Aliases for EVI2B Gene

Aliases for EVI2B Gene

  • Ecotropic Viral Integration Site 2B 2 3 5
  • Ecotropic Viral Integration Site 2B Protein Homolog 3 4
  • Protein EVI2B 3 4
  • EVI-2B 3 4
  • EVDB 3 4
  • CD361 Antigen 4
  • D17S376 3
  • CD361 3

External Ids for EVI2B Gene

Previous GeneCards Identifiers for EVI2B Gene

  • GC17P029671
  • GC17M031537
  • GC17M029480
  • GC17M029776
  • GC17M026654
  • GC17M029630
  • GC17M025842

Summaries for EVI2B Gene

GeneCards Summary for EVI2B Gene

EVI2B (Ecotropic Viral Integration Site 2B) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for EVI2B Gene

  • Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.

Gene Wiki entry for EVI2B Gene

Additional gene information for EVI2B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EVI2B Gene

Genomics for EVI2B Gene

GeneHancer (GH) Regulatory Elements for EVI2B Gene

Promoters and enhancers for EVI2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J031306 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 752.9 +3.5 3548 9.5 SMARCE1 CC2D1A ELF1 TEAD4 CBFA2T2 MLLT1 SP7 ZNF687 SMARCA4 TRIM24 EVI2B EVI2A OMG RAB11FIP4 CRLF3 ADAP2 ENSG00000265118 NF1
GH17J031315 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 750.4 -5.0 -5032 7.3 ZNF24 GATA3 TCF7L2 ZNF362 MYC CEBPB MAX POLR2A MLLT1 ZNF687 EVI2A ENSG00000265118 EVI2B OMG NF1
GH17J031486 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.5 -177.4 -177369 10.5 ZNF24 ZBTB40 SP1 CTCF ZBTB6 SMARCE1 POLR2A NR2F1 NR2F6 MIXL1 ZNF207 RAB11FIP4 ENSG00000264456 UTP6 SH3GL1P2 RNF135 SUZ12 EVI2B ENSG00000263531 SUZ12P1
GH17J031677 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -364.8 -364812 3.6 ETV6 RELA MLLT1 ZNF687 CREM IKZF1 BACH1 TRIM22 IKZF2 LARP7 MIR193A C17orf75 EVI2A TEFM EVI2B RHOT1 piR-48799-047 lnc-RAB11FIP4-3
GH17J031578 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -266.5 -266506 4.1 MYC NFIB ZNF687 IKZF1 ZIC2 POLR2A IKZF2 CEBPB JUND DPF2 MIR193A RAB11FIP4 EVI2A EVI2B ENSG00000266877 lnc-RAB11FIP4-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVI2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EVI2B gene promoter:
  • AML1a
  • c-Myb
  • Evi-1
  • FOXC1
  • HTF
  • Ik-3
  • Nkx6-1

Genomic Locations for EVI2B Gene

Genomic Locations for EVI2B Gene
chr17:31,302,870-31,314,389
(GRCh38/hg38)
Size:
11,520 bases
Orientation:
Minus strand
chr17:29,630,784-29,641,130
(GRCh37/hg19)
Size:
10,347 bases
Orientation:
Minus strand

Genomic View for EVI2B Gene

Genes around EVI2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVI2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVI2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVI2B Gene

Proteins for EVI2B Gene

  • Protein details for EVI2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34910-EVI2B_HUMAN
    Recommended name:
    Protein EVI2B
    Protein Accession:
    P34910
    Secondary Accessions:
    • B7Z4A7

    Protein attributes for EVI2B Gene

    Size:
    448 amino acids
    Molecular mass:
    48666 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVI2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EVI2B Gene

Post-translational modifications for EVI2B Gene

  • Glycosylation at Asn50 and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for EVI2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVI2B Gene

Domains & Families for EVI2B Gene

Gene Families for EVI2B Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Protein Domains for EVI2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EVI2B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55224, highly similar to EVI2B protein (B7Z4A7_HUMAN)
  • Ecotropic viral integration site 2B, isoform CRA_a (E1P630_HUMAN)
  • Ecotropic viral integration site 2B protein homolog (EVI2B_HUMAN)
  • Ecotropic viral integration site 2B (Q9BRW1_HUMAN)
genes like me logo Genes that share domains with EVI2B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EVI2B Gene

Function for EVI2B Gene

Molecular function for EVI2B Gene

UniProtKB/Swiss-Prot Function:
Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells.
UniProtKB/Swiss-Prot Induction:
Up-regulated by full-length CEBPA.
GENATLAS Biochemistry:
murine myeloid leukemia associated gene (Evi-2) homolog B (embedded in NF1 first intron in opposite orientation),involved in melanocyte and keratinocyte differentiation,same as D17S376

Phenotypes From GWAS Catalog for EVI2B Gene

genes like me logo Genes that share phenotypes with EVI2B: view

Animal Models for EVI2B Gene

MGI Knock Outs for EVI2B:
  • Evi2b Evi2b<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for EVI2B Gene

miRTarBase miRNAs that target EVI2B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EVI2B Gene

