Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] See more...
Aliases for ETS2 Gene
Aliases for ETS2 Gene
- ETS Proto-Oncogene 2, Transcription Factor 2 3 5
- V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 2 3
- Protein C-Ets-2 3 4
- V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) 2
- V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2 3
- V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 3
- Oncogene ETS-2 3
- ETS2IT1 3
- ETS2 5
External Ids for ETS2 Gene
- HGNC: 3489
- Entrez Gene: 2114
- Ensembl: ENSG00000157557
- OMIM: 164740
- UniProtKB: P15036
Previous GeneCards Identifiers for ETS2 Gene
- GC21P036755
- GC21P039097
- GC21P039098
- GC21P039099
- GC21P040177
- GC21P025647
Summaries for ETS2 Gene
-
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for ETS2 Gene
ETS2 (ETS Proto-Oncogene 2, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS2 include Choriocarcinoma and Down Syndrome. Among its related pathways are C-MYB transcription factor network and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ETS1.
UniProtKB/Swiss-Prot Summary for ETS2 Gene
-
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
Additional gene information for ETS2 Gene
- HGNC(3489)
- Entrez Gene(2114)
- Ensembl(ENSG00000157557)
- OMIM(164740)
- UniProtKB(P15036)
- Open Targets Platform(ENSG00000157557)
- Monarch Initiative
- Search for ETS2 at DataMed
- Search for ETS2 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ETS2 Gene
Genomics for ETS2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ETS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ETS2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ETS2
- Top Transcription factor binding sites by QIAGEN in the ETS2 gene promoter:
-
- C/EBPbeta
- CREB
- deltaCREB
- GATA-1
- GR
- GR-alpha
- GR-beta
- p53
Genomic Locations for ETS2 Gene
Genomic Locations for ETS2 Gene
- chr21:38,805,183-38,824,955
- (GRCh38/hg38)
- Size:
- 19,773 bases
- Orientation:
- Plus strand
- chr21:40,177,231-40,196,879
- (GRCh37/hg19)
- Size:
- 19,649 bases
- Orientation:
- Plus strand
Genomic View for ETS2 Gene
Genes around ETS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.2 by HGNC
- 21q22.2 by Entrez Gene
- 21q22.2 by Ensembl
ETS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ETS2 Gene
Proteins for ETS2 Gene
-
Protein details for ETS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15036-ETS2_HUMAN
- Recommended name:
- Protein C-ets-2
- Protein Accession:
- P15036
- A6NM68
- D3DSH6
- Q53Y89
Protein attributes for ETS2 Gene
- Size:
- 469 amino acids
- Molecular mass:
- 53001 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ETS2 Gene
- Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ETS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ETS2 Antibody
- GeneTex Anti-ETS2 antibody and Anti-ETS2.3 antibody
- BioLegend ETS2 Antibody
- Novus Biologicals Antibodies for ETS2
-
Abcam antibodies for ETS2
- Invitrogen Antibodies for ETS2 (AFLGC-ETS2)
-
Boster Bio Antibodies for ETS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ETS2
Protein Products
-
OriGene Purified Proteins for ETS2
- Search Origene for MassSpec and Protein Over-expression Lysates for ETS2
- Origene Custom Protein Services for ETS2
- ProSpec Recombinant Proteins for ETS2
-
Signalway Proteins for ETS2
-
Abcam proteins for ETS2
Assay Products
- antibodies-online: Show 6 available ETS2 Elisa Kits ranked by validation data
- Compare Top ETS2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ETS2 Gene
Domains & Families for ETS2 Gene
Gene Families for ETS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ETS2 Gene
- InterPro:
- Blocks:
-
- Sterile alpha motif (SAM)/Pointed domain
- ProtoNet:
Suggested Antigen Peptide Sequences for ETS2 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein C-ets-2 (ETS2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15036- Family:
-
- Belongs to the ETS family.
