Aliases for ETV3L Gene

Aliases for ETV3L Gene

  • ETS Variant Transcription Factor 3 Like 2 3
  • ETS Variant 3 Like 2 3 5
  • ETS Translocation Variant 3-Like Protein 3 4
  • Ets Variant Gene 3-Like 2 3
  • Ets Variant 3-Like 3

External Ids for ETV3L Gene

Previous GeneCards Identifiers for ETV3L Gene

  • GC01M155330
  • GC01M157061
  • GC01M128420

Summaries for ETV3L Gene

GeneCards Summary for ETV3L Gene

ETV3L (ETS Variant Transcription Factor 3 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ETV3.

UniProtKB/Swiss-Prot Summary for ETV3L Gene

Additional gene information for ETV3L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ETV3L Gene

Genomics for ETV3L Gene

GeneHancer (GH) Regulatory Elements for ETV3L Gene

Promoters and enhancers for ETV3L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J157112 Enhancer 0.4 FANTOM5 500.7 -0.7 -651 0.4 KDM1A ETV3L ETV3 RRNAD1 lnc-LRRC71-3 CYCSP52
GH01J157113 Enhancer 0.2 ENCODE 500.7 -1.4 -1412 0.2 ETV3L CYCSP52 lnc-LRRC71-3
GH01J157131 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -23.1 -23148 8.9 ZBTB40 ZNF217 EP300 NRF1 POLR2G GTF2E2 PHF8 FOS ZFX ZNF10 ETV3 ETV3L RRNAD1 CYCSP52 lnc-LRRC71-3
GH01J157153 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.1 -42.4 -42436 2.9 ZNF217 CTCF USF1 TEAD4 ZNF639 ZIC2 ZBTB10 TARDBP REST RAD21 ETV3 ETV3L RRNAD1 HSALNG0007659 ENSG00000229961
GH01J157147 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 -34.7 -34689 4.6 FOS ZNF316 ARNT ZNF592 MEF2B PBX2 SPI1 NFE2 FOSL1 EHMT2 HSALNG0007659 ETV3L ENSG00000229961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ETV3L on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ETV3L

Top Transcription factor binding sites by QIAGEN in the ETV3L gene promoter:
  • AML1a
  • COMP1
  • GATA-1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for ETV3L Gene

Genomic Locations for ETV3L Gene
chr1:157,092,043-157,112,412
(GRCh38/hg38)
Size:
20,370 bases
Orientation:
Minus strand
chr1:157,061,835-157,069,600
(GRCh37/hg19)
Size:
7,766 bases
Orientation:
Minus strand

Genomic View for ETV3L Gene

Genes around ETV3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3L Gene

Proteins for ETV3L Gene

  • Protein details for ETV3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN32-ETV3L_HUMAN
    Recommended name:
    ETS translocation variant 3-like protein
    Protein Accession:
    Q6ZN32

    Protein attributes for ETV3L Gene

    Size:
    361 amino acids
    Molecular mass:
    39948 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ETV3L Gene

Post-translational modifications for ETV3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETV3L Gene

No data available for DME Specific Peptides for ETV3L Gene

Domains & Families for ETV3L Gene

Gene Families for ETV3L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV3L Gene

Suggested Antigen Peptide Sequences for ETV3L Gene

GenScript: Design optimal peptide antigens:
  • ETS translocation variant 3-like protein (ETV3L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZN32

UniProtKB/Swiss-Prot:

ETV3L_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3L: view

Function for ETV3L Gene

Molecular function for ETV3L Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator.

Phenotypes From GWAS Catalog for ETV3L Gene

Gene Ontology (GO) - Molecular Function for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3L: view
genes like me logo Genes that share phenotypes with ETV3L: view

Animal Model Products

Clone Products

  • Addgene plasmids for ETV3L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ETV3L Gene

Localization for ETV3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV3L gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ETV3L Gene

Pathways & Interactions for ETV3L Gene

PathCards logo

SuperPathways for ETV3L Gene

No Data Available

Interacting Proteins for ETV3L Gene

;

Gene Ontology (GO) - Biological Process for ETV3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0030154 cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with ETV3L: view

No data available for Pathways by source and SIGNOR curated interactions for ETV3L Gene

Drugs & Compounds for ETV3L Gene

No Compound Related Data Available

Transcripts for ETV3L Gene

mRNA/cDNA for ETV3L Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for ETV3L

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3L Gene

No ASD Table

Relevant External Links for ETV3L Gene

GeneLoc Exon Structure for
ETV3L

Expression for ETV3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ETV3L Gene

mRNA differential expression in normal tissues according to GTEx for ETV3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ETV3L

SOURCE GeneReport for Unigene cluster for ETV3L Gene:

Hs.127138

Evidence on tissue expression from TISSUES for ETV3L Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ETV3L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV3L Gene

Orthologs for ETV3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3L 31 30
  • 99.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv3l 30
  • 83.25 (n)
cow
(Bos Taurus)
Mammalia ETV3L 31 30
  • 83.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3L 31 30
  • 81.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Etv3l 17 30
  • 75.73 (n)
chicken
(Gallus gallus)
Aves ETV3L 31
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3L 31
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii erfl3 31
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for ETV3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3L Gene

ENSEMBL:
Gene Tree for ETV3L (if available)
TreeFam:
Gene Tree for ETV3L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ETV3L: view image

Paralogs for ETV3L Gene

(4) SIMAP similar genes for ETV3L Gene using alignment to 1 proteins:

  • ETV3L_HUMAN
genes like me logo Genes that share paralogs with ETV3L: view

Variants for ETV3L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ETV3L Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
734580 Likely Benign: not provided 157,097,868(-) G/A NONSENSE
767711 Benign: not provided 157,098,803(-) G/C MISSENSE_VARIANT
775611 Benign: not provided 157,099,176(-) T/C SYNONYMOUS_VARIANT
782231 Benign: not provided 157,092,839(-) C/T MISSENSE_VARIANT
791815 Benign: not provided 157,098,880(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ETV3L Gene

Variation tolerance for ETV3L Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.79; 83.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ETV3L Gene

Human Gene Mutation Database (HGMD)
ETV3L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV3L

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ETV3L Gene

Disorders for ETV3L Gene

Additional Disease Information for ETV3L

No disorders were found for ETV3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ETV3L Gene

Publications for ETV3L Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54

Products for ETV3L Gene

Sources for ETV3L Gene