Aliases for F2RL1 Gene
Aliases for F2RL1 Gene
External Ids for F2RL1 Gene
- HGNC: 3538
- Entrez Gene: 2150
- Ensembl: ENSG00000164251
- OMIM: 600933
- UniProtKB: P55085
Previous HGNC Symbols for F2RL1 Gene
- GPR11
Previous GeneCards Identifiers for F2RL1 Gene
- GC05P074920
- GC05P076349
- GC05P076153
- GC05P076198
- GC05P076150
- GC05P071322
- GC05P076120
Summaries for F2RL1 Gene
-
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]
GeneCards Summary for F2RL1 Gene
F2RL1 (F2R Like Trypsin Receptor 1) is a Protein Coding gene. Diseases associated with F2RL1 include Orofacial Granulomatosis and Pulmonary Vein Stenosis. Among its related pathways are Cytoskeletal Signaling and African trypanosomiasis. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is F2R.
UniProtKB/Swiss-Prot for F2RL1 Gene
-
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
-
Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for F2RL1 Gene
Genomics for F2RL1 Gene
GeneHancer (GH) Regulatory Elements for F2RL1 Gene
Promoters and enhancers for F2RL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around F2RL1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the F2RL1 gene promoter:
-
- GATA-1
- c-Jun
- c-Fos
- AP-1
- AREB6
- HNF-1
- HNF-1A
- Sox9
- RFX1
Regulatory Element Products
Genomic Locations for F2RL1 Gene
Genomic Locations for F2RL1 Gene
- chr5:76,818,933-76,835,315
- (GRCh38/hg38)
- Size:
- 16,383 bases
- Orientation:
- Plus strand
- chr5:76,114,758-76,131,140
- (GRCh37/hg19)
- Size:
- 16,383 bases
- Orientation:
- Plus strand
Genomic View for F2RL1 Gene
Genes around F2RL1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q13.3 by Entrez Gene
- 5q13.3 by HGNC
- 5q13.3 by Ensembl
F2RL1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for F2RL1 Gene
Proteins for F2RL1 Gene
-
Protein details for F2RL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55085-PAR2_HUMAN
- Recommended name:
- Proteinase-activated receptor 2
- Protein Accession:
- P55085
- Q13317
- Q13346
- Q53XJ8
Protein attributes for F2RL1 Gene
- Size:
- 397 amino acids
- Molecular mass:
- 44126 Da
- Quaternary structure:
-
- Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).
- Miscellaneous:
-
- Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.
Protein Expression for F2RL1 Gene
Post-translational modifications for F2RL1 Gene
- A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888). Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14 (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888, PubMed:23202369). Subsequent cleavage by serine proteases, including neutrophil elastase and cathepsin G, leads to receptor deactivation (PubMed:12594060). At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference (PubMed:12171601). In addition to conventional trypsin-like proteases activated by other proteases and glycosidases derived from bacteria, fungi and insects (PubMed:11447194, PubMed:11441110, PubMed:17404307, PubMed:18474671, PubMed:19864598). Activated by serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13 (PubMed:11441110, PubMed:17404307). Activated by P.gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains (PubMed:11447194). Activated by S.griseus exogenous chitinase (PubMed:18474671). Activated by A.alternata aspartate protease; the cleavage generates non-conventional processed forms (PubMed:19864598).
- N-glycosylated and sialylated.
- Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
- Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.
