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Aliases for ESRRA Gene

Aliases for ESRRA Gene

  • Estrogen Related Receptor Alpha 2 3 5
  • Nuclear Receptor Subfamily 3 Group B Member 1 3 4
  • Estrogen Receptor-Like 1 3 4
  • ERR-Alpha 3 4
  • ESRL1 3 4
  • NR3B1 3 4
  • ERR1 3 4
  • Estrogen-Related Nuclear Receptor Alpha 3
  • Estrogen-Related Receptor Alpha 4
  • Steroid Hormone Receptor ERR1 3
  • ERRalpha 3
  • ERRa 3

External Ids for ESRRA Gene

Previous HGNC Symbols for ESRRA Gene

  • ESRL1

Previous GeneCards Identifiers for ESRRA Gene

  • GC11P066588
  • GC11P065754
  • GC11P064323
  • GC11P063848
  • GC11P063829
  • GC11P064073
  • GC11P060400

Summaries for ESRRA Gene

Entrez Gene Summary for ESRRA Gene

  • The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for ESRRA Gene

ESRRA (Estrogen Related Receptor Alpha) is a Protein Coding gene. Diseases associated with ESRRA include Endometrial Cancer and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ESRRB.

UniProtKB/Swiss-Prot for ESRRA Gene

  • Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5-TNAAGGTCA-3. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

Tocris Summary for ESRRA Gene

  • Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal function of the cardiovascular and nervous systems.

Gene Wiki entry for ESRRA Gene

Additional gene information for ESRRA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESRRA Gene

Genomics for ESRRA Gene

GeneHancer (GH) Regulatory Elements for ESRRA Gene

Promoters and enhancers for ESRRA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064303 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.5 497 4.5 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ESRRA SF1 POLA2 ZFPL1 C11orf95 SYVN1 FAU PLCB3 ATG2A NAALADL1
GH11I064205 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -97.9 -97933 4.4 HDGF PKNOX1 ATF1 SMAD1 ARNT YY1 TCF12 POLR2B ZNF766 ZNF143 FERMT3 TRPT1 ZFPL1 PLCB3 SF1 TRMT112 ENSG00000257086 GPR137 BAD KCNK4
GH11I064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 11.4 -34.8 -34828 7.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC GPR137 ZFPL1 SF1 POLA2 PLCB3 TRMT112 DNAJC4 ENSG00000257086 FAU LOC102723878
GH11I064347 Enhancer 0.8 ENCODE 11.8 +42.9 42853 1.9 BCOR KLF1 JUN CHD4 MAX ZMYM3 CEBPG POLR2A FOXK2 PATZ1 LOC102723878 MIR1237 TRMT112 PRDX5 ESRRA CATSPERZ ENSG00000207024 KCNK4-TEX40 KCNK4 BAD
GH11I064354 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.4 +52.4 52446 6.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B YY1 RPS6KA4 LOC102723878 PLCB3 ENSG00000231680 TRPT1 MARK2 PPP1R14B ESRRA PRDX5 TRMT112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ESRRA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ESRRA gene promoter:

Genomic Locations for ESRRA Gene

Genomic Locations for ESRRA Gene
chr11:64,305,528-64,316,743
(GRCh38/hg38)
Size:
11,216 bases
Orientation:
Plus strand
chr11:64,073,044-64,084,215
(GRCh37/hg19)

Genomic View for ESRRA Gene

Genes around ESRRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESRRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESRRA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESRRA Gene

Proteins for ESRRA Gene

  • Protein details for ESRRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11474-ERR1_HUMAN
    Recommended name:
    Steroid hormone receptor ERR1
    Protein Accession:
    P11474
    Secondary Accessions:
    • Q14514

    Protein attributes for ESRRA Gene

    Size:
    423 amino acids
    Molecular mass:
    45510 Da
    Quaternary structure:
    • Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation.
    SequenceCaution:
    • Sequence=AAB17015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA35778.1; Type=Frameshift; Positions=345, 354; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESRRA Gene

    Alternative splice isoforms for ESRRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRRA Gene

Post-translational modifications for ESRRA Gene

  • Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
  • Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
  • Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ESRRA Gene

Domains & Families for ESRRA Gene

Gene Families for ESRRA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

P11474

UniProtKB/Swiss-Prot:

ERR1_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
genes like me logo Genes that share domains with ESRRA: view

Function for ESRRA Gene

Molecular function for ESRRA Gene

GENATLAS Biochemistry:
estrogen-related receptor A,orphan receptors family,steroid/thyroid hormone receptor superfamily,involved in the expression of SV40 major late promoter modulator of ESR response of lactoferrin promoter,regulator of medium chain acyl CoA dehydrogenase
UniProtKB/Swiss-Prot Function:
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5-TNAAGGTCA-3. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
UniProtKB/Swiss-Prot Induction:
Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.

Phenotypes From GWAS Catalog for ESRRA Gene

Gene Ontology (GO) - Molecular Function for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA,TAS 9286700
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ESRRA: view
genes like me logo Genes that share phenotypes with ESRRA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ESRRA

CRISPR Products

Targeted motifs for ESRRA Gene
HOMER Transcription Factor Regulatory Elements motif ESRRA
  • Consensus sequence: CAAAGGTCAG Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESRRA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ESRRA Gene

Localization for ESRRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRRA Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESRRA gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 4
mitochondrion 2
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,IEA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with ESRRA: view

Pathways & Interactions for ESRRA Gene

genes like me logo Genes that share pathways with ESRRA: view

Pathways by source for ESRRA Gene

Gene Ontology (GO) - Biological Process for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IMP,IEA 23836911
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with ESRRA: view

No data available for SIGNOR curated interactions for ESRRA Gene

Drugs & Compounds for ESRRA Gene

(41) Drugs for ESRRA Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diethylstilbestrol Approved, Investigational Pharma Agonist, Target 5
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 228
flavone Approved, Experimental Pharma Antagonist, Target, agonist 0
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1400
Estriol Approved, Investigational, Vet_approved Pharma Agonist 0

(8) Additional Compounds for ESRRA Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,7-dihydroxy-4-methoxyisoflavone
Agonist
7,4-dihydroxyisoflavone
Agonist
ICI 182,780
129453-61-8

(5) Tocris Compounds for ESRRA Gene

Compound Action Cas Number
AC 186 Potent and selective ERbeta agonist; neuroprotective 1421854-16-1
beta-Estradiol Endogenous ER agonist 50-28-2
ICI 182,780 Estrogen receptor antagonist 129453-61-8
PPT Subtype-selective ERalpha agonist 263717-53-9
Tamoxifen citrate Estrogen receptor partial agonist/antagonist 54965-24-1

(20) ApexBio Compounds for ESRRA Gene

Compound Action Cas Number
Altrenogest 850-52-2
Bazedoxifene HCl 198480-56-7
Clomiphene citrate 50-41-9
Equol 531-95-3
Estradiol Sex hormone 50-28-2
Estradiol Cypionate 313-06-4
Estriol 50-27-1
Estrone Estrogenic hormone 53-16-7
Ethinyl Estradiol Oral contraceptive 57-63-6
Ethisterone Progestogen hormone 434-03-7
Ethynodiol diacetate 297-76-7
Fulvestrant Estrogen receptor antagonist,high affinity 129453-61-8
Gestodene 60282-87-3
Hexestrol 84-16-2
Medroxyprogesterone acetate Steroidal progestin 71-58-9
Ospemifene 128607-22-7
Raloxifene HCl Estrogen receptor (ER) 82640-04-8
Tamoxifen Citrate Antiestrogen drug 54965-24-1
Toremifene Citrate 89778-27-8
XCT790 ERRα agonist 725247-18-7
genes like me logo Genes that share compounds with ESRRA: view

Drug Products

Transcripts for ESRRA Gene

Unigene Clusters for ESRRA Gene

Estrogen-related receptor alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ESRRA

Alternative Splicing Database (ASD) splice patterns (SP) for ESRRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for ESRRA Gene

GeneLoc Exon Structure for
ESRRA
ECgene alternative splicing isoforms for
ESRRA

Expression for ESRRA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESRRA Gene

mRNA differential expression in normal tissues according to GTEx for ESRRA Gene

This gene is overexpressed in Muscle - Skeletal (x5.2) and Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for ESRRA Gene

This gene is overexpressed in Lung (50.6) and Peripheral blood mononuclear cells (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ESRRA Gene



Protein tissue co-expression partners for ESRRA Gene

NURSA nuclear receptor signaling pathways regulating expression of ESRRA Gene:

ESRRA

SOURCE GeneReport for Unigene cluster for ESRRA Gene:

Hs.110849

Evidence on tissue expression from TISSUES for ESRRA Gene

  • Kidney(4.4)
  • Nervous system(2.9)
  • Muscle(2.5)
  • Heart(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ESRRA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ESRRA Gene

Orthologs for ESRRA Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ESRRA 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ESRRA 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Esrra 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ESRRA 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ESRRA 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12278 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10209 33
zebrafish
(Danio rerio)
Actinopterygii esrra 34
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ERR 35 34
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for ESRRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESRRA Gene

ENSEMBL:
Gene Tree for ESRRA (if available)
TreeFam:
Gene Tree for ESRRA (if available)

Paralogs for ESRRA Gene

Paralogs for ESRRA Gene

Pseudogenes.org Pseudogenes for ESRRA Gene

genes like me logo Genes that share paralogs with ESRRA: view

Variants for ESRRA Gene

Sequence variations from dbSNP and Humsavar for ESRRA Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000415828 -- 64,313,626(+) T/C intron_variant
rs1000553878 -- 64,305,327(+) G/T upstream_transcript_variant
rs1000689952 -- 64,306,201(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001840955 -- 64,304,310(+) C/T upstream_transcript_variant
rs1001910761 -- 64,306,322(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ESRRA Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
nsv1070042 CNV deletion 25765185
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv475066 CNV novel sequence insertion 20440878
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for ESRRA Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ESRRA Gene

Human Gene Mutation Database (HGMD)
ESRRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ESRRA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESRRA Gene

Disorders for ESRRA Gene

MalaCards: The human disease database

(2) MalaCards diseases for ESRRA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search ESRRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ESRRA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ESRRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ESRRA Gene

Publications for ESRRA Gene

  1. Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes. (PMID: 16755280) Larsen LH … Pedersen O (International journal of obesity (2005) 2007) 3 22 44 58
  2. A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters. (PMID: 16150865) Barry JB … Giguère V (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 22 58
  3. A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. (PMID: 15883633) Laflamme N … Rousseau F (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005) 3 22 44 58
  4. Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha. (PMID: 15337744) Kallen J … Fournier B (The Journal of biological chemistry 2004) 3 4 22 58
  5. The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). (PMID: 12522104) Schreiber SN … Kralli A (The Journal of biological chemistry 2003) 3 4 22 58

Products for ESRRA Gene

  • Addgene plasmids for ESRRA

Sources for ESRRA Gene

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