Aliases for ETS2 Gene
- ETS Proto-Oncogene 2, Transcription Factor 2 3 5
- V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 2 3
- Protein C-Ets-2 3 4
- V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) 2
- V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2 3
- V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 3
- Oncogene ETS-2 3
- ETS2IT1 3
External Ids for ETS2 Gene
Previous GeneCards Identifiers for ETS2 Gene
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for ETS2 Gene
ETS2 (ETS Proto-Oncogene 2, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS2 include Choriocarcinoma and Down Syndrome. Among its related pathways are Cellular Senescence (REACTOME) and Macrophage Differentiation and Growth Inhibition by METS. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ETS1.
UniProtKB/Swiss-Prot Summary for ETS2 Gene
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.