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Aliases for EVX1 Gene

Aliases for EVX1 Gene

  • Even-Skipped Homeobox 1 2 3 5
  • EVX-1 3 4
  • Eve, Even-Skipped Homeobox Homolog 1 (Drosophila) 2
  • Even-Skipped Homeo Box 1 (Homolog Of Drosophila) 3
  • Homeobox Even-Skipped Homolog Protein 1 3
  • Eve, Even-Skipped Homeo Box Homolog 1 3
  • Eve, Even-Skipped Homeobox Homolog 1 3

External Ids for EVX1 Gene

Previous GeneCards Identifiers for EVX1 Gene

  • GC07P026924
  • GC07P026990
  • GC07P027024
  • GC07P027055
  • GC07P027248
  • GC07P027165
  • GC07P027282
  • GC07P027252
  • GC07P027253
  • GC07P027254
  • GC07P027255
  • GC07P027256
  • GC07P027258
  • GC07P027260
  • GC07P027264

Summaries for EVX1 Gene

Entrez Gene Summary for EVX1 Gene

  • This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for EVX1 Gene

EVX1 (Even-Skipped Homeobox 1) is a Protein Coding gene. Diseases associated with EVX1 include Central Hypoventilation Syndrome, Congenital. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX2.

UniProtKB/Swiss-Prot for EVX1 Gene

  • May play a role in the specification of neuronal cell types.

Additional gene information for EVX1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVX1 Gene

Genomics for EVX1 Gene

GeneHancer (GH) Regulatory Elements for EVX1 Gene

Promoters and enhancers for EVX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J027235 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.4 -6.6 -6614 1.8 ELF3 SIN3A MZF1 RAD21 ZNF335 GLIS2 ELK1 SCRT2 ZNF654 ZBTB11 EVX1 HOXA10-AS ENSG00000253308 ENSG00000277553
GH07J027191 Promoter/Enhancer 1 EPDnew dbSUPER 650.2 -50.6 -50624 0.1 GLIS2 POLR2A SUZ12 ZBTB26 EZH2 ENSG00000253508 EVX1 ENSG00000278020
GH07J027243 Enhancer 0.3 ENCODE 650.7 +1.5 1492 0.2 EZH2 EVX1 EVX1-AS
GH07J028035 Enhancer 1.4 FANTOM5 Ensembl ENCODE 9.5 +797.2 797209 8.7 PKNOX1 ATF1 FOXA2 IRF4 ATF7 FOS RUNX3 DEK RXRA JUNB EVX1-AS ENSG00000253308 EVX1 CREB5 LOC105375208 GC07P028046 JAZF1
GH07J027920 Enhancer 1 Ensembl ENCODE 10.6 +678.8 678770 0.6 MZF1 SIN3A BMI1 FEZF1 ZNF2 RAD21 RFX5 ZNF335 ZNF213 ZSCAN5C ENSG00000253508 HOTTIP HOXA13 HOXA11 HOXA11-AS HOXA10 HOXA9 ENSG00000253308 EVX1 EVX1-AS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EVX1 gene promoter:
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • Nkx2-5
  • Sox5
  • IRF-7A
  • GATA-1
  • Lmo2

Genomic Locations for EVX1 Gene

Genomic Locations for EVX1 Gene
chr7:27,242,545-27,250,493
(GRCh38/hg38)
Size:
7,949 bases
Orientation:
Plus strand
chr7:27,282,164-27,290,112
(GRCh37/hg19)
Size:
7,949 bases
Orientation:
Plus strand

Genomic View for EVX1 Gene

Genes around EVX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVX1 Gene

Proteins for EVX1 Gene

  • Protein details for EVX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49640-EVX1_HUMAN
    Recommended name:
    Homeobox even-skipped homolog protein 1
    Protein Accession:
    P49640
    Secondary Accessions:
    • A4D199
    • B4DQJ0

    Protein attributes for EVX1 Gene

    Size:
    407 amino acids
    Molecular mass:
    42440 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVX1 Gene

Post-translational modifications for EVX1 Gene

No Post-translational modifications

Other Protein References for EVX1 Gene

Antibody Products

  • Boster Bio Antibodies for EVX1
  • Santa Cruz Biotechnology (SCBT) Antibodies for EVX1

No data available for DME Specific Peptides for EVX1 Gene

Domains & Families for EVX1 Gene

Gene Families for EVX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for EVX1 Gene

