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Aliases for EXOC7 Gene

Aliases for EXOC7 Gene

  • Exocyst Complex Component 7 2 3 3 5
  • Exocyst Complex Component Exo70 3 4
  • EXO70 3 4
  • KIAA1067 4
  • YJL085W 3
  • 2-5-3p 3
  • Exo70p 3
  • BLOM4 3
  • EX070 3
  • EXOC1 3

External Ids for EXOC7 Gene

Previous GeneCards Identifiers for EXOC7 Gene

  • GC17M074674
  • GC17M071588
  • GC17M074077
  • GC17M069506

Summaries for EXOC7 Gene

Entrez Gene Summary for EXOC7 Gene

  • The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for EXOC7 Gene

EXOC7 (Exocyst Complex Component 7) is a Protein Coding gene. Diseases associated with EXOC7 include Eastern Equine Encephalitis and Bardet-Biedl Syndrome 18. Among its related pathways are Organelle biogenesis and maintenance and Sertoli-Sertoli Cell Junction Dynamics.

UniProtKB/Swiss-Prot for EXOC7 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Wiki entry for EXOC7 Gene

Additional gene information for EXOC7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC7 Gene

Genomics for EXOC7 Gene

GeneHancer (GH) Regulatory Elements for EXOC7 Gene

Promoters and enhancers for EXOC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076102 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.4 +17.6 17571 2.5 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B EXOC7 H3F3B MIR6868
GH17J076120 Enhancer 1.2 Ensembl ENCODE 650.7 -0.2 -249 2.3 HDGF ATF1 ARNT SIN3A ZNF2 ZNF48 GTF3C2 GLIS2 ARID2 ZNF143 EXOC7 NUP85 SRSF2 NT5C UNK MFSD11 ENSG00000266980 METTL23 GGA3 HMGN2P43
GH17J076734 Promoter/Enhancer 3 UCNEbase EPDnew Ensembl ENCODE dbSUPER 36.2 -615.7 -615683 7.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SRSF2 MFSD11 MIR636 UNK ENSG00000267342 TRIM65 ENSG00000266980 SEPT9 ENSG00000267546 CDK3
GH17J076258 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.2 -146.4 -146399 19.6 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A UBALD2 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 METTL23 MFSD11 EXOC7
GH17J075507 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20 +608.0 608028 11.8 CLOCK MLX ZFP64 DMAP1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 TSEN54 CASKIN2 ENSG00000266980 NUP85 ENSG00000267342 NT5C LLGL2 NAT9 EXOC7 UNK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOC7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EXOC7 gene promoter:
  • Max1
  • c-Myc
  • SRF
  • SRF (504 AA)
  • Arnt

Genomic Locations for EXOC7 Gene

Genomic Locations for EXOC7 Gene
chr17:76,080,993-76,121,576
(GRCh38/hg38)
Size:
40,584 bases
Orientation:
Minus strand
chr17:74,077,086-74,117,657
(GRCh37/hg19)
Size:
40,572 bases
Orientation:
Minus strand

Genomic View for EXOC7 Gene

Genes around EXOC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC7 Gene

Proteins for EXOC7 Gene

  • Protein details for EXOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT5-EXOC7_HUMAN
    Recommended name:
    Exocyst complex component 7
    Protein Accession:
    Q9UPT5
    Secondary Accessions:
    • B5MC69
    • B8XXP2
    • Q8ND93
    • Q8WV91
    • Q96FF0
    • Q9H8C3
    • Q9H9X3
    • Q9HA32

    Protein attributes for EXOC7 Gene

    Size:
    735 amino acids
    Molecular mass:
    83382 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).
    SequenceCaution:
    • Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC7 Gene

neXtProt entry for EXOC7 Gene

Post-translational modifications for EXOC7 Gene

  • Ubiquitination at Lys65 and Lys40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EXOC7 Gene

Domains & Families for EXOC7 Gene

Gene Families for EXOC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EXOC7 Gene

Suggested Antigen Peptide Sequences for EXOC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT5

UniProtKB/Swiss-Prot:

EXOC7_HUMAN :
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • Belongs to the EXO70 family.
Domain:
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • The C-terminus is required for translocation to the plasma membrane.
Family:
  • Belongs to the EXO70 family.
genes like me logo Genes that share domains with EXOC7: view

Function for EXOC7 Gene

Molecular function for EXOC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Phenotypes From GWAS Catalog for EXOC7 Gene

Gene Ontology (GO) - Molecular Function for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16148947
genes like me logo Genes that share ontologies with EXOC7: view
genes like me logo Genes that share phenotypes with EXOC7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EXOC7

