Aliases for EXOSC10 Gene
External Ids for EXOSC10 Gene
Previous HGNC Symbols for EXOSC10 Gene
Previous GeneCards Identifiers for EXOSC10 Gene
GeneCards Summary for EXOSC10 Gene
EXOSC10 (Exosome Component 10) is a Protein Coding gene. Diseases associated with EXOSC10 include Diffuse Scleroderma and Systemic Scleroderma. Among its related pathways are rRNA processing in the nucleus and cytosol and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is EXD1.
UniProtKB/Swiss-Prot Summary for EXOSC10 Gene
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.