Aliases for EVI5 Gene

Aliases for EVI5 Gene

  • Ecotropic Viral Integration Site 5 2 3 5
  • NB4S 2 3 4
  • Ecotropic Viral Integration Site 5 Protein Homolog 3 4
  • Neuroblastoma Stage 4S Gene Protein 3 4
  • EVI-5 3 4
  • DJ846D11.1 (Ecotropic Viral Integration Site 5) 3
  • Neuroblastoma Stage 4S Gene 2
  • EVI5 5

External Ids for EVI5 Gene

Previous GeneCards Identifiers for EVI5 Gene

  • GC01M093448
  • GC01M092183
  • GC01M092311
  • GC01M092446
  • GC01M092691
  • GC01M092746
  • GC01M092974
  • GC01M091095

Summaries for EVI5 Gene

GeneCards Summary for EVI5 Gene

EVI5 (Ecotropic Viral Integration Site 5) is a Protein Coding gene. Diseases associated with EVI5 include Neuroblastoma. Among its related pathways are Aurora B signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is EVI5L.

UniProtKB/Swiss-Prot Summary for EVI5 Gene

  • Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.

Gene Wiki entry for EVI5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EVI5 Gene

Genomics for EVI5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EVI5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J092959 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 261.2 -169.1 -169141 4.1 BCLAF1 ZNF207 ZNF600 ZNF654 IKZF1 CEBPA ATF3 POLR2A ZIC2 YY1 DIPK1A EVI5 lnc-FAM69A-3 lnc-MTF2-4 DR1 MTF2
GH01J092791 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 257.3 +0.1 89 1 MYC NCOR1 IKZF1 ZNF592 NONO FEZF1 ARNT TAF9B NBN NKRF EVI5 DIPK1A piR-50443-022 GFI1
GH01J092482 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.2 +307.8 307812 6 EZH2 BCLAF1 ZNF207 ZNF600 ZNF580 ATF2 POLR2A CEBPA ZNF10 ZIC2 GFI1 MN308751 lnc-EVI5-1 DIPK1A CCDC18-AS1 MTF2 SNORD21 EVI5 SNORA66 GLMN
GH01J092949 Enhancer 1.1 ENCODE dbSUPER 21.7 -159.5 -159459 4.6 BCLAF1 NCOR1 IKZF1 CEBPA YY1 MXD4 REST TARDBP TRIM22 HOMEZ EVI5 SNORA66 SNORD21 RPL5 DIPK1A LOC100127934
GH01J092783 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 13 +7.7 7712 4.2 NCOR1 IKZF1 MYC ZNF600 ZNF580 ZNF592 KLF9 CEBPA ZNF10 NFIC lnc-FAM69A-2 EVI5 lnc-RPL5-2 GFI1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVI5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EVI5

Top Transcription factor binding sites by QIAGEN in the EVI5 gene promoter:
  • aMEF-2
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • CHOP-10
  • HNF-1
  • HNF-1A
  • MEF-2A
  • p53
  • RSRFC4

Genomic Locations for EVI5 Gene

Latest Assembly
chr1:92,508,696-92,792,413
(GRCh38/hg38)
Size:
283,718 bases
Orientation:
Minus strand

Previous Assembly
chr1:92,974,253-93,257,967
(GRCh37/hg19 by Entrez Gene)
Size:
283,715 bases
Orientation:
Minus strand

chr1:92,974,253-93,257,961
(GRCh37/hg19 by Ensembl)
Size:
283,709 bases
Orientation:
Minus strand

Genomic View for EVI5 Gene

Genes around EVI5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI5 Gene

Proteins for EVI5 Gene

  • Protein details for EVI5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60447-EVI5_HUMAN
    Recommended name:
    Ecotropic viral integration site 5 protein homolog
    Protein Accession:
    O60447
    Secondary Accessions:
    • A6NKX8
    • B9A6J0
    • Q9H1Y9

    Protein attributes for EVI5 Gene

    Size:
    810 amino acids
    Molecular mass:
    92949 Da
    Quaternary structure:
    • Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.
    Miscellaneous:
    • Depletion of EVI5 by RNAi causes cell cycle arrest and mitotic abnormalities.

