Aliases for EXOSC8 Gene
External Ids for EXOSC8 Gene
Previous GeneCards Identifiers for EXOSC8 Gene
This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009]
GeneCards Summary for EXOSC8 Gene
EXOSC8 (Exosome Component 8) is a Protein Coding gene. Diseases associated with EXOSC8 include Pontocerebellar Hypoplasia, Type 1C and Pontocerebellar Hypoplasia Type 1. Among its related pathways are ATP/ITP metabolism and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include AU-rich element binding and exoribonuclease activity. An important paralog of this gene is EXOSC9.
UniProtKB/Swiss-Prot Summary for EXOSC8 Gene
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.