Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a rol... See more...
Aliases for EXOC7 Gene
Aliases for EXOC7 Gene
External Ids for EXOC7 Gene
- HGNC: 23214
- Entrez Gene: 23265
- Ensembl: ENSG00000182473
- OMIM: 608163
- UniProtKB: Q9UPT5
Previous GeneCards Identifiers for EXOC7 Gene
- GC17M074674
- GC17M071588
- GC17M074077
- GC17M069506
Summaries for EXOC7 Gene
-
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
GeneCards Summary for EXOC7 Gene
EXOC7 (Exocyst Complex Component 7) is a Protein Coding gene. Diseases associated with EXOC7 include Myasthenic Syndrome, Congenital, 4C, Associated With Acetylcholine Receptor Deficiency and Bardet-Biedl Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Actin Nucleation by ARP-WASP Complex.
UniProtKB/Swiss-Prot Summary for EXOC7 Gene
-
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).
Additional gene information for EXOC7 Gene
- HGNC(23214)
- Entrez Gene(23265)
- Ensembl(ENSG00000182473)
- OMIM(608163)
- UniProtKB(Q9UPT5)
- Open Targets Platform(ENSG00000182473)
- Search for EXOC7 at DataMed
- Search for EXOC7 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EXOC7 Gene
Genomics for EXOC7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EXOC7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EXOC7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EXOC7
- Top Transcription factor binding sites by QIAGEN in the EXOC7 gene promoter:
-
- Arnt
- c-Myc
- Max1
- SRF
- SRF (504 AA)
Genomic Locations for EXOC7 Gene
Genomic Locations for EXOC7 Gene
- chr17:76,080,993-76,121,576
- (GRCh38/hg38)
- Size:
- 40,584 bases
- Orientation:
- Minus strand
- chr17:74,077,086-74,117,657
- (GRCh37/hg19)
- Size:
- 40,572 bases
- Orientation:
- Minus strand
Genomic View for EXOC7 Gene
Genes around EXOC7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
EXOC7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EXOC7 Gene
Proteins for EXOC7 Gene
-
Protein details for EXOC7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UPT5-EXOC7_HUMAN
- Recommended name:
- Exocyst complex component 7
- Protein Accession:
- Q9UPT5
- B5MC69
- B8XXP2
- Q8ND93
- Q8WV91
- Q96FF0
- Q9H8C3
- Q9H9X3
- Q9HA32
Protein attributes for EXOC7 Gene
- Size:
- 735 amino acids
- Molecular mass:
- 83382 Da
- Quaternary structure:
-
- The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).
- SequenceCaution:
-
- Sequence=BAA83019.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 4]: May be due to intron retention.
Protein Expression for EXOC7 Gene
Post-translational modifications for EXOC7 Gene
Other Protein References for EXOC7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences EXOC7 Antibody
-
Custom Antibody ServicesOriGene Antibodies for EXOC7
- Novus Biologicals Antibodies for EXOC7
-
Abcam antibodies for EXOC7
- Invitrogen Antibodies for EXOC7 (AFLGC-EXOC7)
-
Santa Cruz Biotechnology (SCBT) Antibodies for EXOC7
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOC7
- Origene Custom Protein Services for EXOC7
- Novus Biologicals proteins for EXOC7
No data available for DME Specific Peptides for EXOC7 Gene
Domains & Families for EXOC7 Gene
Gene Families for EXOC7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transporters
Protein Domains for EXOC7 Gene
- InterPro:
- Blocks:
-
- Exo70 exocyst complex subunit
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOC7 Gene
- GenScript: Design optimal peptide antigens:
-
- Exocyst complex component Exo70 (EXOC7_HUMAN)
- 2-5-3p (Q5G0E1_HUMAN)
- EXOC7 protein (Q96BU6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UPT5UniProtKB/Swiss-Prot:
EXOC7_HUMAN :- The N-terminus is involved in SEC8 and ARHQ binding.
- Belongs to the EXO70 family.
- Domain:
-
- The N-terminus is involved in SEC8 and ARHQ binding.
- The C-terminus is required for translocation to the plasma membrane.
- Family:
-
- Belongs to the EXO70 family.
