Aliases for ETV3 Gene

Aliases for ETV3 Gene

  • ETS Variant Transcription Factor 3 2 3
  • ETS Variant 3 2 3 5
  • Ets Variant Gene 3, ETS Family Transcriptional Repressor 2 3
  • Mitogenic Ets Transcriptional Suppressor 3 4
  • ETS Domain Transcriptional Repressor PE1 3 4
  • ETS Translocation Variant 3 3 4
  • METS 3 4
  • PE-1 3 4
  • PE1 3 4

External Ids for ETV3 Gene

Previous GeneCards Identifiers for ETV3 Gene

  • GC01M154963
  • GC01M152859
  • GC01M153872
  • GC01M154311
  • GC01M153907
  • GC01M155357
  • GC01M157090
  • GC01M128452

Summaries for ETV3 Gene

GeneCards Summary for ETV3 Gene

ETV3 (ETS Variant Transcription Factor 3) is a Protein Coding gene. Diseases associated with ETV3 include Dendritic Cell Tumor and Polyneuropathy Due To Drug. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is ERF.

UniProtKB/Swiss-Prot Summary for ETV3 Gene

  • Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.

Additional gene information for ETV3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ETV3 Gene

Genomics for ETV3 Gene

GeneHancer (GH) Regulatory Elements for ETV3 Gene

Promoters and enhancers for ETV3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J157131 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 533.1 +3.0 3031 8.9 ZBTB40 ZNF217 EP300 NRF1 POLR2G GTF2E2 PHF8 FOS ZFX ZNF10 ETV3 ETV3L RRNAD1 CYCSP52 lnc-LRRC71-3
GH01J157105 Enhancer 1.1 FANTOM5 ENCODE 31 +32.0 31969 1.8 RXRA SP1 FOS EP300 RELA RCOR1 BCL11A TCF12 CREB1 CREB3L1 ETV3 BGLAP ARHGEF11 RRNAD1 ETV3L HSALNG0007655
GH01J157153 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 20.8 -16.3 -16257 2.9 ZNF217 CTCF USF1 TEAD4 ZNF639 ZIC2 ZBTB10 TARDBP REST RAD21 ETV3 ETV3L RRNAD1 HSALNG0007659 ENSG00000229961
GH01J156740 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +391.8 391761 13.7 RXRA FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 HDGF MRPL24 GON4L RRNAD1 KHDC4 ENSG00000237842 SSR2 CCT3 GLMP SYT11
GH01J157142 Enhancer 0.7 FANTOM5 dbSUPER 23.1 -3.8 -3789 0.3 SPI1 IKZF1 IKZF2 PKNOX1 EED DPF2 ETV3 ETV3L RRNAD1 HSALNG0007659
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ETV3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ETV3

Top Transcription factor binding sites by QIAGEN in the ETV3 gene promoter:
  • AML1a
  • STAT3

Genomic Locations for ETV3 Gene

Genomic Locations for ETV3 Gene
chr1:157,121,191-157,138,591
(GRCh38/hg38)
Size:
17,401 bases
Orientation:
Minus strand
chr1:157,090,983-157,108,383
(GRCh37/hg19)
Size:
17,401 bases
Orientation:
Minus strand

Genomic View for ETV3 Gene

Genes around ETV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETV3 Gene

Proteins for ETV3 Gene

  • Protein details for ETV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41162-ETV3_HUMAN
    Recommended name:
    ETS translocation variant 3
    Protein Accession:
    P41162
    Secondary Accessions:
    • B4E3M7
    • Q8TAC8
    • Q9BX30

    Protein attributes for ETV3 Gene

    Size:
    512 amino acids
    Molecular mass:
    57001 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60949.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for ETV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ETV3 Gene

Post-translational modifications for ETV3 Gene

  • Ubiquitination at Lys224
  • Modification sites at PhosphoSitePlus

Other Protein References for ETV3 Gene

No data available for DME Specific Peptides for ETV3 Gene

Domains & Families for ETV3 Gene

Gene Families for ETV3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ETV3 Gene

Suggested Antigen Peptide Sequences for ETV3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79173, highly similar to ETS translocation variant 3 (B4E3M7_HUMAN)
  • Mitogenic Ets transcriptional suppressor (ETV3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41162

UniProtKB/Swiss-Prot:

ETV3_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETV3: view

Function for ETV3 Gene

Molecular function for ETV3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
GENATLAS Biochemistry:
ETS variant gene 3,expressed in numerous cell lines,divergent member of the winged helix-turn-helix superfamily

