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This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] See more...
Aliases for ETNK1 Gene
Aliases for ETNK1 Gene
External Ids for ETNK1 Gene
- HGNC: 24649
- NCBI Entrez Gene: 55500
- Ensembl: ENSG00000139163
- OMIM®: 609858
- UniProtKB/Swiss-Prot: Q9HBU6
Previous GeneCards Identifiers for ETNK1 Gene
- GC12P022670
- GC12P022778
- GC12P022544
Summaries for ETNK1 Gene
-
This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for ETNK1 Gene
ETNK1 (Ethanolamine Kinase 1) is a Protein Coding gene. Diseases associated with ETNK1 include Atypical Chronic Myeloid Leukemia and Systemic Mastocytosis. Among its related pathways are Glycerophospholipid biosynthesis and phosphatidylethanolamine biosynthesis II. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and ethanolamine kinase activity. An important paralog of this gene is ETNK2.
UniProtKB/Swiss-Prot Summary for ETNK1 Gene
-
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
Additional gene information for ETNK1 Gene
- HGNC (24649)
- NCBI Entrez Gene (55500)
- Ensembl (ENSG00000139163)
- OMIM® (609858)
- UniProtKB/Swiss-Prot (Q9HBU6)
- Open Targets Platform(ENSG00000139163)
- Search for ETNK1 at DataMed
- Search for ETNK1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ETNK1 Gene
Genomics for ETNK1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ETNK1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J022623 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.6 | 1584 | 5.9 | TBP ZBTB10 SP1 MXD4 CEBPA MNT IKZF1 SMAD5 MBD2 POLR2A | ENSG00000257023 ETNK1 LOC105369691 C2CD5 lnc-CMAS-4 | |
| GH12J023564 | Enhancer | 0.9 | UCNEbase Ensembl | 10.8 | +939.7 | 939684 | 0.9 | FEZF1 GTF2E2 ZNF843 BCL11B PRDM6 ZNF19 MEIS2 BCL6B TRIM28 ZBTB8A | ENSG00000256473 SOX5 ETNK1 piR-33432-106 HSALNG0089849 lnc-SOX5-5 | |
| GH12J022254 | Enhancer | 0.7 | Ensembl ENCODE CraniofacialAtlas | 5.4 | -369.5 | -369511 | 3.1 | YY1 MAFK RFX1 | RNU1-149P ETNK1 lnc-ST8SIA1-2 RF00017-1109 ST8SIA1 CMAS | |
| GH12J022234 | Enhancer | 0.3 | Ensembl | 5.6 | -390.2 | -390192 | 0.6 | SPI1 MAFK | RNU1-149P ETNK1 piR-57460-119 lnc-ST8SIA1-2 CMAS ST8SIA1 | |
| GH12J022245 | Enhancer | 0.3 | Ensembl | 5.7 | -378.8 | -378774 | 1.4 | CEBPB | ETNK1 ST8SIA1 lnc-ST8SIA1-2 piR-57460-119 CMAS |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ETNK1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ETNK1
- Top Transcription factor binding sites by QIAGEN in the ETNK1 gene promoter:
-
- AP-1
- E47
- GATA-6
- HTF
- Lhx3a
- LHX3b
- Pax-4a
- Sp1
- Spz1
Genomic Locations for ETNK1 Gene
Latest Assembly
- chr12:22,625,075-22,690,665
- (GRCh38/hg38)
- Size:
- 65,591 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:22,778,105-22,843,599
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 65,495 bases
- Orientation:
- Plus strand
- chr12:22,778,009-22,843,599
- (GRCh37/hg19 by Ensembl)
- Size:
- 65,591 bases
- Orientation:
- Plus strand
Genomic View for ETNK1 Gene
Genes around ETNK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.1 by HGNC
- 12p12.1 by Entrez Gene
- 12p12.1 by Ensembl
ETNK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ETNK1 Gene
Proteins for ETNK1 Gene
-
Protein details for ETNK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBU6-EKI1_HUMAN
- Recommended name:
- Ethanolamine kinase 1
- Protein Accession:
- Q9HBU6
- G5E969
Protein attributes for ETNK1 Gene
- Size:
- 452 amino acids
- Molecular mass:
- 50968 Da
- Quaternary structure:
- No Data Available
Protein Expression for ETNK1 Gene
Post-translational modifications for ETNK1 Gene
Other Protein References for ETNK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- GeneTex Anti-ETNK1 antibody [N2C3]
-
Custom Antibody ServicesOriGene Antibodies for ETNK1
- Novus Biologicals Antibodies for ETNK1
-
Abcam antibodies for ETNK1
- Invitrogen Antibodies for ETNK1 (AFLGC-ETNK1)
-
Custom Antibody ServicesProSci Antibodies for ETNK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ETNK1
Protein products for research
-
OriGene Purified Proteins for ETNK1
- Search Origene for MassSpec and Protein Over-expression Lysates for ETNK1
- Origene Custom Protein Services for ETNK1
- antibodies-online: Show 5 available Ethanolamine Kinase 1 Proteins ranked by validation data
- Compare Top Ethanolamine Kinase 1 Proteins
-
Quality Products:
-
Abcam proteins for ETNK1
Assay products for research
- antibodies-online: Show 4 available Ethanolamine Kinase 1 Elisa Kits ranked by validation data
- Compare Top Ethanolamine Kinase 1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ETNK1 Gene
Domains & Families for ETNK1 Gene
Gene Families for ETNK1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ETNK1 Gene
- InterPro:
- Blocks:
-
- Choline/ethanolamine kinase
- ProtoNet:
Suggested Antigen Peptide Sequences for ETNK1 Gene
- GenScript: Design optimal peptide antigens:
-
- Ethanolamine kinase 1 (EKI1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HBU6- Family:
-
- Belongs to the choline/ethanolamine kinase family.
Function for ETNK1 Gene
Molecular function for ETNK1 Gene
- UniProtKB/Swiss-Prot Function:
- Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + ethanolamine = ADP + H(+) + phosphoethanolamine; Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216; EC=2.7.1.82; Evidence={ECO:0000269|PubMed:11044454};.
Enzyme Numbers (IUBMB) for ETNK1 Gene
Phenotypes From GWAS Catalog for ETNK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004305 | ethanolamine kinase activity | IEA,IDA | 11044454 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
Phenotypes for ETNK1 Gene
- MGI mutant phenotypes for ETNK1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ETNK1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- shRNA abundance <= 25%
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Increased cell viability after pRB stimulation
- Decreased viability in esophageal squamous lineage; decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased mitotic index
Animal Models for ETNK1 Gene
- MGI Knock Outs for ETNK1:
-
- Etnk1 Etnk1<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ETNK1 - Starting at $85 >
- * ETNK1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETNK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETNK1
miRNA for ETNK1 Gene
- miRTarBase miRNAs that target ETNK1
-
- mmu-miR-301b-3p (MIRT007775)
- mmu-miR-362-5p (MIRT008875)
- mmu-miR-17-5p (MIRT009870)
- mmu-miR-26a-5p (MIRT011140)
- mmu-miR-19b-3p (MIRT012357)
- hsa-miR-1-3p (MIRT023834)
- hsa-miR-21-5p (MIRT030884)
- hsa-miR-378a-5p (MIRT043971)
- hsa-miR-15b-5p (MIRT046537)
- hsa-miR-374a-5p (MIRT063330)
- hsa-miR-374b-5p (MIRT063334)
- hsa-miR-4639-5p (MIRT063335)
- hsa-miR-2113 (MIRT063341)
- hsa-miR-142-5p (MIRT063351)
- hsa-miR-519c-3p (MIRT063354)
- hsa-miR-519b-3p (MIRT063355)
- hsa-miR-519a-3p (MIRT063356)
- hsa-miR-559 (MIRT063357)
- hsa-miR-548b-5p (MIRT063358)
- hsa-miR-548a-5p (MIRT063359)
- hsa-miR-548c-5p (MIRT063360)
- hsa-miR-548d-5p (MIRT063361)
- hsa-miR-548j-5p (MIRT063364)
- hsa-miR-548k (MIRT063365)
- hsa-miR-548l (MIRT063366)
- hsa-miR-548h-5p (MIRT063367)
- hsa-miR-548i (MIRT063368)
- hsa-miR-548w (MIRT063369)
- hsa-miR-4282 (MIRT063371)
- hsa-miR-548y (MIRT063373)
- hsa-miR-548o-5p (MIRT063374)
- hsa-miR-548ab (MIRT063375)
- hsa-miR-548ad-5p (MIRT063376)
- hsa-miR-548ae-5p (MIRT063377)
- hsa-miR-548ak (MIRT063378)
- hsa-miR-548am-5p (MIRT063379)
- hsa-miR-548ap-5p (MIRT063380)
- hsa-miR-5197-3p (MIRT063381)
- hsa-miR-548aq-5p (MIRT063382)
- hsa-miR-548ar-5p (MIRT063383)
- hsa-miR-548as-5p (MIRT063384)
- hsa-miR-548au-5p (MIRT063385)
- hsa-miR-5590-3p (MIRT063386)
- hsa-miR-548av-5p (MIRT063387)
- hsa-miR-548ay-5p (MIRT063388)
- hsa-miR-8054 (MIRT063389)
- hsa-miR-548bb-5p (MIRT063390)
- hsa-miR-15a-5p (MIRT063394)
- hsa-miR-16-5p (MIRT063395)
- hsa-miR-195-5p (MIRT063399)
- hsa-miR-513a-3p (MIRT112812)
- hsa-miR-513c-3p (MIRT112813)
- hsa-miR-3606-3p (MIRT112814)
- hsa-miR-23a-3p (MIRT133654)
- hsa-miR-23b-3p (MIRT133659)
- hsa-miR-130a-5p (MIRT133660)
- hsa-miR-23c (MIRT133669)
- hsa-miR-205-5p (MIRT133673)
- hsa-miR-499a-3p (MIRT133678)
- hsa-miR-499b-3p (MIRT133685)
- hsa-miR-1279 (MIRT185182)
- hsa-miR-199a-3p (MIRT185223)
- hsa-miR-199b-3p (MIRT185224)
- hsa-miR-936 (MIRT185225)
- hsa-miR-3129-5p (MIRT185226)
- hsa-miR-4330 (MIRT271430)
- hsa-miR-4695-3p (MIRT271431)
- hsa-miR-1245b-3p (MIRT271432)
- hsa-miR-7641 (MIRT271434)
- hsa-miR-222-5p (MIRT336213)
- hsa-miR-6504-3p (MIRT336214)
- hsa-miR-556-3p (MIRT537545)
- hsa-miR-4433a-3p (MIRT537546)
- hsa-miR-4459 (MIRT537547)
- hsa-miR-4768-3p (MIRT537548)
- hsa-miR-205-3p (MIRT537549)
- hsa-miR-520e (MIRT537550)
- hsa-miR-520d-3p (MIRT537551)
- hsa-miR-520c-3p (MIRT537552)
- hsa-miR-520b (MIRT537553)
- hsa-miR-520a-3p (MIRT537554)
- hsa-miR-373-3p (MIRT537555)
- hsa-miR-372-3p (MIRT537556)
- hsa-miR-302e (MIRT537557)
- hsa-miR-302d-3p (MIRT537558)
- hsa-miR-302c-3p (MIRT537559)
- hsa-miR-302b-3p (MIRT537560)
- hsa-miR-302a-3p (MIRT537561)
- hsa-miR-5692c (MIRT537562)
- hsa-miR-5692b (MIRT537563)
- hsa-miR-369-3p (MIRT537564)
- hsa-miR-5010-3p (MIRT558062)
- hsa-miR-6847-3p (MIRT558063)
- hsa-miR-218-5p (MIRT558064)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETNK1
- Browse OriGene Inhibitory RNA Products For ETNK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETNK1
Clone products for research
- Applied Biological Materials (abm): Clones for ETNK1 - Starting at $45 >
- * ETNK1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ETNK1
- Addgene plasmids for ETNK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETNK1
Cell Lines for research
-
Horizon Cell Lines for ETNK1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ETNK1 Gene
Localization for ETNK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ETNK1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0016020 | membrane | HDA | 19946888 |
Pathways & Interactions for ETNK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycerophospholipid biosynthesis |
.01
|
|
| 2 | Metabolism |
.40
|
|
| 3 | phosphatidylethanolamine biosynthesis II | ||
Pathways by source for ETNK1 Gene
1 BioSystems pathway for ETNK1 Gene
5 Reactome pathways for ETNK1 Gene
2 KEGG pathways for ETNK1 Gene
UniProtKB/Swiss-Prot Q9HBU6-EKI1_HUMAN
- Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Interacting Proteins for ETNK1 Gene
Selected Interacting proteins:
Q9HBU6-EKI1_HUMAN
ENSP00000266517
for ETNK1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for ETNK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006646 | phosphatidylethanolamine biosynthetic process | TAS | -- |
| GO:0008654 | phospholipid biosynthetic process | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for ETNK1 Gene
Drugs & Compounds for ETNK1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
Transcripts for ETNK1 Gene
mRNA/cDNA for ETNK1 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000266517 7063 nts (view in UCSC)
- ENST00000335148 1083 nts (view in UCSC)
- ENST00000538218 1659 nts (view in UCSC)
- ENST00000539974 441 nts (view in UCSC)
- ENST00000544191 500 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ETNK1 - Starting at $85 >
- * ETNK1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ETNK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ETNK1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ETNK1
- Browse OriGene Inhibitory RNA Products For ETNK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ETNK1
Clone products for research
