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This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, a... See more...
Aliases for ETS1 Gene
Aliases for ETS1 Gene
External Ids for ETS1 Gene
- HGNC: 3488
- NCBI Entrez Gene: 2113
- Ensembl: ENSG00000134954
- OMIM®: 164720
- UniProtKB/Swiss-Prot: P14921
Previous HGNC Symbols for ETS1 Gene
- EWSR2
Previous GeneCards Identifiers for ETS1 Gene
- GC11M130331
- GC11M129841
- GC11M128362
- GC11M127869
- GC11M127866
- GC11M127833
- GC11M124277
- GC11M128328
Summaries for ETS1 Gene
-
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for ETS1 Gene
ETS1 (ETS Proto-Oncogene 1, Transcription Factor) is a Protein Coding gene. Diseases associated with ETS1 include Jacobsen Syndrome and Systemic Lupus Erythematosus. Among its related pathways are ERK Signaling and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is ETS2.
UniProtKB/Swiss-Prot Summary for ETS1 Gene
-
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Additional gene information for ETS1 Gene
- HGNC (3488)
- NCBI Entrez Gene (2113)
- Ensembl (ENSG00000134954)
- OMIM® (164720)
- UniProtKB/Swiss-Prot (P14921)
- Open Targets Platform(ENSG00000134954)
- Monarch Initiative
- Search for ETS1 at DataMed
- Search for ETS1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ETS1 Gene
Genomics for ETS1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ETS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ETS1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ETS1
- Top Transcription factor binding sites by QIAGEN in the ETS1 gene promoter:
-
- AML1a
Genomic Locations for ETS1 Gene
Latest Assembly
- chr11:128,458,761-128,587,593
- (GRCh38/hg38)
- Size:
- 128,833 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:128,328,660-128,457,453
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 128,794 bases
- Orientation:
- Minus strand
- chr11:128,328,656-128,457,453
- (GRCh37/hg19 by Ensembl)
- Size:
- 128,798 bases
- Orientation:
- Minus strand
Genomic View for ETS1 Gene
Genes around ETS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.3 by HGNC
- 11q24.3 by Entrez Gene
- 11q24.3 by Ensembl
ETS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ETS1 Gene
Proteins for ETS1 Gene
-
Protein details for ETS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14921-ETS1_HUMAN
- Recommended name:
- Protein C-ets-1
- Protein Accession:
- P14921
- A9UL17
- F5GYX9
- Q14278
- Q16080
- Q6N087
- Q96AC5
Protein attributes for ETS1 Gene
- Size:
- 441 amino acids
- Molecular mass:
- 50408 Da
- Quaternary structure:
-
- Binds DNA as a homodimer; homodimerization is required for transcription activation. Interacts with MAF and MAFB. Interacts with PAX5; the interaction alters DNA-binding properties (By similarity). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity.
- Miscellaneous:
-
- [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A.
Three dimensional structures from OCA and Proteopedia for ETS1 Gene
Protein Expression for ETS1 Gene
Post-translational modifications for ETS1 Gene
- Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.
- Ubiquitinated; which induces proteasomal degradation.
-
Ubiquitination at Lys2, Lys8, Lys245, Lys50, and Lys58
- NX_P14921 (NX_P14921-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ETS1 Gene
Antibodies for research
- LifeSpan BioSciences ETS1 / ETS-1 Monoclonal Antibody and ETS1 / ETS-1 Antibody
- G Biosciences Immunotag™ ETS1 Antibody
- GeneTex Anti-ETS1 antibody and Anti-ETS1 antibody [JM92-32]
-
Custom Antibody ServicesOriGene Antibodies for ETS1
- Novus Biologicals Antibodies for ETS1
-
Abcam antibodies for ETS1
- Invitrogen Antibodies for ETS1 (AFLGC-ETS1)
-
Custom Antibody ServicesProSci Antibodies for ETS1
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [14-902]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [16-168]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [31-151]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [51-398]
- Protein C-ets-1 [55-366]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [79-787]
-
Santa Cruz Biotechnology (SCBT) Antibodies for ETS1
- Sino Biological Antibodies for ETS1
Protein products for research
- G Biosciences Human ETS1/EWSR2, Lyophilized
- RayBiotech Recombinant Human ETS1/P54
- Search Origene for MassSpec and Protein Over-expression Lysates for ETS1
- Origene Custom Protein Services for ETS1
- ProSpec Recombinant Proteins for ETS1
-
ProSci Proteins for ETS1
-
Abcam proteins for ETS1
Assay products for research
- RayBiotech Custom Human Ets-1/p54 ELISA
- antibodies-online: Show 14 available ETS1 Elisa Kits ranked by validation data
- Compare Top ETS1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ETS1 Gene
Domains & Families for ETS1 Gene
Gene Families for ETS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ETS1 Gene
- InterPro:
- Blocks:
-
- Sterile alpha motif (SAM)/Pointed domain
- ProtoNet:
Suggested Antigen Peptide Sequences for ETS1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ets-1 p27 (A9UL17_HUMAN)
- p54 (ETS1_HUMAN)
- ETS1 protein (Q6FG54_HUMAN)
- V-ets erythroblastosis virus E26 oncogene homolog 1 (Avian), isoform CRA_a (Q96AC5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P14921- Family:
-
- Belongs to the ETS family.
Function for ETS1 Gene
Molecular function for ETS1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by retinoic acid, VEGF, TNF-alpha/TNFA, lipopolysaccharide and in response to hypoxia (at protein level).
- GENATLAS Biochemistry:
- avian erythroblastosis virus E26 (v-ets) oncogene homolog 1
Phenotypes From GWAS Catalog for ETS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12119294 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA,ISA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 15001984 |
| GO:0003677 | DNA binding | ISS | -- |
| GO:0003700 | DNA-binding transcription factor activity | IDA | 11909962 |
Phenotypes for ETS1 Gene
- MGI mutant phenotypes for ETS1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for ETS1:
Animal Models for ETS1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ETS1 - Starting at $85 >
- * ETS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ETS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETS1
miRNA for ETS1 Gene
- miRTarBase miRNAs that target ETS1
-
- hsa-miR-9-5p (MIRT000641)
- hsa-miR-200b-3p (MIRT003783)
- hsa-miR-31-5p (MIRT004975)
- hsa-miR-155-5p (MIRT005104)
- hsa-miR-193b-3p (MIRT005516)
- hsa-miR-208a-3p (MIRT005541)
- mmu-miR-326-3p (MIRT005596)
- hsa-miR-221-3p (MIRT006063)
- hsa-miR-222-3p (MIRT006064)
- hsa-miR-125b-5p (MIRT006387)
- mmu-miR-541-5p (MIRT008118)
- mmu-miR-223-3p (MIRT009535)
- hsa-miR-10a-5p (MIRT047624)
- hsa-miR-30c-5p (MIRT047908)
- hsa-miR-145-5p (MIRT053038)
- hsa-miR-200c-3p (MIRT053059)
- mmu-miR-155-5p (MIRT053266)
- hsa-miR-1-3p (MIRT054150)
- hsa-miR-499a-5p (MIRT054151)
- mmu-miR-1a-3p (MIRT054360)
- hsa-miR-1202 (MIRT394649)
- hsa-miR-3972 (MIRT394650)
- hsa-miR-5006-5p (MIRT394652)
