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Aliases for ESM1 Gene

Aliases for ESM1 Gene

  • Endothelial Cell Specific Molecule 1 2 3 5
  • Endothelial Cell-Specific Molecule 1 2 3
  • ESM-1 3 4
  • Endocan 3

External Ids for ESM1 Gene

Previous GeneCards Identifiers for ESM1 Gene

  • GC05M054436
  • GC05M055702
  • GC05M054244
  • GC05M054289
  • GC05M054309
  • GC05M051247

Summaries for ESM1 Gene

Entrez Gene Summary for ESM1 Gene

  • This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ESM1 Gene

ESM1 (Endothelial Cell Specific Molecule 1) is a Protein Coding gene. Among its related pathways are Gastric Cancer Network 1. Gene Ontology (GO) annotations related to this gene include integrin binding and hepatocyte growth factor receptor binding.

UniProtKB/Swiss-Prot for ESM1 Gene

  • Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

Gene Wiki entry for ESM1 Gene

Additional gene information for ESM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESM1 Gene

Genomics for ESM1 Gene

GeneHancer (GH) Regulatory Elements for ESM1 Gene

Promoters and enhancers for ESM1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J054984 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 650.3 +36.9 36873 2.1 BMI1 ZNF2 ZNF335 ZNF366 SCRT2 FOS REST ZEB2 PRDM6 CBX8 ESM1 ENSG00000249016 GZMA GZMK ENSG00000240535 GPX8
GH05J055022 Promoter/Enhancer 0.8 EPDnew ENCODE 658.5 -1.5 -1528 3.8 RFX5 ESM1 GZMK LOC102467081 GPX8 ENSG00000240535
GH05J055002 Enhancer 0.4 dbSUPER 5.8 +17.9 17882 3.6 JUN MAFK ENSG00000240535 ENSG00000249016 GZMA GZMK ESM1
GH05J054989 Enhancer 0.6 ENCODE dbSUPER 0.3 +31.6 31636 2.2 JUN ZIC2 ENSG00000249016 GZMK ENSG00000240535 ESM1
GH05J054982 Enhancer 0.5 Ensembl dbSUPER 0.3 +40.2 40170 0.6 POLR2A ENSG00000249016 ESM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ESM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ESM1 gene promoter:
  • NF-kappaB1
  • NF-kappaB
  • POU2F1
  • POU2F1a
  • HTF
  • NF-kappaB2
  • HSF1 (long)
  • HSF1short

Genomic Locations for ESM1 Gene

Genomic Locations for ESM1 Gene
44,808 bases
Minus strand
44,808 bases
Minus strand

Genomic View for ESM1 Gene

Genes around ESM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESM1 Gene

Proteins for ESM1 Gene

  • Protein details for ESM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endothelial cell-specific molecule 1
    Protein Accession:
    Secondary Accessions:
    • B2R4G3
    • Q15330
    • Q3V4E3
    • Q96ES3

    Protein attributes for ESM1 Gene

    184 amino acids
    Molecular mass:
    20095 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ESM1 Gene


neXtProt entry for ESM1 Gene

Post-translational modifications for ESM1 Gene

Other Protein References for ESM1 Gene

No data available for DME Specific Peptides for ESM1 Gene

Domains & Families for ESM1 Gene

Gene Families for ESM1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ESM1 Gene

Suggested Antigen Peptide Sequences for ESM1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ESM1: view

No data available for UniProtKB/Swiss-Prot for ESM1 Gene

Function for ESM1 Gene

Molecular function for ESM1 Gene

UniProtKB/Swiss-Prot Function:
Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
UniProtKB/Swiss-Prot Induction:
By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4.
GENATLAS Biochemistry:
endothelial cell-specific molecule 1,restrictively expressed in lung tissue,regulated by TNF,IL1B and IFNG

Phenotypes From GWAS Catalog for ESM1 Gene

Gene Ontology (GO) - Molecular Function for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005171 hepatocyte growth factor receptor binding IPI 11590178
GO:0005178 integrin binding IPI 11544294
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with ESM1: view
genes like me logo Genes that share phenotypes with ESM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ESM1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ESM1 Gene

Localization for ESM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESM1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESM1 gene
Compartment Confidence
extracellular 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ESM1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ESM1 Gene

Pathways & Interactions for ESM1 Gene

SuperPathway Contained pathways
1 Gastric Cancer Network 1
genes like me logo Genes that share pathways with ESM1: view

Pathways by source for ESM1 Gene

1 BioSystems pathway for ESM1 Gene

Interacting Proteins for ESM1 Gene

Gene Ontology (GO) - Biological Process for ESM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001558 regulation of cell growth IEA --
GO:0002040 sprouting angiogenesis IMP 20616313
GO:0008284 positive regulation of cell proliferation IDA 11590178
GO:1902204 positive regulation of hepatocyte growth factor receptor signaling pathway IDA 11590178
genes like me logo Genes that share ontologies with ESM1: view

No data available for SIGNOR curated interactions for ESM1 Gene

Drugs & Compounds for ESM1 Gene

No Compound Related Data Available

Transcripts for ESM1 Gene

mRNA/cDNA for ESM1 Gene

Unigene Clusters for ESM1 Gene

Endothelial cell-specific molecule 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ESM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for ESM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ESM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ESM1 Gene

This gene is overexpressed in Kidney - Cortex (x9.5), Lung (x9.1), and Minor Salivary Gland (x7.6).

Protein differential expression in normal tissues from HIPED for ESM1 Gene

This gene is overexpressed in Blymphocyte (35.1), Tlymphocyte (21.0), and Neutrophil (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ESM1 Gene

Protein tissue co-expression partners for ESM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ESM1 Gene:


SOURCE GeneReport for Unigene cluster for ESM1 Gene:


mRNA Expression by UniProt/SwissProt for ESM1 Gene:

Tissue specificity: Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Evidence on tissue expression from TISSUES for ESM1 Gene

  • Nervous system(4.5)
  • Heart(4.4)
  • Lung(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with ESM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ESM1 Gene

Orthologs for ESM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ESM1 34 33
  • 99.82 (n)
(Bos Taurus)
Mammalia ESM1 34 33
  • 84.88 (n)
(Canis familiaris)
Mammalia ESM1 34 33
  • 83.24 (n)
(Mus musculus)
Mammalia Esm1 16 34 33
  • 80.87 (n)
(Rattus norvegicus)
Mammalia Esm1 33
  • 79.23 (n)
(Monodelphis domestica)
Mammalia ESM1 34
  • 68 (a)
(Gallus gallus)
Aves ESM1 34 33
  • 74.32 (n)
(Anolis carolinensis)
Reptilia ESM1 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia esm1 33
  • 69.8 (n)
(Danio rerio)
Actinopterygii esm1 34 33
  • 56.48 (n)
Species where no ortholog for ESM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESM1 Gene

Gene Tree for ESM1 (if available)
Gene Tree for ESM1 (if available)
Evolutionary constrained regions (ECRs) for ESM1: view image

Paralogs for ESM1 Gene

(1) SIMAP similar genes for ESM1 Gene using alignment to 2 proteins:

  • M0R154_HUMAN
genes like me logo Genes that share paralogs with ESM1: view

No data available for Paralogs for ESM1 Gene

Variants for ESM1 Gene

Sequence variations from dbSNP and Humsavar for ESM1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000254501 -- 54,979,692(-) A/C intron_variant
rs1000743008 -- 54,986,195(-) T/A upstream_transcript_variant
rs1001377369 -- 54,986,485(-) C/G upstream_transcript_variant
rs1001581135 -- 54,980,375(-) T/C intron_variant
rs1001665878 -- 54,980,984(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ESM1 Gene

Variant ID Type Subtype PubMed ID
nsv830301 CNV gain 17160897

Variation tolerance for ESM1 Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ESM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESM1 Gene

Disorders for ESM1 Gene

Additional Disease Information for ESM1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ESM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESM1 Gene

Publications for ESM1 Gene

  1. ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines. (PMID: 8702785) Lassalle P … Tonnel AB (The Journal of biological chemistry 1996) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. (PMID: 20616313) Brütsch R … Fischer A (Circulation research 2010) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. (PMID: 11025405) Bechard D … Lassalle P (Journal of vascular research 2000) 3 22 58

Products for ESM1 Gene

Sources for ESM1 Gene

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