The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of ... See more...

Aliases for EXOC3 Gene

Aliases for EXOC3 Gene

  • Exocyst Complex Component 3 2 3 4 5
  • Exocyst Complex Component Sec6 3 4
  • SEC6L1 3 4
  • Sec6p 2 3
  • SEC6 3 4
  • SEC6-Like 1 (S. Cerevisiae) 2
  • Sec 6 Homolog 3
  • SEC6-Like 1 3
  • EXOC3 5

External Ids for EXOC3 Gene

Previous HGNC Symbols for EXOC3 Gene

  • SEC6L1

Previous GeneCards Identifiers for EXOC3 Gene

  • GC05P000497

Summaries for EXOC3 Gene

Entrez Gene Summary for EXOC3 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

GeneCards Summary for EXOC3 Gene

EXOC3 (Exocyst Complex Component 3) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Insulin Pathway. Gene Ontology (GO) annotations related to this gene include SNARE binding. An important paralog of this gene is EXOC3L1.

UniProtKB/Swiss-Prot Summary for EXOC3 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EXOC3 Gene

Genomics for EXOC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EXOC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EXOC3

Top Transcription factor binding sites by QIAGEN in the EXOC3 gene promoter:
  • AREB6
  • Egr-4
  • HNF-4alpha1
  • HNF-4alpha2
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • NRSF form 1
  • NRSF form 2

Genomic Locations for EXOC3 Gene

Latest Assembly
chr5:443,175-471,937
(GRCh38/hg38)
Size:
28,763 bases
Orientation:
Plus strand

Previous Assembly
chr5:443,291-467,405
(GRCh37/hg19 by Entrez Gene)
Size:
24,115 bases
Orientation:
Plus strand

chr5:443,273-472,052
(GRCh37/hg19 by Ensembl)
Size:
28,780 bases
Orientation:
Plus strand

Genomic View for EXOC3 Gene

Genes around EXOC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC3 Gene

Proteins for EXOC3 Gene

  • Protein details for EXOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60645-EXOC3_HUMAN
    Recommended name:
    Exocyst complex component 3
    Protein Accession:
    O60645
    Secondary Accessions:
    • Q6P2E8
    • Q8TEN6
    • Q8WUW0
    • Q96DI4

    Protein attributes for EXOC3 Gene

    Size:
    745 amino acids
    Molecular mass:
    85567 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity). Interacts with BIRC6/bruce. Interacts with MYRIP (By similarity).
    SequenceCaution:
    • Sequence=BAB84912.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for EXOC3 Gene

Post-translational modifications for EXOC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EXOC3 Gene

No data available for DME Specific Peptides for EXOC3 Gene

Domains & Families for EXOC3 Gene

Gene Families for EXOC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EXOC3 Gene

InterPro:
Blocks:
  • Exocyst complex component Sec6

Suggested Antigen Peptide Sequences for EXOC3 Gene

GenScript: Design optimal peptide antigens:
  • Exocyst complex component Sec6 (EXOC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60645

UniProtKB/Swiss-Prot:

EXOC3_HUMAN :
  • Belongs to the SEC6 family.
Family:
  • Belongs to the SEC6 family.
genes like me logo Genes that share domains with EXOC3: view

Function for EXOC3 Gene

Molecular function for EXOC3 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC3 Gene

Gene Ontology (GO) - Molecular Function for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA 21873635
GO:0005515 protein binding IPI 18329369
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with EXOC3: view
genes like me logo Genes that share phenotypes with EXOC3: view

Animal Models for EXOC3 Gene

MGI Knock Outs for EXOC3:
  • Exoc3 Exoc3<tm2b(EUCOMM)Hmgu>

miRNA for EXOC3 Gene

miRTarBase miRNAs that target EXOC3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EXOC3 Gene

Localization for EXOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC3 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Midbody. Golgi apparatus. Cell projection, neuron projection. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). During mitosis, early recruitment to the midbody requires RALA, but not RALB, and EXOC2. In late stages of cytokinesis, localization to the midbody is RALB-dependent (PubMed:18756269). {ECO:0000250 UniProtKB:O54921, ECO:0000269 PubMed:18756269}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC3 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
extracellular 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA,IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0030426 growth cone IEA --
genes like me logo Genes that share ontologies with EXOC3: view

Pathways & Interactions for EXOC3 Gene

genes like me logo Genes that share pathways with EXOC3: view

Pathways by source for EXOC3 Gene

1 GeneGo (Thomson Reuters) pathway for EXOC3 Gene
  • Cytoskeleton remodeling_RalA regulation pathway
2 Qiagen pathways for EXOC3 Gene
  • CDC42 Pathway
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for EXOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,IBA 21873635
GO:0015031 protein transport IEA --
GO:0051601 exocyst localization IBA 21873635
genes like me logo Genes that share ontologies with EXOC3: view

No data available for SIGNOR curated interactions for EXOC3 Gene

Drugs & Compounds for EXOC3 Gene

No Compound Related Data Available

Transcripts for EXOC3 Gene

mRNA/cDNA for EXOC3 Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC3

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC3 Gene

No ASD Table

Relevant External Links for EXOC3 Gene

GeneLoc Exon Structure for
EXOC3

Expression for EXOC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

Protein differential expression in normal tissues from HIPED for EXOC3 Gene

This gene is overexpressed in Bone (19.4) and Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC3 Gene



Protein tissue co-expression partners for EXOC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EXOC3

SOURCE GeneReport for Unigene cluster for EXOC3 Gene:

Hs.481464

mRNA Expression by UniProt/SwissProt for EXOC3 Gene:

O60645-EXOC3_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for EXOC3 Gene

  • Nervous system(4.8)
  • Intestine(4.4)
  • Spleen(4.4)
  • Lung(4.3)
  • Liver(3.1)
  • Skin(2.6)
  • Kidney(2.5)
  • Muscle(2.1)
  • Adrenal gland(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with EXOC3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC3 Gene

Orthologs for EXOC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EXOC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EXOC3 29 30
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 94 (a)
OneToMany
EXOC3 29
  • 88.32 (n)
-- 30
  • 64 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia EXOC3 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Exoc3 29 16 30
  • 86.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EXOC3 29 30
  • 86.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Exoc3 29
  • 86.4 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia EXOC3 30
  • 86 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EXOC3 29 30
  • 75.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EXOC3 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia exoc3 29
  • 71.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24117 29
Zebrafish
(Danio rerio)
Actinopterygii exoc3 29 30
  • 73.04 (n)
OneToOne
Dr.7300 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009058 29
  • 51.48 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta sec6 29 30
  • 50.46 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea sec-6 29 30
  • 45.07 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC6 32
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 47 (a)
OneToMany
Species where no ortholog for EXOC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EXOC3 Gene

ENSEMBL:
Gene Tree for EXOC3 (if available)
TreeFam:
Gene Tree for EXOC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EXOC3: view image
Alliance of Genome Resources:
Additional Orthologs for EXOC3

Paralogs for EXOC3 Gene

Paralogs for EXOC3 Gene

(3) SIMAP similar genes for EXOC3 Gene using alignment to 4 proteins:

  • EXOC3_HUMAN
  • D6RB59_HUMAN
  • D6RBR9_HUMAN
  • H0Y995_HUMAN
genes like me logo Genes that share paralogs with EXOC3: view

Variants for EXOC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EXOC3 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs115207857 Benign: not provided 446,331(+) C/T
NM_007277.5(EXOC3):c.126C>T (p.Ser42=)
SYNONYMOUS
rs143939660 Benign: not provided 453,913(+) C/G
NM_007277.5(EXOC3):c.908C>G (p.Pro303Arg)
MISSENSE
rs180921423 Benign: not provided 447,622(+) G/A
NM_007277.5(EXOC3):c.234G>A (p.Ser78=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EXOC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EXOC3 Gene

Variant ID Type Subtype PubMed ID
dgv9479n54 CNV gain 21841781
esv1945211 CNV deletion 18987734
esv2547373 CNV deletion 19546169
esv2752071 CNV gain 17911159
esv2759315 CNV loss 17122850
esv3603744 CNV gain 21293372
esv3603745 CNV gain 21293372
esv3603747 CNV loss 21293372
esv3603748 CNV gain 21293372
esv3894107 CNV gain 25118596
nsv1019215 CNV gain 25217958
nsv1027279 CNV gain 25217958
nsv1030767 CNV gain 25217958
nsv1032584 CNV gain 25217958
nsv1032824 CNV gain 25217958
nsv10647 CNV gain 18304495
nsv1133013 OTHER inversion 24896259
nsv1147234 OTHER inversion 26484159
nsv461889 CNV gain 19166990
nsv461890 CNV gain 19166990
nsv4673 CNV insertion 18451855
nsv4674 CNV insertion 18451855
nsv513205 CNV loss 21212237
nsv527666 CNV loss 19592680
nsv596626 CNV gain 21841781
nsv596628 CNV gain 21841781
nsv596629 CNV gain 21841781
nsv830183 CNV gain+loss 17160897
nsv830184 CNV gain 17160897

Variation tolerance for EXOC3 Gene

Residual Variation Intolerance Score: 15.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EXOC3
Leiden Open Variation Database (LOVD)
EXOC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC3 Gene

Disorders for EXOC3 Gene

Additional Disease Information for EXOC3

No disorders were found for EXOC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOC3 Gene

Publications for EXOC3 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4
  2. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PMID: 18329369) Pohl C … Jentsch S (Cell 2008) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PMID: 12693554) Jikuya H … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2003) 3 4
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3

Products for EXOC3 Gene

Sources for EXOC3 Gene