The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At leas... See more...

Aliases for EXOC2 Gene

Aliases for EXOC2 Gene

  • Exocyst Complex Component 2 2 3 4 5
  • Exocyst Complex Component Sec5 3 4
  • SEC5L1 3 4
  • Sec5p 2 3
  • SEC5 3 4
  • SEC5-Like 1 (S. Cerevisiae) 2
  • SEC5-Like 1 3
  • FLJ11026 2
  • EXOC2 5

External Ids for EXOC2 Gene

Previous HGNC Symbols for EXOC2 Gene

  • SEC5L1

Previous GeneCards Identifiers for EXOC2 Gene

  • GC06M000431

Summaries for EXOC2 Gene

Entrez Gene Summary for EXOC2 Gene

  • The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for EXOC2 Gene

EXOC2 (Exocyst Complex Component 2) is a Protein Coding gene. Diseases associated with EXOC2 include Anterior Segment Dysgenesis 3 and Photoallergic Dermatitis. Among its related pathways are Ras signaling pathway and Remodeling of Adherens Junctions. Gene Ontology (GO) annotations related to this gene include protein kinase binding and Ral GTPase binding.

UniProtKB/Swiss-Prot Summary for EXOC2 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Gene Wiki entry for EXOC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EXOC2 Gene

Genomics for EXOC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EXOC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EXOC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EXOC2

Top Transcription factor binding sites by QIAGEN in the EXOC2 gene promoter:
  • AML1a
  • AREB6
  • Egr-4
  • FOXC1
  • FOXD3
  • FOXF2
  • FOXO1
  • FOXO1a
  • IRF-1

Genomic Locations for EXOC2 Gene

Latest Assembly
207,988 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
207,986 bases
Minus strand

(GRCh37/hg19 by Ensembl)
207,985 bases
Minus strand

Genomic View for EXOC2 Gene

Genes around EXOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EXOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EXOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC2 Gene

Proteins for EXOC2 Gene

  • Protein details for EXOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Exocyst complex component 2
    Protein Accession:
    Secondary Accessions:
    • B2RBE6
    • Q5JPC8
    • Q96AN6
    • Q9NUZ8
    • Q9UJM7

    Protein attributes for EXOC2 Gene

    924 amino acids
    Molecular mass:
    104066 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity). Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (PubMed:12459492). Interacts with RALA and RALB (PubMed:18756269, PubMed:19166349).
    • Sequence=BAA91963.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for EXOC2 Gene

Post-translational modifications for EXOC2 Gene

  • Ubiquitination at Lys206, Lys281, Lys296, and Lys902
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EXOC2 Gene

Domains & Families for EXOC2 Gene

Gene Families for EXOC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for EXOC2 Gene

  • Cell surface receptor IPT/TIG

Suggested Antigen Peptide Sequences for EXOC2 Gene

GenScript: Design optimal peptide antigens:
  • Exocyst complex component Sec5 (EXOC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Interacts with RALA through the TIG domain.
  • Belongs to the SEC5 family.
  • Interacts with RALA through the TIG domain.
  • Belongs to the SEC5 family.
genes like me logo Genes that share domains with EXOC2: view

Function for EXOC2 Gene

Molecular function for EXOC2 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Phenotypes From GWAS Catalog for EXOC2 Gene

Gene Ontology (GO) - Molecular Function for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12459492
GO:0019901 protein kinase binding IPI 24056301
GO:0031267 small GTPase binding IPI 24056301
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with EXOC2: view
genes like me logo Genes that share phenotypes with EXOC2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC2 Gene

Localization for EXOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC2 Gene

Midbody, Midbody ring. Note=Recruitment to the midbody does not require RALA, nor RALB (PubMed:18756269). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000269 PubMed:16213214, ECO:0000269 PubMed:18756269}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EXOC2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
extracellular 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA,IDA 24056301
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane HDA 19946888
GO:0090543 Flemming body IEA --
genes like me logo Genes that share ontologies with EXOC2: view

Pathways & Interactions for EXOC2 Gene

genes like me logo Genes that share pathways with EXOC2: view

Pathways by source for EXOC2 Gene

2 GeneGo (Thomson Reuters) pathways for EXOC2 Gene
  • Cytoskeleton remodeling_RalA regulation pathway
  • Cytoskeleton remodeling_RalB regulation pathway
3 Qiagen pathways for EXOC2 Gene
  • CDC42 Pathway
  • Epithelial Tight Junctions
  • Remodeling of Adherens Junctions