    Alternative splice isoforms for EVI5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI5 Gene

Post-translational modifications for EVI5 Gene

  • Probably phosphorylated by PLK1; may be required for degradation during mitosis.
  • Ubiquitinated. Degradation during prophase is ubiquitin-dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EVI5 Gene

Domains & Families for EVI5 Gene

Gene Families for EVI5 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EVI5 Gene

InterPro:
Blocks:
  • Binding-protein-dependent transport systems inner membrane component
  • RabGAP/TBC domain

Suggested Antigen Peptide Sequences for EVI5 Gene

GenScript: Design optimal peptide antigens:
  • Ecotropic viral integration site 5 (B9A6J0_HUMAN)
  • Neuroblastoma stage 4S gene protein (EVI5_HUMAN)
genes like me logo Genes that share domains with EVI5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EVI5 Gene

Function for EVI5 Gene

Molecular function for EVI5 Gene

UniProtKB/Swiss-Prot Function:
Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
UniProtKB/Swiss-Prot Induction:
Down-regulated during mitosis through proteasomal degradation.
GENATLAS Biochemistry:
ecotropic viral integration site 5,neuroblastoma,infant from stage 4S candidate gene,widely expressed,homolog to HRP1 (TRE-2) and mouse TBC1,fused with TRNG10 to form a chimeric fusion protein in constitutional translocation t(1;10)(p22;q21)

Phenotypes From GWAS Catalog for EVI5 Gene

Gene Ontology (GO) - Molecular Function for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA,IDA 17562788
GO:0005515 protein binding IPI 16439210
GO:0031267 small GTPase binding IPI 17562788
genes like me logo Genes that share ontologies with EVI5: view
genes like me logo Genes that share phenotypes with EVI5: view

Animal Models for EVI5 Gene

MGI Knock Outs for EVI5:
  • Evi5 Evi5<tm1a(KOMP)Wtsi>

miRNA for EVI5 Gene

miRTarBase miRNAs that target EVI5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVI5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVI5 Gene

Localization for EVI5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI5 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 3
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA 17562788
genes like me logo Genes that share ontologies with EVI5: view

Pathways & Interactions for EVI5 Gene

PathCards logo

SuperPathways for EVI5 Gene

SuperPathway Contained pathways
1 Aurora B signaling
genes like me logo Genes that share pathways with EVI5: view

Pathways by source for EVI5 Gene

1 BioSystems pathway for EVI5 Gene

SIGNOR curated interactions for EVI5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for EVI5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0007049 cell cycle IEA --
GO:0042147 retrograde transport, endosome to Golgi IMP 17562788
GO:0043087 regulation of GTPase activity IEA --
GO:0043547 positive regulation of GTPase activity IDA 17562788
genes like me logo Genes that share ontologies with EVI5: view

Drugs & Compounds for EVI5 Gene

No Compound Related Data Available

Transcripts for EVI5 Gene

mRNA/cDNA for EVI5 Gene

8 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVI5

Alternative Splicing Database (ASD) splice patterns (SP) for EVI5 Gene

No ASD Table

Relevant External Links for EVI5 Gene

GeneLoc Exon Structure for
EVI5

Expression for EVI5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EVI5 Gene

Protein differential expression in normal tissues from HIPED for EVI5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (50.1) and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVI5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EVI5

SOURCE GeneReport for Unigene cluster for EVI5 Gene:

Hs.594434

mRNA Expression by UniProt/SwissProt for EVI5 Gene:

O60447-EVI5_HUMAN
Tissue specificity: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.

Evidence on tissue expression from TISSUES for EVI5 Gene

  • Nervous system(4.5)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with EVI5: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI5 Gene

Orthologs for EVI5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EVI5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EVI5 29 30
  • 99.71 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EVI5 30
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia EVI5 29 30
  • 91.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EVI5 29 30
  • 91.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Evi5 29 16 30
  • 89.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Evi5 29
  • 87.14 (n)
Oppossum
(Monodelphis domestica)
Mammalia EVI5 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EVI5 29 30
  • 72.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EVI5 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia evi5 29
  • 65.86 (n)
Str.3031 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.12898 29
Zebrafish
(Danio rerio)
Actinopterygii evi5b 29 30
  • 72.21 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002354 29
  • 51.49 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Evi5 29
  • 49.31 (n)
CG11727 30 31
  • 40 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea tbc-4 29
  • 55.04 (n)
T24D11.1 31
  • 50 (a)
eat-17 30
  • 34 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP5 30
  • 18 (a)
ManyToMany
GYL1 30 32
  • 16 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G02460 29
  • 52.04 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0412600 29
  • 50.89 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3125 30
  • 45 (a)
OneToMany
Species where no ortholog for EVI5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EVI5 Gene

