F2RL1 Gene (Protein Coding)

F2R Like Trypsin Receptor 1

GC05P076818
GIFtS:
47
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth musc... See more...

Aliases for F2RL1 Gene

Aliases for F2RL1 Gene

  • F2R Like Trypsin Receptor 1 2 3 5
  • Coagulation Factor II (Thrombin) Receptor-Like 1 2 3
  • Proteinase-Activated Receptor 2 3 4
  • G-Protein Coupled Receptor 11 3 4
  • Thrombin Receptor-Like 1 3 4
  • GPR11 3 4
  • PAR2 3 4
  • Coagulation Factor II Receptor-Like 1 4
  • Proteinase-Activated Receptor-2 2
  • Protease-Activated Receptor 2 3
  • PAR-2 4

External Ids for F2RL1 Gene

Previous HGNC Symbols for F2RL1 Gene

  • GPR11

Previous GeneCards Identifiers for F2RL1 Gene

  • GC05P074920
  • GC05P076349
  • GC05P076153
  • GC05P076198
  • GC05P076150
  • GC05P071322
  • GC05P076120

Summaries for F2RL1 Gene

Entrez Gene Summary for F2RL1 Gene

  • This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]

GeneCards Summary for F2RL1 Gene

F2RL1 (F2R Like Trypsin Receptor 1) is a Protein Coding gene. Diseases associated with F2RL1 include Pulmonary Vein Stenosis and Orofacial Granulomatosis. Among its related pathways are p70S6K Signaling and Development Endothelin-1/EDNRA signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is F2R.

UniProtKB/Swiss-Prot Summary for F2RL1 Gene

  • Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.

Tocris Summary for F2RL1 Gene

  • Protease-activated receptors (PARs, also known as thrombin receptors) are G-protein-coupled receptors, activated by cleavage of their N-terminal domains by serine proteases. Hydrolysis reveals a tethered peptide ligand, which affects transmembrane signaling.

Gene Wiki entry for F2RL1 Gene

Additional gene information for F2RL1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for F2RL1 Gene

Genomics for F2RL1 Gene

GeneHancer (GH) Regulatory Elements for F2RL1 Gene

Promoters and enhancers for F2RL1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around F2RL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the F2RL1 gene promoter:
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • GATA-1
  • HNF-1
  • HNF-1A
  • RFX1
  • Sox9

Genomic Locations for F2RL1 Gene

Genomic Locations for F2RL1 Gene
chr5:76,818,933-76,835,315
(GRCh38/hg38)
Size:
16,383 bases
Orientation:
Plus strand
chr5:76,114,758-76,131,140
(GRCh37/hg19)
Size:
16,383 bases
Orientation:
Plus strand

Genomic View for F2RL1 Gene

Genes around F2RL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
F2RL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for F2RL1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for F2RL1 Gene

Proteins for F2RL1 Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for F2RL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55085-PAR2_HUMAN
    Recommended name:
    Proteinase-activated receptor 2
    Protein Accession:
    P55085
    Secondary Accessions:
    • Q13317
    • Q13346
    • Q53XJ8

    Protein attributes for F2RL1 Gene

    Size:
    397 amino acids
    Molecular mass:
    44126 Da
    Quaternary structure:
    • Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).
    Miscellaneous:
    • Synthetic PAR agonist peptides (APs) that mimic the first six amino acids of the newly formed N-terminus activate the native, uncleaved receptor nonenzymatically by binding directly to the corresponding second extracellular loop to mediate signaling.

    Three dimensional structures from OCA and Proteopedia for F2RL1 Gene

neXtProt entry for F2RL1 Gene

Protein Expression for F2RL1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for F2RL1 Gene

  • A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888). Activating serine proteases include trypsin, mast cell tryptase, coagulation factors VII and Xa, myeloblastin/PRTN3 and membrane-type serine protease 1/ST14 (PubMed:10831593, PubMed:19864598, PubMed:9020112, PubMed:10805786, PubMed:16478888, PubMed:23202369). Subsequent cleavage by serine proteases, including neutrophil elastase and cathepsin G, leads to receptor deactivation (PubMed:12594060). At least in part, implicated proteases are also shown to activate the receptor; the glycosylation status of the receptor is thought to contribute to the difference (PubMed:12171601). In addition to conventional trypsin-like proteases activated by other proteases and glycosidases derived from bacteria, fungi and insects (PubMed:11447194, PubMed:11441110, PubMed:17404307, PubMed:18474671, PubMed:19864598). Activated by serine protease allergens such as dust mite Der p3 and Der p9 and mold Pen c13 (PubMed:11441110, PubMed:17404307). Activated by P.gingivalis arginine-specific (trypsin-like) cysteine proteinases called gingipains (PubMed:11447194). Activated by S.griseus exogenous chitinase (PubMed:18474671). Activated by A.alternata aspartate protease; the cleavage generates non-conventional processed forms (PubMed:19864598).
  • N-glycosylated and sialylated.
  • Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.
  • Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation.
  • Glycosylation at Asn30, Thr45, Ser46, Thr49, Thr54, and Asn222
  • Ubiquitination at Lys368
  • Modification sites at PhosphoSitePlus

