ESRRA Gene (Protein Coding)

Estrogen Related Receptor Alpha

GC11P064305
GIFtS:
48
The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A p... See more...

Aliases for ESRRA Gene

Aliases for ESRRA Gene

  • Estrogen Related Receptor Alpha 2 3 5
  • Nuclear Receptor Subfamily 3 Group B Member 1 3 4
  • Steroid Hormone Receptor ERR1 3 4
  • Estrogen Receptor-Like 1 3 4
  • ERR-Alpha 3 4
  • ESRL1 3 4
  • NR3B1 3 4
  • ERR1 3 4
  • Estrogen-Related Nuclear Receptor Alpha 3
  • Estrogen-Related Receptor Alpha 4
  • ERRalpha 3
  • ERRa 3

External Ids for ESRRA Gene

Previous HGNC Symbols for ESRRA Gene

  • ESRL1

Previous GeneCards Identifiers for ESRRA Gene

  • GC11P066588
  • GC11P065754
  • GC11P064323
  • GC11P063848
  • GC11P063829
  • GC11P064073
  • GC11P060400

Summaries for ESRRA Gene

Entrez Gene Summary for ESRRA Gene

  • The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]

GeneCards Summary for ESRRA Gene

ESRRA (Estrogen Related Receptor Alpha) is a Protein Coding gene. Diseases associated with ESRRA include Amelogenesis Imperfecta, Type Ig and Endometrial Cancer. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ESRRB.

UniProtKB/Swiss-Prot Summary for ESRRA Gene

  • Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.

Tocris Summary for ESRRA Gene

  • Estrogen controls many cellular processes including growth, differentiation and function of the reproductive system. Estrogen is also responsible for the growth and maintenance of the skeleton and the normal function of the cardiovascular and nervous systems.

Gene Wiki entry for ESRRA Gene

Additional gene information for ESRRA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ESRRA Gene

Genomics for ESRRA Gene

GeneHancer (GH) Regulatory Elements for ESRRA Gene

Promoters and enhancers for ESRRA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ESRRA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ESRRA gene promoter:
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ESRRA Gene

Genomic Locations for ESRRA Gene
chr11:64,305,524-64,316,743
(GRCh38/hg38)
Size:
11,220 bases
Orientation:
Plus strand
chr11:64,073,044-64,084,215
(GRCh37/hg19)
Size:
11,172 bases
Orientation:
Plus strand

Genomic View for ESRRA Gene

Genes around ESRRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESRRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESRRA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ESRRA Gene

Proteins for ESRRA Gene

Products:

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  3. Assay

  • Protein details for ESRRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11474-ERR1_HUMAN
    Recommended name:
    Steroid hormone receptor ERR1
    Protein Accession:
    P11474
    Secondary Accessions:
    • Q14514

    Protein attributes for ESRRA Gene

    Size:
    423 amino acids
    Molecular mass:
    45510 Da
    Quaternary structure:
    • Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transcriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation. Interacts with MAPK15; promotes re-localization of ESRRA to the cytoplasm through a XPO1-dependent mechanism then inhibits ESRRA transcriptional activity.
    SequenceCaution:
    • Sequence=AAB17015.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA35778.1; Type=Frameshift; Positions=345, 354; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ESRRA Gene

    Alternative splice isoforms for ESRRA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ESRRA Gene

Protein Expression for ESRRA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ESRRA Gene

  • Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
  • Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding.
  • Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ESRRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for ESRRA

No data available for DME Specific Peptides for ESRRA Gene

Domains & Families for ESRRA Gene

Gene Families for ESRRA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ESRRA Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ESRRA Gene

GenScript: Design optimal peptide antigens:
  • Estrogen-related receptor alpha (A8CGI6_HUMAN)
  • Nuclear receptor subfamily 3 group B member 1 (ERR1_HUMAN)
  • HCG2016877, isoform CRA_b (Q569H8_HUMAN)
  • ESRRA protein (Q6GMQ8_HUMAN)
  • ESRRA protein (Q96I02_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P11474

UniProtKB/Swiss-Prot:

ERR1_HUMAN :
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.
genes like me logo Genes that share domains with ESRRA: view

Function for ESRRA Gene

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  2. CRISPR
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Molecular function for ESRRA Gene

UniProtKB/Swiss-Prot Function:
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
UniProtKB/Swiss-Prot Induction:
Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.
GENATLAS Biochemistry:
estrogen-related receptor A,orphan receptors family,steroid/thyroid hormone receptor superfamily,involved in the expression of SV40 major late promoter modulator of ESR response of lactoferrin promoter,regulator of medium chain acyl CoA dehydrogenase

Phenotypes From GWAS Catalog for ESRRA Gene

Gene Ontology (GO) - Molecular Function for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA,TAS 9286700
genes like me logo Genes that share ontologies with ESRRA: view
genes like me logo Genes that share phenotypes with ESRRA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ESRRA

CRISPR Products

Targeted motifs for ESRRA Gene
HOMER Transcription Factor Regulatory Elements motif ESRRA
  • Consensus sequence: CAAAGGTCAG Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ESRRA

Clone Products

  • Addgene plasmids for ESRRA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ESRRA Gene

Localization for ESRRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESRRA Gene

Nucleus. Cytoplasm. Note=Co-localizes to the cytoplasm only in presence of MAPK15. {ECO:0000269 PubMed:21190936}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESRRA gene
Compartment Confidence
nucleus 5
extracellular 4
cytoskeleton 4
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA,IDA 21190936
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 21190936
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with ESRRA: view

Pathways & Interactions for ESRRA Gene

genes like me logo Genes that share pathways with ESRRA: view

Pathways by source for ESRRA Gene

1 Qiagen pathway for ESRRA Gene
  • PGC1Alpha Pathway
1 Cell Signaling Technology pathway for ESRRA Gene

SIGNOR curated interactions for ESRRA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ESRRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IMP,IEA 23836911
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007005 mitochondrion organization TAS --
GO:0030278 regulation of ossification IEA --
genes like me logo Genes that share ontologies with ESRRA: view

Drugs & Compounds for ESRRA Gene

Products:

  1. Drug

(37) Drugs for ESRRA Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Diethylstilbestrol Approved, Investigational Pharma Antagonist, Agonist, Target 6
Fulvestrant Approved, Investigational Pharma Antagonist Estrogen receptor antagonist,high affinity, Hormone therapy 275
flavone Approved, Experimental Pharma Antagonist, Target, agonist 0
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1379
Estradiol cypionate Approved, Investigational, Vet_approved Pharma 0

(11) Additional Compounds for ESRRA Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5,7-dihydroxy-4'-methoxyisoflavone
Agonist
7,4'-dihydroxyisoflavone
Agonist, Activator
AC 186
1421854-16-1
beta-Estradiol
50-28-2
ICI 182,780
129453-61-8

(5) Tocris Compounds for ESRRA Gene

Compound Action Cas Number
AC 186 Potent and selective ERbeta agonist; neuroprotective 1421854-16-1
beta-Estradiol Endogenous ER agonist 50-28-2
ICI 182,780 Estrogen receptor antagonist 129453-61-8
PPT Subtype-selective ERalpha agonist 263717-53-9
Tamoxifen citrate Estrogen receptor partial agonist/antagonist 54965-24-1

(20) ApexBio Compounds for ESRRA Gene

Compound Action Cas Number
Altrenogest 850-52-2
Bazedoxifene HCl 198480-56-7
Clomiphene citrate 50-41-9
Equol 531-95-3
Estradiol Sex hormone 50-28-2
Estradiol Cypionate 313-06-4
Estriol 50-27-1
Estrone Estrogenic hormone 53-16-7
Ethinyl Estradiol Oral contraceptive 57-63-6
Ethisterone Progestogen hormone 434-03-7
Ethynodiol diacetate 297-76-7
Fulvestrant Estrogen receptor antagonist,high affinity 129453-61-8
Gestodene 60282-87-3
Hexestrol 84-16-2
Medroxyprogesterone acetate Steroidal progestin 71-58-9
Ospemifene 128607-22-7
Raloxifene HCl Estrogen receptor (ER) 82640-04-8
Tamoxifen Citrate Antiestrogen drug 54965-24-1
Toremifene Citrate 89778-27-8
XCT790 ERRα agonist 725247-18-7
genes like me logo Genes that share compounds with ESRRA: view

Transcripts for ESRRA Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ESRRA Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(828) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ESRRA

Clone Products

  • Addgene plasmids for ESRRA

Alternative Splicing Database (ASD) splice patterns (SP) for ESRRA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for ESRRA Gene

GeneLoc Exon Structure for
ESRRA
ECgene alternative splicing isoforms for
ESRRA

Expression for ESRRA Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESRRA Gene

mRNA expression in normal human tissues for ESRRA Gene
mRNA expression by GTEx for ESRRA GenemRNA expression by BioGPS for ESRRA Gene

mRNA differential expression in normal tissues according to GTEx for ESRRA Gene

This gene is overexpressed in Muscle - Skeletal (x5.2) and Heart - Left Ventricle (x4.4).

Protein differential expression in normal tissues from HIPED for ESRRA Gene

This gene is overexpressed in Lung (50.6) and Peripheral blood mononuclear cells (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ESRRA Gene



Protein tissue co-expression partners for ESRRA Gene

NURSA nuclear receptor signaling pathways regulating expression of ESRRA Gene:

ESRRA

SOURCE GeneReport for Unigene cluster for ESRRA Gene:

Hs.110849

Evidence on tissue expression from TISSUES for ESRRA Gene

  • Kidney(4.4)
  • Nervous system(2.9)
  • Muscle(2.5)
  • Heart(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with ESRRA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ESRRA Gene

Orthologs for ESRRA Gene

This gene was present in the common ancestor of animals.

Orthologs for ESRRA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia ESRRA 33
  • 100 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia ESRRA 33
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Esrra 33
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ESRRA 33
  • 69 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ESRRA 33
  • 77 (a)
 OneToOne
African clawed frog
(Xenopus laevis)
 Amphibia Xl.10209 32
tropical clawed frog
(Silurana tropicalis)
 Amphibia Str.12278 32
zebrafish
(Danio rerio)
 Actinopterygii esrra 33
  • 64 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta ERR 33 34
  • 34 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 41 (a)
 OneToMany
Species where no ortholog for ESRRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESRRA Gene

ENSEMBL:
Gene Tree for ESRRA (if available)
TreeFam:
Gene Tree for ESRRA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ESRRA: view image

Paralogs for ESRRA Gene

Paralogs for ESRRA Gene

(24) SIMAP similar genes for ESRRA Gene using alignment to 8 proteins:

  • ERR1_HUMAN
  • A8CGI6_HUMAN
  • F5GWT5_HUMAN
  • F5H0E9_HUMAN
  • H0YGT3_HUMAN
  • Q569H8_HUMAN
  • Q6GMQ8_HUMAN
  • Q96I02_HUMAN

Pseudogenes.org Pseudogenes for ESRRA Gene

genes like me logo Genes that share paralogs with ESRRA: view

Variants for ESRRA Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for ESRRA Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000415828 -- 64,313,626(+) T/C intron_variant
rs1000553878 -- 64,305,327(+) G/T upstream_transcript_variant
rs1000689952 -- 64,306,201(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001840955 -- 64,304,310(+) C/T upstream_transcript_variant
rs1001910761 -- 64,306,322(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ESRRA Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
nsv1070042 CNV deletion 25765185
nsv357 CNV insertion 18451855
nsv469961 CNV loss 18288195
nsv475066 CNV novel sequence insertion 20440878
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for ESRRA Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ESRRA Gene

Human Gene Mutation Database (HGMD)
ESRRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ESRRA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESRRA Gene

Disorders for ESRRA Gene

MalaCards: The human disease database

(4) MalaCards diseases for ESRRA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amelogenesis imperfecta, type ig
  • ai1g
endometrial cancer
  • endometrial cancer, familial
breast cancer
  • breast cancer, familial
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search ESRRA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ESRRA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ESRRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ESRRA Gene

Publications for ESRRA Gene

  1. Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop. (PMID: 18441008) Greschik H … Moras D (The Journal of biological chemistry 2008) 3 4 23 56
  2. Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes. (PMID: 16755280) Larsen LH … Pedersen O (International journal of obesity (2005) 2007) 3 23 43 56
  3. A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters. (PMID: 16150865) Barry JB … Giguère V (Molecular endocrinology (Baltimore, Md.) 2006) 3 4 23 56
  4. A frequent regulatory variant of the estrogen-related receptor alpha gene associated with BMD in French-Canadian premenopausal women. (PMID: 15883633) Laflamme N … Rousseau F (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005) 3 23 43 56
  5. Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha. (PMID: 15337744) Kallen J … Fournier B (The Journal of biological chemistry 2004) 3 4 23 56

ExternalLinks

View latest publications for ESRRA gene in Mastermind

Products for ESRRA Gene

  • Addgene plasmids for ESRRA

Sources for ESRRA Gene