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Aliases for EXOC8 Gene

Aliases for EXOC8 Gene

  • Exocyst Complex Component 8 2 3 3 5
  • Exocyst Complex 84 KDa Subunit 3 4
  • Exo84p 3
  • EXO84 3
  • SEC84 3

External Ids for EXOC8 Gene

Previous GeneCards Identifiers for EXOC8 Gene

  • GC01M228503
  • GC01M227775
  • GC01M229535
  • GC01M231469
  • GC01M201951

Summaries for EXOC8 Gene

Entrez Gene Summary for EXOC8 Gene

  • This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

GeneCards Summary for EXOC8 Gene

EXOC8 (Exocyst Complex Component 8) is a Protein Coding gene. Diseases associated with EXOC8 include Bardet-Biedl Syndrome 18 and Joubert Syndrome 1. Among its related pathways are Organelle biogenesis and maintenance and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include Ral GTPase binding.

UniProtKB/Swiss-Prot for EXOC8 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC8 Gene

Additional gene information for EXOC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC8 Gene

Genomics for EXOC8 Gene

GeneHancer (GH) Regulatory Elements for EXOC8 Gene

Promoters and enhancers for EXOC8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J231333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 423 7.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SPRTN PIR33664 EXOC8 SNRPD2P2 RN7SL837P RPS24P4 LINC01737 C1orf131 LINC00582 EGLN1
GH01J230976 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 6.2 +359.2 359245 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TTC13 ARV1 C1orf131 EXOC8 FAM89A LOC101927604 SPRTN GC01P230904
GH01J231393 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.4 -57.3 -57337 4 FOXA2 SIN3A ZNF2 BRCA1 YY1 ATF7 FOS KLF13 SP3 RXRA EGLN1 SPRTN C1orf131 COG2 EXOC8 GNPAT PIR59803
GH01J231357 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.7 -20.1 -20082 0.9 PKNOX1 RB1 SIN3A ZNF2 RAD21 RFX5 ZNF121 ARID2 ZNF366 ZSCAN5C SPRTN EXOC8 DISC1 PIR59803
GH01J231527 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 4.7 -191.2 -191177 3.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TSNAX TSNAX-DISC1 ENSG00000233461 EGLN1 C1orf131 COG2 DISC1 GNPAT EXOC8 SPRTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EXOC8 gene promoter:
  • E2F
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F-5
  • c-Myb
  • GATA-1
  • HOXA9
  • HOXA9B

Genomic Locations for EXOC8 Gene

Genomic Locations for EXOC8 Gene
5,142 bases
Minus strand
5,119 bases
Minus strand

Genomic View for EXOC8 Gene

Genes around EXOC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC8 Gene

Proteins for EXOC8 Gene

  • Protein details for EXOC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 8
    Protein Accession:
    Secondary Accessions:
    • B3KU33
    • Q5TE82

    Protein attributes for EXOC8 Gene

    725 amino acids
    Molecular mass:
    81799 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH domain) with GTP-bound RALA and RALB (PubMed:14525976, PubMed:18756269). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605).
    • Sequence=CAI23095.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EXOC8 Gene

Post-translational modifications for EXOC8 Gene

  • Ubiquitination at Lys60 and isoforms=29
  • Modification sites at PhosphoSitePlus

Other Protein References for EXOC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EXOC8 Gene

Domains & Families for EXOC8 Gene

Gene Families for EXOC8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EXOC8 Gene

Suggested Antigen Peptide Sequences for EXOC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EXO84 family.
  • Belongs to the EXO84 family.
genes like me logo Genes that share domains with EXOC8: view

Function for EXOC8 Gene

Molecular function for EXOC8 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC8 Gene

Gene Ontology (GO) - Molecular Function for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0017160 Ral GTPase binding IPI 24056301
genes like me logo Genes that share ontologies with EXOC8: view
genes like me logo Genes that share phenotypes with EXOC8: view

Animal Models for EXOC8 Gene

MGI Knock Outs for EXOC8:
  • Exoc8 Exoc8<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for EXOC8 Gene

miRTarBase miRNAs that target EXOC8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EXOC8 Gene

Localization for EXOC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC8 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, ECO:0000250 UniProtKB:O54924}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC8 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 5
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IDA 24056301
GO:0005737 cytoplasm IEA --
GO:0005770 late endosome IDA 24344185
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC8: view

Pathways & Interactions for EXOC8 Gene

genes like me logo Genes that share pathways with EXOC8: view

Pathways by source for EXOC8 Gene

1 GeneGo (Thomson Reuters) pathway for EXOC8 Gene
2 Qiagen pathways for EXOC8 Gene

Gene Ontology (GO) - Biological Process for EXOC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001927 exocyst assembly IBA --
GO:0006887 exocytosis IEA --
GO:0007032 endosome organization IMP 24344185
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy TAS 21241894
genes like me logo Genes that share ontologies with EXOC8: view

No data available for SIGNOR curated interactions for EXOC8 Gene

Drugs & Compounds for EXOC8 Gene

(1) Drugs for EXOC8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC8: view

Transcripts for EXOC8 Gene

mRNA/cDNA for EXOC8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EXOC8 Gene

Exocyst complex component 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC8

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC8 Gene

No ASD Table

Relevant External Links for EXOC8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC8 Gene

Protein differential expression in normal tissues from HIPED for EXOC8 Gene

This gene is overexpressed in Bone (27.7) and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC8 Gene

Protein tissue co-expression partners for EXOC8 Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOC8 Gene:


SOURCE GeneReport for Unigene cluster for EXOC8 Gene:

genes like me logo Genes that share expression patterns with EXOC8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC8 Gene

Orthologs for EXOC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC8 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia EXOC8 34 33
  • 90.67 (n)
(Bos Taurus)
Mammalia EXOC8 34 33
  • 90.07 (n)
(Monodelphis domestica)
Mammalia EXOC8 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Exoc8 33
  • 83.01 (n)
(Mus musculus)
Mammalia Exoc8 16 34 33
  • 82.87 (n)
(Ornithorhynchus anatinus)
Mammalia EXOC8 34
  • 71 (a)
(Gallus gallus)
Aves EXOC8 34 33
  • 76.7 (n)
(Anolis carolinensis)
Reptilia EXOC8 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc8 33
  • 71.91 (n)
(Danio rerio)
Actinopterygii exoc8 34 33
  • 70.53 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004207 33
  • 43.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta exo84 34 33
  • 42.59 (n)
(Caenorhabditis elegans)
Secernentea exoc-8 34 33
  • 43.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for EXOC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC8 Gene

Gene Tree for EXOC8 (if available)
Gene Tree for EXOC8 (if available)
Evolutionary constrained regions (ECRs) for EXOC8: view image

Paralogs for EXOC8 Gene

No data available for Paralogs for EXOC8 Gene

Variants for EXOC8 Gene

Sequence variations from dbSNP and Humsavar for EXOC8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs483352868 uncertain-significance, Joubert syndrome 231,336,952(-) T/C coding_sequence_variant, missense_variant
rs1000012705 -- 231,338,047(-) T/G upstream_transcript_variant
rs1000067424 -- 231,334,781(-) C/G 3_prime_UTR_variant
rs1000655369 -- 231,332,300(-) G/A downstream_transcript_variant
rs1001046222 -- 231,339,640(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC8 Gene

Variant ID Type Subtype PubMed ID
nsv827197 CNV loss 20364138

Variation tolerance for EXOC8 Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC8 Gene

Disorders for EXOC8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EXOC8 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 18
  • bbs18
joubert syndrome 1
  • jbts1
- elite association - COSMIC cancer census association via MalaCards
Search EXOC8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EXOC8

genes like me logo Genes that share disorders with EXOC8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC8 Gene

Publications for EXOC8 Gene

  1. SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. (PMID: 21658605) Parrini MC … Camonis J (Molecular cell 2011) 3 4 58
  2. Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis. (PMID: 20145037) Issaq SH … Counter CM (Molecular cancer research : MCR 2010) 3 22 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for EXOC8 Gene

Sources for EXOC8 Gene

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