Aliases for EVPL Gene
Aliases for EVPL Gene
External Ids for EVPL Gene
- HGNC: 3503
- Entrez Gene: 2125
- Ensembl: ENSG00000167880
- OMIM: 601590
- UniProtKB: Q92817
Previous GeneCards Identifiers for EVPL Gene
- GC17P073900
- GC17M077029
- GC17M074467
- GC17M074600
- GC17M071514
- GC17M074002
- GC17M069428
Summaries for EVPL Gene
-
This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016]
GeneCards Summary for EVPL Gene
EVPL (Envoplakin) is a Protein Coding gene. Diseases associated with EVPL include Paraneoplastic Pemphigus and Pemphigus. Among its related pathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Gene Ontology (GO) annotations related to this gene include structural molecule activity and intermediate filament binding. An important paralog of this gene is PPL.
UniProtKB/Swiss-Prot for EVPL Gene
-
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVPL Gene
Genomics for EVPL Gene
GeneHancer (GH) Regulatory Elements for EVPL Gene
Promoters and enhancers for EVPL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EVPL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EVPL gene promoter:
-
- PPAR-gamma2
- PPAR-gamma1
- E47
- NF-kappaB1
- RORalpha1
- ATF6
- MyoD
- AP-4
- HOXA5
- AhR
Regulatory Element Products
Genomic Locations for EVPL Gene
Genomic Locations for EVPL Gene
- chr17:76,004,502-76,027,452
- (GRCh38/hg38)
- Size:
- 22,951 bases
- Orientation:
- Minus strand
- chr17:74,000,583-74,023,533
- (GRCh37/hg19)
- Size:
- 22,951 bases
- Orientation:
- Minus strand
Genomic View for EVPL Gene
Genes around EVPL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
- 17q25.1 by Ensembl
EVPL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EVPL Gene
Proteins for EVPL Gene
-
Protein details for EVPL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92817-EVPL_HUMAN
- Recommended name:
- Envoplakin
- Protein Accession:
- Q92817
- A0AUV5
Protein attributes for EVPL Gene
- Size:
- 2033 amino acids
- Molecular mass:
- 231604 Da
- Quaternary structure:
-
- May form a homodimer or a heterodimer with PPL.
Protein Expression for EVPL Gene
Post-translational modifications for EVPL Gene
Other Protein References for EVPL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EVPL
- Novus Biologicals Antibodies for EVPL
- Invitrogen Antibodies for EVPL (AFLGC-EVPL)
- GeneTex EVPL Antibody for EVPL
-
Santa Cruz Biotechnology (SCBT) Antibodies for EVPL
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for EVPL
- Origene Custom Protein Services for EVPL
- Novus Biologicals proteins for EVPL
- Search GeneTex for Proteins for EVPL
Assay Products
No data available for DME Specific Peptides for EVPL Gene
Domains & Families for EVPL Gene
Gene Families for EVPL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for EVPL Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EVPL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92817- Family:
-
- Belongs to the plakin or cytolinker family.
Function for EVPL Gene
Molecular function for EVPL Gene
- UniProtKB/Swiss-Prot Function:
- Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
- UniProtKB/Swiss-Prot Induction:
- During differentiation of epidermal keratinocytes.
- GENATLAS Biochemistry:
- envoplakin,membrane-associated precursor of the epidermal cornified envelope,210 kDa,plakin family of cell junction proteins,paraneoplastic pemphigus antigen complex, homolog to DSP (see symbol)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IDA,IEA | 10908733 |
| GO:0019215 | intermediate filament binding | IEA | -- |
| GO:0030674 | protein binding, bridging | IDA | 10908733 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for EVPL Gene
- MGI mutant phenotypes for EVPL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EVPL:
Animal Models for EVPL Gene
- MGI Knock Outs for EVPL:
-
- Evpl Evpl<tm1Fmw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EVPL
-
CRISPR Products
-
OriGene CRISPR knockouts for EVPL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EVPL
- genomics-online: gRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- Applied Biological Materials CRISPR for EVPL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EVPL
- GenScript: Design CRISPR guide RNA sequences for EVPL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EVPL
- Browse OriGene Inhibitory RNA Products For EVPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVPL
- genomics-online: shRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
Clone Products
- Sino Biological Human cDNA Clone for EVPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EVPL
- Applied Biological Materials Clones for EVPL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EVPL
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EVPL Gene
Localization for EVPL Gene
Subcellular locations from UniProtKB/Swiss-Prot for EVPL Gene
- Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Intermediate filaments (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0030054 | cell junction | IEA | -- |
Pathways & Interactions for EVPL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
| 3 | Cytoskeleton remodeling Neurofilaments | ||
Pathways by source for EVPL Gene
3 Reactome pathways for EVPL Gene
1 GeneGo (Thomson Reuters) pathway for EVPL Gene
Interacting Proteins for EVPL Gene
GPS-Prot Interaction Network for EVPL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | TAS,IEA | 8707850 |
| GO:0018149 | peptide cross-linking | IDA | 10908733 |
| GO:0030216 | keratinocyte differentiation | IDA | 10908733 |
| GO:0031424 | keratinization | IEA | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for EVPL Gene
Transcripts for EVPL Gene
mRNA/cDNA for EVPL Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (63) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000589231 585 bps (uc060kgn.1)
- ENST00000301607 6614 bps (uc002jqi.3)
- ENST00000586740 6223 bps (uc010wss.2)
- ENST00000587569 6592 bps (uc060kgo.1)
- ENST00000593037 545 bps (uc060kgp.1)
CRISPR Products
-
OriGene CRISPR knockouts for EVPL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EVPL
- genomics-online: gRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- Applied Biological Materials CRISPR for EVPL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EVPL
- GenScript: Design CRISPR guide RNA sequences for EVPL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EVPL
- Browse OriGene Inhibitory RNA Products For EVPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVPL
- genomics-online: shRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
Clone Products
- Sino Biological Human cDNA Clone for EVPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EVPL
- Applied Biological Materials Clones for EVPL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for EVPL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
-
Epidermis (Integumentary System)
- Corneocytes Stratified Epidermis
- Granular Keratinocytes Stratified Epidermis
-
Epithelial Cells
- Corneocytes Stratified Epidermis
- Granular Keratinocytes Stratified Epidermis
mRNA differential expression in normal tissues according to GTEx for EVPL Gene
This gene is overexpressed in Esophagus - Mucosa (x16.1), Skin - Sun Exposed (Lower leg) (x9.1), Skin - Not Sun Exposed (Suprapubic) (x8.6), and Vagina (x5.7).
