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Aliases for EVA1C Gene

Aliases for EVA1C Gene

  • Eva-1 Homolog C 2 3 5
  • Family With Sequence Similarity 176, Member C 2 3
  • Protein FAM176C 3 4
  • C21orf63 3 4
  • C21orf64 3 4
  • FAM176C 3 4
  • SUE21 3 4
  • Chromosome 21 Open Reading Frame 64 2
  • Chromosome 21 Open Reading Frame 63 2
  • Eva-1 Homolog C (C. Elegans) 2
  • Protein Eva-1 Homolog C 3
  • PRED34 3
  • B18 3
  • B19 3

External Ids for EVA1C Gene

Previous HGNC Symbols for EVA1C Gene

  • C21orf64
  • C21orf63
  • FAM176C

Previous GeneCards Identifiers for EVA1C Gene

  • GC21P033786

Summaries for EVA1C Gene

GeneCards Summary for EVA1C Gene

EVA1C (Eva-1 Homolog C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is EVA1B.

UniProtKB/Swiss-Prot for EVA1C Gene

  • Binds heparin.

Additional gene information for EVA1C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1C Gene

Genomics for EVA1C Gene

GeneHancer (GH) Regulatory Elements for EVA1C Gene

Promoters and enhancers for EVA1C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J032410 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 669.3 +1.5 1465 5.4 ATF1 SIN3A FEZF1 ZNF48 ZNF121 GLIS2 KLF7 SP3 REST TSHZ1 EVA1C URB1 SCAF4 MIS18A TCP10L URB1-AS1 ENSG00000252045 SNORA80A CFAP298 IL10RB
GH21J032769 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 46.2 +359.7 359661 3.9 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 PAXBP1 C21orf62-AS1 SON TMEM50B DONSON CFAP298 MIS18A EVA1C URB1 GART
GH21J032492 Enhancer 1.3 Ensembl ENCODE dbSUPER 54 +83.0 82988 4.6 PKNOX1 ZNF493 ZFP64 FEZF1 BATF ZNF48 RFX5 ZNF213 EGR1 ZNF350 PAXBP1 TMEM50B SCAF4 EVA1C URB1 CFAP298 MIS18A C21orf62-AS1 ENSG00000238390 ENSG00000252045
GH21J032611 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.3 +200.8 200755 2.9 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ZFP41 CFAP298 ENSG00000265590 SCAF4 PAXBP1 SON TMEM50B GART MIS18A EVA1C DONSON
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVA1C on UCSC Golden Path with GeneCards custom track

Genomic Locations for EVA1C Gene

Genomic Locations for EVA1C Gene
103,709 bases
Plus strand
103,394 bases
Plus strand

Genomic View for EVA1C Gene

Genes around EVA1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVA1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVA1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1C Gene

Proteins for EVA1C Gene

  • Protein details for EVA1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein eva-1 homolog C
    Protein Accession:
    Secondary Accessions:
    • A6ND58
    • Q8IXZ0

    Protein attributes for EVA1C Gene

    441 amino acids
    Molecular mass:
    49483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for EVA1C Gene


neXtProt entry for EVA1C Gene

Post-translational modifications for EVA1C Gene

  • Glycosylation at Asn165 and isoforms=362
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EVA1C Gene

Domains & Families for EVA1C Gene

Gene Families for EVA1C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EVA1C Gene

Suggested Antigen Peptide Sequences for EVA1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVA1 family.
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1C: view

Function for EVA1C Gene

Molecular function for EVA1C Gene

UniProtKB/Swiss-Prot Function:
Binds heparin.

Phenotypes From GWAS Catalog for EVA1C Gene

Gene Ontology (GO) - Molecular Function for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IMP 19470522
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with EVA1C: view
genes like me logo Genes that share phenotypes with EVA1C: view

Animal Models for EVA1C Gene

MGI Knock Outs for EVA1C:

Animal Model Products

  • Taconic Biosciences Mouse Models for EVA1C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVA1C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EVA1C Gene

Localization for EVA1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1C Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVA1C gene
Compartment Confidence
nucleus 3
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 colocalizes_with extracellular region IDA 19470522
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVA1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EVA1C Gene

Pathways & Interactions for EVA1C Gene

SuperPathways for EVA1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for EVA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with EVA1C: view

No data available for Pathways by source and SIGNOR curated interactions for EVA1C Gene

Drugs & Compounds for EVA1C Gene

No Compound Related Data Available

Transcripts for EVA1C Gene

Unigene Clusters for EVA1C Gene

Eva-1 homolog C (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVA1C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP8: - -
SP9: - - - -

Relevant External Links for EVA1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVA1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVA1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EVA1C Gene

This gene is overexpressed in Gallbladder (40.7) and Prostate (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EVA1C Gene

Protein tissue co-expression partners for EVA1C Gene

NURSA nuclear receptor signaling pathways regulating expression of EVA1C Gene:


SOURCE GeneReport for Unigene cluster for EVA1C Gene:


mRNA Expression by UniProt/SwissProt for EVA1C Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EVA1C Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with EVA1C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVA1C Gene

Orthologs for EVA1C Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EVA1C 34 33
  • 99.4 (n)
(Canis familiaris)
Mammalia EVA1C 34 33
  • 90.33 (n)
(Bos Taurus)
Mammalia EVA1C 34 33
  • 87.91 (n)
(Mus musculus)
Mammalia Eva1c 16 34 33
  • 85.76 (n)
(Rattus norvegicus)
Mammalia Eva1c 33
  • 85.68 (n)
(Monodelphis domestica)
Mammalia EVA1C 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia EVA1C 34
  • 64 (a)
(Gallus gallus)
Aves LOC100857603 33
  • 71.24 (n)
EVA1C 34
  • 61 (a)
(Anolis carolinensis)
Reptilia EVA1C 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1c 33
  • 62.34 (n)
(Danio rerio)
Actinopterygii eva1c 34 33
  • 52.08 (n)
EVA1C (4 of 9) 34
  • 26 (a)
EVA1C (7 of 9) 34
  • 25 (a)
ddx41 34
  • 25 (a)
EVA1C (2 of 9) 34
  • 25 (a)
EVA1C (1 of 9) 34
  • 25 (a)
EVA1C (8 of 9) 34
  • 23 (a)
EVA1C (6 of 9) 34
  • 19 (a)
EVA1C (5 of 9) 34
  • 18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42402 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea eva-1 34
  • 20 (a)
Species where no ortholog for EVA1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1C Gene

Gene Tree for EVA1C (if available)
Gene Tree for EVA1C (if available)
Evolutionary constrained regions (ECRs) for EVA1C: view image

Paralogs for EVA1C Gene

Paralogs for EVA1C Gene

(2) SIMAP similar genes for EVA1C Gene using alignment to 5 proteins:

  • A6ND58_HUMAN
  • B5MC74_HUMAN
  • C9JS02_HUMAN
genes like me logo Genes that share paralogs with EVA1C: view

Variants for EVA1C Gene

Sequence variations from dbSNP and Humsavar for EVA1C Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000012484 -- 32,420,207(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000027786 -- 32,499,484(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000029428 -- 32,488,809(+) C/T intron_variant
rs1000070224 -- 32,473,626(+) C/T intron_variant
rs1000122376 -- 32,432,745(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EVA1C Gene

Variant ID Type Subtype PubMed ID
esv1162904 CNV insertion 17803354
esv1348711 CNV deletion 17803354
esv2670130 CNV deletion 23128226
esv2723343 CNV deletion 23290073
esv2723344 CNV deletion 23290073
esv2723345 CNV deletion 23290073
esv3419325 CNV insertion 20981092
esv3557643 CNV deletion 23714750
esv3646885 CNV gain 21293372
esv3646886 CNV gain 21293372
esv3893405 CNV gain 25118596
nsv1063676 CNV gain 25217958
nsv1066657 CNV gain 25217958
nsv1126606 CNV deletion 24896259
nsv1142327 CNV tandem duplication 24896259
nsv187017 CNV insertion 16902084
nsv187110 CNV deletion 16902084
nsv187413 CNV deletion 16902084
nsv3494 CNV insertion 18451855
nsv834085 CNV gain 17160897
nsv962671 CNV duplication 23825009
nsv962672 CNV duplication 23825009
nsv962673 CNV duplication 23825009
nsv979532 CNV duplication 23825009

Variation tolerance for EVA1C Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 54.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVA1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVA1C Gene

Disorders for EVA1C Gene

Additional Disease Information for EVA1C

No disorders were found for EVA1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVA1C Gene

Publications for EVA1C Gene

  1. Human C21orf63 is a heparin-binding protein. (PMID: 19470522) Mitsunaga K … Angata T (Journal of biochemistry 2009) 2 3 4 58
  2. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A … Antonarakis SE (Genomics 2001) 2 3 4 58
  3. The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. (PMID: 24040182) James G … Beverdam A (PloS one 2013) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for EVA1C Gene

Sources for EVA1C Gene

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