Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
EXOC2 (Exocyst Complex Component 2) is a Protein Coding gene. Diseases associated with EXOC2 include Anterior Segment Dysgenesis 3. Among its related pathways are Organelle biogenesis and maintenance and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include protein kinase binding and Ral GTPase binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 12459492 |
GO:0017160 | Ral GTPase binding | IPI | 24056301 |
GO:0019901 | protein kinase binding | IPI | 24056301 |
GO:0047485 | protein N-terminus binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000145 | exocyst | IEA,IDA | 24056301 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
GO:0090543 | Flemming body | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cargo trafficking to the periciliary membrane | ||
2 | Organelle biogenesis and maintenance |
.56
|
|
3 | Peptide hormone metabolism | ||
4 | Vesicle-mediated transport | ||
5 | Ras signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006887 | exocytosis | IEA,IBA | 21873635 |
GO:0006893 | Golgi to plasma membrane transport | IEA,IBA | 21873635 |
GO:0015031 | protein transport | IEA | -- |
GO:0016192 | vesicle-mediated transport | IBA | 21873635 |
GO:2000535 | regulation of entry of bacterium into host cell | IMP | 20579884 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: |
ExUns: | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | - | - | - | ||||||||||||||
SP3: | |||||||||||||||||
SP4: | |||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EXOC2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EXOC2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | EXOC2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EXOC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Exoc2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Exoc2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | EXOC2 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EXOC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EXOC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | exoc2 30 |
|
||
Str.10084 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | exoc2 30 31 |
|
OneToOne | |
zgc63558 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4905 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001733 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | sec5 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | sec-5 30 31 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | SEC5A 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0421900 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.12002 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712583 | Benign: not provided | 564,063(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
727093 | Benign: not provided | 564,658(-) | G/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
732647 | Benign: not provided | 656,681(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
768058 | Benign: not provided | 656,416(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
776105 | Benign: not provided | 598,095(-) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
anterior segment dysgenesis 3 |
|
|