Phenotypes From GWAS Catalog for ETV3 Gene

Gene Ontology (GO) - Molecular Function for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ETV3: view
genes like me logo Genes that share phenotypes with ETV3: view

Animal Model Products

CRISPR Products

miRNA for ETV3 Gene

miRTarBase miRNAs that target ETV3

Clone Products

  • Addgene plasmids for ETV3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ETV3 Gene

Localization for ETV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETV3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETV3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0017053 transcriptional repressor complex IEA --
GO:0090571 RNA polymerase II transcription repressor complex IEA --
genes like me logo Genes that share ontologies with ETV3: view

Pathways & Interactions for ETV3 Gene

PathCards logo

SuperPathways for ETV3 Gene

SuperPathway Contained pathways
1 Macrophage Differentiation and Growth Inhibition by METS
.30
genes like me logo Genes that share pathways with ETV3: view

Pathways by source for ETV3 Gene

1 Qiagen pathway for ETV3 Gene
  • Macrophage Differentiation and Growth Inhibition by METS

Gene Ontology (GO) - Biological Process for ETV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0008150 biological_process ND --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with ETV3: view

No data available for SIGNOR curated interactions for ETV3 Gene

Drugs & Compounds for ETV3 Gene

No Compound Related Data Available

Transcripts for ETV3 Gene

mRNA/cDNA for ETV3 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ETV3

Alternative Splicing Database (ASD) splice patterns (SP) for ETV3 Gene

No ASD Table

Relevant External Links for ETV3 Gene

GeneLoc Exon Structure for
ETV3

Expression for ETV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ETV3 Gene

Protein differential expression in normal tissues from HIPED for ETV3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (41.3), CD8 Tcells (12.1), and Skin (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ETV3 Gene



Protein tissue co-expression partners for ETV3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ETV3

SOURCE GeneReport for Unigene cluster for ETV3 Gene:

Hs.105636

Evidence on tissue expression from TISSUES for ETV3 Gene

  • Nervous system(4.4)
  • Bone marrow(4.2)
  • Heart(3.4)
  • Muscle(2.7)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with ETV3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETV3 Gene

Orthologs for ETV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ETV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETV3 31 30
  • 99.67 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ETV3 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ETV3 31 30
  • 90.96 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ETV3 31 30
  • 90.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Etv3 30
  • 86.86 (n)
mouse
(Mus musculus)
Mammalia Etv3 17 31 30
  • 85.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ETV3 31
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ETV3 31 30
  • 74.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETV3 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia etv3 30
  • 66.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32326 30
zebrafish
(Danio rerio)
Actinopterygii si:ch211-265g22.4 31
  • 40 (a)
ManyToMany
erf 31
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 36 (a)
OneToMany
Cin.5256 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5256 30
Species where no ortholog for ETV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETV3 Gene

ENSEMBL:
Gene Tree for ETV3 (if available)
TreeFam:
Gene Tree for ETV3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ETV3: view image

Paralogs for ETV3 Gene

(2) SIMAP similar genes for ETV3 Gene using alignment to 1 proteins:

  • ETV3_HUMAN
genes like me logo Genes that share paralogs with ETV3: view

Variants for ETV3 Gene

Additional dbSNP identifiers (rs#s) for ETV3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ETV3 Gene

Variant ID Type Subtype PubMed ID
esv2718474 CNV deletion 23290073
nsv3121 CNV deletion 18451855
nsv946427 CNV duplication 23825009

Variation tolerance for ETV3 Gene

Gene Damage Index Score: 0.74; 15.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ETV3 Gene

Human Gene Mutation Database (HGMD)
ETV3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETV3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ETV3 Gene

Disorders for ETV3 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ETV3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dendritic cell tumor
  • dendritic cell sarcoma, not otherwise specified
polyneuropathy due to drug
malt worker's lung
  • alveolitis due to aspergillus clavatus
coronary artery anomaly
  • coronary heart disease
left bundle branch hemiblock
  • left bundle branch block
- elite association - COSMIC cancer census association via MalaCards
Search ETV3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ETV3

genes like me logo Genes that share disorders with ETV3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETV3 Gene

Publications for ETV3 Gene

  1. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. (PMID: 8020980) Klemsz M … Hoffman R (Genomics 1994) 2 3 4 54
  2. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41 54
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. (PMID: 12007404) Klappacher GW … Glass CK (Cell 2002) 3 4 54

Products for ETV3 Gene

Sources for ETV3 Gene