Other Protein References for F2RL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for F2RL1
  • Boster Bio Antibodies for F2RL1

No data available for DME Specific Peptides for F2RL1 Gene

Domains & Families for F2RL1 Gene

Gene Families for F2RL1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for F2RL1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for F2RL1 Gene

GenScript: Design optimal peptide antigens:
  • Thrombin receptor-like 1 (PAR2_HUMAN)
  • Protease-activated receptor 2 (Q53XJ8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P55085

UniProtKB/Swiss-Prot:

PAR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with F2RL1: view

Function for F2RL1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
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Molecular function for F2RL1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho (PubMed:28445455). Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 (PubMed:23202369). Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion (PubMed:10086357). Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
GENATLAS Biochemistry:
coagulation factor II (thrombin) receptor proteinase-activated receptor 2,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for F2RL1 Gene

Gene Ontology (GO) - Molecular Function for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding ISS --
GO:0004930 G protein-coupled receptor activity TAS,ISS --
GO:0005102 signaling receptor binding TAS 8615752
GO:0005515 protein binding IPI 10725339
GO:0015057 thrombin-activated receptor activity IEA --
genes like me logo Genes that share ontologies with F2RL1: view
genes like me logo Genes that share phenotypes with F2RL1: view

Animal Models for F2RL1 Gene

MGI Knock Outs for F2RL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for F2RL1

CRISPR Products

miRNA for F2RL1 Gene

miRTarBase miRNAs that target F2RL1

Clone Products

  • Addgene plasmids for F2RL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for F2RL1 Gene

Localization for F2RL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for F2RL1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for F2RL1 gene
Compartment Confidence
plasma membrane 5
endosome 5
golgi apparatus 4
extracellular 2
cytoskeleton 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 22547407
GO:0005794 Golgi apparatus TAS 8615752
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 17848177
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with F2RL1: view

Pathways & Interactions for F2RL1 Gene

genes like me logo Genes that share pathways with F2RL1: view

Pathways by source for F2RL1 Gene

1 BioSystems pathway for F2RL1 Gene
1 Qiagen pathway for F2RL1 Gene
  • p70S6K Signaling
2 Cell Signaling Technology pathways for F2RL1 Gene

SIGNOR curated interactions for F2RL1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for F2RL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002286 T cell activation involved in immune response ISS,IEA --
GO:0002376 immune system process IEA --
GO:0002690 positive regulation of leukocyte chemotaxis IDA 17991872
GO:0002741 positive regulation of cytokine secretion involved in immune response IDA 11441110
GO:0003104 positive regulation of glomerular filtration IEA,ISS --
genes like me logo Genes that share ontologies with F2RL1: view

Drugs & Compounds for F2RL1 Gene

Products:

  1. Drug

(61) Drugs for F2RL1 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-furoyl-LIGRLO-amide Pharma Full agonist, Agonist 0
SLIGKV-NH2 Pharma PAR2 agonist, PAR2 receptor agonist 0
SLIGRL-NH2 Pharma PAR2 activator, PAR2-activating peptide 0
Thrombin Receptor Agonist Peptide Pharma Causes platelet aggregation and secretion 0
2-furoyl-LIGRL[N-(Alexa Fluor 594)-O]-NH<sub>2 </sub> Pharma 0

(37) Additional Compounds for F2RL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for F2RL1 Gene

Compound Action Cas Number
AY-NH2 Selective PAR4 agonist 352017-71-1
SLIGKV-NH2 PAR2 receptor agonist 190383-13-2
SLIGRL-NH2 PAR2-activating peptide 171436-38-7
TFLLR-NH2 PAR1-activating peptide 197794-83-5
Thrombin Receptor Agonist Peptide Causes platelet aggregation and secretion 137339-65-2

(8) ApexBio Compounds for F2RL1 Gene

Compound Action Cas Number
2-Furoyl-LIGRLO-amide 729589-58-6
AC 264613 PAR2 agonist,potent and selective 1051487-82-1
AC 55541 PAR2 agonist,potent and selective 916170-19-9
LRGILS-NH2 245329-01-5
SLIGKV-NH2 PAR2 agonist 190383-13-2
SLIGRL-NH2 PAR2 activator 171436-38-7
Thrombin Receptor Activator for Peptide 5 (TRAP-5) 141685-53-2
Thrombin Receptor Agonist Peptide 137339-65-2
genes like me logo Genes that share compounds with F2RL1: view

Transcripts for F2RL1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for F2RL1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for F2RL1

Alternative Splicing Database (ASD) splice patterns (SP) for F2RL1 Gene

No ASD Table

Relevant External Links for F2RL1 Gene

GeneLoc Exon Structure for
F2RL1
ECgene alternative splicing isoforms for
F2RL1

Expression for F2RL1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for F2RL1 Gene

mRNA expression in normal human tissues for F2RL1 Gene
mRNA expression by BioGPS for F2RL1 GenemRNA expression by GTEx for F2RL1 Gene

mRNA differential expression in normal tissues according to GTEx for F2RL1 Gene

This gene is overexpressed in Colon - Transverse (x9.4), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Skin - Sun Exposed (Lower leg) (x5.3).