Localization for EVI2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVI2B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVI2B gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
cytoskeleton 0
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for EVI2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 1903357
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVI2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EVI2B Gene

Pathways & Interactions for EVI2B Gene

PathCards logo

SuperPathways for EVI2B Gene

No Data Available

Interacting Proteins for EVI2B Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000333779 P34910-EVI2B_HUMAN for EVI2B Gene via STRING IID

Gene Ontology (GO) - Biological Process for EVI2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030854 positive regulation of granulocyte differentiation ISS --
GO:0043066 negative regulation of apoptotic process ISS --
GO:0045660 positive regulation of neutrophil differentiation ISS --
GO:0061515 myeloid cell development ISS --
GO:0071157 negative regulation of cell cycle arrest ISS --
genes like me logo Genes that share ontologies with EVI2B: view

No data available for Pathways by source and SIGNOR curated interactions for EVI2B Gene

Drugs & Compounds for EVI2B Gene

No Compound Related Data Available

Transcripts for EVI2B Gene

mRNA/cDNA for EVI2B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(174) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVI2B Gene

No ASD Table

Relevant External Links for EVI2B Gene

GeneLoc Exon Structure for
EVI2B
ECgene alternative splicing isoforms for
EVI2B

Expression for EVI2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVI2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EVI2B Gene

This gene is overexpressed in Serum (54.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVI2B Gene



Protein tissue co-expression partners for EVI2B Gene

NURSA nuclear receptor signaling pathways regulating expression of EVI2B Gene:

EVI2B

SOURCE GeneReport for Unigene cluster for EVI2B Gene:

Hs.5509

mRNA Expression by UniProt/SwissProt for EVI2B Gene:

P34910-EVI2B_HUMAN
Tissue specificity: Bone marrow, peripheral blood mononuclear cells, fibroblasts and Epstein-Barr virus-transformed lymphoblastoid cell lines. Strongly expressed in granulocytic cells, and weakly on lymphocytes cells.

Evidence on tissue expression from TISSUES for EVI2B Gene

  • Blood(4.8)
  • Bone marrow(4.4)
  • Spleen(2.7)
  • Lung(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with EVI2B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVI2B Gene

Orthologs for EVI2B Gene

This gene was present in the common ancestor of mammals.

Orthologs for EVI2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVI2B 33 32
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EVI2B 33 32
  • 85.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EVI2B 33 32
  • 82.51 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Evi2b 32
  • 73.28 (n)
mouse
(Mus musculus)
Mammalia Evi2a-evi2b 32
  • 72.39 (n)
Evi2b 17 33
  • 57 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia EVI2B 33
  • 40 (a)
OneToOne
Species where no ortholog for EVI2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EVI2B Gene

ENSEMBL:
Gene Tree for EVI2B (if available)
TreeFam:
Gene Tree for EVI2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EVI2B: view image

Paralogs for EVI2B Gene

No data available for Paralogs for EVI2B Gene

Variants for EVI2B Gene

Sequence variations from dbSNP and Humsavar for EVI2B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs9903564 likely-benign, not provided, - 31,305,453(-) C/T coding_sequence_variant, missense_variant
rs115271229 benign, not provided 31,304,852(-) C/A coding_sequence_variant, missense_variant
rs17884293 benign, not provided 31,304,591(-) G/C coding_sequence_variant, missense_variant
rs1000448883 -- 31,304,457(-) C/T coding_sequence_variant, missense_variant
rs1000515480 -- 31,303,556(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EVI2B Gene

Variant ID Type Subtype PubMed ID
dgv5520n54 CNV loss 21841781
esv3326282 CNV insertion 20981092
nsv1061870 CNV loss 25217958
nsv574671 CNV gain 21841781
nsv833413 CNV gain+loss 17160897
nsv953876 CNV duplication 24416366

Variation tolerance for EVI2B Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVI2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVI2B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVI2B Gene

Disorders for EVI2B Gene

Additional Disease Information for EVI2B

No disorders were found for EVI2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVI2B Gene

Publications for EVI2B Gene

  1. cDNA sequence and genomic structure of EV12B, a gene lying within an intron of the neurofibromatosis type 1 gene. (PMID: 1903357) Cawthon RM … Culver M (Genomics 1991) 2 3 4 23 56
  2. EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors. (PMID: 28186500) Zjablovskaja P … Alberich-Jorda M (Cell death and differentiation 2017) 3 4 56
  3. TAGLN expression is upregulated in NF1-associated malignant peripheral nerve sheath tumors by hypomethylation in its promoter and subpromoter regions. (PMID: 25109740) Park GH … Jeong SY (Oncology reports 2014) 3 56
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 56
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L … McKnight A (Retrovirology 2011) 3 56

Products for EVI2B Gene

Sources for EVI2B Gene