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Aliases for ETS2 Gene

Aliases for ETS2 Gene

  • ETS Proto-Oncogene 2, Transcription Factor 2 3 5
  • V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) 2
  • V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2 3
  • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 3
  • Protein C-Ets-2 3
  • Oncogene ETS-2 3
  • ETS2IT1 3

External Ids for ETS2 Gene

Previous GeneCards Identifiers for ETS2 Gene

  • GC21P036755
  • GC21P039097
  • GC21P039098
  • GC21P039099
  • GC21P040177
  • GC21P025647

Summaries for ETS2 Gene

Entrez Gene Summary for ETS2 Gene

  • This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

CIViC summary for ETS2 Gene

GeneCards Summary for ETS2 Gene

ETS2 (ETS Proto-Oncogene 2, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS2 include Choriocarcinoma and Down Syndrome. Among its related pathways are MIF Action Through Endocytic Pathway and C-MYB transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ETS1.

UniProtKB/Swiss-Prot for ETS2 Gene

  • Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Gene Wiki entry for ETS2 Gene

Additional gene information for ETS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ETS2 Gene

Genomics for ETS2 Gene

GeneHancer (GH) Regulatory Elements for ETS2 Gene

Promoters and enhancers for ETS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J038800 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 686.4 +2.5 2466 15.5 CLOCK MLX FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 MEF2D ETS2 HMGN1 ERG ENSG00000229986
GH21J038830 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 36.1 +26.4 26394 2 PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B YBX1 YY1 ZNF766 ETS2 HMGN1 ENSG00000229986 RPSAP64 ERG
GH21J039093 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 33.1 +291.3 291343 6.6 PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 YY1 ZNF143 ETS2 ENSG00000235888 RPSAP64 HMGN1 LCA5L RPL23AP12 ENSG00000237609
GH21J038837 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.5 +34.5 34544 3.8 PKNOX1 ATF1 ZNF766 FOS ATF7 RXRA PPARG ZNF592 ATF4 MAFF ETS2 ENSG00000229986
GH21J039079 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.7 +274.3 274294 1.2 ELF3 FOXA2 MLX ARID4B RAD21 RARA YY1 ZNF614 EGR1 CREM ETS2 ENSG00000235888 ENSG00000237721 RPL23AP12 ENSG00000237609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ETS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ETS2 gene promoter:
  • CREB
  • deltaCREB
  • GATA-1
  • p53
  • C/EBPbeta
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for ETS2 Gene

Genomic Locations for ETS2 Gene
chr21:38,805,307-38,824,955
(GRCh38/hg38)
Size:
19,649 bases
Orientation:
Plus strand
chr21:40,177,231-40,196,879
(GRCh37/hg19)
Size:
19,649 bases
Orientation:
Plus strand

Genomic View for ETS2 Gene

Genes around ETS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ETS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ETS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ETS2 Gene

Proteins for ETS2 Gene

  • Protein details for ETS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15036-ETS2_HUMAN
    Recommended name:
    Protein C-ets-2
    Protein Accession:
    P15036
    Secondary Accessions:
    • A6NM68
    • D3DSH6
    • Q53Y89

    Protein attributes for ETS2 Gene

    Size:
    469 amino acids
    Molecular mass:
    53001 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ETS2 Gene

neXtProt entry for ETS2 Gene

Post-translational modifications for ETS2 Gene

  • Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ETS2 Gene

No data available for DME Specific Peptides for ETS2 Gene

Domains & Families for ETS2 Gene

Gene Families for ETS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ETS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15036

UniProtKB/Swiss-Prot:

ETS2_HUMAN :
  • Belongs to the ETS family.
Family:
  • Belongs to the ETS family.
genes like me logo Genes that share domains with ETS2: view

Function for ETS2 Gene

Molecular function for ETS2 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
GENATLAS Biochemistry:
avian erythroblastosis virus E26 (v-ets) oncogene homolog 2,activating stromelysin-1 (MMP3) and collagenase 1 (MMP8) promoters,likely involved in skeletal development,required to maintain the transformed state of human prostate cancer cells

Phenotypes From GWAS Catalog for ETS2 Gene

Gene Ontology (GO) - Molecular Function for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12637547
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12637547
GO:0003677 DNA binding TAS 10918595
genes like me logo Genes that share ontologies with ETS2: view
genes like me logo Genes that share phenotypes with ETS2: view

Animal Models for ETS2 Gene

MGI Knock Outs for ETS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS2

Clone Products

  • Addgene plasmids for ETS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETS2 Gene

Localization for ETS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ETS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ETS2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ETS2: view

Pathways & Interactions for ETS2 Gene

genes like me logo Genes that share pathways with ETS2: view

SIGNOR curated interactions for ETS2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ETS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12637547
GO:0001501 skeletal system development TAS 8596630
GO:0001712 ectodermal cell fate commitment IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ETS2: view

Drugs & Compounds for ETS2 Gene

(4) Drugs for ETS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for ETS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ETS2: view

Transcripts for ETS2 Gene

mRNA/cDNA for ETS2 Gene

Unigene Clusters for ETS2 Gene

V-ets erythroblastosis virus E26 oncogene homolog 2 (avian):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS2

Clone Products

  • Addgene plasmids for ETS2

Alternative Splicing Database (ASD) splice patterns (SP) for ETS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - -
SP3:
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -

Relevant External Links for ETS2 Gene

GeneLoc Exon Structure for
ETS2
ECgene alternative splicing isoforms for
ETS2

Expression for ETS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ETS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ETS2 Gene:

ETS2

SOURCE GeneReport for Unigene cluster for ETS2 Gene:

Hs.644231

Evidence on tissue expression from TISSUES for ETS2 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Lung(4)
  • Pancreas(3.3)
  • Liver(3.2)
  • Blood(2.7)
  • Heart(2.3)
  • Muscle(2.2)
  • Bone marrow(2.1)
  • Spleen(2.1)
  • Skin(2)
genes like me logo Genes that share expression patterns with ETS2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETS2 Gene

Orthologs for ETS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ETS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ETS2 34 33
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ETS2 34 33
  • 88.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ETS2 34 33
  • 87.49 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ets2 33
  • 86.71 (n)
mouse
(Mus musculus)
Mammalia Ets2 16 34 33
  • 85.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ETS2 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ETS2 34 33
  • 76.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ETS2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ets2 33
  • 70.17 (n)
Str.3274 33
African clawed frog
(Xenopus laevis)
Amphibia ets2a-A 33
zebrafish
(Danio rerio)
Actinopterygii ets2 34 33
  • 64.56 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pnt 34 35
  • 27 (a)
OneToMany
Species where no ortholog for ETS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ETS2 Gene

ENSEMBL:
Gene Tree for ETS2 (if available)
TreeFam:
Gene Tree for ETS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ETS2: view image

Paralogs for ETS2 Gene

Paralogs for ETS2 Gene

(2) SIMAP similar genes for ETS2 Gene using alignment to 2 proteins:

  • ETS2_HUMAN
  • C9JAG2_HUMAN

Pseudogenes.org Pseudogenes for ETS2 Gene

genes like me logo Genes that share paralogs with ETS2: view

Variants for ETS2 Gene

Sequence variations from dbSNP and Humsavar for ETS2 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000151383 -- 38,820,903(+) C/T intron_variant
rs1000202922 -- 38,806,622(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000270999 -- 38,813,509(+) T/C intron_variant
rs1000433915 -- 38,806,872(+) G/A 5_prime_UTR_variant, intron_variant
rs1000500791 -- 38,820,570(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ETS2 Gene

Variant ID Type Subtype PubMed ID
nsv1058591 CNV gain 25217958
nsv3518 CNV insertion 18451855

Variation tolerance for ETS2 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ETS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ETS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETS2 Gene

Disorders for ETS2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ETS2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma
  • chorioepithelioma
down syndrome
  • trisomy 21
hyperhidrosis, gustatory
  • hyprg
chromosomal disease
  • chromosomal disorders
- elite association - COSMIC cancer census association via MalaCards
Search ETS2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ETS2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ETS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ETS2 Gene

Publications for ETS2 Gene

  1. Molecular organization and differential polyadenylation sites of the human ETS2 gene. (PMID: 2250910) Watson DK … Papas TS (Oncogene 1990) 3 4 22 58
  2. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. (PMID: 24218572) Guen VJ … Colas P (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. (PMID: 20145133) Zabuawala T … Ostrowski MC (Cancer research 2010) 3 22 58
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58

Products for ETS2 Gene

Sources for ETS2 Gene

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