- mmu-miR-222-3p (MIRT437891)
- hsa-miR-23b-3p (MIRT438321)
- hsa-miR-570-3p (MIRT537542)
- hsa-miR-584-3p (MIRT537543)
- hsa-miR-7852-3p (MIRT537544)
- mmu-miR-466i-3p (MIRT592728)
- mmu-miR-362-3p (MIRT592729)
- mmu-miR-329-3p (MIRT592730)
- mmu-miR-342-3p (MIRT592731)
- mmu-miR-344f-5p (MIRT592732)
- mmu-miR-148b-3p (MIRT592733)
- mmu-miR-148a-3p (MIRT592734)
- mmu-miR-152-3p (MIRT592735)
- mmu-miR-1960 (MIRT592736)
- hsa-miR-377-3p (MIRT613085)
- hsa-miR-5003-5p (MIRT613086)
- hsa-miR-4262 (MIRT613087)
- hsa-miR-181d-5p (MIRT613088)
- hsa-miR-181c-5p (MIRT613089)
- hsa-miR-181b-5p (MIRT613090)
- hsa-miR-181a-5p (MIRT613091)
- hsa-miR-543 (MIRT613092)
- hsa-miR-4776-3p (MIRT613093)
- hsa-miR-1228-3p (MIRT613094)
- hsa-miR-362-3p (MIRT613095)
- hsa-miR-329-3p (MIRT613096)
- hsa-miR-8485 (MIRT613097)
- hsa-miR-8064 (MIRT615011)
- hsa-miR-4643 (MIRT615012)
- hsa-miR-1825 (MIRT630473)
- hsa-miR-632 (MIRT680088)
- hsa-miR-4288 (MIRT680089)
- hsa-miR-346 (MIRT680090)
- hsa-miR-2276-3p (MIRT680091)
- hsa-miR-4772-3p (MIRT680092)
- hsa-miR-3680-3p (MIRT688337)
- hsa-miR-557 (MIRT688338)
- hsa-miR-507 (MIRT688339)
- hsa-miR-450b-5p (MIRT688340)
- hsa-miR-4666b (MIRT688341)
- hsa-miR-5011-3p (MIRT688342)
- hsa-miR-19b-2-5p (MIRT688343)
- hsa-miR-19b-1-5p (MIRT688344)
- hsa-miR-19a-5p (MIRT688345)
- hsa-miR-4328 (MIRT688346)
- hsa-miR-654-3p (MIRT688347)
- hsa-miR-506-3p (MIRT731241)
- hsa-miR-144-3p (MIRT731264)
- hsa-miR-199a-5p (MIRT731995)
- bta-miR-155 (MIRT733506)
- bta-miR-222 (MIRT733507)
- hsa-miR-324-5p (MIRT733943)
- rno-miR-208b-3p (MIRT734036)
Transcription Factor Targets for ETS1 Gene
Targeted motifs for ETS1 Gene
HOMER Transcription Factor Regulatory Elements motif ETS1
- Consensus sequence: ACAGGAAGTG Submotif: canonical Cell Type: Jurkat GEO ID: GSE17954
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS1
- Browse OriGene Inhibitory RNA Products For ETS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS1
Clone products for research
- Applied Biological Materials (abm): Clones for ETS1 - Starting at $45 >
- * ETS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207015
- MG223021
- MR207015
- MR207015L3
- MR207015L4
- MR223021
- MR223021L3
- MR223021L4
- RC215203
- RC215203L1
- RC215203L2
- RC215203L3
- RC215203L4
- RC227466
- RC227466L1
- RC227466L2
- RC227466L3
- RC227466L4
- RC228157
- RC228157L1
- RC228157L2
- RC228157L3
- RC228157L4
- RG215203
- RG227466
- RG228157
- RR215523
- RR215523L3
- RR215523L4
- MR207015L3V
- MR207015L4V
- MR223021L3V
- MR223021L4V
- RC215203L1V
- RC215203L2V
- RC215203L3V
- RC215203L4V
- RC227466L1V
- RC227466L2V
- RC227466L3V
- RC227466L4V
- RC228157L1V
- RC228157L2V
- RC228157L3V
- RC228157L4V
- RR215523L3V
- RR215523L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ETS1
- Addgene plasmids for ETS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS1
Cell Lines for research
-
Horizon Cell Lines for ETS1
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for ETS1 Gene
Localization for ETS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ETS1 Gene
- Cytoplasm. Nucleus. Note=Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. {ECO:0000269 PubMed:19377509}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 11909962 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0042025 | host cell nucleus | IEA | -- |
Pathways & Interactions for ETS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | B cell receptor signaling pathway (KEGG) | ||
| 3 | Angiogenesis (CST) | ||
| 4 | Cellular senescence (KEGG) | ||
| 5 | Human T-cell leukemia virus 1 infection | ||
Pathways by source for ETS1 Gene
2 Sino Biological pathways for ETS1 Gene
12 BioSystems pathways for ETS1 Gene
3 Reactome pathways for ETS1 Gene
1 PharmGKB pathway for ETS1 Gene
5 KEGG pathways for ETS1 Gene
1 GeneGo (Thomson Reuters) pathway for ETS1 Gene
