143 ATF7 ZNF202 SP5 F2R ENSG00000225407 F2RL2 F2RL1 POC5 RPL7P23 GC05P076755
GH05J076621 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 663.2 +0.5 502 2.1 SIN3A CTBP1 ZNF316 POLR2A FOSL2 FOS ZNF600 NFE2 MAFK NFE2L2 F2RL2 GC05P076611 IQGAP2
GH05J076657 Enhancer 1 ENCODE 22.2 -34.5 -34490 1.5 SMAD1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ATF7 NCOA1 F2RL2 LOC101929109 IQGAP2 ENSG00000225407 F2R GC05P076611 ENSG00000277188
GH05J076580 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +41.4 41358 2.8 BMI1 BATF IRF4 ZNF143 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CREM IQGAP2 LOC101929109 F2RL2 S100Z GC05M076583 GC05M076503
GH05J076606 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 7.5 +15.5 15487 3.2 ATF1 TAF9B ZBTB40 ZNF335 ZNF143 FOS ATF7 RUNX3 CREM EGR2 IQGAP2 LOC101929109 F2RL2 GC05P076600
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F2RL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F2RL2 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • Ik-1
  • AML1a
  • GR-beta
  • GR-alpha

Genomic Locations for F2RL2 Gene

Genomic Locations for F2RL2 Gene
7,953 bases
Minus strand
7,953 bases
Minus strand

Genomic View for F2RL2 Gene

Genes around F2RL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for F2RL2 Gene

Proteins for F2RL2 Gene

  • Protein details for F2RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proteinase-activated receptor 3
    Protein Accession:
    Secondary Accessions:
    • B2R754
    • B4DQ13
    • Q52M68
    • Q7Z3W3

    Protein attributes for F2RL2 Gene

    374 amino acids
    Molecular mass:
    42508 Da
    Quaternary structure:
    • Interacts with INSC/inscuteable and probably GPSM2.
    • Sequence=CAD97628.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

    Alternative splice isoforms for F2RL2 Gene


neXtProt entry for F2RL2 Gene

Post-translational modifications for F2RL2 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
  • Glycosylation at Asn331, Asn82, and Asn25
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for F2RL2 Gene

Domains & Families for F2RL2 Gene

Gene Families for F2RL2 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for F2RL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL2: view

Function for F2RL2 Gene

Molecular function for F2RL2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor-like 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for F2RL2 Gene

Gene Ontology (GO) - Molecular Function for F2RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 9087410
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity TAS --
GO:0005515 protein binding IPI 16458856
GO:0015057 thrombin-activated receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with F2RL2: view
genes like me logo Genes that share phenotypes with F2RL2: view

Animal Models for F2RL2 Gene

MGI Knock Outs for F2RL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for F2RL2

miRNA for F2RL2 Gene

miRTarBase miRNAs that target F2RL2

Clone Products

  • Addgene plasmids for F2RL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL2 Gene

Localization for F2RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2RL2 gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for F2RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9087410
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with F2RL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for F2RL2 Gene

Pathways & Interactions for F2RL2 Gene

genes like me logo Genes that share pathways with F2RL2: view

SIGNOR curated interactions for F2RL2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for F2RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007596 blood coagulation TAS 9087410
GO:0007599 hemostasis IEA --
GO:0009611 response to wounding TAS 9087410
genes like me logo Genes that share ontologies with F2RL2: view

Drugs & Compounds for F2RL2 Gene

(10) Drugs for F2RL2 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vorapaxar Approved Pharma PAR-1 antagonist,potent and orally active 16
Thrombin Receptor Activator for Peptide 5 (TRAP-5) Pharma 0

(10) Additional Compounds for F2RL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with F2RL2: view

Transcripts for F2RL2 Gene

mRNA/cDNA for F2RL2 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for F2RL2 Gene

Coagulation factor II (thrombin) receptor-like 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for F2RL2

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL2 Gene

No ASD Table

Relevant External Links for F2RL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for F2RL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F2RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for F2RL2 Gene

This gene is overexpressed in Minor Salivary Gland (x4.7) and Esophagus - Muscularis (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of F2RL2 Gene:


SOURCE GeneReport for Unigene cluster for F2RL2 Gene:


mRNA Expression by UniProt/SwissProt for F2RL2 Gene:

Tissue specificity: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.

Evidence on tissue expression from TISSUES for F2RL2 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with F2RL2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for F2RL2 Gene

Orthologs for F2RL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia F2RL2 34 33
  • 99.64 (n)
(Canis familiaris)
Mammalia F2RL2 34 33
  • 88.56 (n)
(Bos Taurus)
Mammalia F2RL2 34 33
  • 87.81 (n)
(Mus musculus)
Mammalia F2rl2 16 34 33
  • 77.24 (n)
(Rattus norvegicus)
Mammalia F2rl2 33
  • 76.67 (n)
(Ornithorhynchus anatinus)
Mammalia F2RL2 34
  • 70 (a)
(Monodelphis domestica)
Mammalia F2RL2 34
  • 67 (a)
(Gallus gallus)
Aves F2RL2 34 33
  • 66.76 (n)
(Anolis carolinensis)
Reptilia F2RL2 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia f2rl2 33
  • 61.77 (n)
(Danio rerio)
Actinopterygii LOC100333265 33
  • 48.75 (n)
F2RL2 (1 of 2) 34
  • 37 (a)
f2rl2 34
  • 29 (a)
Species where no ortholog for F2RL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL2 Gene

Gene Tree for F2RL2 (if available)
Gene Tree for F2RL2 (if available)
Evolutionary constrained regions (ECRs) for F2RL2: view image

Paralogs for F2RL2 Gene

Paralogs for F2RL2 Gene

(19) SIMAP similar genes for F2RL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with F2RL2: view

Variants for F2RL2 Gene

Sequence variations from dbSNP and Humsavar for F2RL2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001085233 -- 76,624,945(-) G/A upstream_transcript_variant
rs1001203235 -- 76,616,463(-) T/C 3_prime_UTR_variant
rs1001477786 -- 76,620,969(-) A/G intron_variant
rs1001755422 -- 76,622,156(-) G/C intron_variant
rs1001866844 -- 76,623,765(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for F2RL2 Gene

Variant ID Type Subtype PubMed ID
dgv5702n100 CNV loss 25217958
dgv9884n54 CNV loss 21841781
nsv1022032 CNV gain 25217958
nsv1031881 CNV gain 25217958

Variation tolerance for F2RL2 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F2RL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL2 Gene

Disorders for F2RL2 Gene

Additional Disease Information for F2RL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for F2RL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for F2RL2 Gene

Publications for F2RL2 Gene

  1. Protease-activated receptor 3 is a second thrombin receptor in humans. (PMID: 9087410) Ishihara H … Coughlin SR (Nature 1997) 2 3 4 22 58
  2. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. (PMID: 10079109) Kahn ML … Coughlin SR (The Journal of clinical investigation 1999) 3 4 22 58
  3. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. (PMID: 9722561) Kahn ML … Coughlin SR (The Journal of biological chemistry 1998) 2 3 22 58
  4. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets. (PMID: 9614115) Schmidt VA … Bahou WF (The Journal of biological chemistry 1998) 3 4 22 58
  5. Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells: distinct role of PAR1 and PAR3 signaling. (PMID: 20442298) Wysoczynski M … Ratajczak MZ (Molecular cancer research : MCR 2010) 3 22 58

Products for F2RL2 Gene

Sources for F2RL2 Gene

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