Aliases for EXOSC7 Gene

Aliases for EXOSC7 Gene

  • Exosome Component 7 2 3 4 5
  • RRP42 2 3 4
  • P8 2 3 4
  • Ribosomal RNA-Processing Protein 42 3 4
  • Exosome Complex Component RRP42 3 4
  • KIAA0116 2 4
  • HRrp42p 2 3
  • Rrp42p 2 3
  • EAP1 2 3
  • Exosome Complex Exonuclease RRP42 3
  • EXOSC7 5

External Ids for EXOSC7 Gene

Previous GeneCards Identifiers for EXOSC7 Gene

  • GC03P044979
  • GC03P044992
  • GC03P045016
  • GC03P045178
  • GC03P045213
  • GC03P045233
  • GC03P045294
  • GC03P045025
  • GC03P045069
  • GC03P045105
  • GC03P045141

Summaries for EXOSC7 Gene

GeneCards Summary for EXOSC7 Gene

EXOSC7 (Exosome Component 7) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity. An important paralog of this gene is EXOSC9.

UniProtKB/Swiss-Prot Summary for EXOSC7 Gene

  • Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Gene Wiki entry for EXOSC7 Gene

Additional gene information for EXOSC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EXOSC7 Gene

Genomics for EXOSC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EXOSC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOSC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EXOSC7

Top Transcription factor binding sites by QIAGEN in the EXOSC7 gene promoter:
  • AML1a
  • GATA-1
  • NF-1
  • NF-1/L
  • POU2F1
  • POU2F1a
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for EXOSC7 Gene

Genomic Locations for EXOSC7 Gene
chr3:44,975,241-45,036,066
(GRCh38/hg38)
Size:
60,826 bases
Orientation:
Plus strand
chr3:45,016,733-45,077,558
(GRCh37/hg19)
Size:
60,826 bases
Orientation:
Plus strand

Genomic View for EXOSC7 Gene

Genes around EXOSC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOSC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOSC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC7 Gene

Proteins for EXOSC7 Gene

  • Protein details for EXOSC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15024-EXOS7_HUMAN
    Recommended name:
    Exosome complex component RRP42
    Protein Accession:
    Q15024
    Secondary Accessions:
    • Q96E72

    Protein attributes for EXOSC7 Gene

    Size:
    291 amino acids
    Molecular mass:
    31821 Da
    Quaternary structure:
    • Component of the RNA exosome complex (PubMed:29906447). Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with EXOSC1. Interacts with ZC3HAV1.

    Three dimensional structures from OCA and Proteopedia for EXOSC7 Gene

neXtProt entry for EXOSC7 Gene

Post-translational modifications for EXOSC7 Gene

  • Ubiquitination at Lys205, Lys244, and Lys260
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOSC7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOSC7 Gene

Domains & Families for EXOSC7 Gene

Gene Families for EXOSC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EXOSC7 Gene

GenScript: Design optimal peptide antigens:
  • p8 (EXOS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15024

UniProtKB/Swiss-Prot:

EXOS7_HUMAN :
  • Belongs to the RNase PH family.
Family:
  • Belongs to the RNase PH family.
genes like me logo Genes that share domains with EXOSC7: view

Function for EXOSC7 Gene

Molecular function for EXOSC7 Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

Phenotypes From GWAS Catalog for EXOSC7 Gene

Gene Ontology (GO) - Molecular Function for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity TAS 11849973
GO:0003723 RNA binding TAS 11849973
GO:0004532 NOT exoribonuclease activity IDA 17174896
GO:0005515 protein binding IPI 11719186
GO:0017091 AU-rich element binding IBA 21873635
genes like me logo Genes that share ontologies with EXOSC7: view
genes like me logo Genes that share phenotypes with EXOSC7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOSC7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOSC7 Gene

Localization for EXOSC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC7 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOSC7 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IBA 21873635
GO:0000177 cytoplasmic exosome (RNase complex) IBA 21873635
GO:0000178 exosome (RNase complex) TAS 11849973
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with EXOSC7: view

