Aliases for EVI5L Gene

Aliases for EVI5L Gene

  • Ecotropic Viral Integration Site 5 Like 2 3 5
  • Ecotropic Viral Integration Site 5-Like Protein 3 4
  • EVI5-Like Protein 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • EVI5L 5

External Ids for EVI5L Gene

Previous GeneCards Identifiers for EVI5L Gene

  • GC19P007817
  • GC19P007802
  • GC19P007895
  • GC19P007569

Summaries for EVI5L Gene

GeneCards Summary for EVI5L Gene

EVI5L (Ecotropic Viral Integration Site 5 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is EVI5.

UniProtKB/Swiss-Prot Summary for EVI5L Gene

  • Functions as a GTPase-activating protein (GAP) with a broad specificity.

Additional gene information for EVI5L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EVI5L Gene

Genomics for EVI5L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EVI5L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J007829 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 0.0 -17 2.4 SP1 CREB1 ATF7 PRDM10 ZNF629 RFX1 LEF1 IKZF1 BACH1 FOS EVI5L ELAVL1 HNRNPM PRR36 LRRC8E piR-32214-337 CLEC4M
GH19J007831 Enhancer 0.9 ENCODE dbSUPER 600.7 +1.5 1502 0.2 CTCF PRDM10 IKZF1 PRDM1 ZIC2 SP2 EGR1 CHD2 RCOR1 ZBTB48 EVI5L lnc-PRR36-4 PRR36
GH19J007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -307.3 -307317 2.6 SP1 CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 NFKBIZ KDM1A ZNF692 MCOLN1 ENSG00000269371 HNRNPM ELAVL1 XAB2 ZNF557 ZNF414 MAP2K7 SNAPC2 TIMM44
GH19J008388 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +562.6 562626 10.3 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 RAB11B-AS1 RAB11B HNRNPM ELAVL1 ZNF699 ZNF558 ZNF317 XAB2 ENSG00000270614 ENSG00000269300
GH19J007874 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +44.1 44083 1.8 PRDM10 RFX1 ZIC2 POLR2A PATZ1 ZNF600 SCRT2 RFX3 KLF9 ZFX PRR36 lnc-PRR36-1 EVI5L NONHSAG024662.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVI5L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EVI5L

Top Transcription factor binding sites by QIAGEN in the EVI5L gene promoter:
  • AREB6
  • Gfi-1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for EVI5L Gene

Genomic Locations for EVI5L Gene
chr19:7,830,218-7,864,976
(GRCh38/hg38)
Size:
34,759 bases
Orientation:
Plus strand
chr19:7,895,119-7,929,862
(GRCh37/hg19)
Size:
34,744 bases
Orientation:
Plus strand

Genomic View for EVI5L Gene

Genes around EVI5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5L Gene

Proteins for EVI5L Gene

  • Protein details for EVI5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CN4-EVI5L_HUMAN
    Recommended name:
    EVI5-like protein
    Protein Accession:
    Q96CN4
    Secondary Accessions:
    • B9A6I9

    Protein attributes for EVI5L Gene

    Size:
    794 amino acids
    Molecular mass:
    91376 Da
    Quaternary structure:
    • May interact with RAB10.

    Alternative splice isoforms for EVI5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI5L Gene

Post-translational modifications for EVI5L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVI5L Gene

No data available for DME Specific Peptides for EVI5L Gene

Domains & Families for EVI5L Gene

Gene Families for EVI5L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EVI5L Gene

InterPro:
Blocks:
  • Binding-protein-dependent transport systems inner membrane component
  • RabGAP/TBC domain
ProtoNet:

Suggested Antigen Peptide Sequences for EVI5L Gene

GenScript: Design optimal peptide antigens:
  • Ecotropic viral integration site 5-like protein (EVI5L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96CN4

UniProtKB/Swiss-Prot:

EVI5L_HUMAN :
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
Domain:
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.
genes like me logo Genes that share domains with EVI5L: view

Function for EVI5L Gene

Molecular function for EVI5L Gene

UniProtKB/Swiss-Prot Function:
Functions as a GTPase-activating protein (GAP) with a broad specificity.