ENSEMBL:
Gene Tree for EVI5 (if available)
TreeFam:
Gene Tree for EVI5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EVI5: view image
Alliance of Genome Resources:
Additional Orthologs for EVI5

Paralogs for EVI5 Gene

Variants for EVI5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EVI5 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11808092 Benign: not specified 92,607,671(-) C/Ap.Gln612His
NM_005665.6(EVI5):c.1836G>T (p.Gln612His)
MISSENSE
rs141343784 Benign: not provided 92,607,683(-) C/T
NM_005665.6(EVI5):c.1824G>A (p.Val608=)
SYNONYMOUS
rs143611208 Likely Benign: not provided 92,695,323(-) A/G
NM_005665.6(EVI5):c.1028T>C (p.Ile343Thr)
MISSENSE
rs144597007 Likely Benign: not provided 92,513,722(-) C/T
NM_005665.6(EVI5):c.2367G>A (p.Glu789=)
SYNONYMOUS_VARIANT,THREE_PRIME_UTR
rs200507358 Uncertain Significance: EVI5-related condition 92,665,959(-) G/A
NM_005665.6(EVI5):c.1324C>T (p.Arg442Cys)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EVI5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EVI5 Gene

Variant ID Type Subtype PubMed ID
esv1001160 CNV insertion 20482838
esv1233172 CNV insertion 17803354
esv1938423 CNV deletion 18987734
esv2533438 CNV insertion 19546169
esv2656994 CNV deletion 23128226
esv2669727 CNV deletion 23128226
esv2674141 CNV deletion 23128226
esv2714684 CNV deletion 23290073
esv3442538 CNV insertion 20981092
esv3565837 CNV deletion 23714750
esv3565848 CNV deletion 23714750
esv3578011 CNV loss 25503493
esv3578012 CNV loss 25503493
esv3586812 CNV loss 21293372
esv3586814 CNV loss 21293372
esv3586816 CNV loss 21293372
esv3586817 CNV loss 21293372
esv3586818 CNV loss 21293372
esv3586819 CNV loss 21293372
nsv1004381 CNV gain 25217958
nsv1008602 CNV gain 25217958
nsv1141898 OTHER inversion 24896259
nsv159896 CNV insertion 16902084
nsv475722 CNV novel sequence insertion 20440878
nsv523354 CNV gain 19592680
nsv830603 CNV loss 17160897
nsv955453 CNV deletion 24416366
nsv997898 CNV gain 25217958

Variation tolerance for EVI5 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVI5 Gene

Human Gene Mutation Database (HGMD)
EVI5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVI5
Leiden Open Variation Database (LOVD)
EVI5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI5 Gene

Disorders for EVI5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EVI5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
neuroblastoma
  • nb
- elite association - COSMIC cancer census association via MalaCards
Search EVI5 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EVI5_HUMAN
  • Note=A chromosomal aberration involving EVI5 is found is a patient with stage 4S neuroblastoma. Translocation t(1;10)(p22;q21) that forms a EVI5-TRNG10 fusion protein. TRNG10 is a probable structural transcript which is normally not translated. {ECO:0000269 PubMed:9618176}.

Additional Disease Information for EVI5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EVI5: view

No data available for Genatlas for EVI5 Gene

Publications for EVI5 Gene

  1. EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar SL … Cowell JK (Experimental cell research 2006) 3 4 22
  2. EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin. (PMID: 16033705) Faitar SL … Cowell JK (Genomics 2005) 3 4 22
  3. NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma. (PMID: 9618176) Roberts T … Cowell JK (Human molecular genetics 1998) 2 3 4
  4. Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. (PMID: 20087403) Alcina A … Matesanz F (European journal of human genetics : EJHG 2010) 3 40
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 40

Products for EVI5 Gene

Sources for EVI5 Gene