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This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
ETNK1 (Ethanolamine Kinase 1) is a Protein Coding gene. Diseases associated with ETNK1 include Atypical Chronic Myeloid Leukemia and Systemic Mastocytosis. Among its related pathways are Glycerophospholipid biosynthesis and phosphatidylethanolamine biosynthesis II. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and ethanolamine kinase activity. An important paralog of this gene is ETNK2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J022623 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 250.7 | +1.6 | 1584 | 5.9 | TBP ZBTB10 SP1 MXD4 CEBPA MNT IKZF1 SMAD5 MBD2 POLR2A | ENSG00000257023 ETNK1 LOC105369691 C2CD5 lnc-CMAS-4 | |
GH12J023564 | Enhancer | 0.9 | UCNEbase Ensembl | 10.8 | +939.7 | 939684 | 0.9 | FEZF1 GTF2E2 ZNF843 BCL11B PRDM6 ZNF19 MEIS2 BCL6B TRIM28 ZBTB8A | ENSG00000256473 SOX5 ETNK1 piR-33432-106 HSALNG0089849 lnc-SOX5-5 | |
GH12J022254 | Enhancer | 0.7 | Ensembl ENCODE CraniofacialAtlas | 5.4 | -369.5 | -369511 | 3.1 | YY1 MAFK RFX1 | RNU1-149P ETNK1 lnc-ST8SIA1-2 RF00017-1109 ST8SIA1 CMAS | |
GH12J022234 | Enhancer | 0.3 | Ensembl | 5.6 | -390.2 | -390192 | 0.6 | SPI1 MAFK | RNU1-149P ETNK1 piR-57460-119 lnc-ST8SIA1-2 CMAS ST8SIA1 | |
GH12J022245 | Enhancer | 0.3 | Ensembl | 5.7 | -378.8 | -378774 | 1.4 | CEBPB | ETNK1 ST8SIA1 lnc-ST8SIA1-2 piR-57460-119 CMAS |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004305 | ethanolamine kinase activity | IEA,IDA | 11044454 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0016020 | membrane | HDA | 19946888 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glycerophospholipid biosynthesis |
.01
|
|
2 | Metabolism |
.40
|
|
3 | phosphatidylethanolamine biosynthesis II |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006646 | phosphatidylethanolamine biosynthetic process | TAS | -- |
GO:0008654 | phospholipid biosynthetic process | IEA | -- |
GO:0016310 | phosphorylation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
58-64-0 |
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ETNK1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ETNK1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ETNK1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Etnk1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Etnk1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ETNK1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ETNK1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ETNK1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ETNK1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | etnk1 30 31 |
|
OneToOne | |
wufb38f12 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | eas 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000010 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ckc-1 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | EKI1 31 |
|
ManyToMany | |
CKI1 31 |
|
ManyToMany | |||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02726 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1866 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
atypical chronic myeloid leukemia |
|
|
systemic mastocytosis |
|
|
chronic myelomonocytic leukemia |
|
|
bladder neck obstruction |
|
|
myelodysplastic/myeloproliferative neoplasm |
|
|