- Applied Biological Materials (abm): Clones for ETNK1 - Starting at $45 >
- * ETNK1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ETNK1
- Addgene plasmids for ETNK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ETNK1
Relevant External Links for ETNK1 Gene
- GeneLoc Exon Structure for
- ETNK1
Expression for ETNK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Liver, secretome (49.4) and Plasma (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ETNK1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ETNK1
SOURCE GeneReport for Unigene cluster for ETNK1 Gene:
Hs.29464mRNA Expression by UniProt/SwissProt for ETNK1 Gene:
Q9HBU6-EKI1_HUMAN
Tissue specificity:
Expressed in kidney, liver, placenta, heart, leukocyte, ovary and testis.
Evidence on tissue expression from TISSUES for ETNK1 Gene
- Nervous system(4.8)
- Intestine(3.7)
Primer products for research
-
OriGene qPCR primer pairs for ETNK1
-
OriGene qPCR primer pairs and template standards for ETNK1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ETNK1 Gene
Orthologs for ETNK1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ETNK1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ETNK1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ETNK1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Etnk1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Etnk1 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ETNK1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ETNK1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ETNK1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ETNK1 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | etnk1 30 31 |
|
OneToOne | |
| wufb38f12 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | eas 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000010 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ckc-1 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EKI1 31 |
|
ManyToMany | |
| CKI1 31 |
|
ManyToMany | |||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02726 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1866 31 |
|
OneToMany |
- Species where no ortholog for ETNK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ETNK1 Gene
- ENSEMBL:
- Gene Tree for ETNK1 (if available)
- TreeFam:
- Gene Tree for ETNK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ETNK1: view image
Paralogs for ETNK1 Gene
(2) SIMAP similar genes for ETNK1 Gene using alignment to 3 proteins:
- EKI1_HUMAN
- H0YFP7_HUMAN
- H0YH69_HUMAN
Pseudogenes.org Pseudogenes for ETNK1 Gene
Variants for ETNK1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.17;
51.76% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ETNK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ETNK1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ETNK1 Gene
Disorders for ETNK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| atypical chronic myeloid leukemia |
|
|
| systemic mastocytosis |
|
|
| chronic myelomonocytic leukemia |
|
|
| bladder neck obstruction |
|
|
| myelodysplastic/myeloproliferative neoplasm |
|
|
Search ETNK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ETNK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ETNK1 Gene
Publications for ETNK1 Gene
- Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway. (PMID: 11044454) Lykidis A … Jackowski S (The Journal of biological chemistry 2001) 2 3 4 23
- Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. (PMID: 11912161) Zafarana G … Looijenga LH (Cancer research 2002) 2 3 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for ETNK1 Gene
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- antibodies-online: Show 23 available Ethanolamine Kinase 1 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ETNK1
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Sources for ETNK1 Gene
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