Phenotypes From GWAS Catalog for EVI5L Gene

Gene Ontology (GO) - Molecular Function for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA,IDA 17646400
GO:0005515 protein binding IPI 16189514
GO:0017137 Rab GTPase binding IPI 17646400
genes like me logo Genes that share ontologies with EVI5L: view
genes like me logo Genes that share phenotypes with EVI5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVI5L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVI5L Gene

Localization for EVI5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI5L gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVI5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for EVI5L Gene

Pathways & Interactions for EVI5L Gene

PathCards logo

SuperPathways for EVI5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVI5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IEA,IDA 17646400
GO:0090630 activation of GTPase activity IBA 21873635
GO:1902018 negative regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with EVI5L: view

No data available for Pathways by source and SIGNOR curated interactions for EVI5L Gene

Drugs & Compounds for EVI5L Gene

No Compound Related Data Available

Transcripts for EVI5L Gene

mRNA/cDNA for EVI5L Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVI5L

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - -
SP3:

Relevant External Links for EVI5L Gene

GeneLoc Exon Structure for
EVI5L

Expression for EVI5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EVI5L Gene

Protein differential expression in normal tissues from HIPED for EVI5L Gene

This gene is overexpressed in Adrenal (45.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVI5L Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EVI5L

SOURCE GeneReport for Unigene cluster for EVI5L Gene:

Hs.26870

Evidence on tissue expression from TISSUES for EVI5L Gene

  • Nervous system(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with EVI5L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI5L Gene

Orthologs for EVI5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EVI5L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EVI5L 30 31
  • 99.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Evi5l 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EVI5L 30 31
  • 93.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EVI5L 30 31
  • 92.88 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EVI5L 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 21 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves EVI5L 31
  • 82 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EVI5L 31
  • 91 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia evi5l 30
  • 69.81 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-239f4.1 30
  • 70.24 (n)
EVI5L 31
  • 60 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG11727 31
  • 42 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea eat-17 31
  • 35 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP5 31
  • 17 (a)
ManyToMany
GYL1 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3125 31
  • 44 (a)
OneToMany
Species where no ortholog for EVI5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EVI5L Gene

ENSEMBL:
Gene Tree for EVI5L (if available)
TreeFam:
Gene Tree for EVI5L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EVI5L: view image

Paralogs for EVI5L Gene

(1) SIMAP similar genes for EVI5L Gene using alignment to 3 proteins:

  • EVI5L_HUMAN
  • M0QYX4_HUMAN
  • M0R1Y1_HUMAN

Pseudogenes.org Pseudogenes for EVI5L Gene

genes like me logo Genes that share paralogs with EVI5L: view

Variants for EVI5L Gene

Additional dbSNP identifiers (rs#s) for EVI5L Gene

Structural Variations from Database of Genomic Variants (DGV) for EVI5L Gene

Variant ID Type Subtype PubMed ID
dgv1704n106 CNV duplication 24896259
dgv1986e59 CNV duplication 20981092
nsv1060887 CNV gain 25217958
nsv1072317 CNV deletion 25765185
nsv1076462 CNV duplication 25765185
nsv1120354 CNV tandem duplication 24896259
nsv1142928 CNV tandem duplication 24896259
nsv1146932 CNV duplication 26484159
nsv525499 CNV loss 19592680
nsv833732 CNV gain 17160897
nsv833733 CNV gain 17160897

Variation tolerance for EVI5L Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVI5L Gene

Human Gene Mutation Database (HGMD)
EVI5L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVI5L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EVI5L Gene

Disorders for EVI5L Gene

Additional Disease Information for EVI5L

No disorders were found for EVI5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI5L Gene

Publications for EVI5L Gene

  1. The Evi5 family in cellular physiology and pathology. (PMID: 23669355) Lim YS … Tang BL (FEBS letters 2013) 2 3
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 41
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4
  4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. (PMID: 16923123) Itoh T … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for EVI5L Gene

Sources for EVI5L Gene