Pathways & Interactions for EXOSC7 Gene

genes like me logo Genes that share pathways with EXOSC7: view

Pathways by source for EXOSC7 Gene

1 GeneGo (Thomson Reuters) pathway for EXOSC7 Gene
  • ATP/ITP metabolism

Gene Ontology (GO) - Biological Process for EXOSC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0006364 rRNA processing TAS 11849973
GO:0006401 RNA catabolic process NAS 11719186
GO:0016075 rRNA catabolic process IBA 21873635
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA 21873635
genes like me logo Genes that share ontologies with EXOSC7: view

No data available for SIGNOR curated interactions for EXOSC7 Gene

Drugs & Compounds for EXOSC7 Gene

No Compound Related Data Available

Transcripts for EXOSC7 Gene

mRNA/cDNA for EXOSC7 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOSC7

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - -
SP6:

Relevant External Links for EXOSC7 Gene

GeneLoc Exon Structure for
EXOSC7

Expression for EXOSC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOSC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EXOSC7 Gene

This gene is overexpressed in Lung (29.8), Peripheral blood mononuclear cells (11.0), and Urine (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOSC7 Gene



Protein tissue co-expression partners for EXOSC7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EXOSC7

SOURCE GeneReport for Unigene cluster for EXOSC7 Gene:

Hs.719958

Evidence on tissue expression from TISSUES for EXOSC7 Gene

  • Nervous system(4.6)
  • Bone marrow(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with EXOSC7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC7 Gene

Orthologs for EXOSC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EXOSC7 30 31
  • 98.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EXOSC7 30 31
  • 92.1 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EXOSC7 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Exosc7 30 17 31
  • 89.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EXOSC7 30 31
  • 89.69 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC7 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Exosc7 30
  • 88.55 (n)
Chicken
(Gallus gallus)
Aves EXOSC7 30 31
  • 78.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 85 (a)
OneToMany
-- 31
  • 76 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia exosc7 30
  • 71.95 (n)
Zebrafish
(Danio rerio)
Actinopterygii exosc7 30 31
  • 69.87 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010483 30
  • 56.63 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Rrp42 30 31
  • 54.83 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea exos-7 31
  • 32 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP45 31
  • 19 (a)
OneToMany
RRP42 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G07750 30
  • 48.71 (n)
Rice
(Oryza sativa)
Liliopsida Os12g0403800 30
  • 49.94 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Species where no ortholog for EXOSC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EXOSC7 Gene

ENSEMBL:
Gene Tree for EXOSC7 (if available)
TreeFam:
Gene Tree for EXOSC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EXOSC7: view image

Paralogs for EXOSC7 Gene

Paralogs for EXOSC7 Gene

(1) SIMAP similar genes for EXOSC7 Gene using alignment to 1 proteins:

  • EXOS7_HUMAN
genes like me logo Genes that share paralogs with EXOSC7: view

Variants for EXOSC7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EXOSC7 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs34512144 - p.Arg169Gln
rs6794 - p.Val274Leu

Additional dbSNP identifiers (rs#s) for EXOSC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for EXOSC7 Gene

Variant ID Type Subtype PubMed ID
esv2675874 CNV deletion 23128226
esv3596042 CNV loss 21293372
nsv508914 CNV insertion 20534489
nsv834676 CNV gain+loss 17160897

Variation tolerance for EXOSC7 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOSC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOSC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC7 Gene

Disorders for EXOSC7 Gene

No disorders were found for EXOSC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOSC7 Gene

Publications for EXOSC7 Gene

  1. Protein-protein interactions of hCsl4p with other human exosome subunits. (PMID: 11812149) Raijmakers R … Pruijn GJ (Journal of molecular biology 2002) 2 3 4 23
  2. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen CY … Karin M (Cell 2001) 2 3 4
  3. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y … Gao G (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
  4. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4
  5. Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q … Lima CD (Cell 2006) 3 4

Products for EXOSC7 Gene

Sources for EXOSC7 Gene