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Aliases for EXOC3L4 Gene

Aliases for EXOC3L4 Gene

  • Exocyst Complex Component 3 Like 4 2 3 5
  • C14orf73 3 4
  • Exocyst Complex Component 3-Like Protein 4 3
  • Chromosome 14 Open Reading Frame 73 2
  • SEC6-Like Protein C14orf73 3

External Ids for EXOC3L4 Gene

Previous HGNC Symbols for EXOC3L4 Gene

  • C14orf73

Previous GeneCards Identifiers for EXOC3L4 Gene

  • GC14P103567
  • GC14P103100
  • GC14P103102
  • GC14P103182

Summaries for EXOC3L4 Gene

GeneCards Summary for EXOC3L4 Gene

EXOC3L4 (Exocyst Complex Component 3 Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is TNFAIP2.

Additional gene information for EXOC3L4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3L4 Gene

Genomics for EXOC3L4 Gene

GeneHancer (GH) Regulatory Elements for EXOC3L4 Gene

Promoters and enhancers for EXOC3L4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103097 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.4 +5.6 5641 4.3 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 IRF4 YY1 SLC30A9 SP5 GC14M103075 EXOC3L4 ENSG00000259444 TNFAIP2
GH14J103093 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 656.9 +0.4 411 2.1 DRAP1 ELF3 IRF2 TFAP4 SAP130 ARID4B KLF17 GLI4 KMT2B RAD21 EXOC3L4 ENSG00000259444 CDC42BPB RCOR1 GC14M103075
GH14J103185 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 4.2 +93.5 93480 4.9 PKNOX1 INSM2 ARID4B ZNF48 RAD21 YY1 ZNF335 ZNF614 ZNF143 RCOR1 LINC00605 TNFAIP2 EXOC3L4 GCSHP2 GC14M103156
GH14J103853 Enhancer 1.3 Ensembl ENCODE dbSUPER 4.6 +761.0 761005 3.3 PKNOX1 DMAP1 ZNF2 ZBTB7B GLIS2 ELK1 ZNF207 ZNF548 FOS SP3 XRCC3 BAG5 ENSG00000202275 ENSG00000269958 ENSG00000260285 EXOC3L4 PPP1R13B LINC00637 LOC105370689 LOC105370690
GH14J103204 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 2.7 +112.9 112943 6 PKNOX1 ARNT ZNF133 GLI4 BRCA1 ZNF280A TCF12 CBX5 GATA2 ZNF416 ENSG00000270705 ENSG00000278071 XRCC3 CDC42BPB RCOR1 BAG5 PPP1R13B MOK TNFAIP2 LINC00605
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EXOC3L4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EXOC3L4 Gene

Genomic Locations for EXOC3L4 Gene
16,153 bases
Plus strand
10,416 bases
Plus strand

Genomic View for EXOC3L4 Gene

Genes around EXOC3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3L4 Gene

Proteins for EXOC3L4 Gene

  • Protein details for EXOC3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 3-like protein 4
    Protein Accession:
    Secondary Accessions:
    • Q14CR2

    Protein attributes for EXOC3L4 Gene

    722 amino acids
    Molecular mass:
    79896 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EXOC3L4 Gene

Post-translational modifications for EXOC3L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EXOC3L4 Gene

Domains & Families for EXOC3L4 Gene

Gene Families for EXOC3L4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EXOC3L4 Gene


Suggested Antigen Peptide Sequences for EXOC3L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SEC6 family.
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3L4: view

Function for EXOC3L4 Gene

Phenotypes From GWAS Catalog for EXOC3L4 Gene

Gene Ontology (GO) - Molecular Function for EXOC3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
genes like me logo Genes that share ontologies with EXOC3L4: view
genes like me logo Genes that share phenotypes with EXOC3L4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOC3L4 Gene

Localization for EXOC3L4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC3L4 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for EXOC3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IBA --
genes like me logo Genes that share ontologies with EXOC3L4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for EXOC3L4 Gene

Pathways & Interactions for EXOC3L4 Gene

SuperPathways for EXOC3L4 Gene

No Data Available

Interacting Proteins for EXOC3L4 Gene

Gene Ontology (GO) - Biological Process for EXOC3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,IBA --
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3L4: view

No data available for Pathways by source and SIGNOR curated interactions for EXOC3L4 Gene

Drugs & Compounds for EXOC3L4 Gene

No Compound Related Data Available

Transcripts for EXOC3L4 Gene

mRNA/cDNA for EXOC3L4 Gene

Unigene Clusters for EXOC3L4 Gene

Exocyst complex component 3-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3L4 Gene

No ASD Table

Relevant External Links for EXOC3L4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EXOC3L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC3L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC3L4 Gene

This gene is overexpressed in Liver (x27.8) and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for EXOC3L4 Gene

This gene is overexpressed in Nasal epithelium (36.2), Testis (8.9), and Peripheral blood mononuclear cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EXOC3L4 Gene

Protein tissue co-expression partners for EXOC3L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of EXOC3L4 Gene:


SOURCE GeneReport for Unigene cluster for EXOC3L4 Gene:


Evidence on tissue expression from TISSUES for EXOC3L4 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with EXOC3L4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC3L4 Gene

Orthologs for EXOC3L4 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC3L4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC3L4 34 33
  • 99.08 (n)
(Bos Taurus)
Mammalia EXOC3L4 34 33
  • 79.64 (n)
(Canis familiaris)
Mammalia EXOC3L4 33
  • 79.35 (n)
-- 34
  • 77 (a)
-- 34
  • 69 (a)
(Rattus norvegicus)
Mammalia Exoc3l4 33
  • 77.7 (n)
(Mus musculus)
Mammalia Exoc3l4 16 34 33
  • 76.96 (n)
(Monodelphis domestica)
Mammalia EXOC3L4 34
  • 42 (a)
(Gallus gallus)
Aves EXOC3L4 34 33
  • 48.58 (n)
(Anolis carolinensis)
Reptilia EXOC3L4 34
  • 23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3l4 33
  • 40.41 (n)
(Danio rerio)
Actinopterygii exoc3l4 34 33
  • 41.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec6 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea sec-6 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Species where no ortholog for EXOC3L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3L4 Gene

Gene Tree for EXOC3L4 (if available)
Gene Tree for EXOC3L4 (if available)
Evolutionary constrained regions (ECRs) for EXOC3L4: view image

Paralogs for EXOC3L4 Gene

Paralogs for EXOC3L4 Gene Pseudogenes for EXOC3L4 Gene

genes like me logo Genes that share paralogs with EXOC3L4: view

Variants for EXOC3L4 Gene

Sequence variations from dbSNP and Humsavar for EXOC3L4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000072844 -- 103,101,098(+) G/T intron_variant
rs1000456285 -- 103,092,508(+) G/T upstream_transcript_variant
rs1000855439 -- 103,107,701(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001061676 -- 103,101,138(+) C/T intron_variant
rs1001131814 -- 103,102,502(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC3L4 Gene

Variant ID Type Subtype PubMed ID
nsv952257 CNV deletion 24416366
nsv9168 CNV loss 18304495
nsv832882 CNV loss 17160897
nsv565971 CNV loss 21841781
nsv565970 CNV loss 21841781
nsv512378 CNV loss 21212237
nsv1136187 CNV deletion 24896259
nsv1071174 CNV deletion 25765185
esv3635574 CNV gain 21293372
esv2749161 CNV deletion 23290073
esv2450303 CNV deletion 19546169
esv2116804 CNV deletion 18987734

Variation tolerance for EXOC3L4 Gene

Gene Damage Index Score: 11.34; 92.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC3L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3L4 Gene

Disorders for EXOC3L4 Gene

Additional Disease Information for EXOC3L4

No disorders were found for EXOC3L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3L4 Gene

Publications for EXOC3L4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  4. Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations. (PMID: 22010049) Middelberg RP … Whitfield JB (Human molecular genetics 2012) 3 58
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers JC … Kooner JS (Nature genetics 2011) 3 58

Products for EXOC3L4 Gene

Sources for EXOC3L4 Gene

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