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Aliases for EVA1B Gene

Aliases for EVA1B Gene

  • Eva-1 Homolog B 2 3 5
  • Family With Sequence Similarity 176, Member B 2 3
  • Protein FAM176B 3 4
  • C1orf78 3 4
  • FAM176B 3 4
  • Chromosome 1 Open Reading Frame 78 2
  • Eva-1 Homolog B (C. Elegans) 2
  • Protein Eva-1 Homolog B 3

External Ids for EVA1B Gene

Previous HGNC Symbols for EVA1B Gene

  • C1orf78
  • FAM176B

Previous GeneCards Identifiers for EVA1B Gene

  • GC01M036788

Summaries for EVA1B Gene

GeneCards Summary for EVA1B Gene

EVA1B (Eva-1 Homolog B) is a Protein Coding gene. An important paralog of this gene is EVA1A.

Additional gene information for EVA1B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1B Gene

Genomics for EVA1B Gene

GeneHancer (GH) Regulatory Elements for EVA1B Gene

Promoters and enhancers for EVA1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I036320 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559 +1.4 1443 5.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 CBX5 ZNF143 ENSG00000116883 EVA1B AGO3 GC01P036318 SH3D21
GH01I036384 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37.8 -64.0 -63979 7.8 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF416 ZNF143 SP3 NFYC STK40 EVA1B THRAP3 LOC105378647 TRAPPC3 AGO3 ENSG00000116883 SH3D21 SNORA63C OSCP1
GH01I036154 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 30.5 +167.5 167487 4.5 PKNOX1 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 ZNF143 ZNF548 MAP7D1 TRAPPC3 SFPQ ZMYM4 AGO3 RPL5P4 THRAP3 COL8A2 EVA1B LOC105378647
GH01I035717 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 19.5 +605.6 605577 2 HDGF ARNT SIN3A YY1 ZNF207 SP3 REST SMARCB1 ZNF592 SMARCA4 C1orf216 ZMYM1 ENSG00000230163 LOC653160 SFPQ ZMYM6 LOC105378647 EVA1B RPL5P4 THRAP3
GH01I036266 Enhancer 0.9 dbSUPER 30.6 +57.5 57514 0.8 ZNF493 ZNF529 ZFP64 MZF1 ZEB1 ZNF121 ZNF23 ZNF213 ZNF302 ZNF354C ZMYM4 AGO3 RPL5P4 THRAP3 COL8A2 EVA1B LOC105378647 TRAPPC3 AGO4 UBE2V2P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EVA1B on UCSC Golden Path with GeneCards custom track

Genomic Locations for EVA1B Gene

Genomic Locations for EVA1B Gene
chr1:36,322,030-36,324,154
(GRCh38/hg38)
Size:
2,125 bases
Orientation:
Minus strand
chr1:36,787,632-36,789,755
(GRCh37/hg19)

Genomic View for EVA1B Gene

Genes around EVA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1B Gene

Proteins for EVA1B Gene

  • Protein details for EVA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVM1-EVA1B_HUMAN
    Recommended name:
    Protein eva-1 homolog B
    Protein Accession:
    Q9NVM1
    Secondary Accessions:
    • D3DPS7

    Protein attributes for EVA1B Gene

    Size:
    165 amino acids
    Molecular mass:
    18374 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVA1B Gene

Post-translational modifications for EVA1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EVA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EVA1B Gene

Domains & Families for EVA1B Gene

Gene Families for EVA1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EVA1B Gene

ProtoNet:

Suggested Antigen Peptide Sequences for EVA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVM1

UniProtKB/Swiss-Prot:

EVA1B_HUMAN :
  • Belongs to the EVA1 family.
Family:
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1B: view

Function for EVA1B Gene

Phenotypes From GWAS Catalog for EVA1B Gene

Gene Ontology (GO) - Molecular Function for EVA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with EVA1B: view
genes like me logo Genes that share phenotypes with EVA1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EVA1B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for EVA1B Gene

Localization for EVA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVA1B gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EVA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EVA1B: view

Pathways & Interactions for EVA1B Gene

SuperPathways for EVA1B Gene

No Data Available

Interacting Proteins for EVA1B Gene

Selected Interacting proteins: Q9NVM1-EVA1B_HUMAN for EVA1B Gene via IID UniProtKB

Symbol External ID(s) Details
SGTA

Gene Ontology (GO) - Biological Process for EVA1B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for EVA1B Gene

Drugs & Compounds for EVA1B Gene

No Compound Related Data Available

Transcripts for EVA1B Gene

mRNA/cDNA for EVA1B Gene

Unigene Clusters for EVA1B Gene

Eva-1 homolog B (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1B Gene

No ASD Table

Relevant External Links for EVA1B Gene

GeneLoc Exon Structure for
EVA1B
ECgene alternative splicing isoforms for
EVA1B

Expression for EVA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVA1B Gene

Protein differential expression in normal tissues from HIPED for EVA1B Gene

This gene is overexpressed in Adrenal (29.4) and Gallbladder (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVA1B Gene



NURSA nuclear receptor signaling pathways regulating expression of EVA1B Gene:

EVA1B

SOURCE GeneReport for Unigene cluster for EVA1B Gene:

Hs.87016

Evidence on tissue expression from TISSUES for EVA1B Gene

  • Liver(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with EVA1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EVA1B Gene

Orthologs for EVA1B Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EVA1B 33 34
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia EVA1B 33 34
  • 91.72 (n)
dog
(Canis familiaris)
Mammalia EVA1B 33 34
  • 91.72 (n)
mouse
(Mus musculus)
Mammalia Eva1b 33 16 34
  • 86.71 (n)
rat
(Rattus norvegicus)
Mammalia Eva1b 33
  • 79.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia EVA1B 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves EVA1B 33 34
  • 70.56 (n)
lizard
(Anolis carolinensis)
Reptilia EVA1B 34
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii eva1ba 33
  • 61.29 (n)
eva1bb 34
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42402 34
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eva-1 34
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
ManyToMany
Species where no ortholog for EVA1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for EVA1B Gene

ENSEMBL:
Gene Tree for EVA1B (if available)
TreeFam:
Gene Tree for EVA1B (if available)

Paralogs for EVA1B Gene

Paralogs for EVA1B Gene

(1) SIMAP similar genes for EVA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EVA1B: view

Variants for EVA1B Gene

Sequence variations from dbSNP and Humsavar for EVA1B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000297447 -- 36,322,118(-) C/G/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000965000 -- 36,322,797(-) A/G intron_variant
rs1001333537 -- 36,323,084(-) G/A 5_prime_UTR_variant, intron_variant
rs1002037077 -- 36,322,744(-) G/A/T intron_variant
rs1003347480 -- 36,325,535(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for EVA1B Gene

Variant ID Type Subtype PubMed ID
esv2758931 CNV loss 17122850
nsv444 CNV deletion 18451855
nsv524394 CNV loss 19592680
nsv545997 CNV loss 21841781
nsv834702 CNV loss 17160897

Variation tolerance for EVA1B Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVA1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EVA1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVA1B Gene

Disorders for EVA1B Gene

Additional Disease Information for EVA1B

No disorders were found for EVA1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVA1B Gene

Publications for EVA1B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for EVA1B Gene

Sources for EVA1B Gene

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