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Aliases for EVX2 Gene

Aliases for EVX2 Gene

  • Even-Skipped Homeobox 2 2 3 5
  • EVX-2 3 4
  • Even-Skipped Homeo Box 2 (Homolog Of Drosophila Eve) 3
  • Eve, Even-Skipped Homeobox Homolog 2 (Drosophila) 2
  • Homeobox Even-Skipped Homolog Protein 2 3
  • Eve, Even-Skipped Homeo Box Homolog 2 3

External Ids for EVX2 Gene

Previous GeneCards Identifiers for EVX2 Gene

  • GC02U990026
  • GC02M175605
  • GC02M176908
  • GC02M177147
  • GC02M176770
  • GC02M176653
  • GC02M168822

Summaries for EVX2 Gene

Entrez Gene Summary for EVX2 Gene

  • This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

GeneCards Summary for EVX2 Gene

EVX2 (Even-Skipped Homeobox 2) is a Protein Coding gene. Diseases associated with EVX2 include Synpolydactyly and Split-Hand/Foot Malformation 5. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is EVX1.

Additional gene information for EVX2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX2 Gene

Genomics for EVX2 Gene

GeneHancer (GH) Regulatory Elements for EVX2 Gene

Promoters and enhancers for EVX2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I176075 Enhancer 1.1 VISTA UCNEbase 0.4 +9.8 9785 1.3 POLR2A SMARCA4 RNF2 ZNF407 BMI1 EZH2 LNPK EVX2 GC02M176020
GH02I176080 Enhancer 0.8 ENCODE 0.4 +5.7 5699 0.1 ATF1 RB1 ZNF76 ZNF2 RAD21 ZNF766 GLIS2 ZNF143 RCOR1 CREM EVX2 GC02M176020
GH02I176073 Enhancer 0.8 UCNEbase 0.4 +12.1 12086 0.5 PKNOX1 HLF ZBTB8A FOXA1 ZNF664 OSR2 PRDM6 EZH2 HOXD11 HOXD12 HOXD10 HOXD1 HAGLR LNPK EVX2 GC02M176020
GH02I176078 Enhancer 0.7 UCNEbase 0.4 +7.1 7082 0.3 CBX8 RNF2 SUZ12 NRF1 BMI1 EZH2 EVX2 GC02M176020
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EVX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EVX2 gene promoter:

Genomic Locations for EVX2 Gene

Genomic Locations for EVX2 Gene
9,777 bases
Minus strand

Genomic View for EVX2 Gene

Genes around EVX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX2 Gene

Proteins for EVX2 Gene

  • Protein details for EVX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox even-skipped homolog protein 2
    Protein Accession:

    Protein attributes for EVX2 Gene

    476 amino acids
    Molecular mass:
    47800 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVX2 Gene

Post-translational modifications for EVX2 Gene

No Post-translational modifications

Other Protein References for EVX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVX2 Gene

Domains & Families for EVX2 Gene

Gene Families for EVX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for EVX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the even-skipped homeobox family.
  • Belongs to the even-skipped homeobox family.
genes like me logo Genes that share domains with EVX2: view

Function for EVX2 Gene

Molecular function for EVX2 Gene

GENATLAS Biochemistry:
Drosophila even-skipped pair rule gene homolog 2 (murine Evx2),homeo domain encoding gene,expressed in limbs

Gene Ontology (GO) - Molecular Function for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EVX2: view
genes like me logo Genes that share phenotypes with EVX2: view

Animal Models for EVX2 Gene

MGI Knock Outs for EVX2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVX2 Gene

Localization for EVX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with EVX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EVX2 Gene

Pathways & Interactions for EVX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0035108 limb morphogenesis IEA --
genes like me logo Genes that share ontologies with EVX2: view

No data available for Pathways by source and SIGNOR curated interactions for EVX2 Gene

Drugs & Compounds for EVX2 Gene

No Compound Related Data Available

Transcripts for EVX2 Gene

mRNA/cDNA for EVX2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EVX2 Gene

Even-skipped homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVX2 Gene

No ASD Table

Relevant External Links for EVX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX2 Gene

This gene is overexpressed in Testis (x17.4), Cervix - Ectocervix (x10.2), Vagina (x7.7), Colon - Sigmoid (x6.3), and Cervix - Endocervix (x5.7).

Protein differential expression in normal tissues from HIPED for EVX2 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for EVX2 Gene

Protein tissue co-expression partners for EVX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of EVX2 Gene:


SOURCE GeneReport for Unigene cluster for EVX2 Gene:

genes like me logo Genes that share expression patterns with EVX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVX2 Gene

Orthologs for EVX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVX2 33 34
  • 99.44 (n)
(Monodelphis domestica)
Mammalia EVX2 34
  • 91 (a)
(Canis familiaris)
Mammalia EVX2 33 34
  • 90.27 (n)
(Rattus norvegicus)
Mammalia Evx2 33
  • 88.66 (n)
(Mus musculus)
Mammalia Evx2 33 16 34
  • 86.16 (n)
(Gallus gallus)
Aves EVX2 33 34
  • 76.81 (n)
(Anolis carolinensis)
Reptilia EVX2 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evx2 33
  • 69.42 (n)
(Danio rerio)
Actinopterygii evx2 33 34
  • 67.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta eve 35 34
  • 71 (a)
(Caenorhabditis elegans)
Secernentea vab-7 34
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for EVX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX2 Gene

Gene Tree for EVX2 (if available)
Gene Tree for EVX2 (if available)

Paralogs for EVX2 Gene

Paralogs for EVX2 Gene

(1) SIMAP similar genes for EVX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EVX2: view

Variants for EVX2 Gene

Sequence variations from dbSNP and Humsavar for EVX2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000025466 -- 176,079,771(-) G/A downstream_transcript_variant
rs1000035439 -- 176,080,070(-) G/A downstream_transcript_variant
rs1001240068 -- 176,085,202(-) T/G upstream_transcript_variant
rs1002481431 -- 176,084,654(-) C/T upstream_transcript_variant
rs1002778136 -- 176,084,893(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EVX2 Gene

Variant ID Type Subtype PubMed ID
dgv676n67 CNV gain 20364138
dgv7173n54 CNV loss 21841781
nsv517968 CNV loss 19592680
nsv520227 CNV loss 19592680
nsv527187 CNV loss 19592680
nsv583670 CNV loss 21841781

Variation tolerance for EVX2 Gene

Residual Variation Intolerance Score: 68.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVX2 Gene

Disorders for EVX2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for EVX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • syndactyly type 2
split-hand/foot malformation 5
  • shfm5
chromosome 2q35 duplication syndrome
  • syndactyly, type i; sdty1
- elite association - COSMIC cancer census association via MalaCards
Search EVX2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EVX2

genes like me logo Genes that share disorders with EVX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EVX2 Gene

Publications for EVX2 Gene

  1. EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2. (PMID: 1675198) D'Esposito M … Boncinelli E (Genomics 1991) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Genome-wide association study of periodontal pathogen colonization. (PMID: 22699663) Divaris K … Offenbacher S (Journal of dental research 2012) 3 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. (PMID: 11778160) Goodman FR … Scambler PJ (American journal of human genetics 2002) 3 58

Products for EVX2 Gene

Sources for EVX2 Gene

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