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Aliases for EVI5L Gene

Aliases for EVI5L Gene

  • Ecotropic Viral Integration Site 5 Like 2 3 5
  • Ecotropic Viral Integration Site 5-Like Protein 3 4
  • EVI5-Like Protein 3

External Ids for EVI5L Gene

Previous GeneCards Identifiers for EVI5L Gene

  • GC19P007817
  • GC19P007802
  • GC19P007895
  • GC19P007569

Summaries for EVI5L Gene

GeneCards Summary for EVI5L Gene

EVI5L (Ecotropic Viral Integration Site 5 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is EVI5.

UniProtKB/Swiss-Prot for EVI5L Gene

  • Functions as a GTPase-activating protein (GAP) with a broad specificity.

Additional gene information for EVI5L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVI5L Gene

Genomics for EVI5L Gene

GeneHancer (GH) Regulatory Elements for EVI5L Gene

Promoters and enhancers for EVI5L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007829 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.0 16 2.2 HDGF PKNOX1 FOXA2 SIN3A ZBTB7B YY1 E2F8 ZNF143 FOS KLF13 EVI5L ELAVL1 HNRNPM ZNF557 XAB2 PRR36 LRRC8E ENSG00000268120
GH19J007831 Enhancer 1 ENCODE dbSUPER 650.7 +1.5 1487 0.2 CTCF KLF1 PKNOX1 SAP130 ARID4B DMAP1 KLF14 ZIC2 KDM3A RAD21 EVI5L ENSG00000268120
GH19J007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 -307.4 -307376 2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MCOLN1 GC19M007510 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 ZNF414 TIMM44 SNAPC2
GH19J008388 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.1 +562.6 562611 10.3 MLX IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC GLIS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ZNF559 ENSG00000269300
GH19J007852 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 +23.2 23230 1.3 PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 PRR36 RNA5SP463 LRRC8E EVI5L ENSG00000268120
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVI5L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EVI5L gene promoter:
  • AREB6
  • Gfi-1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for EVI5L Gene

Genomic Locations for EVI5L Gene
34,744 bases
Plus strand
34,744 bases
Plus strand

Genomic View for EVI5L Gene

Genes around EVI5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5L Gene

Proteins for EVI5L Gene

  • Protein details for EVI5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EVI5-like protein
    Protein Accession:
    Secondary Accessions:
    • B9A6I9

    Protein attributes for EVI5L Gene

    794 amino acids
    Molecular mass:
    91376 Da
    Quaternary structure:
    • May interact with RAB10.

    Alternative splice isoforms for EVI5L Gene


neXtProt entry for EVI5L Gene

Post-translational modifications for EVI5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVI5L Gene

No data available for DME Specific Peptides for EVI5L Gene

Domains & Families for EVI5L Gene

Gene Families for EVI5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for EVI5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
genes like me logo Genes that share domains with EVI5L: view

Function for EVI5L Gene

Molecular function for EVI5L Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) with a broad specificity.

Phenotypes From GWAS Catalog for EVI5L Gene

Gene Ontology (GO) - Molecular Function for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 17646400
GO:0005515 protein binding IPI 16189514
GO:0017137 Rab GTPase binding IPI 17646400
genes like me logo Genes that share ontologies with EVI5L: view
genes like me logo Genes that share phenotypes with EVI5L: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI5L Gene

Localization for EVI5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI5L gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVI5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EVI5L Gene

Pathways & Interactions for EVI5L Gene

SuperPathways for EVI5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA,IDA 17646400
GO:0090630 activation of GTPase activity IBA --
genes like me logo Genes that share ontologies with EVI5L: view

No data available for Pathways by source and SIGNOR curated interactions for EVI5L Gene

Drugs & Compounds for EVI5L Gene

No Compound Related Data Available

Transcripts for EVI5L Gene

mRNA/cDNA for EVI5L Gene

Unigene Clusters for EVI5L Gene

Ecotropic viral integration site 5-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - -

Relevant External Links for EVI5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVI5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVI5L Gene

Protein differential expression in normal tissues from HIPED for EVI5L Gene

This gene is overexpressed in Adrenal (45.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVI5L Gene

NURSA nuclear receptor signaling pathways regulating expression of EVI5L Gene:


SOURCE GeneReport for Unigene cluster for EVI5L Gene:


Evidence on tissue expression from TISSUES for EVI5L Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with EVI5L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI5L Gene

Orthologs for EVI5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EVI5L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVI5L 34 33
  • 99.5 (n)
(Mus musculus)
Mammalia Evi5l 34
  • 96 (a)
(Canis familiaris)
Mammalia EVI5L 34 33
  • 93.71 (n)
(Bos Taurus)
Mammalia EVI5L 34 33
  • 92.88 (n)
(Monodelphis domestica)
Mammalia EVI5L 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
(Gallus gallus)
Aves EVI5L 34
  • 82 (a)
(Anolis carolinensis)
Reptilia EVI5L 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia evi5l 33
  • 69.81 (n)
(Danio rerio)
Actinopterygii si:ch211-239f4.1 33
  • 70.24 (n)
EVI5L 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11727 34
  • 42 (a)
(Caenorhabditis elegans)
Secernentea eat-17 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP5 34
  • 17 (a)
GYL1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3125 34
  • 44 (a)
Species where no ortholog for EVI5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVI5L Gene

Gene Tree for EVI5L (if available)
Gene Tree for EVI5L (if available)
Evolutionary constrained regions (ECRs) for EVI5L: view image

Paralogs for EVI5L Gene

Paralogs for EVI5L Gene

(1) SIMAP similar genes for EVI5L Gene using alignment to 3 proteins:

  • M0R1Y1_HUMAN Pseudogenes for EVI5L Gene

genes like me logo Genes that share paralogs with EVI5L: view

Variants for EVI5L Gene

Sequence variations from dbSNP and Humsavar for EVI5L Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000045849 -- 7,832,809(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000049662 -- 7,838,964(+) C/A/G genic_upstream_transcript_variant, intron_variant
rs1000102939 -- 7,859,616(+) C/T intron_variant
rs1000124516 -- 7,838,832(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000228951 -- 7,865,150(+) T/C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EVI5L Gene

Variant ID Type Subtype PubMed ID
dgv1704n106 CNV duplication 24896259
dgv1986e59 CNV duplication 20981092
nsv1060887 CNV gain 25217958
nsv1072317 CNV deletion 25765185
nsv1076462 CNV duplication 25765185
nsv1120354 CNV tandem duplication 24896259
nsv1142928 CNV tandem duplication 24896259
nsv1146932 CNV duplication 26484159
nsv525499 CNV loss 19592680
nsv833732 CNV gain 17160897
nsv833733 CNV gain 17160897

Variation tolerance for EVI5L Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVI5L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5L Gene

Disorders for EVI5L Gene

Additional Disease Information for EVI5L

No disorders were found for EVI5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI5L Gene

Publications for EVI5L Gene

  1. The Evi5 family in cellular physiology and pathology. (PMID: 23669355) Lim YS … Tang BL (FEBS letters 2013) 2 3 58
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 44 58
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 58
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PMID: 16923123) Itoh T … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for EVI5L Gene

Sources for EVI5L Gene

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