- Immune response MIF-mediated glucocorticoid regulation
1 R&D Systems pathway for ETS1 Gene
5 Qiagen pathways for ETS1 Gene
- ERK Signaling
- HGF Pathway
- Macrophage Differentiation and Growth Inhibition by METS
- MIF Action Through Endocytic Pathway
- Nur77-Induced AICD in Macrophage
1 Cell Signaling Technology pathway for ETS1 Gene
Interacting Proteins for ETS1 Gene
Selected Interacting proteins:
P14921-ETS1_HUMAN
ENSP00000376436
for ETS1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ETS1
SIGNOR curated interactions for ETS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006366 | transcription by RNA polymerase II | IDA | -- |
Drugs & Compounds for ETS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human ETS1/EWSR2, Lyophilized
- RayBiotech Recombinant Human ETS1/P54
Transcripts for ETS1 Gene
mRNA/cDNA for ETS1 Gene
- 4 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000319397 2231 nts (view in UCSC)
- ENST00000392668 5139 nts (view in UCSC)
- ENST00000525404 655 nts (view in UCSC)
- ENST00000526145 3389 nts (view in UCSC)
- ENST00000527676 628 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ETS1 - Starting at $85 >
- * ETS1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ETS1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETS1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS1
- Browse OriGene Inhibitory RNA Products For ETS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS1
Clone products for research
- Applied Biological Materials (abm): Clones for ETS1 - Starting at $45 >
- * ETS1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG207015
- MG223021
- MR207015
- MR207015L3
- MR207015L4
- MR223021
- MR223021L3
- MR223021L4
- RC215203
- RC215203L1
- RC215203L2
- RC215203L3
- RC215203L4
- RC227466
- RC227466L1
- RC227466L2
- RC227466L3
- RC227466L4
- RC228157
- RC228157L1
- RC228157L2
- RC228157L3
- RC228157L4
- RG215203
- RG227466
- RG228157
- RR215523
- RR215523L3
- RR215523L4
- MR207015L3V
- MR207015L4V
- MR223021L3V
- MR223021L4V
- RC215203L1V
- RC215203L2V
- RC215203L3V
- RC215203L4V
- RC227466L1V
- RC227466L2V
- RC227466L3V
- RC227466L4V
- RC228157L1V
- RC228157L2V
- RC228157L3V
- RC228157L4V
- RR215523L3V
- RR215523L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ETS1
- Addgene plasmids for ETS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: |
Relevant External Links for ETS1 Gene
- GeneLoc Exon Structure for
- ETS1
Expression for ETS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Outflow Tract Cushion Cells Outflow Tract Cushion
- Mesenchymal Cells Epicardium
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Cardiac Fibroblasts Myocardium
-
Blood (Hematopoietic System)
- pre Conventional Dendritic Cells Peripheral Blood
- Conventional Dendritic Cells II Spleen
- Hematopoietic Bone Marrow
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells "Branchial Arch 3,4,6"
- Cranial Neural Crest Cells Cranial Neural Crest
- Cardiac Neural Crest Cells Cardiac Neural Crest
- Skeletal Muscle (Muscoskeletal System)
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells "Branchial Arch 3,4,6"
-
Liver (Hepatobiliary System)
- Periportal Hepatocytes Liver Lobule
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Spleen (Hematopoietic System)
- Neural Ectoderm (Nervous System)
- Germ Cells (Reproductive System)
- Gonad
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Liver (37.8), Blymphocyte (13.6), and CD8 Tcells (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ETS1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ETS1
SOURCE GeneReport for Unigene cluster for ETS1 Gene:
Hs.369438mRNA Expression by UniProt/SwissProt for ETS1 Gene:
P14921-ETS1_HUMAN
Tissue specificity:
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
Evidence on tissue expression from TISSUES for ETS1 Gene
- Lung(4.6)
- Lymph node(3.3)
- Spleen(3.3)
- Intestine(3.1)
- Heart(3)
- Kidney(2.8)
- Muscle(2.8)
- Liver(2.8)
- Blood(2.8)
- Skin(2.7)
- Bone marrow(2.7)
- Nervous system(2.5)
- Thyroid gland(2.4)
- Stomach(2.4)
- Pancreas(2.1)
- Adrenal gland(2)
Primer products for research
-
OriGene qPCR primer pairs for ETS1
-
OriGene qPCR primer pairs and template standards for ETS1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETS1 Gene
Orthologs for ETS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ETS1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ETS1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ETS1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ets1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ets1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ETS1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ETS1 30 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ETS1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ETS1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100170599 30 |
|
||
| Str.1672 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ets1a-A-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ets1 30 |
|
||
| ETS1 31 |
|
OneToOne | |||
| idibd1116 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | pnt 31 32 |
|
OneToMany |
- Species where no ortholog for ETS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ETS1 Gene
- ENSEMBL:
- Gene Tree for ETS1 (if available)
- TreeFam:
- Gene Tree for ETS1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ETS1: view image
Paralogs for ETS1 Gene
Paralogs for ETS1 Gene
(4) SIMAP similar genes for ETS1 Gene using alignment to 4 proteins:
- ETS1_HUMAN
- Q6FG54_HUMAN
- Q96AC5_HUMAN
- V9GYD6_HUMAN
Pseudogenes.org Pseudogenes for ETS1 Gene
Variants for ETS1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ETS1 Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs118149282 | Benign: not provided | 128,480,393(-) |
G/A NM_001143820.2(ETS1):c.921C>T (p.Arg307=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs142279599 | Uncertain Significance: not specified | 128,485,068(-) |
T/C NM_001143820.2(ETS1):c.617A>G (p.Tyr206Cys) |
MISSENSE_VARIANT,INTRON | |
| rs145793592 | Benign: not provided | 128,573,095(-) |
G/A NM_001143820.2(ETS1):c.36C>T (p.Pro12=) |
SYNONYMOUS | |
| rs149636924 | Benign: not provided | 128,486,082(-) |
C/T NM_001143820.2(ETS1):c.600G>A (p.Ser200=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs1565372210 | Pathogenic: 11q partial monosomy syndrome | 128,480,265(-) |
TCCTTG/AA NM_001143820.2(ETS1):c.1044_1049delinsTT (p.Lys349fs) |
FRAMESHIFT_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1237588 | CNV | deletion | 17803354 |
| esv1757388 | CNV | insertion | 17803354 |
| esv25513 | CNV | loss | 19812545 |
| esv2745237 | CNV | deletion | 23290073 |
| esv2745238 | CNV | deletion | 23290073 |
| esv2745239 | CNV | deletion | 23290073 |
| esv274885 | CNV | gain+loss | 21479260 |
| esv275204 | CNV | gain+loss | 21479260 |
| esv275584 | CNV | loss | 21479260 |
| esv3305475 | CNV | mobile element insertion | 20981092 |
| esv3325680 | CNV | insertion | 20981092 |
| esv3579955 | CNV | loss | 25503493 |
| esv3579956 | CNV | loss | 25503493 |
| esv3628046 | CNV | loss | 21293372 |
| esv8500 | OTHER | inversion | 19470904 |
| nsv442246 | CNV | loss | 18776908 |
| nsv517012 | CNV | loss | 19592680 |
| nsv952758 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.73;
15.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ETS1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ETS1 Gene
Disorders for ETS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| jacobsen syndrome |
|
|
| systemic lupus erythematosus |
|
|
| ewing sarcoma |
|
|
| fuchs' heterochromic uveitis |
|
|
| benign meningioma |
|
|
Search ETS1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ETS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Family of Databases