Function for EXOC7 Gene
Molecular function for EXOC7 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).
Phenotypes From GWAS Catalog for EXOC7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16148947 |
Phenotypes for EXOC7 Gene
- GenomeRNAi human phenotypes for EXOC7:
Animal Model Products
-
Taconic Biosciences Mouse Models for EXOC7
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EXOC7 - Select products 50% OFF >
- * EXOC7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EXOC7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EXOC7
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOC7
miRNA for EXOC7 Gene
- miRTarBase miRNAs that target EXOC7
-
- mmu-miR-15a-5p (MIRT011912)
- hsa-miR-155-5p (MIRT020501)
- hsa-miR-615-3p (MIRT040126)
- hsa-miR-18a-3p (MIRT040867)
- hsa-miR-331-3p (MIRT043463)
- hsa-miR-125b-5p (MIRT045968)
- hsa-miR-3684 (MIRT495780)
- hsa-miR-655-3p (MIRT495781)
- hsa-miR-374c-5p (MIRT495782)
- hsa-miR-6749-3p (MIRT642106)
- hsa-miR-6792-3p (MIRT642107)
- hsa-miR-4691-5p (MIRT642108)
- hsa-miR-4777-3p (MIRT642109)
- hsa-miR-6791-5p (MIRT642110)
- hsa-miR-4292 (MIRT642111)
- hsa-miR-4308 (MIRT642112)
- hsa-miR-6777-3p (MIRT642113)
- hsa-miR-483-3p (MIRT642114)
- hsa-miR-6833-3p (MIRT658480)
- hsa-miR-4768-5p (MIRT658481)
- hsa-miR-7152-5p (MIRT658482)
- hsa-miR-3074-5p (MIRT658483)
- hsa-miR-6888-3p (MIRT658484)
- hsa-miR-4753-3p (MIRT658485)
- hsa-miR-6873-3p (MIRT658486)
- hsa-miR-6868-3p (MIRT658487)
- hsa-miR-6740-3p (MIRT658488)
- hsa-miR-627-3p (MIRT658489)
- hsa-miR-942-5p (MIRT658490)
- hsa-miR-3120-5p (MIRT658491)
- hsa-miR-130b-5p (MIRT658492)
- hsa-miR-6817-3p (MIRT658493)
- hsa-miR-7110-3p (MIRT658494)
- hsa-miR-1248 (MIRT658495)
- hsa-miR-1237-3p (MIRT658496)
- hsa-miR-1266-3p (MIRT658497)
- hsa-miR-19b-3p (MIRT727736)
- hsa-miR-19a-3p (MIRT727737)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EXOC7
- Browse OriGene Inhibitory RNA Products For EXOC7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC7
Clone Products
- Applied Biological Materials (abm): Clones for EXOC7 - Select products 50% OFF >
- * EXOC7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209780
- MG224011
- MG224831
- MR209780
- MR209780L3
- MR209780L4
- MR224011
- MR224011L3
- MR224011L4
- MR224831
- MR224831L3
- MR224831L4
- RC213052
- RC213052L3
- RC213052L4
- RC222329
- RC222329L3
- RC222329L4
- RC227494
- RC227494L3
- RC227494L4
- RC227511
- RC227511L3
- RC227511L4
- RC227527
- RC227527L1
- RC227527L2
- RC227527L3
- RC227527L4
- RC236166
- RC239229
- RG213052
- RG222329
- RG227494
- RG227511
- RG227527
- RR201896
- RR201896L3
- RR201896L4
- MR209780L3V
- MR209780L4V
- MR224011L3V
- MR224011L4V
- MR224831L3V
- MR224831L4V
- RC213052L3V
- RC213052L4V
- RC222329L3V
- RC222329L4V
- RC227494L3V
- RC227494L4V
- RC227511L3V
- RC227511L4V
- RC227527L1V
- RC227527L2V
- RC227527L3V
- RC227527L4V
- RR201896L3V
- RR201896L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EXOC7
- Addgene plasmids for EXOC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EXOC7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC7 Gene
Localization for EXOC7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOC7 Gene
- Cytoplasm, cytosol. Cell membrane. Peripheral membrane protein. Midbody, Midbody ring. Note=Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250 UniProtKB:O35250, ECO:0000269 PubMed:16213214}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 3 |
| golgi apparatus | 3 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000145 | exocyst | IEA,IBA | 21873635 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005815 | microtubule organizing center | IDA | 18000879 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for EXOC7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cargo trafficking to the periciliary membrane | ||
| 2 | Organelle biogenesis and maintenance |
.56
|
|
| 3 | Peptide hormone metabolism | ||
| 4 | Vesicle-mediated transport | ||
| 5 | Regulation of lipid metabolism Insulin signaling-generic cascades | ||
Pathways by source for EXOC7 Gene
4 BioSystems pathways for EXOC7 Gene
10 Reactome pathways for EXOC7 Gene
2 KEGG pathways for EXOC7 Gene
2 Qiagen pathways for EXOC7 Gene
- CDC42 Pathway
- Epithelial Tight Junctions
Interacting Proteins for EXOC7 Gene
Selected Interacting proteins:
Q9UPT5-EXOC7_HUMAN
ENSP00000334100
for EXOC7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EXOC7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006887 | exocytosis | IEA,IBA | 21873635 |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016241 | regulation of macroautophagy | TAS | 21241894 |
| GO:2000535 | regulation of entry of bacterium into host cell | IMP | 20579884 |
Drugs & Compounds for EXOC7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for EXOC7 Gene
mRNA/cDNA for EXOC7 Gene
- 10 REFSEQ mRNAs :
- 27 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000332065 4596 nts (view in UCSC)
- ENST00000335146 3519 nts (view in UCSC)
- ENST00000357231 1924 nts (view in UCSC)
- ENST00000405068 2958 nts (view in UCSC)
- ENST00000405575 2208 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for EXOC7 - Select products 50% OFF >
- * EXOC7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for EXOC7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EXOC7
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOC7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EXOC7
- Browse OriGene Inhibitory RNA Products For EXOC7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC7
Clone Products
- Applied Biological Materials (abm): Clones for EXOC7 - Select products 50% OFF >
- * EXOC7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209780
- MG224011
- MG224831
- MR209780
- MR209780L3
- MR209780L4
- MR224011
- MR224011L3
- MR224011L4
- MR224831
- MR224831L3
- MR224831L4
- RC213052
- RC213052L3
- RC213052L4
- RC222329
- RC222329L3
- RC222329L4
- RC227494
- RC227494L3
- RC227494L4
- RC227511
- RC227511L3
- RC227511L4
- RC227527
- RC227527L1
- RC227527L2
- RC227527L3
- RC227527L4
- RC236166
- RC239229
- RG213052
- RG222329
- RG227494
- RG227511
- RG227527
- RR201896
- RR201896L3
- RR201896L4
- MR209780L3V
- MR209780L4V
- MR224011L3V
- MR224011L4V
- MR224831L3V
- MR224831L4V
- RC213052L3V
- RC213052L4V
- RC222329L3V
- RC222329L4V
- RC227494L3V
- RC227494L4V
- RC227511L3V
- RC227511L4V
- RC227527L1V
- RC227527L2V
- RC227527L3V
- RC227527L4V
- RR201896L3V
- RR201896L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EXOC7
- Addgene plasmids for EXOC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EXOC7
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - |
| ExUns: | 17a | · | 17b | · | 17c | · | 17d | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | · | 21c | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||
| SP15: |
Relevant External Links for EXOC7 Gene
- GeneLoc Exon Structure for
- EXOC7
Expression for EXOC7 Gene
This gene is overexpressed in Bone (48.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC7 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EXOC7
SOURCE GeneReport for Unigene cluster for EXOC7 Gene:
Hs.514496Evidence on tissue expression from TISSUES for EXOC7 Gene
- Nervous system(4.9)
- Eye(4.5)
- Skin(2.9)
- Kidney(2.7)
- Adrenal gland(2.7)
- Pancreas(2.6)
- Intestine(2.6)
- Muscle(2.4)
- Heart(2.3)
- Blood(2.2)
- Liver(2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for EXOC7
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC7 Gene
Orthologs for EXOC7 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EXOC7 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | EXOC7 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EXOC7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EXOC7 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC100911734 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Exoc7 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | EXOC7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | EXOC7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | EXOC7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.4315 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | exoc7 30 31 |
|
OneToOne | |
| wufj67f11 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9364 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006682 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | exo70 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | exoc-7 31 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | EXO70A1 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os12g0159700 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for EXOC7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for EXOC7 Gene
- ENSEMBL:
- Gene Tree for EXOC7 (if available)
- TreeFam:
- Gene Tree for EXOC7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EXOC7: view image
Paralogs for EXOC7 Gene
(1) SIMAP similar genes for EXOC7 Gene using alignment to 9 proteins:
- EXOC7_HUMAN
- B4DJ07_HUMAN
- B5MCY9_HUMAN
- C9JKC2_HUMAN
- C9JME6_HUMAN
- K7ENP8_HUMAN
- K7ERQ5_HUMAN
- Q5G0E1_HUMAN
- Q96BU6_HUMAN
Pseudogenes.org Pseudogenes for EXOC7 Gene
No data available for Paralogs for EXOC7 Gene
Variants for EXOC7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EXOC7 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 775337 | Benign: not provided | 76,086,093(-) | T/C | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.59;
30.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EXOC7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC7 Gene
Disorders for EXOC7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency |
|
|
| bardet-biedl syndrome |
|
|
Search EXOC7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EXOC7
No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC7 Gene
Publications for EXOC7 Gene
- The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds. (PMID: 25380822) Fernandes MC … Andrews NW (Journal of cell science 2015) 2 3
- Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. (PMID: 15705715) Xu KF … Vaughan M (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 23
- Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PMID: 16148947) Fielding AB … Gould GW (The EMBO journal 2005) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for EXOC7 Gene
- Custom Antibody ServicesOriGene Antibodies for EXOC7
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOC7
- Origene Custom Protein Services for EXOC7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EXOC7
- Browse OriGene Inhibitory RNA Products For EXOC7
- OriGene qPCR primer pairs for EXOC7
- OriGene CRISPR knockouts for EXOC7
- MG209780
- MG224011
- MG224831
- MR209780
- MR209780L3
- MR209780L4
- MR224011
- MR224011L3
- MR224011L4
- MR224831
- MR224831L3
- MR224831L4
- RC213052
- RC213052L3
- RC213052L4
- RC222329
- RC222329L3
- RC222329L4
- RC227494
- RC227494L3
- RC227494L4
- RC227511
- RC227511L3
- RC227511L4
- RC227527
- RC227527L1
- RC227527L2
- RC227527L3
- RC227527L4
- RC236166
- RC239229
- RG213052
- RG222329
- RG227494
- RG227511
- RG227527
- RR201896
- RR201896L3
- RR201896L4
- MR209780L3V
- MR209780L4V
- MR224011L3V
- MR224011L4V
- MR224831L3V
- MR224831L4V
- RC213052L3V
- RC213052L4V
- RC222329L3V
- RC222329L4V
- RC227494L3V
- RC227494L4V
- RC227511L3V
- RC227511L4V
- RC227527L1V
- RC227527L2V
- RC227527L3V
- RC227527L4V
- RR201896L3V
- RR201896L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EXOC7
- Sino Biological Human cDNA Clone for EXOC7
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EXOC7
- Novus Biologicals proteins for EXOC7
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for EXOC7
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for EXOC7
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for EXOC7 (AFLGC-EXOC7)
- VectorBuilder Custom and pre-made DNA vectors for EXOC7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for EXOC7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for EXOC7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for EXOC7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for EXOC7
- Addgene plasmids for EXOC7
- antibodies-online: Show 13 available EXOC7 Antibodies ranked by validation data
- Compare Top EXOC7 Antibodies
- antibodies-online: Search results for available EXOC7 related products ranked by validation data
- antibodies-online: Show 6 available EXOC7 Proteins ranked by validation data
- Compare Top EXOC7 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for EXOC7
- Search Santa Cruz Biotechnology (SCBT) for EXOC7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EXOC7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EXOC7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EXOC7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for EXOC7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC7
Sources for EXOC7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB