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The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
EXOC3 (Exocyst Complex Component 3) is a Protein Coding gene. Diseases associated with EXOC3 include Lynch Syndrome. Among its related pathways are Peptide hormone metabolism and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000149 | SNARE binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 18329369 |
GO:0045296 | cadherin binding | HDA | 25468996 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000145 | exocyst | IEA,IBA | 21873635 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0030426 | growth cone | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cargo trafficking to the periciliary membrane | ||
2 | Organelle biogenesis and maintenance |
.56
|
|
3 | Peptide hormone metabolism | ||
4 | Vesicle-mediated transport | ||
5 | Actin Nucleation by ARP-WASP Complex |
CDC42 Pathway
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006887 | exocytosis | IEA,IBA | 21873635 |
GO:0015031 | protein transport | IEA | -- |
GO:0051601 | exocyst localization | IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EXOC3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
EXOC3 30 |
|
||||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | EXOC3 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Exoc3 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EXOC3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Exoc3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | EXOC3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EXOC3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EXOC3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | exoc3 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24117 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | exoc3 30 31 |
|
OneToOne | |
Dr.7300 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009058 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sec6 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | sec-6 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC6 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs115207857 | Benign: not provided | 446,331(+) |
C/T NM_007277.5(EXOC3):c.126C>T (p.Ser42=) |
SYNONYMOUS | |
rs143939660 | Benign: not provided | 453,913(+) |
C/G NM_007277.5(EXOC3):c.908C>G (p.Pro303Arg) |
MISSENSE | |
rs180921423 | Benign: not provided | 447,622(+) |
G/A NM_007277.5(EXOC3):c.234G>A (p.Ser78=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv9479n54 | CNV | gain | 21841781 |
esv1945211 | CNV | deletion | 18987734 |
esv2547373 | CNV | deletion | 19546169 |
esv2752071 | CNV | gain | 17911159 |
esv2759315 | CNV | loss | 17122850 |
esv3603744 | CNV | gain | 21293372 |
esv3603745 | CNV | gain | 21293372 |
esv3603747 | CNV | loss | 21293372 |
esv3603748 | CNV | gain | 21293372 |
esv3894107 | CNV | gain | 25118596 |
nsv1019215 | CNV | gain | 25217958 |
nsv1027279 | CNV | gain | 25217958 |
nsv1030767 | CNV | gain | 25217958 |
nsv1032584 | CNV | gain | 25217958 |
nsv1032824 | CNV | gain | 25217958 |
nsv10647 | CNV | gain | 18304495 |
nsv1133013 | OTHER | inversion | 24896259 |
nsv1147234 | OTHER | inversion | 26484159 |
nsv461889 | CNV | gain | 19166990 |
nsv461890 | CNV | gain | 19166990 |
nsv4673 | CNV | insertion | 18451855 |
nsv4674 | CNV | insertion | 18451855 |
nsv513205 | CNV | loss | 21212237 |
nsv527666 | CNV | loss | 19592680 |
nsv596626 | CNV | gain | 21841781 |
nsv596628 | CNV | gain | 21841781 |
nsv596629 | CNV | gain | 21841781 |
nsv830183 | CNV | gain+loss | 17160897 |
nsv830184 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lynch syndrome |
|
|