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ESAM (Endothelial Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Cell surface interactions at the vascular wall. An important paralog of this gene is IGSF11.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 26607202 |
GO:0098632 | cell-cell adhesion mediator activity | IDA | 20298433 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005911 | cell-cell junction | IDA | 20298433 |
GO:0005912 | adherens junction | IEA | -- |
GO:0005923 | bicellular tight junction | IEA | -- |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell adhesion molecules (CAMs) | ||
2 | Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling | ||
3 | Integrin Pathway |
Transendothelial Migration of Leukocytes
.38
|
|
4 | Cell surface interactions at the vascular wall | ||
5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA | -- |
GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | IEA | -- |
GO:0030833 | regulation of actin filament polymerization | IDA | 20298433 |
GO:0034613 | cellular protein localization | IDA | 20298433 |
GO:0035633 | maintenance of permeability of blood-brain barrier | NAS | 30280653 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP7: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ESAM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ESAM 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ESAM 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Esam 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Esam 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ESAM 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ESAM 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ESAM 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ESAM 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | esam 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC562934 30 |
|
||
esamb 31 |
|
OneToMany | |||
esama 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
781240 | Benign: not provided | 124,754,349(-) | G/T | INTRON_VARIANT | |
rs12792040 | - | p.Arg273Cys |
No disorders were found for ESAM Gene.