- Glycosylation at Asn222, Thr45, and isoforms=30
- Ubiquitination at isoforms=368
- Modification sites at PhosphoSitePlus
Other Protein References for F2RL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for F2RL1 (PAR2)
- Novus Biologicals Antibodies for F2RL1
-
Abcam antibodies for F2RL1
- Invitrogen Antibodies for F2RL1 (AFLGC-F2RL1)
- Search GeneTex for Antibodies for F2RL1
-
Boster Bio Antibodies for F2RL1
-
Santa Cruz Biotechnology (SCBT) Antibodies for F2RL1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for F2RL1
- Origene Custom Protein Services for F2RL1
- Search GeneTex for Proteins for F2RL1
-
Abcam proteins for F2RL1
Assay Products
No data available for DME Specific Peptides for F2RL1 Gene
Domains & Families for F2RL1 Gene
Gene Families for F2RL1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
- Transporters
Protein Domains for F2RL1 Gene
Suggested Antigen Peptide Sequences for F2RL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P55085- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for F2RL1 Gene
Molecular function for F2RL1 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at Ser-536; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
- GENATLAS Biochemistry:
- coagulation factor II (thrombin) receptor proteinase-activated receptor 2,G protein coupled receptor superfamily
Phenotypes From GWAS Catalog for F2RL1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001965 | G-protein alpha-subunit binding | ISS | -- |
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | ISS,TAS | -- |
| GO:0005102 | signaling receptor binding | TAS | 8615752 |
| GO:0005515 | protein binding | IPI | 15708858 |
Phenotypes for F2RL1 Gene
- MGI mutant phenotypes for F2RL1:
-
inferred from 7 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- GenomeRNAi human phenotypes for F2RL1:
-
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for F2RL1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for F2RL1
- Cyagen custom Knockout/knockin (KOKI) mouse models for F2RL1
-
CRISPR Products
-
OriGene CRISPR knockouts for F2RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F2RL1
- genomics-online: gRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- Applied Biological Materials CRISPR for F2RL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for F2RL1
- GenScript: Design CRISPR guide RNA sequences for F2RL1
miRNA for F2RL1 Gene
- miRTarBase miRNAs that target F2RL1
-
- hsa-mir-1-3p (MIRT023577)
- hsa-mir-190a-3p (MIRT359183)
- hsa-mir-410-3p (MIRT359185)
- hsa-mir-511-3p (MIRT359186)
- hsa-mir-1277-5p (MIRT359188)
- hsa-mir-4495 (MIRT359189)
- hsa-mir-5011-5p (MIRT359191)
- hsa-mir-223-5p (MIRT509885)
- hsa-mir-205-3p (MIRT509886)
- hsa-mir-640 (MIRT523836)
- hsa-mir-6821-3p (MIRT523837)
- hsa-mir-6790-3p (MIRT523838)
- hsa-mir-1224-3p (MIRT523839)
- hsa-mir-6813-3p (MIRT523840)
- hsa-mir-744-3p (MIRT629089)
- hsa-mir-4423-5p (MIRT629090)
- hsa-mir-6501-5p (MIRT629091)
- hsa-mir-4430 (MIRT629092)
- hsa-mir-3652 (MIRT629093)
- hsa-mir-122-5p (MIRT629094)
- hsa-mir-504-3p (MIRT629095)
- hsa-mir-3135b (MIRT629096)
- hsa-mir-367-5p (MIRT629097)
- hsa-mir-1266-3p (MIRT629098)
- hsa-mir-454-3p (MIRT629099)
- hsa-mir-4295 (MIRT629100)
- hsa-mir-3666 (MIRT629101)
- hsa-mir-301b-3p (MIRT629102)
- hsa-mir-301a-3p (MIRT629103)
- hsa-mir-130b-3p (MIRT629104)
- hsa-mir-130a-3p (MIRT629105)
- hsa-mir-5089-5p (MIRT685226)
- hsa-mir-6878-3p (MIRT685227)
- hsa-mir-466 (MIRT685228)
- hsa-mir-4672 (MIRT685229)
- hsa-mir-3941 (MIRT685230)
- hsa-mir-6744-3p (MIRT685231)
- hsa-mir-4757-5p (MIRT685232)
- hsa-mir-5589-5p (MIRT685233)
- hsa-mir-4731-5p (MIRT685234)
- hsa-mir-6778-3p (MIRT685235)
- hsa-mir-6506-5p (MIRT685236)
- hsa-mir-619-5p (MIRT685237)
- hsa-mir-150-5p (MIRT685238)
- hsa-mir-212-5p (MIRT685239)
- hsa-mir-186-3p (MIRT685240)
- hsa-mir-520h (MIRT685241)
- hsa-mir-520g-3p (MIRT685242)
- hsa-mir-512-3p (MIRT685243)
- hsa-mir-603 (MIRT685244)
- hsa-mir-362-3p (MIRT685245)
- hsa-mir-329-3p (MIRT685246)
- hsa-mir-8485 (MIRT685247)
- hsa-mir-520e (MIRT685248)
- hsa-mir-520d-3p (MIRT685249)
- hsa-mir-520c-3p (MIRT685250)
- hsa-mir-520b (MIRT685251)
- hsa-mir-520a-3p (MIRT685252)
- hsa-mir-373-3p (MIRT685253)
- hsa-mir-372-3p (MIRT685254)
- hsa-mir-302e (MIRT685255)
- hsa-mir-302d-3p (MIRT685256)
- hsa-mir-302c-3p (MIRT685257)
- hsa-mir-302b-3p (MIRT685258)
- hsa-mir-302a-3p (MIRT685259)
- hsa-mir-93-5p (MIRT685260)
- hsa-mir-526b-3p (MIRT685261)
- hsa-mir-519d-3p (MIRT685262)
- hsa-mir-20b-5p (MIRT685263)
- hsa-mir-20a-5p (MIRT685264)
- hsa-mir-17-5p (MIRT685265)
- hsa-mir-106b-5p (MIRT685266)
- hsa-mir-106a-5p (MIRT685267)
- hsa-mir-6833-3p (MIRT724006)
- hsa-mir-4768-5p (MIRT724007)
- hsa-mir-6894-3p (MIRT724008)
- hsa-mir-6514-3p (MIRT724009)
- hsa-mir-6873-3p (MIRT724010)
- hsa-mir-5581-5p (MIRT724011)
- hsa-mir-4297 (MIRT724012)
- hsa-mir-4763-5p (MIRT724013)
- hsa-mir-942-5p (MIRT724014)
- hsa-mir-1304-3p (MIRT724015)
- hsa-mir-6747-3p (MIRT724016)
- hsa-mir-483-3p (MIRT724017)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for F2RL1
- Browse OriGene Inhibitory RNA Products For F2RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F2RL1
- genomics-online: shRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for F2RL1
- Addgene plasmids for F2RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F2RL1
- Applied Biological Materials Clones for F2RL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for F2RL1 (PAR2)
Cell Line Products
-
Horizon Cell Lines for F2RL1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL1 Gene
Localization for F2RL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for F2RL1 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| golgi apparatus | 4 |
| extracellular | 2 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005769 | early endosome | IDA | 22547407 |
| GO:0005794 | Golgi apparatus | TAS | 8615752 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA | 17848177 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for F2RL1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | RET signaling | ||
| 4 | African trypanosomiasis | ||
| 5 | Development Endothelin-1/EDNRA signaling | ||
Pathways by source for F2RL1 Gene
1 BioSystems pathway for F2RL1 Gene
8 Reactome pathways for F2RL1 Gene
3 KEGG pathways for F2RL1 Gene
1 Qiagen pathway for F2RL1 Gene
2 Cell Signaling Technology pathways for F2RL1 Gene
Interacting Proteins for F2RL1 Gene
Selected Interacting proteins:
ENSP00000296677
P55085-PAR2_HUMAN
for F2RL1 Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for F2RL1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002286 | T cell activation involved in immune response | IEA,ISS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002690 | positive regulation of leukocyte chemotaxis | IDA | 17991872 |
| GO:0002741 | positive regulation of cytokine secretion involved in immune response | IDA | 11441110 |
| GO:0003104 | positive regulation of glomerular filtration | IEA,ISS | -- |
Drugs & Compounds for F2RL1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 2-furoyl-LIGRLO-amide | Pharma | Full agonist, Agonist | 0 | |||
| SLIGKV-NH2 | Pharma | PAR2 agonist, PAR2 receptor agonist | 0 | |||
| SLIGRL-NH2 | Pharma | PAR2 activator, PAR2-activating peptide | 0 | |||
| Thrombin Receptor Agonist Peptide | Pharma | Causes platelet aggregation and secretion | 0 | |||
| 2-furoyl-LIGRL[N-(Alexa Fluor 594)-O]-NH<sub>2 </sub> | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for F2RL1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AY-NH2 | Selective PAR4 agonist | 352017-71-1 |
| SLIGKV-NH2 | PAR2 receptor agonist | 190383-13-2 |
| SLIGRL-NH2 | PAR2-activating peptide | 171436-38-7 |
| TFLLR-NH2 | PAR1-activating peptide | 197794-83-5 |
| Thrombin Receptor Agonist Peptide | Causes platelet aggregation and secretion | 137339-65-2 |
Drug Products
Transcripts for F2RL1 Gene
mRNA/cDNA for F2RL1 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000514165 607 bps (uc063esd.1)
- ENST00000296677 2914 bps (uc003keo.4)
Unigene Clusters for F2RL1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for F2RL1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F2RL1
- genomics-online: gRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- Applied Biological Materials CRISPR for F2RL1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for F2RL1
- GenScript: Design CRISPR guide RNA sequences for F2RL1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for F2RL1
- Browse OriGene Inhibitory RNA Products For F2RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F2RL1
- genomics-online: shRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for F2RL1
- Addgene plasmids for F2RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F2RL1
- Applied Biological Materials Clones for F2RL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for F2RL1 (PAR2)
Expression for F2RL1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Renal Collecting Duct System
- Ureteric Bud
- Mesenchymal Stem Cells (Uncategorized)
- Inner Cell Mass (Early Embryonic Tissues)
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Epiblast Stem Cell line 5
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Placenta (Extraembryonic Tissues)
- Umbilical Cord (Extraembryonic Tissues)
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for F2RL1 Gene
This gene is overexpressed in Colon - Transverse (x9.4), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Skin - Sun Exposed (Lower leg) (x5.3).
This gene is overexpressed in Cerebrospinal fluid (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F2RL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of F2RL1 Gene:
F2RL1SOURCE GeneReport for Unigene cluster for F2RL1 Gene:
Hs.744181mRNA Expression by UniProt/SwissProt for F2RL1 Gene:
P55085-PAR2_HUMAN
Tissue specificity:
Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubMed:7556175, PubMed:8615752). Expressed in endothelial cells (PubMed:23202369).
Evidence on tissue expression from TISSUES for F2RL1 Gene
- Kidney(4.4)
- Pancreas(4.4)
- Intestine(2.5)
- Skin(2.5)
- Lung(2.2)
- Blood(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for F2RL1
-
OriGene qPCR primer pairs and template standards for F2RL1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for F2RL1 Gene
Orthologs for F2RL1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | F2RL1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | F2RL1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | F2RL1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | F2rl1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | F2rl1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | F2RL1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | F2RL1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | F2RL1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | f2rl1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.5507 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | f2rl1.2 34 33 |
|
OneToMany | |
| f2rl1.1 34 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9406 33 |
|
- Species where no ortholog for F2RL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for F2RL1 Gene
- ENSEMBL:
- Gene Tree for F2RL1 (if available)
- TreeFam:
- Gene Tree for F2RL1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for F2RL1: view image
Paralogs for F2RL1 Gene
Paralogs for F2RL1 Gene
(23) SIMAP similar genes for F2RL1 Gene using alignment to 2 proteins:
- PAR2_HUMAN
- D6RJH3_HUMAN
Variants for F2RL1 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000180334 | -- | 76,824,069(+) | C/T | intron_variant | |
| rs1000195683 | -- | 76,823,898(+) | T/C | intron_variant | |
| rs1000209871 | -- | 76,818,140(+) | G/A | upstream_transcript_variant | |
| rs1000396757 | -- | 76,818,727(+) | G/T | upstream_transcript_variant | |
| rs1000459569 | -- | 76,823,155(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5703n100 | CNV | gain | 25217958 |
| dgv9885n54 | CNV | gain | 21841781 |
| esv2763908 | CNV | gain | 21179565 |
| esv3575858 | CNV | gain | 25503493 |
| esv3605474 | CNV | gain | 21293372 |
| esv994503 | CNV | deletion | 20482838 |
Residual Variation Intolerance Score:
54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.37;
27.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for F2RL1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL1 Gene
Disorders for F2RL1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| orofacial granulomatosis |
|
|
| pulmonary vein stenosis |
|
|
| inflammatory bowel disease |
|
Search F2RL1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for F2RL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for F2RL1 Gene
Publications for F2RL1 Gene
- Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. (PMID: 19781631) McIntosh K … Plevin R (Cellular signalling 2010) 3 4 22 58
- Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. (PMID: 19815543) Ricks TK … Trejo J (The Journal of biological chemistry 2009) 3 4 22 58
- Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. (PMID: 18622013) Rallabhandi P … Vogel SN (The Journal of biological chemistry 2008) 3 4 22 58
- Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. (PMID: 17404307) Chiu LL … Chow LP (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 22 58
- Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. (PMID: 16478888) Csernok E … Hellmich B (Blood 2006) 3 4 22 58
Products for F2RL1 Gene
- R&D Systems Antibodies for F2RL1 (PAR2)
- Browse R&D Systems for Human Recombinant Proteins
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- R&D Systems cDNA Clones for F2RL1 (PAR2)
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- GenScript: Design CRISPR guide RNA sequences for F2RL1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Human cDNA Clone for F2RL1
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for F2RL1
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- Taconic Biosciences Mouse Models for F2RL1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for F2RL1 (AFLGC-F2RL1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for F2RL1
- Addgene plasmids for F2RL1
- antibodies-online: Search results for 43 available F2RL1 Antibodies ranked by validation data
- Compare Top F2RL1 Antibodies
- antibodies-online: Search results for 39 available F2RL1 Elisa Kits ranked by validation data
- Compare Top F2RL1 Elisa Kits
- antibodies-online: Search results for 7 available F2RL1 Proteins ranked by validation data
- Compare Top F2RL1 Proteins
- Search GeneTex for Antibodies for F2RL1
- Search GeneTex for Proteins for F2RL1
- Santa Cruz Biotechnology (SCBT) Antibodies for F2RL1
- Search Santa Cruz Biotechnology (SCBT) for F2RL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for F2RL1
- Horizon Cell Lines for F2RL1
- genomics-online: cdna clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- orf clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- genomics-online: gRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- genomics-online: primer clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- genomics-online: shRNA clones - Search results for 117 available F2RL1 gene related products
- Overview of 117 available F2RL1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for F2RL1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for F2RL1
- GeneCopoeia miRNA 3'UTR Target clone products for F2RL1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for F2RL1
- Boster Bio Antibodies for F2RL1
- Browse Boster Bio ELISA Kits
Sources for F2RL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt