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Aliases for EVA1A Gene

Aliases for EVA1A Gene

  • Eva-1 Homolog A, Regulator Of Programmed Cell Death 2 3 5
  • Transmembrane Protein 166 2 3 4
  • Family With Sequence Similarity 176, Member A 2 3
  • Protein FAM176A 3 4
  • FAM176A 3 4
  • TMEM166 3 4
  • Eva-1 Homolog A (C. Elegans) 2
  • Protein Eva-1 Homolog A 3

External Ids for EVA1A Gene

Previous HGNC Symbols for EVA1A Gene

  • TMEM166
  • FAM176A

Previous GeneCards Identifiers for EVA1A Gene

  • GC02M075697

Summaries for EVA1A Gene

GeneCards Summary for EVA1A Gene

EVA1A (Eva-1 Homolog A, Regulator Of Programmed Cell Death) is a Protein Coding gene. An important paralog of this gene is EVA1B.

UniProtKB/Swiss-Prot for EVA1A Gene

  • Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

Additional gene information for EVA1A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EVA1A Gene

Genomics for EVA1A Gene

GeneHancer (GH) Regulatory Elements for EVA1A Gene

Promoters and enhancers for EVA1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J075559 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 655.8 +8.7 8721 3.9 MLX ARID4B DMAP1 ZNF48 GLIS2 NFKBIZ PAF1 SP3 SP5 JUNB EVA1A ENSG00000270696 MRPL19 LOC101927884
GH02J075645 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.2 -77.3 -77294 2.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B MRPL19 EVA1A GC02M075653
GH02J075594 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 672.3 -26.5 -26456 3.4 SP1 JUND FOSL2 ZNF384 MAFK EVA1A ENSG00000230477 ENSG00000221638 GC02M075596
GH02J075604 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 16.4 -37.3 -37309 5.5 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 ZNF548 RUNX3 ZHX2 REST EVA1A ENSG00000221638 MRPL19 TACR1 GCFC2 GC02M075596
GH02J075599 Enhancer 1 Ensembl ENCODE dbSUPER 17.6 -32.0 -32001 4.3 SMARCC1 ZFP64 CEBPB JUND FOS NR2F6 FOSL2 FOXP2 GC02M075596 EVA1A MRPL19 ENSG00000221638 GCFC2 ENSG00000270696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EVA1A on UCSC Golden Path with GeneCards custom track

Genomic Locations for EVA1A Gene

Genomic Locations for EVA1A Gene
100,421 bases
Minus strand
100,421 bases
Minus strand

Genomic View for EVA1A Gene

Genes around EVA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EVA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EVA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EVA1A Gene

Proteins for EVA1A Gene

  • Protein details for EVA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein eva-1 homolog A
    Protein Accession:
    Secondary Accessions:
    • D6W5J3
    • Q9HC41

    Protein attributes for EVA1A Gene

    152 amino acids
    Molecular mass:
    17470 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EVA1A Gene

Post-translational modifications for EVA1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for EVA1A Gene

Domains & Families for EVA1A Gene

Gene Families for EVA1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for EVA1A Gene


Suggested Antigen Peptide Sequences for EVA1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the EVA1 family.
  • Belongs to the EVA1 family.
genes like me logo Genes that share domains with EVA1A: view

Function for EVA1A Gene

Molecular function for EVA1A Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.

Phenotypes From GWAS Catalog for EVA1A Gene

genes like me logo Genes that share phenotypes with EVA1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for EVA1A

CRISPR Products

miRNA for EVA1A Gene

miRTarBase miRNAs that target EVA1A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVA1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EVA1A Gene

Localization for EVA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EVA1A Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EVA1A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 4
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EVA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with EVA1A: view

Pathways & Interactions for EVA1A Gene

SuperPathways for EVA1A Gene

No Data Available

Interacting Proteins for EVA1A Gene

Gene Ontology (GO) - Biological Process for EVA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with EVA1A: view

No data available for Pathways by source and SIGNOR curated interactions for EVA1A Gene

Drugs & Compounds for EVA1A Gene

No Compound Related Data Available

Transcripts for EVA1A Gene

mRNA/cDNA for EVA1A Gene

Unigene Clusters for EVA1A Gene

Eva-1 homolog A (C. elegans):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EVA1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EVA1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: -

Relevant External Links for EVA1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EVA1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EVA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EVA1A Gene

This gene is overexpressed in Liver (x20.0), Pancreas (x6.1), and Kidney - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for EVA1A Gene

This gene is overexpressed in Bone (54.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EVA1A Gene

Protein tissue co-expression partners for EVA1A Gene

NURSA nuclear receptor signaling pathways regulating expression of EVA1A Gene:


SOURCE GeneReport for Unigene cluster for EVA1A Gene:


mRNA Expression by UniProt/SwissProt for EVA1A Gene:

Tissue specificity: Expressed in lung, kidney, liver, pancreas, placenta, but not in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for EVA1A Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with EVA1A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EVA1A Gene

Orthologs for EVA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for EVA1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM166 34
  • 100 (a)
FAM176A 33
  • 99.12 (n)
(Canis familiaris)
Mammalia EVA1A 34
  • 92 (a)
FAM176A 33
  • 88.97 (n)
(Rattus norvegicus)
Mammalia Eva1a 33
  • 84.35 (n)
(Bos Taurus)
Mammalia LOC528994 33
  • 84.28 (n)
(Mus musculus)
Mammalia Eva1a 16 34 33
  • 81.46 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
(Gallus gallus)
Aves -- 34
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eva1a 33
  • 70.74 (n)
(Danio rerio)
Actinopterygii LOC100331241 33
  • 67.39 (n)
eva1ba 34
  • 44 (a)
si:ch211-66i15.5 34
fruit fly
(Drosophila melanogaster)
Insecta CG42402 34
  • 3 (a)
(Caenorhabditis elegans)
Secernentea eva-1 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
Species where no ortholog for EVA1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EVA1A Gene

Gene Tree for EVA1A (if available)
Gene Tree for EVA1A (if available)
Evolutionary constrained regions (ECRs) for EVA1A: view image

Paralogs for EVA1A Gene

Paralogs for EVA1A Gene

(1) SIMAP similar genes for EVA1A Gene using alignment to 4 proteins:

  • C9J5M4_HUMAN
  • C9JX09_HUMAN
genes like me logo Genes that share paralogs with EVA1A: view

Variants for EVA1A Gene

Sequence variations from dbSNP and Humsavar for EVA1A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000005417 -- 75,540,810(-) T/C intron_variant
rs1000078635 -- 75,552,946(-) A/T intron_variant
rs1000103183 -- 75,492,803(-) T/C 3_prime_UTR_variant
rs1000140244 -- 75,569,401(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000142590 -- 75,517,455(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EVA1A Gene

Variant ID Type Subtype PubMed ID
esv24046 CNV gain 19812545
esv2759063 CNV gain+loss 17122850
esv3302671 CNV tandem duplication 20981092
esv3359790 CNV duplication 20981092
esv3361297 CNV duplication 20981092
esv3365774 CNV duplication 20981092
esv3441641 CNV duplication 20981092
esv3591301 CNV gain 21293372
nsv441761 CNV gain 18776908
nsv458219 CNV gain 19166990
nsv470470 CNV gain 18288195
nsv474300 CNV novel sequence insertion 20440878
nsv582221 CNV gain 21841781
nsv818051 CNV gain 17921354
nsv997939 CNV gain 25217958

Variation tolerance for EVA1A Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EVA1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EVA1A Gene

Disorders for EVA1A Gene

Additional Disease Information for EVA1A

No disorders were found for EVA1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EVA1A Gene

Publications for EVA1A Gene

  1. CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. (PMID: 25363290) Lu GD … Hooi SC (Hepatology (Baltimore, Md.) 2015) 2 3 58
  2. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. (PMID: 22227058) Li L … Zhou C (Experimental neurology 2012) 2 3 58
  3. TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis. (PMID: 17492404) Wang L … Chen Y (Apoptosis : an international journal on programmed cell death 2007) 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for EVA1A Gene

Sources for EVA1A Gene

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