Aliases for ESPL1 Gene
External Ids for ESPL1 Gene
Previous GeneCards Identifiers for ESPL1 Gene
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
GeneCards Summary for ESPL1 Gene
ESPL1 (Extra Spindle Pole Bodies Like 1, Separase) is a Protein Coding gene. Diseases associated with ESPL1 include Retinitis Pigmentosa 18 and Cholestasis, Intrahepatic, Of Pregnancy, 1. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Human T-cell leukemia virus 1 infection. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity.
UniProtKB/Swiss-Prot Summary for ESPL1 Gene
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.