- (TGDB)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ETS1 Gene
Publications for ETS1 Gene
- Regulation of the transcription factor Ets-1 by DNA-mediated homo-dimerization. (PMID: 18566588) Lamber EP … Wilmanns M (The EMBO journal 2008) 3 4 23
- SP100 inhibits ETS1 activity in primary endothelial cells. (PMID: 15592518) Yordy JS … Watson DK (Oncogene 2005) 3 4 23
- Sp100 interacts with ETS-1 and stimulates its transcriptional activity. (PMID: 11909962) Wasylyk C … Wasylyk B (Molecular and cellular biology 2002) 3 4 23
- Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme. (PMID: 9333025) Hahn SL … Criqui P (Oncogene 1997) 3 4 23
- Quantitative and qualitative variation of ETS-1 transcripts in hematologic malignancies. (PMID: 8231246) Collyn d'Hooghe M … Kerckaert JP (Leukemia 1993) 3 4 23
ExternalLinks
Products for ETS1 Gene
- Custom Antibody ServicesOriGene Antibodies for ETS1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ETS1
- Origene Custom Protein Services for ETS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETS1
- Browse OriGene Inhibitory RNA Products For ETS1
- OriGene qPCR primer pairs for ETS1
- OriGene qPCR primer pairs and template standards for ETS1
- OriGene CRISPR knockouts for ETS1
- MG207015
- MG223021
- MR207015
- MR207015L3
- MR207015L4
- MR223021
- MR223021L3
- MR223021L4
- RC215203
- RC215203L1
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- RC215203L3
- RC215203L4
- RC227466
- RC227466L1
- RC227466L2
- RC227466L3
- RC227466L4
- RC228157
- RC228157L1
- RC228157L2
- RC228157L3
- RC228157L4
- RG215203
- RG227466
- RG228157
- RR215523
- RR215523L3
- RR215523L4
- MR207015L3V
- MR207015L4V
- MR223021L3V
- MR223021L4V
- RC215203L1V
- RC215203L2V
- RC215203L3V
- RC215203L4V
- RC227466L1V
- RC227466L2V
- RC227466L3V
- RC227466L4V
- RC228157L1V
- RC228157L2V
- RC228157L3V
- RC228157L4V
- RR215523L3V
- RR215523L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ETS1
- Sino Biological Human cDNA Clone for ETS1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ETS1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ETS1
- Novus Biologicals proteins and lysates for ETS1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ETS1
- Abcam proteins for ETS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for ETS1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ETS1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ETS1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ETS1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ETS1
- Addgene plasmids for ETS1
- antibodies-online: Show 60 available ETS1 Antibodies ranked by validation data
- Compare Top ETS1 Antibodies
- antibodies-online: Show 14 available ETS1 Elisa Kits ranked by validation data
- Compare Top ETS1 Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available ETS1 Proteins ranked by validation data
- Compare Top ETS1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ETS1
- Search Santa Cruz Biotechnology (SCBT) for ETS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ETS1
- Custom Antibody ServicesProSci Antibodies for ETS1
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [14-902]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [16-168]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [31-151]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [51-398]
- Protein C-ets-1 [55-366]
- v-ets avian erythroblastosis virus E26 oncogene homolog 1 [79-787]
- ProSci Proteins for ETS1
- Horizon Cell Lines for ETS1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETS1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETS1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ETS1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETS1
Sources for ETS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB