Aliases for ETF1 Gene
External Ids for ETF1 Gene
Previous HGNC Symbols for ETF1 Gene
Previous GeneCards Identifiers for ETF1 Gene
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
GeneCards Summary for ETF1 Gene
ETF1 (Eukaryotic Translation Termination Factor 1) is a Protein Coding gene. Diseases associated with ETF1 include Bone Chondrosarcoma and Human Monocytic Ehrlichiosis. Among its related pathways are Viral mRNA Translation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include ribosome binding.
UniProtKB/Swiss-Prot Summary for ETF1 Gene
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).