This gene is overexpressed in Cervix (33.1), Esophagus (10.6), and Saliva (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVPL Gene
NURSA nuclear receptor signaling pathways regulating expression of EVPL Gene:
EVPLSOURCE GeneReport for Unigene cluster for EVPL Gene:
Hs.500635mRNA Expression by UniProt/SwissProt for EVPL Gene:
Q92817-EVPL_HUMAN
Tissue specificity:
Exclusively expressed in stratified squamous epithelia.
Evidence on tissue expression from TISSUES for EVPL Gene
- Skin(4.6)
- Nervous system(4.1)
- Lung(3.1)
- Blood(2.5)
- Bone marrow(2.3)
Primer Products
-
OriGene qPCR primer pairs for EVPL
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVPL Gene
Orthologs for EVPL Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EVPL 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EVPL 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | EVPL 34 33 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Evpl 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Evpl 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | EVPL 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | evpl 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | evpla 34 33 |
|
ManyToMany | |
| evplb 34 |
|
ManyToMany | |||
| sbcb742 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10086 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | shot 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | vab-10 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for EVPL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EVPL Gene
- ENSEMBL:
- Gene Tree for EVPL (if available)
- TreeFam:
- Gene Tree for EVPL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EVPL: view image
Paralogs for EVPL Gene
Variants for EVPL Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs755302072 | benign, Abnormality of neuronal migration | 76,023,539(-) | C/T | coding_sequence_variant, missense_variant | |
| rs777067468 | benign, Abnormality of neuronal migration | 76,009,079(-) | C/A/T | coding_sequence_variant, missense_variant | |
| rs1000066499 | -- | 76,027,855(-) | A/G | upstream_transcript_variant | |
| rs1000085364 | -- | 76,018,266(-) | G/A | intron_variant | |
| rs1000086153 | -- | 76,022,070(-) | G/C | intron_variant |
Residual Variation Intolerance Score:
95.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.22;
88.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EVPL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVPL Gene
Disorders for EVPL Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paraneoplastic pemphigus |
|
|
| pemphigus |
|
|
| pemphigus foliaceus |
|
|
| pemphigus vulgaris |
|
|
| bullous skin disease |
|
Search EVPL in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EVPL
No data available for UniProtKB/Swiss-Prot and Genatlas for EVPL Gene
Publications for EVPL Gene
- Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25. (PMID: 10409435) Risk JM … Field JK (Genomics 1999) 2 3 4 22 58
- Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25. (PMID: 8938451) Ruhrberg C … Watt FM (Genomics 1996) 2 3 22 58
- Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. (PMID: 8707850) Ruhrberg C … Watt FM (The Journal of cell biology 1996) 3 4 22 58
- Detection of anti-envoplakin and anti-periplakin autoantibodies by ELISA in patients with paraneoplastic pemphigus. (PMID: 18820940) Huang Y … Zhu X (Archives of dermatological research 2009) 3 22 58
- Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas. (PMID: 15756445) Iwaya T … Masuda T (Oncology reports 2005) 3 22 58
Products for EVPL Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for EVPL
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- Novus Biologicals
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- Browse Antibodies
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- Invitrogen Antibodies for EVPL (AFLGC-EVPL)
- Cyagen custom Knockout/knockin (KOKI) mouse models for EVPL
- antibodies-online: Search results for 8 available Envoplakin Antibodies ranked by validation data
- Compare Top Envoplakin Antibodies
- Quality Products:
- antibodies-online: Search results for 17 available Envoplakin Elisa Kits ranked by validation data
- Compare Top Envoplakin Elisa Kits
- antibodies-online: Search results for available Envoplakin related products ranked by validation data
- GeneTex EVPL Antibody for EVPL
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- Santa Cruz Biotechnology (SCBT) Antibodies for EVPL
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- Horizon Cell Lines for EVPL
- genomics-online: cdna clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- orf clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- genomics-online: gRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- genomics-online: primer clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- genomics-online: shRNA clones - Search results for 79 available Envoplakin gene related products
- Overview of 79 available Envoplakin gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EVPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EVPL
- GeneCopoeia miRNA 3'UTR Target clone products for EVPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVPL
Sources for EVPL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
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- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt