Aliases for EXOC8 Gene
External Ids for EXOC8 Gene
Previous GeneCards Identifiers for EXOC8 Gene
This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]
GeneCards Summary for EXOC8 Gene
EXOC8 (Exocyst Complex Component 8) is a Protein Coding gene. Diseases associated with EXOC8 include Bardet-Biedl Syndrome 18 and Joubert Syndrome 1. Among its related pathways are Organelle biogenesis and maintenance and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include Ral GTPase binding.
UniProtKB/Swiss-Prot for EXOC8 Gene
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.