Gene Ontology (GO) - Biological Process for EXOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA,IBA 21873635
GO:0006893 Golgi to plasma membrane transport IEA,IBA 21873635
GO:0015031 protein transport IEA --
GO:2000535 regulation of entry of bacterium into host cell IMP 20579884
genes like me logo Genes that share ontologies with EXOC2: view

No data available for SIGNOR curated interactions for EXOC2 Gene

Drugs & Compounds for EXOC2 Gene

(3) Drugs for EXOC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 65
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC2: view

Transcripts for EXOC2 Gene

mRNA/cDNA for EXOC2 Gene

11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EXOC2

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1: -

ExUns: 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33
SP1: - -
SP2: - - -

Relevant External Links for EXOC2 Gene

GeneLoc Exon Structure for

Expression for EXOC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EXOC2 Gene

Protein differential expression in normal tissues from HIPED for EXOC2 Gene

This gene is overexpressed in Bone (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EXOC2 Gene

Protein tissue co-expression partners for EXOC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EXOC2

SOURCE GeneReport for Unigene cluster for EXOC2 Gene:


mRNA Expression by UniProt/SwissProt for EXOC2 Gene:

Tissue specificity: Widely expressed with highest levels in brain and placenta.

Evidence on tissue expression from TISSUES for EXOC2 Gene

  • Nervous system(4.7)
  • Lymph node(4.4)
  • Adrenal gland(2.2)
  • Skin(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with EXOC2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOC2 Gene

Orthologs for EXOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EXOC2 29 30
  • 99.42 (n)
(Ornithorhynchus anatinus)
Mammalia EXOC2 30
  • 92 (a)
(Monodelphis domestica)
Mammalia EXOC2 30
  • 89 (a)
(Canis familiaris)
Mammalia EXOC2 29 30
  • 88.85 (n)
(Mus musculus)
Mammalia Exoc2 29 16 30
  • 87.3 (n)
(Rattus norvegicus)
Mammalia Exoc2 29
  • 87.27 (n)
(Bos Taurus)
Mammalia EXOC2 29 30
  • 85.14 (n)
(Gallus gallus)
Aves EXOC2 29 30
  • 80.09 (n)
(Anolis carolinensis)
Reptilia EXOC2 30
  • 86 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia exoc2 29
  • 73.95 (n)
Str.10084 29
(Danio rerio)
Actinopterygii exoc2 29 30
  • 70.66 (n)
zgc63558 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4905 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001733 29
  • 46.27 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta sec5 29 30
  • 46.06 (n)
(Caenorhabditis elegans)
Secernentea sec-5 29 30
  • 44.65 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SEC5A 29
  • 41.16 (n)
(Oryza sativa)
Liliopsida Os04g0421900 29
  • 41.47 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 50 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.12002 29
Species where no ortholog for EXOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EXOC2 Gene

Gene Tree for EXOC2 (if available)
Gene Tree for EXOC2 (if available)
Evolutionary constrained regions (ECRs) for EXOC2: view image
Alliance of Genome Resources:
Additional Orthologs for EXOC2

Paralogs for EXOC2 Gene

No data available for Paralogs for EXOC2 Gene

Variants for EXOC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EXOC2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs114105090 Benign: not provided 564,658(-) G/A
NM_018303.6(EXOC2):c.1554C>T (p.Arg518=)
rs143403601 Benign: not provided 656,681(-) G/A
rs145867129 Uncertain Significance: Malignant tumor of prostate 576,834(-) C/T
NM_018303.6(EXOC2):c.1241G>A (p.Arg414His)
rs150422154 Benign: not provided 656,416(-) T/C
rs35770122 Benign: not provided 598,095(-) T/C
NM_018303.6(EXOC2):c.999A>G (p.Glu333=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EXOC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EXOC2 Gene

Variant ID Type Subtype PubMed ID
dgv10267n54 CNV gain 21841781
dgv10268n54 CNV gain+loss 21841781
dgv10269n54 CNV gain 21841781
dgv3248n106 CNV deletion 24896259
dgv3249n106 CNV deletion 24896259
esv1105432 CNV deletion 17803354
esv1209367 CNV insertion 17803354
esv1288084 CNV deletion 17803354
esv1333120 CNV deletion 17803354
esv1399069 CNV deletion 17803354
esv1416044 CNV deletion 17803354
esv1476529 CNV deletion 17803354
esv1502705 CNV deletion 17803354
esv1623218 CNV insertion 17803354
esv1708635 CNV insertion 17803354
esv2052896 CNV deletion 18987734
esv2132988 CNV deletion 18987734
esv2134988 CNV deletion 18987734
esv21609 CNV loss 19812545
esv25398 CNV loss 19812545
esv2548242 CNV deletion 19546169
esv2558058 CNV deletion 19546169
esv2575838 CNV deletion 19546169
esv2670771 CNV deletion 23128226
esv26846 CNV loss 19812545
esv2731355 CNV deletion 23290073
esv2731356 CNV deletion 23290073
esv2731357 CNV deletion 23290073
esv2731358 CNV deletion 23290073
esv2731359 CNV deletion 23290073
esv2731360 CNV deletion 23290073
esv2731363 CNV deletion 23290073
esv2731364 CNV deletion 23290073
esv2731365 CNV deletion 23290073
esv2731366 CNV deletion 23290073
esv2731367 CNV deletion 23290073
esv2731368 CNV deletion 23290073
esv2731369 CNV deletion 23290073
esv2731370 CNV deletion 23290073
esv2731371 CNV deletion 23290073
esv2743266 CNV deletion 23290073
esv27485 CNV loss 19812545
esv2759401 CNV gain+loss 17122850
esv2806 CNV loss 18987735
esv28427 CNV gain+loss 19812545
esv3289051 CNV deletion 24192839
esv3386006 CNV duplication 20981092
esv3567128 CNV deletion 23714750
esv3567129 CNV deletion 23714750
esv3576089 CNV gain 25503493
esv3607835 CNV loss 21293372
esv3607852 CNV loss 21293372
esv3607855 CNV loss 21293372
esv3607857 CNV loss 21293372
esv3607858 CNV loss 21293372
esv3607859 CNV gain 21293372
esv3607860 CNV loss 21293372
esv8276 CNV loss 19470904
esv990956 CNV insertion 20482838
esv995480 CNV deletion 20482838
nsv1023279 CNV gain 25217958
nsv1073527 CNV deletion 25765185
nsv1073947 CNV deletion 25765185
nsv1074900 CNV deletion 25765185
nsv1074901 CNV deletion 25765185
nsv1109756 CNV deletion 24896259
nsv1117602 CNV deletion 24896259
nsv1124016 CNV deletion 24896259
nsv1146202 CNV deletion 26484159
nsv1151863 CNV deletion 26484159
nsv348666 CNV deletion 16902084
nsv349641 CNV deletion 16902084
nsv349892 CNV deletion 16902084
nsv428134 CNV gain 18775914
nsv462609 CNV gain 19166990
nsv513288 CNV loss 21212237
nsv513289 CNV loss 21212237
nsv513290 CNV loss 21212237
nsv513291 CNV loss 21212237
nsv514341 CNV loss 21397061
nsv5167 CNV deletion 18451855
nsv5168 CNV deletion 18451855
nsv5169 CNV deletion 18451855
nsv521248 CNV loss 19592680
nsv522827 CNV loss 19592680
nsv528164 CNV loss 19592680
nsv600781 CNV gain 21841781
nsv600782 CNV gain 21841781
nsv600783 CNV loss 21841781
nsv600784 CNV loss 21841781
nsv600785 CNV gain 21841781
nsv600799 CNV loss 21841781
nsv819424 CNV loss 19587683
nsv820738 CNV deletion 20802225
nsv830569 CNV gain 17160897
nsv830571 CNV loss 17160897
nsv950755 CNV deletion 24416366
nsv955797 CNV deletion 24416366
nsv955934 CNV deletion 24416366

Variation tolerance for EXOC2 Gene

Residual Variation Intolerance Score: 3.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EXOC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC2 Gene

Disorders for EXOC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EXOC2 Gene - From: COP

Disorder Aliases PubMed IDs
anterior segment dysgenesis 3
  • asgd3
photoallergic dermatitis
  • photoallergic contact dermatitis
- elite association - COSMIC cancer census association via MalaCards
Search EXOC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EXOC2

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EXOC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC2 Gene

Publications for EXOC2 Gene

  1. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. (PMID: 12459492) Sjölinder M … Ponstingl H (FEBS letters 2002) 2 3 4 22
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  3. Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. (PMID: 20570966) McGovern DP … International IBD Genetics Consortium (Human molecular genetics 2010) 3 40
  4. Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. (PMID: 19166349) Fenwick RB … Owen D (Biochemistry 2009) 3 4
  5. Genome-wide association study of tanning phenotype in a population of European ancestry. (PMID: 19340012) Nan H … Han J (The Journal of investigative dermatology 2009) 3 40

Products for EXOC2 Gene

Sources for EXOC2 Gene