Graphical View of Domain Structure for InterPro Entry

P49640

UniProtKB/Swiss-Prot:

EVX1_HUMAN :
  • Belongs to the even-skipped homeobox family.
Family:
  • Belongs to the even-skipped homeobox family.
genes like me logo Genes that share domains with EVX1: view

Function for EVX1 Gene

Molecular function for EVX1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the specification of neuronal cell types.
GENATLAS Biochemistry:
Drosophila even-skipped pair rule gene homolog 1 (murine Evx1),homeo domain encoding gene

Phenotypes From GWAS Catalog for EVX1 Gene

Gene Ontology (GO) - Molecular Function for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 1684419
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with EVX1: view
genes like me logo Genes that share phenotypes with EVX1: view

Animal Models for EVX1 Gene

MGI Knock Outs for EVX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVX1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVX1 Gene

Localization for EVX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVX1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with EVX1: view

Pathways & Interactions for EVX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009792 embryo development ending in birth or egg hatching IEA --
GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with EVX1: view

No data available for Pathways by source and SIGNOR curated interactions for EVX1 Gene

Drugs & Compounds for EVX1 Gene

No Compound Related Data Available

Transcripts for EVX1 Gene

mRNA/cDNA for EVX1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EVX1 Gene

Even-skipped homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVX1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVX1 Gene

No ASD Table

Relevant External Links for EVX1 Gene

GeneLoc Exon Structure for
EVX1
ECgene alternative splicing isoforms for
EVX1

Expression for EVX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVX1 Gene

This gene is overexpressed in Bladder (x15.0), Vagina (x10.2), Prostate (x9.6), Cervix - Ectocervix (x4.7), and Testis (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of EVX1 Gene:

EVX1

SOURCE GeneReport for Unigene cluster for EVX1 Gene:

Hs.369879
genes like me logo Genes that share expression patterns with EVX1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVX1 Gene

Orthologs for EVX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EVX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVX1 34 33
  • 99.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EVX1 34 33
  • 91.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EVX1 34 33
  • 91.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Evx1 16 34 33
  • 90.01 (n)
rat
(Rattus norvegicus)
Mammalia Evx1 33
  • 89.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EVX1 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EVX1 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves EVX1 34 33
  • 76.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EVX1 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496893 33
  • 70.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.277 33
zebrafish
(Danio rerio)
Actinopterygii evx1 34 34 33 33
  • 71.39 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta eve 34 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-7 34
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for EVX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVX1 Gene

ENSEMBL:
Gene Tree for EVX1 (if available)
TreeFam:
Gene Tree for EVX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EVX1: view image

Paralogs for EVX1 Gene

Paralogs for EVX1 Gene

(6) SIMAP similar genes for EVX1 Gene using alignment to 4 proteins:

  • EVX1_HUMAN
  • B4DQJ0_HUMAN
  • F8W9J5_HUMAN
  • J3QQJ1_HUMAN
genes like me logo Genes that share paralogs with EVX1: view

Variants for EVX1 Gene

Sequence variations from dbSNP and Humsavar for EVX1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000968982 -- 27,243,853(+) G/A intron_variant
rs1000998666 -- 27,243,567(+) G/C intron_variant
rs1001682756 -- 27,247,092(+) C/G 3_prime_UTR_variant
rs1001962185 -- 27,242,565(+) C/T 5_prime_UTR_variant
rs1002920580 -- 27,246,580(+) A/C/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for EVX1 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv519583 CNV gain 19592680
nsv7393 OTHER inversion 18451855

Variation tolerance for EVX1 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVX1 Gene

Disorders for EVX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EVX1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search EVX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EVX1

genes like me logo Genes that share disorders with EVX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EVX1 Gene

Publications for EVX1 Gene

  1. Isolation and mapping of EVX1, a human homeobox gene homologous to even-skipped, localized at the 5' end of HOX1 locus on chromosome 7. (PMID: 1684419) Faiella A … Simeone A (Nucleic acids research 1991) 2 3 4 22 58
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Transcriptional repression by the human homeobox protein EVX1 in transfected mammalian cells. (PMID: 7499236) Briata P … Corte G (The Journal of biological chemistry 1995) 3 4 58
  5. Contribution of EVX1 in Aggressiveness of Esophageal Squamous Cell Carcinoma. (PMID: 26552663) Mallak AJ … Forghanifard MM (Pathology oncology research : POR 2016) 3 58

Products for EVX1 Gene

Sources for EVX1 Gene

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