Protein differential expression in normal tissues from HIPED for F2RL1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for F2RL1 Gene



Protein tissue co-expression partners for F2RL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of F2RL1 Gene:

F2RL1

SOURCE GeneReport for Unigene cluster for F2RL1 Gene:

Hs.744181

mRNA Expression by UniProt/SwissProt for F2RL1 Gene:

P55085-PAR2_HUMAN
Tissue specificity: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752). Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubMed:7556175, PubMed:8615752). Expressed in endothelial cells (PubMed:23202369).

Evidence on tissue expression from TISSUES for F2RL1 Gene

  • Kidney(4.4)
  • Pancreas(4.4)
  • Intestine(2.5)
  • Skin(2.5)
  • Lung(2.2)
  • Blood(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with F2RL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for F2RL1 Gene

Orthologs for F2RL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for F2RL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia F2RL1 33 32
  • 99.66 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia F2RL1 33 32
  • 85.86 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia F2RL1 33 32
  • 85.2 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia F2rl1 17 33 32
  • 82.17 (n)
rat
(Rattus norvegicus)
 Mammalia F2rl1 32
  • 80.39 (n)
oppossum
(Monodelphis domestica)
 Mammalia F2RL1 33
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia F2RL1 33
  • 69 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves F2RL1 33 32
  • 71.02 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 27 (a)
 ManyToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia f2rl1 32
  • 66.95 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.5507 32
zebrafish
(Danio rerio)
 Actinopterygii f2rl1.2 33 32
  • 58.69 (n)
 OneToMany
f2rl1.1 33
  • 48 (a)
 OneToMany
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9406 32
Species where no ortholog for F2RL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for F2RL1 Gene

ENSEMBL:
Gene Tree for F2RL1 (if available)
TreeFam:
Gene Tree for F2RL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for F2RL1: view image

Paralogs for F2RL1 Gene

Paralogs for F2RL1 Gene

(23) SIMAP similar genes for F2RL1 Gene using alignment to 2 proteins:

  • PAR2_HUMAN
  • D6RJH3_HUMAN
genes like me logo Genes that share paralogs with F2RL1: view

Variants for F2RL1 Gene

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Sequence variations from dbSNP and Humsavar for F2RL1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000180334 -- 76,824,069(+) C/T intron_variant
rs1000195683 -- 76,823,898(+) T/C intron_variant
rs1000209871 -- 76,818,140(+) G/A upstream_transcript_variant
rs1000396757 -- 76,818,727(+) G/T upstream_transcript_variant
rs1000459569 -- 76,823,155(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for F2RL1 Gene

Variant ID Type Subtype PubMed ID
dgv5703n100 CNV gain 25217958
dgv9885n54 CNV gain 21841781
esv2763908 CNV gain 21179565
esv3575858 CNV gain 25503493
esv3605474 CNV gain 21293372
esv994503 CNV deletion 20482838

Variation tolerance for F2RL1 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for F2RL1 Gene

Human Gene Mutation Database (HGMD)
F2RL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
F2RL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for F2RL1 Gene

Disorders for F2RL1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for F2RL1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary vein stenosis
  • pulmonary veins stenosis
orofacial granulomatosis
  • granulomatosis, orofacial
gastroesophageal reflux
  • ger
inflammatory bowel disease
  • inflammatory bowel diseases
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search F2RL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for F2RL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with F2RL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for F2RL1 Gene

Publications for F2RL1 Gene

  1. Proteinase-activated receptor-2 mediated inhibition of TNFalpha-stimulated JNK activation - A novel paradigm for G(q/11) linked GPCRs. (PMID: 19781631) McIntosh K … Plevin R (Cellular signalling 2010) 3 4 23 56
  2. Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization. (PMID: 19815543) Ricks TK … Trejo J (The Journal of biological chemistry 2009) 3 4 23 56
  3. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. (PMID: 18622013) Rallabhandi P … Vogel SN (The Journal of biological chemistry 2008) 3 4 23 56
  4. Mold allergen, pen C 13, induces IL-8 expression in human airway epithelial cells by activating protease-activated receptor 1 and 2. (PMID: 17404307) Chiu LL … Chow LP (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 4 23 56
  5. Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway. (PMID: 16478888) Csernok E … Hellmich B (Blood 2006) 3 4 23 56

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