Function for ETS2 Gene
Molecular function for ETS2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
- GENATLAS Biochemistry:
- avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1 (MMP8) promoters,likely involved in skeletal development,required to maintain the transformed state of human prostate cancer cells
Phenotypes From GWAS Catalog for ETS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12637547 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 12637547 |
| GO:0003677 | DNA binding | TAS | 10918595 |
Phenotypes for ETS2 Gene
- MGI mutant phenotypes for ETS2:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for ETS2:
Animal Models for ETS2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ETS2 - Select products 50% OFF >
- * ETS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ETS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETS2
miRNA for ETS2 Gene
- miRTarBase miRNAs that target ETS2
-
- hsa-miR-199a-3p (MIRT000775)
- hsa-miR-199a-5p (MIRT004398)
- mmu-miR-320-3p (MIRT006295)
- hsa-miR-218-5p (MIRT024245)
- hsa-miR-877-5p (MIRT037225)
- hsa-miR-149-5p (MIRT045544)
- hsa-miR-18a-5p (MIRT050649)
- hsa-miR-196b-5p (MIRT053485)
- hsa-miR-455-5p (MIRT085400)
- hsa-miR-548t-3p (MIRT085401)
- hsa-miR-3646 (MIRT085403)
- hsa-miR-3662 (MIRT085404)
- hsa-miR-548aa (MIRT085405)
- hsa-miR-548ap-3p (MIRT085407)
- hsa-miR-548as-3p (MIRT085408)
- hsa-miR-548at-3p (MIRT085409)
- hsa-miR-548ay-3p (MIRT085410)
- hsa-miR-587 (MIRT254144)
- hsa-miR-1468-3p (MIRT254145)
- hsa-miR-548f-5p (MIRT254147)
- hsa-miR-548g-5p (MIRT254148)
- hsa-miR-548x-5p (MIRT254149)
- hsa-miR-548aj-5p (MIRT254150)
- hsa-miR-548aw (MIRT254152)
- hsa-miR-410-3p (MIRT298547)
- hsa-miR-582-5p (MIRT298548)
- hsa-miR-944 (MIRT298550)
- hsa-miR-607 (MIRT563635)
- hsa-miR-3671 (MIRT563636)
- hsa-miR-190a-3p (MIRT563637)
- hsa-miR-205-3p (MIRT563638)
- hsa-miR-338-5p (MIRT563639)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS2
- Browse OriGene Inhibitory RNA Products For ETS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS2
Clone Products
- Applied Biological Materials (abm): Clones for ETS2 - Select products 50% OFF >
- * ETS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ETS2
- Addgene plasmids for ETS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS2
Cell Line Products
-
Horizon Cell Lines for ETS2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETS2 Gene
Localization for ETS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ETS2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 4 |
| cytosol | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Cytosol (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for ETS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | Human T-cell leukemia virus 1 infection | ||
| 3 | Ras signaling pathway | ||
| 4 | MAPK Erk Pathway |
.32
|
|
| 5 | ERK Signaling |
ERK Signaling
.61
|
|
Pathways by source for ETS2 Gene
1 Sino Biological pathway for ETS2 Gene
2 BioSystems pathways for ETS2 Gene
3 Reactome pathways for ETS2 Gene
2 KEGG pathways for ETS2 Gene
6 Qiagen pathways for ETS2 Gene
- ERK Signaling
- HGF Pathway
- Macrophage Differentiation and Growth Inhibition by METS
- MIF Action Through Endocytic Pathway
- Nur77-Induced AICD in Macrophage
Interacting Proteins for ETS2 Gene
Selected Interacting proteins:
P15036-ETS2_HUMAN
ENSP00000353344
for ETS2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ETS2
SIGNOR curated interactions for ETS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 12637547 |
| GO:0001501 | skeletal system development | TAS | 8596630 |
| GO:0001712 | ectodermal cell fate commitment | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
Drugs & Compounds for ETS2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ETS2 Gene
mRNA/cDNA for ETS2 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360214 4060 nts (view in UCSC)
- ENST00000360938 3668 nts (view in UCSC)
- ENST00000432278 1033 nts (view in UCSC)
- ENST00000456966 972 nts (view in UCSC)
- ENST00000653642 3619 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ETS2 - Select products 50% OFF >
- * ETS2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ETS2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETS2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS2
- Browse OriGene Inhibitory RNA Products For ETS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS2
Clone Products
- Applied Biological Materials (abm): Clones for ETS2 - Select products 50% OFF >
- * ETS2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ETS2
- Addgene plasmids for ETS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - |
Relevant External Links for ETS2 Gene
- GeneLoc Exon Structure for
- ETS2
Expression for ETS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
- Umbilical Cord (Extraembryonic Tissues)
-
Trophoblast (Extraembryonic Tissues)
- Extraembryonic Ectoderm Cells Extraembryonic Ectoderm
- Trophoblast Cells Trophoblast
-
Placenta (Extraembryonic Tissues)
- Primitive Cytotrophoblast Cells Chorion Frondosum
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells (Uncategorized)
- Neural Tube (Nervous System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ETS2
