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Aliases for EXOC3L1 Gene

Aliases for EXOC3L1 Gene

  • Exocyst Complex Component 3 Like 1 2 3 5
  • Protein Jiangli 3 4
  • EXOC3L 3 4
  • Exocyst Complex Component 3-Like Protein 3
  • Exocyst Complex Component 3-Like 1 2
  • Exocyst Complex Component 3-Like 2

External Ids for EXOC3L1 Gene

Previous HGNC Symbols for EXOC3L1 Gene

  • EXOC3L

Previous GeneCards Identifiers for EXOC3L1 Gene

  • GC16M067219

Summaries for EXOC3L1 Gene

GeneCards Summary for EXOC3L1 Gene

EXOC3L1 (Exocyst Complex Component 3 Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3.

UniProtKB/Swiss-Prot for EXOC3L1 Gene

  • As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Gene Wiki entry for EXOC3L1 Gene

Additional gene information for EXOC3L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC3L1 Gene

Genomics for EXOC3L1 Gene

GeneHancer (GH) Regulatory Elements for EXOC3L1 Gene

Promoters and enhancers for EXOC3L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I067192 Enhancer 0.7 Ensembl 550.8 -0.5 -497 0.2 TEAD4 TAL1 JUN KLF17 FOSL1 TCF12 POLR2A FOXK2 NCOR1 CBFA2T2 E2F4 EXOC3L1
GH16I067190 Promoter 0.6 EPDnew 550.8 0.0 0 0.1 ZNF395 E2F4 EXOC3L1 KIAA0895L
GH16I067189 Enhancer 0.2 Ensembl 550.8 +0.3 303 0.2 EXOC3L1 ELMO3 KIAA0895L
GH16I066902 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10 +285.7 285663 4.1 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 ATF7 CES2 KIAA0895L E2F4 NAE1 RRAD FAM96B EDC4 CENPT CTCF EXOC3L1
GH16I066960 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.2 +229.1 229084 1 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF143 ATF7 DEK CES3 FBXL8 TRADD HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for EXOC3L1 Gene

Genomic Locations for EXOC3L1 Gene
chr16:67,184,366-67,190,204
(GRCh38/hg38)
Size:
5,839 bases
Orientation:
Minus strand
chr16:67,218,269-67,224,107
(GRCh37/hg19)

Genomic View for EXOC3L1 Gene

Genes around EXOC3L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3L1 Gene

Proteins for EXOC3L1 Gene

  • Protein details for EXOC3L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VI1-EX3L1_HUMAN
    Recommended name:
    Exocyst complex component 3-like protein
    Protein Accession:
    Q86VI1
    Secondary Accessions:
    • A8K7I9
    • Q8NAD2
    • Q8TEN2

    Protein attributes for EXOC3L1 Gene

    Size:
    746 amino acids
    Molecular mass:
    81678 Da
    Quaternary structure:
    • Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst.

neXtProt entry for EXOC3L1 Gene

Post-translational modifications for EXOC3L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3L1 Gene

No data available for DME Specific Peptides for EXOC3L1 Gene

Domains & Families for EXOC3L1 Gene

Gene Families for EXOC3L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EXOC3L1 Gene

Suggested Antigen Peptide Sequences for EXOC3L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VI1

UniProtKB/Swiss-Prot:

EX3L1_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3L1: view

Function for EXOC3L1 Gene

Molecular function for EXOC3L1 Gene

UniProtKB/Swiss-Prot Function:
As part of the exocyst, may play a role in regulated exocytosis of insulin granules.

Phenotypes From GWAS Catalog for EXOC3L1 Gene

Gene Ontology (GO) - Molecular Function for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with EXOC3L1: view

Phenotypes for EXOC3L1 Gene

genes like me logo Genes that share phenotypes with EXOC3L1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EXOC3L1 Gene

Localization for EXOC3L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Colocalizes with insulin granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC3L1 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst ISS 18480549
GO:0030133 transport vesicle IEA --
GO:0030141 secretory granule IEA,ISS 18480549
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with EXOC3L1: view

Pathways & Interactions for EXOC3L1 Gene

SuperPathways for EXOC3L1 Gene

No Data Available

Interacting Proteins for EXOC3L1 Gene

Gene Ontology (GO) - Biological Process for EXOC3L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,ISS 18480549
GO:0030072 peptide hormone secretion IEA,ISS 18480549
GO:0051601 exocyst localization IBA --
genes like me logo Genes that share ontologies with EXOC3L1: view

No data available for Pathways by source and SIGNOR curated interactions for EXOC3L1 Gene

Drugs & Compounds for EXOC3L1 Gene

No Compound Related Data Available

Transcripts for EXOC3L1 Gene

Unigene Clusters for EXOC3L1 Gene

Exocyst complex component 3-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5: - - - - - -
SP6:

Relevant External Links for EXOC3L1 Gene

GeneLoc Exon Structure for
EXOC3L1
ECgene alternative splicing isoforms for
EXOC3L1

Expression for EXOC3L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EXOC3L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EXOC3L1 Gene

This gene is overexpressed in Spleen (x15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EXOC3L1 Gene



Protein tissue co-expression partners for EXOC3L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EXOC3L1 Gene:

EXOC3L1

SOURCE GeneReport for Unigene cluster for EXOC3L1 Gene:

Hs.647356

Evidence on tissue expression from TISSUES for EXOC3L1 Gene

  • Spleen(4.3)
  • Intestine(4.1)
genes like me logo Genes that share expression patterns with EXOC3L1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC3L1 Gene

Orthologs for EXOC3L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EXOC3L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC3L1 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia KIAA0895L 33
  • 84.35 (n)
EXOC3L1 34
  • 71 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC3L1 33 34
  • 83.81 (n)
rat
(Rattus norvegicus)
Mammalia Exoc3l1 33
  • 81.21 (n)
mouse
(Mus musculus)
Mammalia Exoc3l 33 16 34
  • 79.99 (n)
oppossum
(Monodelphis domestica)
Mammalia EXOC3L1 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC3L1 33 34
  • 56.37 (n)
lizard
(Anolis carolinensis)
Reptilia EXOC3L1 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exoc3l1 33
  • 49.79 (n)
zebrafish
(Danio rerio)
Actinopterygii exoc3l1 33 34
  • 48.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta sec6 34
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sec-6 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToMany
Species where no ortholog for EXOC3L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC3L1 Gene

ENSEMBL:
Gene Tree for EXOC3L1 (if available)
TreeFam:
Gene Tree for EXOC3L1 (if available)

Paralogs for EXOC3L1 Gene

Paralogs for EXOC3L1 Gene

(2) SIMAP similar genes for EXOC3L1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with EXOC3L1: view

Variants for EXOC3L1 Gene

Sequence variations from dbSNP and Humsavar for EXOC3L1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs117403380 A breast cancer sample 67,188,925(-) A/T coding_sequence_variant, missense_variant
rs142958191 A breast cancer sample 67,185,446(-) G/A/T coding_sequence_variant, missense_variant
rs1001789917 -- 67,184,220(-) A/C downstream_transcript_variant
rs1002312187 -- 67,192,088(-) A/G/T upstream_transcript_variant
rs1003554183 -- 67,189,356(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC3L1 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for EXOC3L1 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC3L1 Gene

Human Gene Mutation Database (HGMD)
EXOC3L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC3L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3L1 Gene

Disorders for EXOC3L1 Gene

Additional Disease Information for EXOC3L1

No disorders were found for EXOC3L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3L1 Gene

Publications for EXOC3L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Genetic meta-analysis of 15,901 African Americans identifies variation in EXOC3L1 is associated with HDL concentration. (PMID: 26199122) Lanktree MB … Keating BJ (Journal of lipid research 2015) 3 58
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G … Boerwinkle E (PLoS genetics 2011) 3 58
  5. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. (PMID: 18480549) Saito T … Seino S (Biomedical research (Tokyo, Japan) 2008) 3 58

Products for EXOC3L1 Gene

Sources for EXOC3L1 Gene

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