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC7

Clone Products

  • Addgene plasmids for EXOC7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC7 Gene

Localization for EXOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC7 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Midbody, Midbody ring. Note=Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250 UniProtKB:O35250, ECO:0000269 PubMed:16213214}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
golgi apparatus 3
nucleus 2
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with EXOC7: view

Pathways & Interactions for EXOC7 Gene

genes like me logo Genes that share pathways with EXOC7: view

SIGNOR curated interactions for EXOC7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0015031 protein transport IEA --
GO:0016241 regulation of macroautophagy TAS 21241894
GO:2000535 regulation of entry of bacterium into host cell IMP 20579884
genes like me logo Genes that share ontologies with EXOC7: view

Drugs & Compounds for EXOC7 Gene

(1) Drugs for EXOC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC7: view

Transcripts for EXOC7 Gene

Unigene Clusters for EXOC7 Gene

Exocyst complex component 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC7

Clone Products

  • Addgene plasmids for EXOC7

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13: - -
SP14: -
SP15: - - - -

ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for EXOC7 Gene

GeneLoc Exon Structure for
EXOC7
ECgene alternative splicing isoforms for
EXOC7

Expression for EXOC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC7 Gene

Protein differential expression in normal tissues from HIPED for EXOC7 Gene

This gene is overexpressed in Bone (48.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC7 Gene



Protein tissue co-expression partners for EXOC7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC7 Gene:

EXOC7

SOURCE GeneReport for Unigene cluster for EXOC7 Gene:

Hs.514496

Evidence on tissue expression from TISSUES for EXOC7 Gene

  • Nervous system(4.9)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with EXOC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC7 Gene

Orthologs for EXOC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC7 34
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC7 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC7 34 33
  • 91.12 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC7 34 33
  • 90.35 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911734 33
  • 90.25 (n)
mouse
(Mus musculus)
Mammalia Exoc7 16 34 33
  • 89.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC7 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC7 34 33
  • 80.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC7 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4315 33
zebrafish
(Danio rerio)
Actinopterygii exoc7 34 33
  • 76.12 (n)
OneToOne
wufj67f11 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9364 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006682 33
  • 50.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta exo70 34 33
  • 48.17 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exoc-7 34
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EXO70A1 33
  • 43.41 (n)
rice
(Oryza sativa)
Liliopsida Os12g0159700 33
  • 45.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for EXOC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC7 Gene

ENSEMBL:
Gene Tree for EXOC7 (if available)
TreeFam:
Gene Tree for EXOC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EXOC7: view image

Paralogs for EXOC7 Gene

(1) SIMAP similar genes for EXOC7 Gene using alignment to 9 proteins:

  • EXOC7_HUMAN
  • B4DJ07_HUMAN
  • B5MCY9_HUMAN
  • C9JKC2_HUMAN
  • C9JME6_HUMAN
  • K7ENP8_HUMAN
  • K7ERQ5_HUMAN
  • Q5G0E1_HUMAN
  • Q96BU6_HUMAN

Pseudogenes.org Pseudogenes for EXOC7 Gene

genes like me logo Genes that share paralogs with EXOC7: view

No data available for Paralogs for EXOC7 Gene

Variants for EXOC7 Gene

Sequence variations from dbSNP and Humsavar for EXOC7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000024472 -- 76,102,055(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000056516 -- 76,105,965(-) C/T upstream_transcript_variant
rs1000057755 -- 76,104,132(-) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000241750 -- 76,100,918(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000309336 -- 76,091,975(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC7 Gene

Variant ID Type Subtype PubMed ID
nsv2142 CNV insertion 18451855
nsv509674 CNV insertion 20534489
nsv833546 CNV loss 17160897

Variation tolerance for EXOC7 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC7 Gene

Human Gene Mutation Database (HGMD)
EXOC7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC7 Gene

Disorders for EXOC7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EXOC7 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
eastern equine encephalitis
  • eee
bardet-biedl syndrome 18
  • bbs18
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search EXOC7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EXOC7

genes like me logo Genes that share disorders with EXOC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC7 Gene

Publications for EXOC7 Gene

  1. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. (PMID: 15705715) Xu KF … Vaughan M (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 22 58
  2. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PMID: 16148947) Fielding AB … Gould GW (The EMBO journal 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M … Saltiel AR (Nature 2003) 3 22 58

Products for EXOC7 Gene

  • Addgene plasmids for EXOC7

Sources for EXOC7 Gene

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