SOURCE GeneReport for Unigene cluster for ETS2 Gene:
Hs.644231Evidence on tissue expression from TISSUES for ETS2 Gene
- Nervous system(4.9)
- Intestine(4.8)
- Lung(4.2)
- Pancreas(3.8)
- Liver(3.7)
- Blood(3.1)
- Spleen(3)
- Muscle(3)
- Heart(2.9)
- Skin(2.9)
- Bone marrow(2.8)
- Kidney(2.6)
- Lymph node(2.5)
- Stomach(2.5)
- Eye(2.3)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for ETS2
-
OriGene qPCR primer pairs and template standards for ETS2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETS2 Gene
Orthologs for ETS2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ETS2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ETS2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ETS2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ets2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ets2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ETS2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | ETS2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ETS2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ets2 30 |
|
||
| Str.3274 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ets2a-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ets2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | pnt 31 32 |
|
OneToMany |
- Species where no ortholog for ETS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ETS2 Gene
- ENSEMBL:
- Gene Tree for ETS2 (if available)
- TreeFam:
- Gene Tree for ETS2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ETS2: view image
Paralogs for ETS2 Gene
Paralogs for ETS2 Gene
(2) SIMAP similar genes for ETS2 Gene using alignment to 2 proteins:
- ETS2_HUMAN
- C9JAG2_HUMAN
Pseudogenes.org Pseudogenes for ETS2 Gene
Variants for ETS2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ETS2 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 771783 | Benign: not provided | 38,814,331(+) | A/G | SYNONYMOUS_VARIANT | |
| 780076 | Benign: not provided | 38,818,484(+) | C/A | MISSENSE_VARIANT | |
| 783879 | Benign: not provided | 38,821,689(+) | C/T | SYNONYMOUS_VARIANT | |
| 786688 | Benign: not provided | 38,814,278(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1058591 | CNV | gain | 25217958 |
| nsv3518 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.49;
28.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ETS2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ETS2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETS2 Gene
Disorders for ETS2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| choriocarcinoma |
|
|
| down syndrome |
|
|
| hyperhidrosis, gustatory |
|
|
| megakaryocytic leukemia |
|
|
| prostate cancer |
|
Search ETS2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ETS2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ETS2 Gene
Publications for ETS2 Gene
- Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PMID: 2250910) Watson DK … Papas TS (Oncogene 1990) 3 4 23
- CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen VJ … Colas P (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
- An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (PMID: 20145133) Zabuawala T … Ostrowski MC (Cancer research 2010) 3 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion. (PMID: 19939245) Staun-Ram E … Shalev E (Reproductive biology and endocrinology : RB&E 2009) 3 23
ExternalLinks
Products for ETS2 Gene
- Custom Antibody ServicesOriGene Antibodies for ETS2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ETS2
- Search Origene for MassSpec and Protein Over-expression Lysates for ETS2
- Origene Custom Protein Services for ETS2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS2
- Browse OriGene Inhibitory RNA Products For ETS2
- OriGene qPCR primer pairs for ETS2
- OriGene qPCR primer pairs and template standards for ETS2
- OriGene CRISPR knockouts for ETS2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ETS2
- Sino Biological Human cDNA Clone for ETS2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ETS2
- Novus Biologicals proteins and lysates for ETS2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ETS2
- Abcam proteins for ETS2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ETS2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ETS2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ETS2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ETS2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ETS2
- Addgene plasmids for ETS2
- antibodies-online: Show 55 available ETS2 Antibodies ranked by validation data
- Compare Top ETS2 Antibodies
- antibodies-online: Show 6 available ETS2 Elisa Kits ranked by validation data
- Compare Top ETS2 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available ETS2 Proteins ranked by validation data
- Compare Top ETS2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ETS2
- Search Santa Cruz Biotechnology (SCBT) for ETS2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ETS2
- Horizon Cell Lines for ETS2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ETS2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS2
- Boster Bio Antibodies for ETS2
- Browse Boster Bio ELISA Kits
- Signalway Proteins for ETS2
Sources for ETS2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB